Carbohydrate Polymers最新文献_第9页

Advanced therapeutic strategies using Thermo-sensitive chitosan/pectin hydrogel in the treatment of multiple cancers

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-27 DOI: 10.1016/j.carbpol.2025.123454

Tosha Pandya , Disha Joshi , Zenab Presswala , Mangesh Kulkarni , Riya Patel , Shivani Patel , Sankha Bhattacharya , Bhupendra G. Prajapati

{"title":"Advanced therapeutic strategies using Thermo-sensitive chitosan/pectin hydrogel in the treatment of multiple cancers","authors":"Tosha Pandya , Disha Joshi , Zenab Presswala , Mangesh Kulkarni , Riya Patel , Shivani Patel , Sankha Bhattacharya , Bhupendra G. Prajapati","doi":"10.1016/j.carbpol.2025.123454","DOIUrl":"10.1016/j.carbpol.2025.123454","url":null,"abstract":"<div><div>Current cancer therapies including immunotherapy and chemotherapy produce adverse side effects that demand improved drug distribution methods. Research shows that thermosensitive chitosan/pectin-based hydrogels serve as an effective platform technology for drug delivery during cancer therapy because of their ability to control drug release at specific locations. The hydrogels perform temperature-triggered sol-gel phase shifts which enables prolonged drug delivery together with minimal toxic side effects. The biocompatible and biodegradable properties of these materials enable solutions against drug resistance and tumour heterogeneity challenges. Studies have demonstrated that these hydrogels enhance drug bioavailability, extend circulation time, and improve tumour targeting, leading to increased therapeutic efficacy and reduced systemic toxicity. Their ability to sustain drug release and penetrate tumour microenvironments makes them a promising strategy for overcoming drug resistance and tumour heterogeneity. Their ability to reproduce native tissue properties poses challenges that scientists must address through improved structural optimization approaches. The combination of latest nanotechnology innovations and interdisciplinary studies has sped up the creation of chitosan/pectin hydrogels for cancer treatment applications. This review highlights the significant advancements and demonstrated effectiveness of thermosensitive chitosan/pectin hydrogels in cancer treatment by exploring their design parameters alongside their drug release behaviour while discussing their potential medical applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123454"},"PeriodicalIF":10.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose self-erasing material with dual functions in information encryption 具有信息加密双重功能的纤维素自硬化材料

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-26 DOI: 10.1016/j.carbpol.2025.123444

Hui Liu, Yi Lu, Bitao Peng, Jingxian Wei, Hongli Dai, Lei Wang, Hongxiang Zhu, Hui He

{"title":"Cellulose self-erasing material with dual functions in information encryption","authors":"Hui Liu, Yi Lu, Bitao Peng, Jingxian Wei, Hongli Dai, Lei Wang, Hongxiang Zhu, Hui He","doi":"10.1016/j.carbpol.2025.123444","DOIUrl":"10.1016/j.carbpol.2025.123444","url":null,"abstract":"<div><div>Materials capable of multiple encryption, color-changing visualizations, and time-dependent functionalities are ideal for efficient and secure information storage and transmission. In this study, a time-dependent self-erasing material (TDSEM) containing urease developed through the in-situ synthesis of gold nanoclusters on the surface of cellulose nanocrystal (CNC) chemically bonding fluorescein isothiocyanate. CNC not only played an important role as a long-term stabilizer for the material, but also acted as a bridge facilitating the assembly of organic and inorganic interfaces, enabling the integrated system to achieve multi-color regulation and fluorescence resonance energy transfer. The TDSEM demonstrated excellent pH responsiveness, cyclic stability, and durability. The information was encoded by directly introducing HCl/urea into the TDSEM, and automatically erased over time. Additionally, the fluorescence intensity and color (transitioning from red to orange to green) were modulated over a time scale by adjusting the urea concentration, thus precisely controlling the time to retrieve the correct information (22 min). The confidentiality of the encoded information was enhanced by dual “locking” of time and color, ensuring that decryption only occurred “time color key”. This time-dependent and color-varying dual functions provide valuable insights for the development of advanced information encryption and anti-counterfeiting technologies.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123444"},"PeriodicalIF":10.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double-layer skin equivalents as diffusion models for topical and transdermal drug delivery studies

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-26 DOI: 10.1016/j.carbpol.2025.123446

Runze Zhou , Zhi Xiao , Tianchi Lu , Yaqi Zhang , Ting Liu , Liping Hu , Xing Lu , Feifei Wang , Luyong Zhang , Huixia Lv

{"title":"Double-layer skin equivalents as diffusion models for topical and transdermal drug delivery studies","authors":"Runze Zhou , Zhi Xiao , Tianchi Lu , Yaqi Zhang , Ting Liu , Liping Hu , Xing Lu , Feifei Wang , Luyong Zhang , Huixia Lv","doi":"10.1016/j.carbpol.2025.123446","DOIUrl":"10.1016/j.carbpol.2025.123446","url":null,"abstract":"<div><div><em>In vitro</em> permeation test (IVPT) is a critical part of the prescription screening and evaluation of topical/transdermal drug delivery systems, in which <em>ex vivo</em> human skin or animal skin are generally used as skin membranes. The development of skin equivalents to replace animal/ human skins has high scientific and industrial value owing to the issues such as ethical issues and large variability of real skin. Here, a double-layer skin equivalent (DSE) containing both dermal-simulating structure and epidermal barrier function was developed. The dermal structure was composed of photo-crosslinked glycosaminoglycan, calcium alginate and gelatin; while the epidermal barrier-simulating structure was an electrospun nano-polyurethane-membrane. Mainly contributed to the synergistic effect of polysaccharide and protein composites, the formed DSE had similar compression modulus to that of real full-layer skin. Most of all it exhibited high correlation and similar transdermal drug release behavior with mini-porcine skin for three model drugs with different Log P. The DSE also showed comparable kinetic model fitting results to mini-porcine skin and exhibited a closer resemblance to porcine skin than other skin equivalents reported. Moreover, the penetration resisting ability of the DSE can be adjusted by adjusting the formulation to simulate different types of skin.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123446"},"PeriodicalIF":10.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-Cyclodextrin/resistant dextrin induced disparate gelling behaviors of high-protein liquid systems

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-26 DOI: 10.1016/j.carbpol.2025.123442

Junwei Zhang , Ruitao Zhu , Bowen Zou , Xiaohan Zheng , Rui Zhang , Xiaokang Na , Xianbing Xu , Ming Du , Chao Wu

{"title":"β-Cyclodextrin/resistant dextrin induced disparate gelling behaviors of high-protein liquid systems","authors":"Junwei Zhang , Ruitao Zhu , Bowen Zou , Xiaohan Zheng , Rui Zhang , Xiaokang Na , Xianbing Xu , Ming Du , Chao Wu","doi":"10.1016/j.carbpol.2025.123442","DOIUrl":"10.1016/j.carbpol.2025.123442","url":null,"abstract":"<div><div>High-protein, high-fiber foods are in the spotlight because of their health properties. Due to aggregation during heat treatment when dietary fiber is added, the amount of soy protein that can be used in the formulation of high-protein, high-fiber foods is limited. The effects of two types of soluble dietary fibers, β-cyclodextrin (β-CD) and resistant dextrin (RD), on the tunable thermal stability of soy proteins (SPs) and preheat-modified soy protein particles (SPPs), as well as the underlying mechanisms, were investigated. Results showed that β-CD (0.5–3.0 %, <em>w</em>/<em>v</em>) weakened the gels and introduced some degree of mobility, while RD (0.5–3.0 %, w/v) increased the gel strength and viscoelastic properties of SP and SPP gels. Dynamic light scattering analysis revealed that β-CD mitigated the increase in particle size of SPs and SPPs during heating, delaying gel formation at high protein concentrations. In contrast, RD promoted protein agglomeration into larger particles, speeding up the gelation process. Structural analysis revealed that β-CD preserved the integrity of protein structure, while RD promoted the unfolding of protein structure, leading to protein cross-links and aggregation formation. In summary, the effect of β-CD and RD on soy protein thermal stability provides valuable insights for developing new health-focused, high-protein, high-fiber products.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123442"},"PeriodicalIF":10.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on research advances in efficient approaches to augment hydrothermal techniques for starch functionalization: Mechanisms, properties and potential food applications

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-26 DOI: 10.1016/j.carbpol.2025.123441

Cherakkathodi Sudheesh , Saju Pillai

{"title":"A review on research advances in efficient approaches to augment hydrothermal techniques for starch functionalization: Mechanisms, properties and potential food applications","authors":"Cherakkathodi Sudheesh , Saju Pillai","doi":"10.1016/j.carbpol.2025.123441","DOIUrl":"10.1016/j.carbpol.2025.123441","url":null,"abstract":"<div><div>The applications of hydrothermally modified starches in conventional water media, such as distilled water (DW), are limited due to their poor performance. Therefore, researchers are introducing innovative techniques in various environments, including ethanol solutions, salt solutions, acidic or alkaline conditions, plasma-activated water (PAW), and hydrogen-infused water (HW), to enhance the efficiency of annealing (ANN) and heat moisture treatment (HMT). The present review discusses these new approaches aimed at improving the performance of ANN and HMT, their potential mechanisms for starch modification, the resulting changes in the functional properties of starch, and their role in various food applications. Additionally, it systematically elucidates the challenges, opportunities, and future directions in this field. Unlike classical water-based ANN or HMT, innovative and sustainable approaches adopted for hydrothermal methods drastically enhance the structural stability, resistance to digestive enzymes, and low-temperature storage stability of starch. However, these changes depend on controlled parameters, such as the concentration of ethanol or salt, pH of the medium, incubation time, moisture level, treatment temperature, and starch properties (e.g., amylose/amylopectin ratio) during treatment. This consolidated report on cutting-edge techniques designed to enhance the effectiveness of hydrothermal modifications seeks to expand the potential applications of ANN and HMT in food-grade products.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123441"},"PeriodicalIF":10.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-situ synthesis of magnetic nanoparticles/wood-structural holocellulose hybrid for metal ions adsorption

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-25 DOI: 10.1016/j.carbpol.2025.123436

Yiyu Long , Jingxiang Zhang , Huiyang Bian , Tingting Xu , Shumei Wang , Hongqi Dai , Ying Gao

{"title":"In-situ synthesis of magnetic nanoparticles/wood-structural holocellulose hybrid for metal ions adsorption","authors":"Yiyu Long , Jingxiang Zhang , Huiyang Bian , Tingting Xu , Shumei Wang , Hongqi Dai , Ying Gao","doi":"10.1016/j.carbpol.2025.123436","DOIUrl":"10.1016/j.carbpol.2025.123436","url":null,"abstract":"<div><div>Effective removal of metal ions from water is crucial for reducing pollution during manufacturing processes. To address this issue, we have developed a block Fe<sub>3</sub>O<sub>4</sub>/wood-structural holocellulose hybrids (MW) for removing heavy metal ions from industrial wastewater. By employing chemical pretreatment, solvent-induced self-impregnation, and <em>in-situ</em> deposition, Fe<sub>3</sub>O<sub>4</sub> nanoparticles were attached into the cell's lumen while also embedded within the cell walls, achieving a loading capacity of 35.89 %. The MW exhibited notable magnetic responsiveness. Adsorption experiments were then conducted to evaluate the performance of MW in adsorbing Pb<sup>2+</sup>, and the adsorption mechanism was elucidated based on density functional theory (DFT) calculations. The results demonstrated that MW exhibited high adsorption efficiency for Pb<sup>2+</sup> (537.63 mg/g), This is primarily attributed to the porous structure of MW and the interactions among -COOH, -OH, and Fe<img>O<img> groups within the structure with Pb<sup>2+</sup>. The adsorption process followed the pseudo-second-order kinetic model and the Langmuir isotherm model. After three consecutive reuse cycles, the adsorption capacity remaining at 77.62 % after three cycles. Furthermore, DFT calculations indicated that the composite of Fe<sub>3</sub>O<sub>4</sub> and cellulose could enhance the adsorption energy between Pb<sup>2+</sup> and MW. This indicates that MW offers high adsorption, recyclability, and magnetic control, making it a promising material for wastewater treatment.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123436"},"PeriodicalIF":10.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking natural biomineralization enabling biodegradable and highly lipophobic alginate hydrogels

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-25 DOI: 10.1016/j.carbpol.2025.123438

Xiaowen Huang , Wenwen Yu , Weinan Gu , Shumin Liang , Limin Zhou , Lidong Zhang

引用次数: 0

Tailoring pore structure in nanocellulose cryogels: Enhancing thermal and electromagnetic interference shielding properties 定制纳米纤维素低温凝胶中的孔隙结构：增强热屏蔽和电磁干扰屏蔽性能

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-25 DOI: 10.1016/j.carbpol.2025.123435

Majed Amini , Ali Akbar Isari , Shayan Ghasemi , Gabriel Banvillet , Orlando J. Rojas , Milad Kamkar , Mohammad Arjmand

{"title":"Tailoring pore structure in nanocellulose cryogels: Enhancing thermal and electromagnetic interference shielding properties","authors":"Majed Amini , Ali Akbar Isari , Shayan Ghasemi , Gabriel Banvillet , Orlando J. Rojas , Milad Kamkar , Mohammad Arjmand","doi":"10.1016/j.carbpol.2025.123435","DOIUrl":"10.1016/j.carbpol.2025.123435","url":null,"abstract":"<div><div>Engineering porosity levels in hierarchical cryogels presents an exciting opportunity for advancing electromagnetic interference (EMI) shielding materials. This study introduces a feasible approach to tailoring micro-scale morphology in cellulose nanofiber (CNF)-based cryogels by simply adjusting the freeze-templating temperature, resulting in tunable porosity and enhanced performance characteristics. By varying the freeze-templating temperature, we successfully controlled pore size (ranging from 31 to 178 μm), which influenced the mechanical strength (decreasing from 59 to 14 kPa). To explore the effect of micro-scale porosity on the EMI shielding performance, we rendered the CNF cryogels conductivity upon integrating poly(3,4-ethylenedioxythiophene) (PEDOT) with the cryogels framework via chemical vapor polymerization. Our results demonstrate that the larger pore sizes promoted an absorption-dominant EMI shielding mechanism, with an average absorbance (A) of 0.59 across the X-band frequency range. A specific EMI shielding effectiveness (SSE/t) of 4801.25 dB cm<sup>2</sup> g<sup>−1</sup> was achieved for samples with larger porosities, highlighting the decent performance of these engineered cryogels. Our findings reveal a straightforward yet effective strategy for optimizing porosity to achieve appreciable shielding effectiveness, contributing to the advancement of sustainable, high-performance EMI shielding solutions.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"357 ","pages":"Article 123435"},"PeriodicalIF":10.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of TEMPO-partially oxidized sodium alginate/SF scaffolds with degradation compatibility for skin defect repair

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-25 DOI: 10.1016/j.carbpol.2025.123437

Xinxin Zhao , Wenyuan Wang , Bo Cheng , Binbin Li , Tong Qiu , Lesan Yan , Xinyu Wang

引用次数: 0

Editorial: The 5th International Cellulose Conference (ICC2022+1, Hiroshima)

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-02-24 DOI: 10.1016/j.carbpol.2025.123432

Tomoya Imai, Tadahisa Iwata, Hiroshi Kamitakahara, Tetsuo Kondo

引用次数: 0