Carbohydrate Polymers最新文献_第8页

Gut microbiota-mediated immunomodulation underlies the anti-tumor effects of a novel ginseng polysaccharide 肠道微生物介导的免疫调节是一种新型人参多糖抗肿瘤作用的基础

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-24 DOI: 10.1016/j.carbpol.2025.124458

Chaoyu Li , Shengjin Zhou , Siyu Chen , Zhen Xu , Qinbing Xue , Hao Wang , Ting Liu , Wei Chen , Jie Feng , Jingjing Chen , Miao Yu , Bing Wang , Zheng Qi

{"title":"Gut microbiota-mediated immunomodulation underlies the anti-tumor effects of a novel ginseng polysaccharide","authors":"Chaoyu Li , Shengjin Zhou , Siyu Chen , Zhen Xu , Qinbing Xue , Hao Wang , Ting Liu , Wei Chen , Jie Feng , Jingjing Chen , Miao Yu , Bing Wang , Zheng Qi","doi":"10.1016/j.carbpol.2025.124458","DOIUrl":"10.1016/j.carbpol.2025.124458","url":null,"abstract":"<div><div>A novel ginseng polysaccharide (GP-A) was investigated for its immune modulation and anti-tumor effects in an S180 sarcoma mouse model. GP-A, with a molecular weight of 1.121 × 10<sup>4</sup> g/mol, primarily consists of a polysaccharide main chain formed by →4)-α-D-Glc<em>p</em>-(1 → sugar residues, along with 1,3,5-Ara<em>f</em> and 1,5-Ara<em>f</em> side chains. In vivo, GP-A improved immune organ recovery and serum cytokine levels, restoring immune balance by downregulating IL-10 and upregulating TNF-α and IL-6. GP-A enhanced IL-6-mediated PI3K/AKT signaling, promoting splenic immune cell proliferation and activation, thereby improving the host's anti-tumor immune response and inhibiting tumor cell proliferation. Oral administration of GP-A (100, 200, 400 mg/kg) for 10 days significantly reduced tumor size, volume, and weight, with the 400 mg/kg group achieving a 66.52 % tumor inhibition rate (96.91 % in the CTX group). Additionally, GP-A improved gut microbiota dysbiosis induced by the tumor, increasing <em>Lactobacillus</em> abundance while decreasing <em>Alloprevotella</em> and <em>Bacteroides</em>. It also elevated short-chain fatty acid (SCFA) levels, particularly propionate and butyrate, maintaining gut microecological balance. GP-A exhibited milder and safer immune modulation, suggesting its potential as a novel immune modulator for cancer therapy.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124458"},"PeriodicalIF":12.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose nanofibril-enhanced strong ionic gel with dynamic hydrogen bonds for cryogenic and dehydration-resistant tactile sensing 具有动态氢键的纤维素纳米纤维增强强离子凝胶，用于低温和抗脱水触觉传感

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-23 DOI: 10.1016/j.carbpol.2025.124454

Shibo Feng , Jiale Tan , Yongmao Li , Wenjing Yuan , Wei Yu , Guoxian Li , Chuizhou Meng , Shijie Guo

{"title":"Cellulose nanofibril-enhanced strong ionic gel with dynamic hydrogen bonds for cryogenic and dehydration-resistant tactile sensing","authors":"Shibo Feng , Jiale Tan , Yongmao Li , Wenjing Yuan , Wei Yu , Guoxian Li , Chuizhou Meng , Shijie Guo","doi":"10.1016/j.carbpol.2025.124454","DOIUrl":"10.1016/j.carbpol.2025.124454","url":null,"abstract":"<div><div>The growing demand for high-performance tactile sensors in flexible electronics, such as electronic skins, robots, and wearable devices, has highlighted the need for robust ionic conductors. While traditional hydrogels, organogels, and ionogels are commonly used, their performance is often compromised under extreme conditions like freezing and dehydration. Here, we present a hydrogen bonds reinforced ionic gel, synthesized via a simple casting process using polyvinyl alcohol (PVA), cellulose nanofibril (CNF), and phytic acid (PA) (PVA-CNF-PA gels). The ionic gel demonstrates superior ionic conductivity (0.352 S m<sup>−1</sup>), exceptional stretchability (860 % elongation at break), strong (up to 36.4 MPa), and remarkable environmental stability. Notably, it maintains 0.161 S m<sup>−1</sup> conductivity at −20 °C and >99 % mass retention after 120 days in ambient conditions. When integrated into supercapacitive pressure sensors, PCPGs exhibits a broad sensing range (20 Pa-400 kPa) and high sensitivity (3.5 MPa<sup>−1</sup>), functioning reliably under harsh environmental conditions. These findings position PVA-CNF-PA gels as a promising material for next-generation flexible sensors and ionic conductors.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124454"},"PeriodicalIF":12.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambient dried cellulose paper- based sandwich structural composite with broadband, low reflective, and high EMI shielding efficiency 环境干燥纤维素纸基夹层结构复合材料，具有宽带、低反射和高电磁干扰屏蔽效率

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-23 DOI: 10.1016/j.carbpol.2025.124455

Chunxia Tang , Jian Liu , Yifan Wang , Yunshan Mao , Kaishuang Zhang , Shaohai Fu

{"title":"Ambient dried cellulose paper- based sandwich structural composite with broadband, low reflective, and high EMI shielding efficiency","authors":"Chunxia Tang , Jian Liu , Yifan Wang , Yunshan Mao , Kaishuang Zhang , Shaohai Fu","doi":"10.1016/j.carbpol.2025.124455","DOIUrl":"10.1016/j.carbpol.2025.124455","url":null,"abstract":"<div><div>Most reported shielding materials exhibit reflection-dominated shielding mechanisms, which further leads to the secondary electromagnetic radiation contamination. This work reports a low reflective and scalable cellulose paper- based EMI shielding composite (ACMA) with a sandwich structure <em>via</em> assembling of the MXene containing aerogel layer, MXene coated paper (MP) layer, and highly conductive AgNWs/CNF film (AC) layer in a conductivity gradient. The shielding performances and mechanisms of each layer, AC-MP bi-layer, and AC-MP-aerogel tri-layer are investigated. Results show that the AC film could significantly increase the EMI SE of MP but produce super high R coefficient (0.92). The aerogel layer is effective in decreasing the R coefficient, which is correlated with its MXene content and thickness. The ACMA yields an average EMI SE of 71.46 dB and ultralow R coefficient of 0.1 in the X band when the aerogel has a MXene/BC of 90 % and a thickness of 2.6 mm. A large size ACMA is showcased, and it achieves an average EMI SE ranging from 56.82 dB to 75.85 dB in 2–18 GHz and an absorption- dominated shielding mechanism in 8–18 GHz. In addition, the ACMA also demonstrates excellent thermal camouflage property as the aerogel layer contacts the object.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124455"},"PeriodicalIF":12.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of elevated atmospheric CO2 on hybrid rice (Oryza sativa L.) starch granules: Structural, functional changes and their underlying causes 大气CO2浓度升高对杂交水稻淀粉颗粒的影响：结构、功能变化及其原因

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-23 DOI: 10.1016/j.carbpol.2025.124419

Liquan Jing , Xi Gong , Yang Cai , Yu Su , Mohamed Ait-El-Mokhtar , Mingxing Lu , Zhuo wang , Lianxin Yang , Qing Han , Yunxia Wang

{"title":"Effects of elevated atmospheric CO2 on hybrid rice (Oryza sativa L.) starch granules: Structural, functional changes and their underlying causes","authors":"Liquan Jing , Xi Gong , Yang Cai , Yu Su , Mohamed Ait-El-Mokhtar , Mingxing Lu , Zhuo wang , Lianxin Yang , Qing Han , Yunxia Wang","doi":"10.1016/j.carbpol.2025.124419","DOIUrl":"10.1016/j.carbpol.2025.124419","url":null,"abstract":"<div><div>Elevated atmospheric CO<sub>2</sub> (E-CO<sub>2</sub>) intensifies climate change impacts on crops. Hybrid rice, valued for high yield, is crucial for starch production, yet the influences of E-CO<sub>2</sub> on its starch properties remain unclear. Using a free-air CO<sub>2</sub> enrichment system, we investigated two hybrid rice cultivars (YY538 and YLY900) to understand E-CO<sub>2</sub>-induced changes in starch physicochemical properties and formation mechanisms. E-CO<sub>2</sub> significantly increased the proportion of large-volume (+3.1 %) and large-surface-area (+3.0 %) starch granules, the long-branch-chain proportion (+6.3 %) in amylopectin, double helices (+4.1 %), and crystallinity (+4.7 %), greatly altering starch morphology and molecular structures. Consequently, starch functionality changed accordingly: breakdown, Δ<em>H</em>gel, Δ<em>H</em>ret, and transition temperature rose by 26.3 %, 8.5 %, 74.5 %, and 1.04 °C, respectively, while setback decreased by 39.7 %, yielding softer rice (−21.1 % hardness) and better taste. These changes aligned with higher GBSS (+32.8 %), α/β-amylase (+12.3 %–13.5 %), SSS activity (+27.0 %), and a 47.3 % upregulation of <em>OsGBSS1</em>. Indica-hybrid YLY900 responded more strongly than japonica-hybrid YY538 in most cases, highlighting cultivar-specific adaptation to E-CO<sub>2</sub>-rich climates. Analysis indicates E-CO<sub>2</sub>-induced changes in starch structure and function stem from enhanced gene expression and enzyme activities, with most traits significantly correlated with ethylene production rate. These findings suggest that despite improved taste, future E-CO<sub>2</sub> climates may require more energy for starch processing.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124419"},"PeriodicalIF":12.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the use of ToF-SIMS for analysis of glycosaminoglycans ToF-SIMS用于糖胺聚糖分析的验证

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-23 DOI: 10.1016/j.carbpol.2025.124415

Lorna K. Milne , Arya Ajay D/O Ajayakumar , Imogen L. Holyland , Anna M. Kotowska , John Hogwood , Elaine Gray , Barbara Mulloy , Catherine L.R. Merry , Andrew L. Hook

{"title":"Validation of the use of ToF-SIMS for analysis of glycosaminoglycans","authors":"Lorna K. Milne , Arya Ajay D/O Ajayakumar , Imogen L. Holyland , Anna M. Kotowska , John Hogwood , Elaine Gray , Barbara Mulloy , Catherine L.R. Merry , Andrew L. Hook","doi":"10.1016/j.carbpol.2025.124415","DOIUrl":"10.1016/j.carbpol.2025.124415","url":null,"abstract":"<div><div>Glycosaminoglycans (GAGs) have a range of biological roles and are of particular interest for their pharmaceutical efficacy and their potential as biomarkers or drug targets. Heparin, used globally as an anticoagulant and an antithrombotic, is predominantly derived from porcine sources but bovine and ovine sources are increasingly being considered to reduce the substantial risk of reliance on a single animal species. However, high sensitivity chemical discrimination of heparins from different species is a significant analytical challenge. In this study ToF-SIMS analysis of GAGs is investigated as a methodology to achieve specific chemical discrimination between GAGs of different types and heparins from different animal sources. The ToF-SIMS data acquisition is relatively fast (≈1 min per sample) and requires minimal sample amounts (75 pg of sample analysed). Multivariate analysis (MVA) models enabled high selectivity between GAG type and animal source of heparin, and for the high sensitivity detection of GAG-contaminants within porcine derived heparin. Contaminants are detected down to 0.001 wt%, with the exception of ovine derived heparin where differences could be detected to 0.01 wt%. Assessments of specificity, precision, robustness and quantification limits are conducted to validate the approach for heparin analysis.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124415"},"PeriodicalIF":12.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous chitin powder decorated with ZIF-8-derived nanozyme for diabetic infected wound healing zif -8纳米酶修饰多孔几丁质粉末用于糖尿病感染创面愈合

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-22 DOI: 10.1016/j.carbpol.2025.124440

Xinxiong Wang , Haojie Qiu , Zhongrun Xiang , Longxiang Tang , Huiqing Wang , Lei Xue , Xuefeng Yang

{"title":"Porous chitin powder decorated with ZIF-8-derived nanozyme for diabetic infected wound healing","authors":"Xinxiong Wang , Haojie Qiu , Zhongrun Xiang , Longxiang Tang , Huiqing Wang , Lei Xue , Xuefeng Yang","doi":"10.1016/j.carbpol.2025.124440","DOIUrl":"10.1016/j.carbpol.2025.124440","url":null,"abstract":"<div><div>Due to the hyperglycemic environment, diabetic wounds are highly susceptible to bacterial infections, facilitating their progression to chronic, non-healing wounds. Consequently, there is an urgent need to develop wound dressings capable of reducing wound glucose levels and exerting strong antibacterial activities. In this study, a ZIF-8/Au-GOx (ZAG) nanozyme was grown <em>in situ</em> on fluffy chitin (FC) powder by integrating zeolitic imidazolate framework-8 (ZIF-8), glucose oxidase (GOx), and Au nanoparticles, leading to the development of a multifunctional wound dressing (FC/ZAG) for diabetic wound therapy. Benefiting from the cascade catalytic effect of the loaded ZAG nanozyme, FC/ZAG demonstrated a remarkable hypoglycemic activity and potent antibacterial properties. Additionally, owing to the biocompatibility of FC and the sustained release of Zn<sup>2+</sup>, the FC/ZAG powder exhibited a superior safety profile. In experiments in a mouse model of diabetic wound healing, FC/ZAG exerted significant anti-inflammatory and pro-angiogenic effects, accelerating the healing process of diabetic wounds. These findings highlight the high potential of FC/ZAG as a promising candidate for the development of advanced diabetic wound dressings.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124440"},"PeriodicalIF":12.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of pullulanase and α-amylase on starch-glyceryl monostearate interactions and digestibility in extruded rice flour 普鲁兰酶和α-淀粉酶对挤压米粉中淀粉-单硬脂酸甘油相互作用和消化率的协同作用

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-22 DOI: 10.1016/j.carbpol.2025.124449

Aiquan Jiao , Shiming Zhou , Qingyue Liu , Qing Liu , Yueyue Yang , Zhengyu Jin

{"title":"Synergistic effects of pullulanase and α-amylase on starch-glyceryl monostearate interactions and digestibility in extruded rice flour","authors":"Aiquan Jiao , Shiming Zhou , Qingyue Liu , Qing Liu , Yueyue Yang , Zhengyu Jin","doi":"10.1016/j.carbpol.2025.124449","DOIUrl":"10.1016/j.carbpol.2025.124449","url":null,"abstract":"<div><div>Amylose produced by hydrolysis of the α-1,6 glycosidic bond in starch by pullulanase can form antidigestive V-type complexes with lipids, however its hydrolysis in grain systems is very limited. In this study, α-amylase assisted pullulanase was used to debranch rice flour (RF) in the first extrusion to produce amylose, and the effect of 2 %–8 % glyceryl monostearate (MG) on the structure, physicochemical and digestive properties of debranched RF was investigated in the second extrusion. The amylose content and chain length distribution results showed an increase in amylose content of 201.65 % compared to RF, as well as a shortening of chain length. The solubility and swelling power exhibited a decreasing trend followed by an increase with increasing MG content, reaching their lowest values at 6 %. The extruded rice flour-monoglyceride complexes (EERF-MG) exhibited V-shaped structures with a higher degree of integral intensity than RF. Thermal characterisation revealed that the thermal stability of all samples decreased following extrusion. The RS content of the EERF-MG increased significantly, with the addition of 6 % MG exhibiting the highest RS content of 60.22 %. Overall, extrusion conditioning using dual enzymes and co-processing with monoglyceride complexes significantly improved the anti-digestibility of RF, making it suitable for continuous industrial production.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124449"},"PeriodicalIF":12.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the effect of Litsea pungens Hemsl. oil (LPHO) with different crystalline starches complexed on flavor release and structural properties 山茱萸的药理作用研究。不同结晶淀粉对油脂香味释放和结构特性的影响

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-22 DOI: 10.1016/j.carbpol.2025.124452

Yimeng Shan , Jiaxin Li , Yang Li , Yue Zhang , Fengzhong Wang , Li-Tao Tong

{"title":"Elucidating the effect of Litsea pungens Hemsl. oil (LPHO) with different crystalline starches complexed on flavor release and structural properties","authors":"Yimeng Shan , Jiaxin Li , Yang Li , Yue Zhang , Fengzhong Wang , Li-Tao Tong","doi":"10.1016/j.carbpol.2025.124452","DOIUrl":"10.1016/j.carbpol.2025.124452","url":null,"abstract":"<div><div><em>Litsea pungens</em> Hemsl. Oil possesses a distinctive flavor and notable bioactivity. Differences in the crystalline structure of different types of starch affect the interaction with the flavor. In this study, three different crystalline starches (corn starch (type A), rice starch (type A) potato starch (type B) and pea starch (type C)) were used to encapsulate LPHO to form a complex: COS-L, RIS-L, POS-L and PES-L, respectively. COS-L exhibited the highest encapsulation efficiency (46.27 % ± 2.36 %), flavor retention (84.26 % ± 1.53 %), and complexation index (23.71 % ± 0.21 %). COS-L showed smaller release rates and relatively high storage stability. Sensory evaluation and GC–MS analysis verified that COS-L has better flavor retention. The structural characterization results indicate that COS-L and RIS-L form a V-type crystal structure, while starch and LPHO in POS-L and PES-L showed limited tendency to form V-type crystal structures. Molecular dynamics simulations showed that complexation between key aromatic compounds in LPHO and starch facilitated the establishment of intramolecular hydrogen bonds in the starch molecule, resulting in the formation of a stable V-type structure. The study elucidates the differences in the structure and properties of the complexes that are formed from different starches with LPHO, and elucidates the process of formation of V-type complexes in the complexes.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124452"},"PeriodicalIF":12.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Structural and site-specific N-glycan alterations define the glycoproteomic landscape of thymic aging in rats 结构和位点特异性n -聚糖改变定义了大鼠胸腺衰老的糖蛋白组学景观

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-22 DOI: 10.1016/j.carbpol.2025.124447

Zhida Zhang , Ke Hou , Mengyu Liu , Tong Li , Muyao Yang , Han Hao , Zhuangzhuang Feng , Yongqi Wu , Ye Zhao , Shisheng Sun

{"title":"Structural and site-specific N-glycan alterations define the glycoproteomic landscape of thymic aging in rats","authors":"Zhida Zhang , Ke Hou , Mengyu Liu , Tong Li , Muyao Yang , Han Hao , Zhuangzhuang Feng , Yongqi Wu , Ye Zhao , Shisheng Sun","doi":"10.1016/j.carbpol.2025.124447","DOIUrl":"10.1016/j.carbpol.2025.124447","url":null,"abstract":"<div><div>Thymic aging is a hallmark of immune senescence and systemic physiological decline, yet its underlying molecular mechanisms remain incompletely understood. In this study, we performed a high-resolution glycoproteomic analysis of the aging rat thymus by integrating with quantitative global and phospho-proteome datasets. By identifying 484 upregulated and 866 downregulated site-specific <em>N</em>-glycans after eliminating their protein expression changes, the study revealed four major age-associated glycan feature patterns, including markedly reduced oligo-mannose glycans, significantly increased LacdiNAc glycans with a strong correlation with elevated GalNAc-binding protein MGL, predominantly upregulated Neu5Ac-modified glycopeptides along with largely downregulated Neu5Gc-modified glycopeptides occurring at distinct glycoproteins for different immune processes, as well as upregulated bisecting <em>N</em>-glycans with core-fucosylation (Core-IV). Aging-related glycosylation remodeling is largely driven by altered glycosylation-related enzymes, as well as modulates immune and aging-related signaling pathways. Together, these findings highlight the functional importance of glycosylation in thymic aging and establish a high-resolution molecular map of glycosylation dynamics as a valuable resource for investigating immune decline and age-related diseases.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124447"},"PeriodicalIF":12.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments in polysaccharide-based conductive hydrogels: A review and perspective 多糖基导电水凝胶研究进展综述与展望

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-22 DOI: 10.1016/j.carbpol.2025.124453

Lijun Liu , Yanbo Wang , Xianwei Li , Ping Li , Yizhi Jin , Hongli Yu , Meixing Yan , Yuan Hu

{"title":"Recent developments in polysaccharide-based conductive hydrogels: A review and perspective","authors":"Lijun Liu , Yanbo Wang , Xianwei Li , Ping Li , Yizhi Jin , Hongli Yu , Meixing Yan , Yuan Hu","doi":"10.1016/j.carbpol.2025.124453","DOIUrl":"10.1016/j.carbpol.2025.124453","url":null,"abstract":"<div><div>Polysaccharides, as naturally occurring, bioactive, and environmentally degradable polymers, have garnered increasing attention in the development of hydrogel materials. Their remarkable electrical conductivity and outstanding biocompatibility have led to numerous applications for polysaccharide-derived conductive hydrogels in the field of wound healing. This review highlights recent advancements in this area, beginning with an overview of polysaccharide-based conductive hydrogel materials, which include chitosan-based, cellulose-based, starch-based, cyclodextrin-based, alginate-based, and hyaluronic acid-based conductive hydrogels. Furthermore, the review discusses the key characteristics of these hydrogels. Representative applications of polysaccharide-based conductive hydrogels at various stages of wound healing are summarized, including antibacterial effects during the inflammatory phase, promotion of cell migration and proliferation, and applications in scar repair. Finally, the review addresses current challenges and provides guidance for future research, aiming to advance the field of polysaccharide-based conductive hydrogels in wound healing.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124453"},"PeriodicalIF":12.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0