Carbohydrate Polymers最新文献_第8页

Beyond convention: Construction of β-cyclodextrin-based shape-changing particles capable of light-responsive control and bioactivity application 超越常规：基于β-环糊精的可光响应控制和生物活性应用的形状变化颗粒的构建

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-12 DOI: 10.1016/j.carbpol.2025.123733

Pu-Ying Qi , Li-Hong Shi , Zhi-Cheng Zheng , Fu-Mei Feng , Tai-Hong Zhang , Rong-Shuang Luo , Shuai Tan , A-Ling Tang , Hou-Yun Huang , Xiang Zhou , Hong-Mei Xiang , Li-Wei Liu , Song Yang

{"title":"Beyond convention: Construction of β-cyclodextrin-based shape-changing particles capable of light-responsive control and bioactivity application","authors":"Pu-Ying Qi , Li-Hong Shi , Zhi-Cheng Zheng , Fu-Mei Feng , Tai-Hong Zhang , Rong-Shuang Luo , Shuai Tan , A-Ling Tang , Hou-Yun Huang , Xiang Zhou , Hong-Mei Xiang , Li-Wei Liu , Song Yang","doi":"10.1016/j.carbpol.2025.123733","DOIUrl":"10.1016/j.carbpol.2025.123733","url":null,"abstract":"<div><div>Environmentally triggered major phenomenological switching, including in shape, size, or curvature, is widely found in particles that occur in nature. We demonstrate a generic approach towards dynamically reconfiguring the shape of <em>β</em>-cyclodextrin(<em>β</em>-CD)-based particles to exploit the unique light-responsive behavior that can trigger “stimuli-responsive” controlled release of active molecules. In detail, solely enabled by their architecture, flakes and spheres comprising binary complexes formed between <em>β</em>-CD and antibacterial stilbenes molecule and/or azobenzene derivative underwent active reconfiguration, including reversible shape-shifting and bioactivity switching. Interestingly, these two particles (flakes and spheres) exhibited reversible and reproducible changes in their shape over repeated UV–vis irradiation cycles. The “stimuli-responsive” shape-shifting of nano-system regulated the switch of bioactivity in vitro and in vivo, inhibited biofilm formation, decreased bacterial motility, and disrupted the flagellar biosynthesis process. Overall, we developed a <em>β</em>-CD-based supramolecular assembly system related to the design and shape-adaptable properties of particles, providing a new paradigm on their prospective applications in nanomedicine/nanopesticide delivery.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123733"},"PeriodicalIF":10.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Promoting efficient synthesis and customization of sphingans based on metabolic engineering and synthetic biology strategies 基于代谢工程和合成生物学策略促进鞘鞘细胞的高效合成和定制

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-12 DOI: 10.1016/j.carbpol.2025.123734

Yujia Zhou, Jielun Hu, Yadong Zhong, Shaoping Nie

{"title":"Promoting efficient synthesis and customization of sphingans based on metabolic engineering and synthetic biology strategies","authors":"Yujia Zhou, Jielun Hu, Yadong Zhong, Shaoping Nie","doi":"10.1016/j.carbpol.2025.123734","DOIUrl":"10.1016/j.carbpol.2025.123734","url":null,"abstract":"<div><div>Sphingans are important exopolysaccharides due to their unique functional characteristics and potential application prospects in various fields. In recent years, the chemical structure, biosynthesis and function of sphingans have been studied extensively. With the development of metabolic engineering and synthetic biology, problems that restricting the production capacity and the design of sphingans, such as complex synthetic path and unclear research background of the wildtype strain, would be expected to be solved to some extent. This review describes the structure and biosynthetic pathways of different sphingans, analyzes the feasibility of obtaining high-performance sphingans-producing strains via classical mutagenesis combined with high-throughput screening techniques and chassis cells construction, and focuses on discussing how to efficiently synthesize and customize sphingans based on metabolic engineering and synthetic biology strategies. These strategies include using highly effective tools like genomic metabolic network models (GSMM) and CRISPR to regulate metabolic pathways, as well as customizing sphingans with different molecular weight through molecular weight regulation and controllable substituent modification based on genetic engineering. At last, the main challenges and prospects are discussed.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123734"},"PeriodicalIF":10.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A rapid and efficient microenvironment improving hyaluronic acid microneedle dressing for burn wound synergistic treatment 一种快速高效的微环境改善透明质酸微针敷料用于烧伤创面协同治疗

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-11 DOI: 10.1016/j.carbpol.2025.123707

Lin Lei , Wei Li , Jiajia Wang , Qi Liu , Feng Zeng , Yunqiang Xiang , Xinyuan Fu , Rui Tao , Zhangyou Yang

{"title":"A rapid and efficient microenvironment improving hyaluronic acid microneedle dressing for burn wound synergistic treatment","authors":"Lin Lei , Wei Li , Jiajia Wang , Qi Liu , Feng Zeng , Yunqiang Xiang , Xinyuan Fu , Rui Tao , Zhangyou Yang","doi":"10.1016/j.carbpol.2025.123707","DOIUrl":"10.1016/j.carbpol.2025.123707","url":null,"abstract":"<div><div>Burn wounds are often accompanied by severe oxidative stress, sustained high expression of inflammation and solid bacterial biofilms formation. Therefore, it is urgent and important to develop strategies for effectively penetrate biofilms and rapidly regulate the burn pathological microenvironment. Herein, a multi-functional microneedle system was constructed for burn wounds synergistic treatment. Specifically, the nanocomposites HY@IND NCs with anti-inflammatory and antibacterial properties were obtained by co-assembling with solutol HS-15 (HS), ethyl lauroyl arginate hydrochloride (YG) and indomethacin (IND), which could be quickly ingested by bacteria or cells and had the characteristics of regulating the pathological microenvironment indicators for burns. It is then programmed to be loaded into a functional microneedle (MN) system along with the angiogenic drug deferoxamine (DFO) to obtain HY@IND-DFO MN. <em>In vitro</em> and <em>in vivo</em> experiments showed that it could not only effectively penetrate and destroy bacterial biofilms, but also the released HY@IND NCs could timely and effectively modulate the reactive oxygen species (ROS) and inflammatory microenvironment of the burn wounds as well as inhibit bacteria. More importantly, it could cooperate with DFO to promote wound regeneration and repair process. Briefly, this suitable microneedle drug delivery system may provide potential for the regeneration and repair of refractory wounds.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123707"},"PeriodicalIF":10.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Preparation of Janus cellulose nanocrystals by interfacial SI-ATRP polymerization of Pickering emulsions Pickering乳剂界面SI-ATRP聚合制备Janus纤维素纳米晶

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-11 DOI: 10.1016/j.carbpol.2025.123731

Yelin Hou , Zhen Zhang , Mohd Azmil Mohd Noor , Gilles Sèbe

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Locust bean gum (LBG) – A potential excipient for inhalation purposes: Excipient characterisation and in vitro and in vivo toxicological evaluation 刺槐豆胶(LBG) -一种潜在的吸入用赋形剂：赋形剂特性和体内体外毒理学评价

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-11 DOI: 10.1016/j.carbpol.2025.123729

Jorge F. Pontes , Filipa Guerreiro , Joana P. Silva , Maria P. Almeida , Annalisa Rosso , Ana M. Rosa da Costa , Géraldine Agusti , Giovanna Lollo , Maria Manuela Gaspar , Ana Grenha

{"title":"Locust bean gum (LBG) – A potential excipient for inhalation purposes: Excipient characterisation and in vitro and in vivo toxicological evaluation","authors":"Jorge F. Pontes , Filipa Guerreiro , Joana P. Silva , Maria P. Almeida , Annalisa Rosso , Ana M. Rosa da Costa , Géraldine Agusti , Giovanna Lollo , Maria Manuela Gaspar , Ana Grenha","doi":"10.1016/j.carbpol.2025.123729","DOIUrl":"10.1016/j.carbpol.2025.123729","url":null,"abstract":"<div><div>Dry powders proposed for lung drug delivery typically involve excipients not approved for inhalation. The physicochemical characterisation of excipients is informative regarding their interaction with different body structures. Locust Bean Gum (LBG) has been proposed for diverse applications, including inhalation, benefiting from targeting ability towards phagocytic cells owing to the presence of mannose moieties. The aim of the present study was to characterise the physicochemical parameters of LBG and, for the first time, draw a toxicological profile for this excipient. LBG from three different suppliers was evaluated and eventual changes on polymer characteristics induced by purification and microparticle production were assessed, which were observed to not occur. The commercial samples showed identical FTIR spectra, as well as TGA and DSC profiles, <em>M</em><sub>w</sub> around 3.60 × 10<sup>6</sup> Da, and <em>T</em><sub>g</sub> near −39 °C. All microparticles presented similar morphology and Feret diameters around 4 μm. <em>In vitro</em> assays performed on respiratory (A549) cells evidenced no impact of LBG microparticles on cell viability (> 80 %) when biorelevant concentrations (≈ 0.1 mg/mL) were used. Additionally, inhalation of LBG microparticles by mice provided indications of a safe profile, without induction of allergic reactions. The basis is laid for further exploration of this material in inhalation.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123729"},"PeriodicalIF":10.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dual-drug carboxymethyl chitosan hydrogel: Development, characterization, and in vitro evaluation for periodontal therapy 双药羧甲基壳聚糖水凝胶：牙周治疗的开发、表征和体外评价

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-10 DOI: 10.1016/j.carbpol.2025.123726

Büşra Yılmaz , Yeliz Yıldırım , Nil Yakar , Güven Özdemir , Alpdogan Kantarci , Gülnur Emingil

{"title":"Dual-drug carboxymethyl chitosan hydrogel: Development, characterization, and in vitro evaluation for periodontal therapy","authors":"Büşra Yılmaz , Yeliz Yıldırım , Nil Yakar , Güven Özdemir , Alpdogan Kantarci , Gülnur Emingil","doi":"10.1016/j.carbpol.2025.123726","DOIUrl":"10.1016/j.carbpol.2025.123726","url":null,"abstract":"<div><div>Dual-drug delivery systems offer a novel approach to overcoming the complex challenges of periodontal disease treatment. This study aimed to develop and evaluate a carboxymethyl chitosan-based hydrogel incorporating doxycycline and atorvastatin for local delivery in periodontal therapy. The hydrogel formulations were characterized through Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and electron microscopy to assess their structural and physicochemical properties. The hydrogels were evaluated for drug loading efficiency and drug release profiles, antimicrobial activity, and cytotoxicity. The optimized formulation, containing 25 % atorvastatin and 75 % doxycycline, demonstrated a sustained and controlled release profile over 72 h, ensuring prolonged therapeutic effects. It exhibited significant antibacterial efficacy, particularly against <em>Porphyromonas gingivalis</em>, a keystone pathogen in periodontal disease, with inhibition zones reaching 54 ± 1.53 mm. Cytotoxicity assays on human keratinocyte cells (HaCaT) confirmed high biocompatibility, with over 97 % cell viability for the optimized formulation, whereas formulations with higher atorvastatin content exhibited increased cytotoxicity. These findings highlight the potential of this dual-drug hydrogel system as a promising localized treatment strategy for periodontal disease, offering controlled drug release, potent antimicrobial activity, and favorable biocompatibility. Future <em>in vivo</em> and clinical studies are warranted to validate its therapeutic efficacy and translational potential.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123726"},"PeriodicalIF":10.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to “Chitosan–fucoidan encapsulating cinnamaldehyde composite coating films: Preparation, pH-responsive release, antibacterial activity and preservation for litchi” [Carbohydrate Polymers 333 (2024) 121968] “壳聚糖-岩藻聚糖包封肉桂醛复合涂层：荔枝的制备、ph响应释放、抗菌活性和保存”[碳水化合物聚合物333(2024)121968]的勘误表

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-09 DOI: 10.1016/j.carbpol.2025.123641

Fengyan Liang , Chusi Liu , Jinwen Geng , Nachuan Chen , Weida Lai , Haitong Mo , Kaidong Liu

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Isolation and structural identification of the homogeneous polysaccharide CGPA1 from Calvatia gigantea with wound healing effects 具有创面愈合作用的巨爪多糖CGPA1的分离与结构鉴定

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-09 DOI: 10.1016/j.carbpol.2025.123727

Xiuhua Meng , Wenjian Zhao , Yanan Zhao , Juntong Guo , Xiaoqin Ding , Yanan Gai , Han Lv , Yiwei Wang , Jian Chen

{"title":"Isolation and structural identification of the homogeneous polysaccharide CGPA1 from Calvatia gigantea with wound healing effects","authors":"Xiuhua Meng , Wenjian Zhao , Yanan Zhao , Juntong Guo , Xiaoqin Ding , Yanan Gai , Han Lv , Yiwei Wang , Jian Chen","doi":"10.1016/j.carbpol.2025.123727","DOIUrl":"10.1016/j.carbpol.2025.123727","url":null,"abstract":"<div><div><em>Calvatia gigantea</em> is a traditional Chinese medicinal fungus known for its diverse pharmacological effects, with polysaccharides being one of its main bioactive components. In this study, a novel homogeneous water-soluble polysaccharide (CGPA1) was successfully isolated and purified from the fruiting body of <em>Calvatia gigantea</em>. The molecular weight of CGPA1 was determined to be 11.69 kDa. Structural characterization was performed using a combination of high-performance gel permeation chromatography (HPGPC), Fourier-transform infrared spectroscopy (FTIR), methylation analysis, and nuclear magnetic resonance (NMR) spectroscopy. The analysis data revealed that CGPA1 is primarily composed of galactose, methyl-galactose, mannose, xylose, and glucose in a molar ratio of 60.01:27.16:10.34:1.83:0.67. The backbone structure predominantly consists of α-1,6-Gal-(1 → and α-1,6 (3-MeO)-Gal-(1→, with side chains of α-Gal and α-Man. Morphological analysis using SEM, XRD, and AFM, combined with Congo red experiments, suggesting that CGPA1 adopts an amorphous granular chain conformation. Both <em>in vitro</em> and <em>in vivo</em> tests confirmed that CGPA1 can promote the migration of MSF cells and accelerate the healing of acute injured wounds. It was found to facilitate skin re-epithelialization, and collagen deposition over the healing process.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123727"},"PeriodicalIF":10.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to “Synthesis of controlled size starch nanoparticles (SNPs) title of article” [Carbohydr. Polym. 250 (2020) 116938] “合成粒径可控的淀粉纳米颗粒（SNPs）”的更正文章标题“[碳水化合物。高分子，250 (2020)116938 [j]

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-09 DOI: 10.1016/j.carbpol.2025.123692

G. Gutiérrez , D. Morán , A. Marefati , J. Purhagen , M. Rayner , M. Matos

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Structural characterization of a pectic polysaccharide from Rubus chingii Hu. unripe fruits and its efficacy in inhibiting intestinal lipid absorption in vivo 青藤果胶多糖的结构表征。未成熟水果及其体内抑制肠道脂质吸收的作用

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-05-09 DOI: 10.1016/j.carbpol.2025.123728

Xingxing Wang , Yupeng Liu , Yongbin Xu , Siqi Gao , Qiuying Xu , Huan Gong , Lumeng Yao , Songshan Shi , Shunchun Wang , Huijun Wang , Luping Qin , Jianjun Wu

{"title":"Structural characterization of a pectic polysaccharide from Rubus chingii Hu. unripe fruits and its efficacy in inhibiting intestinal lipid absorption in vivo","authors":"Xingxing Wang , Yupeng Liu , Yongbin Xu , Siqi Gao , Qiuying Xu , Huan Gong , Lumeng Yao , Songshan Shi , Shunchun Wang , Huijun Wang , Luping Qin , Jianjun Wu","doi":"10.1016/j.carbpol.2025.123728","DOIUrl":"10.1016/j.carbpol.2025.123728","url":null,"abstract":"<div><div>Excessive lipid intake is a major contributor to obesity, and inhibiting intestinal lipid absorption is considered an effective strategy to mitigate this condition. In this study, a pectic polysaccharide designated as RCP-2-3 was obtained from <em>Rubus chingii</em> Hu. unripe fruits and its potential inhibitory effect on intestinal lipid absorption <em>in vivo</em> was investigated. Structural studies revealed that RCP-2-3 (8.54 kDa) is a homogeneous pectic polysaccharide composed of homogalacturonan (HG) and rhamnogalacturonan II (RG-II) domains in a 4.4:4.1 mass ratio. Treatment with RCP-2-3 for 7 days effectively reduced postprandial serum triglyceride (TG) accumulation and lipid absorption in BODIPY-labeled soybean oil-fed mice, accompanied by increased lipid excretion. Specifically, RCP-2-3 increased the excretion of long-chain fatty acids in dietary lipids, such as linoleic acid, oleic acid, palmitic acid, and stearic acid. A 28-day administration of RCP-2-3 reduced weight gain and improved dyslipidemia, and promoted lipid excretion in mice subjected to a high-fat diet and high-fat emulsion. In conclusion, RCP-2-3, a natural pectic polysaccharide consisting of HG and RG-II domains, effectively inhibited intestinal lipid absorption and reduced obesity-related parameters. These findings highlight the potential of RCP-2-3 for application in both the food and pharmaceutical industries.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"363 ","pages":"Article 123728"},"PeriodicalIF":10.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0