Carbohydrate Polymers最新文献_第7页

Chitosan obtained from black soldier fly larval cuticles expands the value chain and is effective as a biocontrol agent to combat plant pathogens 从黑实蝇幼虫角质层中提取的壳聚糖拓展了价值链，可作为生物控制剂有效对抗植物病原体

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-16 DOI: 10.1016/j.carbpol.2024.123023

Carolina Escobar Rodríguez , Valeriia Zaremska , Thomas Klammsteiner , Ioannis Kampatsikas , Nils Münstermann , Oliver Weichold , Sabine Gruber

{"title":"Chitosan obtained from black soldier fly larval cuticles expands the value chain and is effective as a biocontrol agent to combat plant pathogens","authors":"Carolina Escobar Rodríguez , Valeriia Zaremska , Thomas Klammsteiner , Ioannis Kampatsikas , Nils Münstermann , Oliver Weichold , Sabine Gruber","doi":"10.1016/j.carbpol.2024.123023","DOIUrl":"10.1016/j.carbpol.2024.123023","url":null,"abstract":"<div><div>The industrial use of certain insects, such as the black soldier fly (BSF, <em>Hermetia illucens</em>), has become a burgeoning way of converting residual biomass into a valuable source of biomolecules for the feed and food industry. Here, the integration of a valuable step as an upcycling technology using biological waste from the 5th instar BSF larvae processing as a source of bioactive chitosan was explored. The goal is to pave the way for sustainable chitosan production from insect-based resources in addition to proteins, lipids, and fertilizers. The macronutrient profile of the larval waste was evaluated for chitosan extraction. After homogenization and mechanical separation of the larval pulp, enzyme-assisted extraction of chitosan from the chitin-rich matrix was performed using different combinations of commercially available proteases and lipases, followed by chemical deacetylation. The antifungal efficacy of the recovered chitosan varied depending on the extracted product and tested fungal plant pathogens. Furthermore, the plant priming effect of chitosan on <em>Beta vulgaris</em> promoted plant vigor and disease resistance. Seed coating resulted in improved germination and primary root growth. Thus, the extraction of chitosan from BSF larval cuticles offers an optimistic outlook for expanding the technological competence of the insect upcycling industries.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 123023"},"PeriodicalIF":10.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional carboxymethyl chitosan-based sponges loaded with epigallocatechin-3-gallate for accelerating wound healing in diabetic rats with full-thickness burns 含有表没食子儿茶素-3-棓酸盐的多功能羧甲基壳聚糖基海绵可加速全厚烧伤糖尿病大鼠的伤口愈合

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-16 DOI: 10.1016/j.carbpol.2024.123025

Yanting Wang, Ziming Zhu, Xiansen Lv, Baoqin Han, Zhiwen Jiang

{"title":"Multifunctional carboxymethyl chitosan-based sponges loaded with epigallocatechin-3-gallate for accelerating wound healing in diabetic rats with full-thickness burns","authors":"Yanting Wang, Ziming Zhu, Xiansen Lv, Baoqin Han, Zhiwen Jiang","doi":"10.1016/j.carbpol.2024.123025","DOIUrl":"10.1016/j.carbpol.2024.123025","url":null,"abstract":"<div><div>Full-thickness burn wounds in diabetes often present significant challenges in terms of timely progression of healing and even mortality. Multifunctional dressings that possess strong absorptivity and mechanical property while effectively regulating inflammation and promoting angiogenesis is therefore crucial. We have developed a novel sponge (CCGE) comprising carboxymethyl chitosan, gelatin, and glycerin for the purpose of promoting accelerated healing of scald wounds in diabetic rats. This sponge is loaded with epigallocatechin-3-gallate, which possesses antioxidant and anti-inflammatory properties. The incorporation of the crosslinker BDDE reinforces its mechanical characteristics by augmenting the interplay between the sponge structure through hydrogen bonding and covalent bonding. Moreover, the crosslinked sponges provide a highly absorptive layer, carboxymethyl chitosan show good biocompatibility and angiogenic effects, and the gelatin provide matrix metalloproteinases-9 targeting. The CCGE sponges exhibit high biocompatibility, facilitate fibroblast migration, and promote tube formation. The application of the CCGE sponges significantly accelerates wound healing of full-thickness scald wounds in diabetic rats, exhibits enhanced collagen synthesis, reduced levels of pro-inflammatory cytokines, and increased blood vessel formation within the wounded area. In summary, this study presents a multifunctional composite CCGE sponge dressing that effectively modulates ROS, inflammation, and angiogenesis to facilitate comprehensive burn wound tissue repair in diabetes.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123025"},"PeriodicalIF":10.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exopolysaccharides from Bifidobacterium longum subsp. infantis and Bifidobacterium adolescentis modulate Toll-like receptor signaling 长双歧杆菌亚种和青春期双歧杆菌的外多糖调节Toll样受体信号转导

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-15 DOI: 10.1016/j.carbpol.2024.123017

Renate Akkerman , Marjolein M.P. Oerlemans , Michela Ferrari , Cynthia Fernández-Lainez , Marthe T.C. Walvoort , Paul de Vos

{"title":"Exopolysaccharides from Bifidobacterium longum subsp. infantis and Bifidobacterium adolescentis modulate Toll-like receptor signaling","authors":"Renate Akkerman , Marjolein M.P. Oerlemans , Michela Ferrari , Cynthia Fernández-Lainez , Marthe T.C. Walvoort , Paul de Vos","doi":"10.1016/j.carbpol.2024.123017","DOIUrl":"10.1016/j.carbpol.2024.123017","url":null,"abstract":"<div><h3>Background</h3><div>Exopolysaccharides (EPS) from probiotic bacteria like bifidobacteria, have gained considerable attention for the beneficial effects they exert in the gastrointestinal environment. Here, we investigated whether EPS isolated from <em>Bifidobacterium longum</em> subsp. <em>infantis</em> and <em>Bifidobacterium adolescentis</em> can interact with Toll-like receptors (TLRs) in a structure-dependent way and subsequently we investigated whether they influence cytokine-production in dendritic cells (DCs).</div></div><div><h3>Results</h3><div>EPS from both <em>B. infantis</em> and <em>B. adolescentis</em> were found to be structurally different and were able to inhibit signaling of TLR2 and TLR4 in an EPS-type dependent fashion. EPS from <em>B. infantis</em> was shown to have stronger inhibitory effects on TLR2/1, whereas EPS from <em>B. adolescentis</em> showed stronger effects for TLR2/6 and TLR4. Incubation of DCs with EPS alone had no effect, however stimulation of DCs with spend-medium of epithelial cells incubated with EPS reduced production of the cytokines MCP-1/CCL2 and TNFα.</div></div><div><h3>Conclusion</h3><div>Here we show that EPS from <em>B. infantis</em> and <em>B. adolescentis</em> have structure-dependent immunomodulatory effects, indicating that EPS might be important effector molecules responsible for the health benefits of bifidobacteria.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 123017"},"PeriodicalIF":10.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation and physical properties of skimmed milk/low-acyl gellan gum double gels: Influence of gelation sequence 脱脂奶/低酰基结冷胶双凝胶的形成和物理性质：凝胶化顺序的影响

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-15 DOI: 10.1016/j.carbpol.2024.123012

Weibo Zhang , Chong Chen , Pengjie Wang , Jingni Xu , Feng Zhang , Jing Wang , Yinhua Zhu , Jie Luo , Liang Zhao , Fazheng Ren

{"title":"Formation and physical properties of skimmed milk/low-acyl gellan gum double gels: Influence of gelation sequence","authors":"Weibo Zhang , Chong Chen , Pengjie Wang , Jingni Xu , Feng Zhang , Jing Wang , Yinhua Zhu , Jie Luo , Liang Zhao , Fazheng Ren","doi":"10.1016/j.carbpol.2024.123012","DOIUrl":"10.1016/j.carbpol.2024.123012","url":null,"abstract":"<div><div>Low-acyl gellan gum (LA) is a typical cold- and Ca<sup>2+</sup>-set gelation polysaccharide and is widely used to improve the stability of yoghurt. Acid and endogenous calcium can induce the formation of skimmed milk (SM)/LA double gels. However, the effect of acidification temperature on the formation and physical properties of SM/LA double gels has not been elucidated. In this study, temperature above and below the LA transition temperature (38 °C) were used as acidification temperatures, which adjusted the gelation sequence of SM and LA. The LA gel prior to the SM gel formed at acidification temperature of 37 °C, exhibiting the highest WHC and G′ among all samples. Moreover, SM/LA-37 double gels showed two networks: one was a porous network and the other was a dense network. By contrast, SM/LA mixtures acidified at 42 °C formed double networks during the cooling stage, and the previously formed SM gel hindered the formation of the LA gel. Consequently, SM/LA-42 double gels showed lower WHC and G′ compared with SM/LA-37 double gels. Overall, gelation sequence substantially affected the physical properties of SM/LA double gels. Our findings provide basis for adopting optimal methods to improve yoghurt quality and revealing the gelation mechanism involved in SM/LA double gels.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 123012"},"PeriodicalIF":10.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance conductive double-network hydrogel base on sodium carboxymethyl cellulose for multifunctional wearable sensors 用于多功能可穿戴传感器的基于羧甲基纤维素钠的高性能导电双网水凝胶

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-15 DOI: 10.1016/j.carbpol.2024.122943

Jinmei Wei , Chenglu Liu , Lin Shi , Yongpin Liu , Huidan Lu

{"title":"High-performance conductive double-network hydrogel base on sodium carboxymethyl cellulose for multifunctional wearable sensors","authors":"Jinmei Wei , Chenglu Liu , Lin Shi , Yongpin Liu , Huidan Lu","doi":"10.1016/j.carbpol.2024.122943","DOIUrl":"10.1016/j.carbpol.2024.122943","url":null,"abstract":"<div><div>Sodium carboxymethyl cellulose showed great potential in wearable intelligent electronic devices due to its low price and good biocompatibility. This research aimed to develop a novel conductive hydrogel with stretchable, self-healing, self-adhesive, antibacterial, 3D printable properties, for the development of multifunctional flexible electronic materials based on sodium carboxymethyl cellulose. A multifunctional conductive hydrogel based on sodium carboxymethyl cellulose (SCMC) was synthesized by simple polymerization of SCMC, acrylic acid (AA) and alkaline calcium bentonite (AC-Bt). The multifunctional hydrogels (PAA-SCMC) possess excellent mechanical property (stress: 0.25 MPa; strain: 1675.0 %), Young's modulus (75.6 kPa), and conductivity (2.25 S/m). The multifunctional PAA-SCMC hydrogels serve as strain sensors (Gauge Factor (GF) = 12.68), temperature sensors (temperature coefficient of resistance (TCR) = −0.887 % °C at 20 °C–60 °C), sweat sensors, and pressure sensors. Importantly, the obtained hydrogels exhibited exceptional self-healing capability, self-adhesive properties, antimicrobial properties and 3D printability. The printed hydrogel has good mechanical properties, conductivity and antibacterial properties. Moreover, the hydrogel sensor possessed prominent sensitivity and cyclic stability to accurately monitor human motion, emotional changes, physiological signals in real time, and a hydrogel-based flexible touch keyboard was also fabricated to recognize writing trajectories. Overall, this study provided novel insights into the simple and efficient synthesis and sustainable manufacturing of environmentally friendly multifunctional flexible electronic skin sensors.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 122943"},"PeriodicalIF":10.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable, robust, and conductive bacterial cellulose @PPy-P macrofibers as resistive strain sensors for smart textiles 可生物降解、坚固耐用且导电的细菌纤维素 @PPy-P 宏纤维作为智能纺织品的电阻应变传感器

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-14 DOI: 10.1016/j.carbpol.2024.122963

Zaixian Yuan , Hai Yin , Min Zheng , Xiao Chen , Wei Peng , Hongfu Zhou , Jun Xing , Li Wang , Sanming Hu

{"title":"Biodegradable, robust, and conductive bacterial cellulose @PPy-P macrofibers as resistive strain sensors for smart textiles","authors":"Zaixian Yuan , Hai Yin , Min Zheng , Xiao Chen , Wei Peng , Hongfu Zhou , Jun Xing , Li Wang , Sanming Hu","doi":"10.1016/j.carbpol.2024.122963","DOIUrl":"10.1016/j.carbpol.2024.122963","url":null,"abstract":"<div><div>Fiber-based resistive strain sensors have attracted significant interest in the development of smart wearable devices due to their portability, flexibility, and easy conformability. However, current fiber-based resistive strain sensors mainly composed of metals and nondegradable polymers are not environmentally friendly and have poor mechanical strength. In this work, we examined biodegradable, robust, and conductive macrofibers fabricated through the in situ polymerization of p-toluenesulfonic acid (P-TSA)-doped polypyrrole (PPy) in bacterial cellulose (BC) nanofibers using wet-stretching and wet-twisting methods. The BC/PPy-P macrofibers possessed excellent conductivity (~7.19 S/cm), with superior mechanical properties (~210 MPa tensile strength and 2 GPa Young's modulus). Importantly, the BC/PPy-P microfiber operating as a resistive strain sensor possessed fast response time (15 s) and long-term stability (up to 1000 cycles), which could be used to effectively detect human movements. Moreover, the matrix material BC of BC/PPy-P macrofibers could be completely degraded within 96 h in the cellulase solution, leaving only PPy-P particles that could be recycled for other use. Therefore, the prepared BC/PPy-P microfibers provided a promising strategy for developing green resistive strain sensing fibers, with great potential to design eco-friendly smart fabric for monitoring human movements.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 122963"},"PeriodicalIF":10.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of interpenetrating network hydrogels based on sugar beet pectin and heteroprotein complex: Structural characteristics and physicochemical properties 基于甜菜果胶和杂蛋白复合物的互穿网络水凝胶的合成与表征：结构特征与理化性质

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-14 DOI: 10.1016/j.carbpol.2024.122959

Lijia Li, Yue Liu, Xiangyun Tan, Fei Teng, Yang Li

{"title":"Synthesis and characterization of interpenetrating network hydrogels based on sugar beet pectin and heteroprotein complex: Structural characteristics and physicochemical properties","authors":"Lijia Li, Yue Liu, Xiangyun Tan, Fei Teng, Yang Li","doi":"10.1016/j.carbpol.2024.122959","DOIUrl":"10.1016/j.carbpol.2024.122959","url":null,"abstract":"<div><div>Hydrogels made from natural polymers have excellent application potential due to their good biocompatibility. However, it is difficult to maximise the benefits of hydrogels when the gel network is formed by a single substance. The purpose of this study was to investigate the relationship between the interaction of modified soybean lipophilic proteins (SLP) and lysozyme (LY) and the formation of heteroprotein complexes. Subsequently, interpenetrating network (IPN) hydrogels were further synthesized on the basis of heteroprotein (HP) complexes and sugar beet pectin (SBP) as the backbone. The strong interaction between SLP and LY drove them to spontaneously form heteroprotein complexes. The HP-SBP IPN imparted good mechanical properties to the hydrogel, which could withstand a maximum pressure of 7500 pa at 88 % strain. Meanwhile, there was still 93.52 % of water being trapped in IPN after freeze-thawing. The HP-SBP IPN hydrogels could effectively protect the encapsulated substance during UV irradiation and maintain its morphology after undergoing dynamic pH changes. Furthermore, the HP-SBP IPN hydrogels could regulate their release ability through their own swelling and achieved more than 88 % release rate in simulated intestinal fluid. Therefore, this study was expected to provide a potential strategy for the synthesis of IPN hydrogels.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 122959"},"PeriodicalIF":10.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manufacturing sulfated cellulose nanofibers using a unique combined DES-based pretreatment-functionalization protocol for metal ion decontamination through porous adsorbents 利用基于 DES 的独特组合预处理-功能化协议制造硫酸化纤维素纳米纤维，通过多孔吸附剂进行金属离子净化

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-14 DOI: 10.1016/j.carbpol.2024.122974

Remedios Montenegro, Esther Rincón, Alejandro Rodríguez, Zoilo González

{"title":"Manufacturing sulfated cellulose nanofibers using a unique combined DES-based pretreatment-functionalization protocol for metal ion decontamination through porous adsorbents","authors":"Remedios Montenegro, Esther Rincón, Alejandro Rodríguez, Zoilo González","doi":"10.1016/j.carbpol.2024.122974","DOIUrl":"10.1016/j.carbpol.2024.122974","url":null,"abstract":"<div><div>This study confirms the efficacy of a unique combined pretreatment-functionalization protocol based on the use of deep eutectic solvent (DES) to obtain sulfated lignocellulose and cellulose nanofibers (SLNF or SNF) hydrogels, which have been successfully shaped as sponge-based adsorbents and fruitfully assessed for the removal of heavy metals from water. A comprehensive characterization study was conducted, demonstrating an excellent degree of sulfation (0.62) in DES-treated wheat straw-derived nanofibers. The direct use of SLNF or SNF hydrogels and their application as porous sponges exhibited highly favorable characteristics for successful ion decontamination. Cu<sup>2+</sup> removal was up to 70 % higher using DES-sulfated nanocellulose hydrogels compared to conventional treated-nanocellulose. Various isotherm models were studied, and the analysis of the kinetic and diffusion studies confirmed the influence of the sample format in the removal behavior. SLNF and SNF-sponges proved to be the most effective in adsorption, achieving Cu<sup>2+</sup> removal rates of up to 60 %. More profitable decontamination processes with lower run times could be guessed when the application of nanocellulose is led through the processing of advanced formats. The easy handling of sponges would avoid the extra costs of the downstream unit operations which are sometimes needed to separate the hydrogel of the decontaminated media.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 122974"},"PeriodicalIF":10.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled preparation of cellulose acetate by deep eutectic solvent homogeneous catalysis 利用深共晶溶剂均相催化技术可控制备醋酸纤维素

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-14 DOI: 10.1016/j.carbpol.2024.122964

Shengtao Zhou , Jun Xu , Zhaohui Zhang , Shiyun Zhu , Jun Li , Wei Zhang , Fengshan Zhang , Kefu Chen

{"title":"Controlled preparation of cellulose acetate by deep eutectic solvent homogeneous catalysis","authors":"Shengtao Zhou , Jun Xu , Zhaohui Zhang , Shiyun Zhu , Jun Li , Wei Zhang , Fengshan Zhang , Kefu Chen","doi":"10.1016/j.carbpol.2024.122964","DOIUrl":"10.1016/j.carbpol.2024.122964","url":null,"abstract":"<div><div>This work proposed a homogeneous preparation strategy of cellulose acetate by using a deep eutectic solvent consisting of zinc chloride/phosphoric acid/water (ZnCl<sub>2</sub>/PA/H<sub>2</sub>O). The results showed that the DES (the molar ratio of ZnCl<sub>2</sub>: PA: H<sub>2</sub>O = 1:1:3) had good solubility for bamboo pulp with high degree of polymerization. The dynamic dissolution behavior of cellulose in DES was also studied. Cellulose was first moistened and swollen and then dissolved. The crystalline state of cellulose changed from type I to type II after regeneration. Under the synergistic effect of acetic anhydride (Ac<sub>2</sub>O), the dissolved cellulose in DES could be uniformly acetylated. The effects of temperature, reaction time and molar ratio of Ac<sub>2</sub>O/anhydrous glucose on degree of substitution (DS) were investigated in their respective ranges (30–50 °C, 2–10 h and 4–24). Cellulose acetate with DS of 0.42–1.81 was successfully prepared. The substituent distribution of the sample was analyzed as C-6 > C-2 > C-3. Moreover, the entire process required no additional catalysts or activation steps, reducing the difficulty of solvent recovery. The insight from this study provides a new idea for the development of greener methods for the homogeneous preparation of cellulose acetate.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 122964"},"PeriodicalIF":10.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing β-glucan conjugated quercetin nanocomplex to function as a promising anti-inflammatory agent via macrophage-targeted delivery 利用β-葡聚糖共轭槲皮素纳米复合物，通过巨噬细胞靶向递送发挥抗炎作用

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-14 DOI: 10.1016/j.carbpol.2024.122952

Yuting Su , Manting Huang , Qiaochun Chen , Jiayi He , Siqian Li , Mingfu Wang

{"title":"Harnessing β-glucan conjugated quercetin nanocomplex to function as a promising anti-inflammatory agent via macrophage-targeted delivery","authors":"Yuting Su , Manting Huang , Qiaochun Chen , Jiayi He , Siqian Li , Mingfu Wang","doi":"10.1016/j.carbpol.2024.122952","DOIUrl":"10.1016/j.carbpol.2024.122952","url":null,"abstract":"<div><div>Quercetin, a promising anti-inflammatory agent, faces challenges related to poor bioavailability and limited practical applications. β-glucan, a natural polysaccharide, can be specifically recognized by macrophages, making it an ideal targeting carrier to enhance therapeutic efficacy for macrophage-related dysfunctions. In this study, β-glucan conjugated quercetin nano-complexes (CM-Cur@QT) were developed to target macrophage and alleviate pro-inflammatory response in M1-like macrophages. The results demonstrated that CM-Cur@QT exhibited a spheric shape with an average diameter around 200 nm. FT-IR, <sup>1</sup>H NMR, XRD and XPS analyses confirmed the complexation of CM-Cur@QT. This complex showed excellent stability during stimulated digestion, protecting QT from degradation while maintaining favorable antioxidant activity. After complexation, CM-Cur@QT displayed sustained uptake kinetics and enhanced accumulation in macrophages, with a 61.88 % increase compared to individual quercetin after 5 h of incubation. Meanwhile, CM-Cur@QT administration induced evidently cell cycle phases transitions and altered phagocytotic activity in M1-like macrophages. Furthermore, CM-Cur@QT reduced intracellular ROS accumulation, achieving a ROS scavenging rate of up to 49.92 %, compared to 25.59 % in quercetin group. This complex also effectively modulated TNF-a, IL-6 and TGF-β secretion profiles in pro-inflammatory macrophages, outperforming individual QT treatment. Notably, CM-Cur@QT facilitated anti-inflammatory effects while minimizing impacts on inactivated M0 macrophages. These findings underscore the potential of CM-Cur@QT as a promising agent for mitigating inflammatory disorders.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 122952"},"PeriodicalIF":10.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0