Carbohydrate Polymers最新文献_第7页

A natural amylopectin based quaternized polymer as a promising biopolymer for efficient dewatering of Chlorella sorokiniana NKPS02 天然支链淀粉季铵化聚合物是一种有前途的高效脱水小球藻NKPS02的生物聚合物

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-09 DOI: 10.1016/j.carbpol.2025.124047

Niwas Kumar, Manjulika Vardhan, Pratyoosh Shukla

{"title":"A natural amylopectin based quaternized polymer as a promising biopolymer for efficient dewatering of Chlorella sorokiniana NKPS02","authors":"Niwas Kumar, Manjulika Vardhan, Pratyoosh Shukla","doi":"10.1016/j.carbpol.2025.124047","DOIUrl":"10.1016/j.carbpol.2025.124047","url":null,"abstract":"<div><div>Microalgae are green biofactories suitable for the production of valuable bioenergy and bioproducts. Obtaining bioproducts from microalgae requires efficient microalgal biomass harvesting which is a significant bottleneck owing to the culture stability of negatively charged microalgal cells, the process is cost and energy-intensive. To overcome this, we developed a natural polymer-based quaternised amylopectin polymer by incorporating cationic reagent glycidyl trimethyl ammonium chloride (GTMAC) via etherification. Here, quaternised amylopectin appears to be a promising biopolymer for efficient dewatering of <em>Chlorella sorokiniana</em> NKPS02, as it resulted in >95% dewatering efficiency at the optimum dosage of 60 mg/L at ambient temperature (25 °C), physiological culture pH (∼7.8). Interestingly, the quaternised amylopectin was found to be biocompatible due to its non-interference with the lipid extraction from harvested biomass and notaffecting microalgal cell integrity. The study showed that the amylopectin-based biopolymer bridging and charge neutralization mechanism was crucial for efficient microalgal harvesting. Thus, the present endeavor exhibited that the quaternised amylopectin can be a promising biomaterial for the harvesting and sustainable valorization of microalgal biomass.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124047"},"PeriodicalIF":10.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of chemical modification of corn starch for the development of films for packaging applications: Impact of glutaraldehyde and organically modified montmorillonite incorporation 玉米淀粉化学改性对包装薄膜发展的影响：戊二醛和有机改性蒙脱土掺入的影响

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-09 DOI: 10.1016/j.carbpol.2025.124019

Sriram Srinivasan , Changfeng Ge , Christopher L. Lewis , S. Shamshath Begum , Asit Baran Samui , Hans Frederick Noyes

{"title":"Effect of chemical modification of corn starch for the development of films for packaging applications: Impact of glutaraldehyde and organically modified montmorillonite incorporation","authors":"Sriram Srinivasan , Changfeng Ge , Christopher L. Lewis , S. Shamshath Begum , Asit Baran Samui , Hans Frederick Noyes","doi":"10.1016/j.carbpol.2025.124019","DOIUrl":"10.1016/j.carbpol.2025.124019","url":null,"abstract":"<div><div>In this current study, hydroxyethyl methacrylate (HEMA) was grafted onto corn starch (CS), proceeding with a chemical modification method to obtain modified CS (CS<sub>M</sub>) with improved properties. When CS and CS<sub>M</sub> were subjected to Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) characterisation, distinct peaks were observed in CS<sub>M</sub>. During FTIR characterisation, peaks at 1714 cm<sup>−1</sup> and 1629 cm<sup>−1</sup> were observed, corresponding to C<img>O stretching of HEMA and secondary amines, respectively. These starch samples were then cast into films using glycerol as a plasticizer. Further, various concentrations of glutaraldehyde (GTA) (2 wt%, 5 wt%, and 8 wt%) and 0.1 wt% of organically modified montmorillonite (OMMT) were utilised to enhance the properties of the CS<sub>M</sub> film samples. Among these, the film with 5 wt% GTA and 0.1 wt% OMMT (CS<sub>MF</sub>-5GO) was optimised. The hydrophobicity was found to improve with the maximum water contact angle (WCA), and minimum water solubility (WS), water absorption (WA), moisture absorption (MA) at 22.7 % RH, and 75 % RH in comparison to other samples. The respective values were found to be, 95.07 <sup>o</sup>, 2.31 %, 189.1 %, 3.49 %, and 1.41 %. The tensile Strenght (TS) was also found to be maximum with a value of 30.22 MPa. The water vapour transmission rate (WVTR) was found to be 3.03 g/m<sup>2</sup>.day.kPa and 86.23 g/m<sup>2</sup>.day.kPa for the dry and wet cup methods, respectively. Further, soil biodegradation characterisation displayed a positive response with >90 % degradation within 10 days, confirming its sustainability.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124019"},"PeriodicalIF":10.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Edible cellulose-based photonic crystals with low-temperature response for food sensing 基于可食用纤维素的低温响应光子晶体用于食物传感

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-09 DOI: 10.1016/j.carbpol.2025.124029

Dong Li , Qing Luo , Qilin Liu , Siyu Chen , Xuezhong Zhang , Chunxia Zhao , Jinbo Cheng , Yuanpeng Wu , Fei Song

{"title":"Edible cellulose-based photonic crystals with low-temperature response for food sensing","authors":"Dong Li , Qing Luo , Qilin Liu , Siyu Chen , Xuezhong Zhang , Chunxia Zhao , Jinbo Cheng , Yuanpeng Wu , Fei Song","doi":"10.1016/j.carbpol.2025.124029","DOIUrl":"10.1016/j.carbpol.2025.124029","url":null,"abstract":"<div><div>Responsive photonic crystals offer the advantages of zero energy consumption and easy recognition, making them ideal for food sensing applications. Temperature monitoring during food storage is crucial for ensuring food safety. However, non-toxic, safe, food-grade temperature sensors are still limited, and tuning the responsive range to accommodate extremely low temperatures remains a significant challenge. Here, we demonstrate edible photonic crystal materials with low-temperatures response for food sensing, fabricated through the co-assembly of hydroxypropyl cellulose (HPC) with edible ethanol. The ethanol effectively reduces freezing point of the HPC photonic crystals, allowing them to maintain the responsiveness at temperatures as low as −35 °C. Moreover, adjusting the ethanol concentration allows for modulation of the structural color and operational temperature range. The moldability of the photonic crystals facilitates the design of intricate patterns or informative labels, enabling the development of a colorimetric sensor capable of visually monitoring storage conditions at −20 °C. These green, safe, and responsive characteristics make cellulose-based photonic crystals promising candidates for applications such as displays, health monitoring, and smart sensing.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124029"},"PeriodicalIF":10.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysaccharide-based nanosystems as vaccine adjuvants: A review 基于多糖的纳米系统作为疫苗佐剂：综述

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-09 DOI: 10.1016/j.carbpol.2025.124017

Xiang Li , Xiaohui Zhang , Lulu Liu , Lei Feng , Bingnan Liu

{"title":"Polysaccharide-based nanosystems as vaccine adjuvants: A review","authors":"Xiang Li , Xiaohui Zhang , Lulu Liu , Lei Feng , Bingnan Liu","doi":"10.1016/j.carbpol.2025.124017","DOIUrl":"10.1016/j.carbpol.2025.124017","url":null,"abstract":"<div><div>Vaccines serve as effective tools for preventing infectious diseases, with adjuvants playing a pivotal role in enhancing immunogenicity, reducing antigen dosage, and minimizing adverse reactions. To mitigate the suboptimal efficacy and safety concerns that constrain current adjuvants, novel formulations exhibiting enhanced safety and potency are required for development. Natural polysaccharides have been employed as vaccine adjuvants. Due to inherent biopharmaceutical limitations—including transient systemic exposure, structural instability, rapid clearance kinetics, and suboptimal bioavailability—their clinical translation as vaccine adjuvants remains constrained, resulting in attenuated immunogenicity. Recent advancements in polysaccharide-based nanosystems have attracted significant attention due to their dual functionality: serving as protective antigen-delivery platforms while concurrently acting as immunostimulants to amplify host immunity. These engineered systems encapsulate polysaccharides and antigens within nanosystems, conferring resistance against enzymatic degradation and enabling sustained release to maintain antigen depot effects. Mechanistically, they enhance vaccine efficacy through multiple pathways: activating antigen-presenting cells (APCs), improving antigen uptake efficiency, achieving targeted delivery, and modulating immune responses, thereby synergistically boosting antigen immunogenicity and overall immune performance. This review examines several promising polysaccharide-based nanosystems adjuvants, outlines their applications in vaccines, and emphasizes their immunomodulatory effects. Furthermore, the potential of polysaccharide-based nanosystems provides valuable theoretical insights for the advancement and application of human vaccine adjuvants.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124017"},"PeriodicalIF":10.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of cellulose nanocrystals using Brønsted Acidic Ionic Liquids (BAILs), based on anionic clusters with changes in the cation and anion's structure 利用Brønsted酸性离子液体（BAILs）制备纤维素纳米晶体，基于阴离子簇，改变正离子和阴离子的结构

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-09 DOI: 10.1016/j.carbpol.2025.124030

Maria G. Paredes , Francisco Pinto , Felipe Olea , Esteban Quijada-Maldonado , Alessandra Lavoratti , Onajite Abafe Diejomaoh , Jude Laverock , Stephen J. Eichhorn , Paulina Pavez

{"title":"Production of cellulose nanocrystals using Brønsted Acidic Ionic Liquids (BAILs), based on anionic clusters with changes in the cation and anion's structure","authors":"Maria G. Paredes , Francisco Pinto , Felipe Olea , Esteban Quijada-Maldonado , Alessandra Lavoratti , Onajite Abafe Diejomaoh , Jude Laverock , Stephen J. Eichhorn , Paulina Pavez","doi":"10.1016/j.carbpol.2025.124030","DOIUrl":"10.1016/j.carbpol.2025.124030","url":null,"abstract":"<div><div>Nine Brønsted Acid Ionic Liquids (BAILs) based on two cationic bases (1-methylimidazolium and pyridinium) and anions derived from sulfuric (SA) and phosphoric (PA) acids, were used as solvents and acid catalysts for the hydrolysis of commercial cellulose to obtain cellulose nanocrystals (CNCs). The BAILs' effect on the reactions was evaluated as a function of the acidity and polarity of the solvents, determined by the Hammett acidity parameter (<em>H</em><sub>0</sub>) (determined experimentally) and by the <em>β</em> parameter of the Kamlet-Taft analysis (determined computationally using COSMOS-RS). Under the same experimental conditions, the change of solvent not only affects the reaction yield of the CNCs but also the final characteristics of the nanomaterials obtained. All CNCs derived from PA-BAILs show a high thermal stability compared to those obtained with SA-BAILs, with T<sub>max</sub> values of ~345 °C and 271 °C respectively. Effective surface modification of the CNCs was assessed using X-ray photoelectron spectroscopy (XPS) analysis, Zeta potentials and surface charge density (SCD) determined by conductometric titration. This study provides a solid foundation for the design of ionic liquid-based systems aimed at producing surface-modified CNCs for advanced applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124030"},"PeriodicalIF":10.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carboxymethyl chitosan-based form-stable phase change materials with ultra-low leakage and excellent low-temperature buffering performance 羧甲基壳聚糖基相变材料具有超低泄漏和优异的低温缓冲性能

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-08 DOI: 10.1016/j.carbpol.2025.124033

Dengshuang Guo , Yuwei Zhang , Kuncong Chen , Shun Wang , Zhongfeng Tang , Baofeng Lin

{"title":"Carboxymethyl chitosan-based form-stable phase change materials with ultra-low leakage and excellent low-temperature buffering performance","authors":"Dengshuang Guo , Yuwei Zhang , Kuncong Chen , Shun Wang , Zhongfeng Tang , Baofeng Lin","doi":"10.1016/j.carbpol.2025.124033","DOIUrl":"10.1016/j.carbpol.2025.124033","url":null,"abstract":"<div><div>In the cold chain transportation field, the commonly used polystyrene foam has drawbacks in degradation and temperature buffering, leading to considerable resource waste and environmental pollution. Here, a novel form-stable phase change material (FSPCM) based on carboxymethyl chitosan/sodium alginate/polyethylene glycol 400 has been prepared by a preforming post-enhancement approach combined with freeze-drying. The preforming post-enhancing strategy resolves the contradiction between mechanical support of natural polymer-based gels and controllable molding, thereby enabling FSPCM to be directly molded into shapes required for practical applications (e.g., packaging boxes). As one of the key performances, the high encapsulation efficiency (50.37 %) of polyethylene glycol 400 endows this FSPCM with robust temperature buffering properties compare to polystyrene foam. Furthermore, the lamellar shell endows the FSPCM with remarkable mechanical properties (Young's modulus of 10.27 MPa), resistance to leakage (no polyethylene glycol 400 leakage was detected after 5 days at 80 °C), and antibacterial properties (showing >99.5 % bactericidal rate against <em>Escherichia coli</em> and <em>Staphylococcus aureus</em>). Additionally, the FSPCM exhibited superior thermal stability and biocompatibility. This study provides new insight into an alternative package design for green and low-temperature buffering to cold chain transportation.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124033"},"PeriodicalIF":10.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the alkaline degradation of oxidized chondroitin sulfate: Implications in Schiff base formation for hydrogel fabrication 氧化硫酸软骨素的碱性降解：希夫碱形成对水凝胶制造的影响

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-08 DOI: 10.1016/j.carbpol.2025.124016

Jose Antonio Duran-Mota , Harrison Moon , Margalida-Esmeralda Artigues Cladera , Salvador Borrós , Nuria Oliva

{"title":"Insights into the alkaline degradation of oxidized chondroitin sulfate: Implications in Schiff base formation for hydrogel fabrication","authors":"Jose Antonio Duran-Mota , Harrison Moon , Margalida-Esmeralda Artigues Cladera , Salvador Borrós , Nuria Oliva","doi":"10.1016/j.carbpol.2025.124016","DOIUrl":"10.1016/j.carbpol.2025.124016","url":null,"abstract":"<div><div>Chondroitin sulfate (CS) shows great promise for hydrogels and scaffolds in tissue engineering due to its biocompatibility and compressive strength. However, its chemical structure limits its use, necessitating modifications like oxidation to render CS with aldehyde groups (oxCS) and enabling hydrogel formation <em>via</em> Schiff base chemistry with amines. While an alkaline pH is essential for this crosslinking, high alkalinity affects the stability of oxCS. Despite extensive studies on CS, the extent of this in oxCS has not been thoroughly explored. This study examines oxCS degradation under alkaline conditions using spectrometric and spectroscopic techniques, suggesting possible pathways associated with decreased aldehyde functionality and reduced potential for Schiff base formation. At pH 10, aldehyde groups diminish by 50 % within 2 h, accompanied by enhanced chain scission compared to CS. These findings are applied as proof of concept in the development of two hydrogel families using 8-arm PEG-amines with varying pKa values, demonstrating the critical impact on oxCS stability and affecting the hydrogels' mechanical properties and performance. All in all, the present work provides essential insights into the design of glycosaminoglycan-based hydrogels and scaffolds. These findings advance the development of tailored biomaterials for tissue engineering, addressing the challenges posed by oxCS's stability under alkaline conditions.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124016"},"PeriodicalIF":10.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Starch nanoparticle platform for oral delivery of sinigrin in colitis therapy 淀粉纳米颗粒平台口服给药紫杉素治疗结肠炎

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-08 DOI: 10.1016/j.carbpol.2025.124032

Hazzel Joy Adra , Hanvit Cha , Moon Han Chang , Dong-Gook Kang , Su-min Kwon , Sang-Mook You , Yu Ri Jeong , Chae Hwan Lee , Ki Sung Park , Seung Pil Pack , Jin Hyup Lee , Young-Rok Kim

{"title":"Starch nanoparticle platform for oral delivery of sinigrin in colitis therapy","authors":"Hazzel Joy Adra , Hanvit Cha , Moon Han Chang , Dong-Gook Kang , Su-min Kwon , Sang-Mook You , Yu Ri Jeong , Chae Hwan Lee , Ki Sung Park , Seung Pil Pack , Jin Hyup Lee , Young-Rok Kim","doi":"10.1016/j.carbpol.2025.124032","DOIUrl":"10.1016/j.carbpol.2025.124032","url":null,"abstract":"<div><div>Sinigrin, a glucosinolate known for its potential therapeutic effects on ulcerative colitis (UC), suffers from rapid gastric clearance and low bioavailability when administered orally. To address these limitations, we developed a novel delivery system using starch nanoparticles (SNPs) to encapsulate sinigrin via a sinigrin-lecithin complex (SNG-L). This approach significantly improved sinigrin's encapsulation efficiency, stability against acidic degradation, and controlled release in simulated intestinal conditions. In vivo studies using a preclinical UC mouse model demonstrated that SNG-L@SNPs effectively targeted and released sinigrin into the intestine, where it was converted into the bioactive compound allyl isothiocyanate (AITC) through the intestinal microflora. This targeted delivery and controlled release system markedly alleviated the pathological manifestations of UC and preserved intestinal barrier integrity by mitigating tight junction disruption and apoptosis of intestinal epithelial cells (IECs) through reduction of oxidative stress. These findings highlight the potential of this precise and sustained drug delivery system as an effective therapeutic strategy for UC management.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124032"},"PeriodicalIF":10.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of relative humidity-driven cinnamaldehyde from β-cyclodextrin inclusion complexes for antimicrobial packaging 相对湿度驱动β-环糊精包合物肉桂醛抗菌包装的机理

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-08 DOI: 10.1016/j.carbpol.2025.124034

Yayue Wang , Lu Lan , Kai Kang , Xinzhong Hu , Tian Ren

{"title":"Mechanism of relative humidity-driven cinnamaldehyde from β-cyclodextrin inclusion complexes for antimicrobial packaging","authors":"Yayue Wang , Lu Lan , Kai Kang , Xinzhong Hu , Tian Ren","doi":"10.1016/j.carbpol.2025.124034","DOIUrl":"10.1016/j.carbpol.2025.124034","url":null,"abstract":"<div><div>Precise control over the release of volatile antimicrobials is crucial for industrial applications. Although β-cyclodextrin inclusion complexes (β-CD-IC) enable humidity-triggered release, the mechanisms remain unclear, hindering systematic optimization for practical use. This study characterized β-CD-IC using encapsulation efficiency (82.7 %), loading capacity (7.6 %), X-ray diffraction (XRD), low-field nuclear magnetic resonance (LF-NMR), and volatile antimicrobial assays. The release kinetics of cinnamaldehyde (CIN) were evaluated under five relative humidity (RH) conditions (22 %, 32 %, 55 %, 85 %, and 98 %), revealing that increasing RH enhanced weakly bound water distribution and strengthened water-β-CD interactions, thereby facilitating the release of CIN. At 98 % RH, the cumulative release reached 57.3 % after 7 days, accompanied by complete inhibition against <em>Staphylococcus aureus</em> and <em>Aspergillus niger</em>. XRD and LF-NMR analyses demonstrated that high RH (≥85 %) induced structural reorganization into hydrated cage-like frameworks, while free water formation competitively displaced CIN from the hydrophobic cavity. Molecular dynamics (MD) simulations further elucidated that water molecules preferentially bound to the C6 hydroxyl groups of β-CD, destabilizing the inclusion complex through reduced binding free energy (from −6264.77 kJ/mol at 22 % RH to −4682.34 kJ/mol at 98 % RH) and increased system entropy. These findings offer a theoretical foundation for optimizing β-CD-IC as smart antimicrobial materials in food packaging.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124034"},"PeriodicalIF":10.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coacervation-assisted self-assembly of short-chain glucans for the fabrication of hierarchically porous starch microparticles 短链葡聚糖的凝聚辅助自组装制备分层多孔淀粉微粒

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-07-08 DOI: 10.1016/j.carbpol.2025.124036

Dong-Gook Kang, Ji-Hyeon Lee, Sang-Mook You , Young-Rok Kim

{"title":"Coacervation-assisted self-assembly of short-chain glucans for the fabrication of hierarchically porous starch microparticles","authors":"Dong-Gook Kang, Ji-Hyeon Lee, Sang-Mook You , Young-Rok Kim","doi":"10.1016/j.carbpol.2025.124036","DOIUrl":"10.1016/j.carbpol.2025.124036","url":null,"abstract":"<div><div>Here, we present a simple, sustainable, and efficient strategy for synthesizing porous starch microspheres (PSMP) with hierarchical porosity. This approach exploits the directed self-assembly of debranched waxy maize starch, specifically short-chain glucans (SCGs), facilitated by the existence of chitosan. The debranching enzyme, pullulanase, plays an integral role in initiating coacervation with chitosan through electrostatic interactions beyond its primary function in starch hydrolysis, thereby creating nucleation sites for SCG assembly. The coacervation process undergoes sequential phases of structural transformation and eventual dissipation, culminating in the creation of a highly porous starch framework. The hierarchical porosity of the resulting starch microparticles is further optimized, enabling precise control over their structural and functional properties. Specifically, the Brunauer–Emmett–Teller (BET) surface area was significantly enhanced from 1.68 to 19.63 m<sup>2</sup>/g, and the total pore volume increased from 0.005 to 0.15 cm<sup>3</sup>/g (<em>p</em> < 0.01 for both). In addition, the PSMPs exhibited an 82 % higher dye adsorption capacity (from 108 to 198 mg/g) and maintained a high resistant starch content (~70 %) after <em>in vitro</em> digestion. By utilizing enzyme-driven coacervation as an integrated step, this approach fundamentally simplifies the fabrication process while enabling the production of highly functional, eco-friendly porous materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"Article 124036"},"PeriodicalIF":10.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0