Carbohydrate Polymers最新文献_第7页

3D-printed programmable hierarchical hole-cavity architectures of fully cellulose nanofibrils for tunable broadband sound absorption 3d打印可编程分层孔腔结构的全纤维素纳米纤维可调宽带吸声

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-27 DOI: 10.1016/j.carbpol.2025.124480

Wei Chen , Luyao Ding , Qingbiao Li , Jiahui Shen , Jiajia Zheng , Xiping Li , Zhonglue Hu , Shaohua Jiang , Shanglin Xiao , Yiming Chen

{"title":"3D-printed programmable hierarchical hole-cavity architectures of fully cellulose nanofibrils for tunable broadband sound absorption","authors":"Wei Chen , Luyao Ding , Qingbiao Li , Jiahui Shen , Jiajia Zheng , Xiping Li , Zhonglue Hu , Shaohua Jiang , Shanglin Xiao , Yiming Chen","doi":"10.1016/j.carbpol.2025.124480","DOIUrl":"10.1016/j.carbpol.2025.124480","url":null,"abstract":"<div><div>The integration of broadband sound absorption with environmental sustainability remains a key challenge in advanced material design. In this work, an innovative 3D-printed cellulose nanofibril (CNF) architecture with a customizable hierarchical “hole-cavity unity” structure was proposed for highly efficient sound absorption. This multi-scale structural design strategy synergistically coupled the perforated-panel acoustic principles with nanoscale viscous dissipation mechanisms. By leveraging the shear-thinning behavior of CNF inks and the precision control of direct ink writing, the sub-millimeter periodic pore arrays were embedded within the continuous nanofibrous network, enabling programmable structural tunability across multiple pore scales. Systematic regulation of infill ratio and sample thickness yielded high sound absorption coefficients (>0.7) over an ultra-broad frequency range of 1.2–6.3 kHz. Combined with low shrinkage, structural customizability, low density, and rapid environmental degradability, the fully bio-based 3D-printed CNF architectures are expected to offer a promising and sustainable solution for developing next-generation acoustic materials for noise control applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124480"},"PeriodicalIF":12.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global immunostimulatory mechanisms of a high-branched glycogen from Glyptocidaris crenularis eggs in RAW264.7 macrophages via BONCAT-based nascent proteomics 基于boncat的新生蛋白质组学研究表明，糖原在RAW264.7巨噬细胞中的免疫刺激机制

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-26 DOI: 10.1016/j.carbpol.2025.124473

Qingchi Wang , Yuhang Luo , Yi Xin , Yuanxiang Jin , Guiling Yang , Quanbin Zhang , Zhengshun Wen

{"title":"Global immunostimulatory mechanisms of a high-branched glycogen from Glyptocidaris crenularis eggs in RAW264.7 macrophages via BONCAT-based nascent proteomics","authors":"Qingchi Wang , Yuhang Luo , Yi Xin , Yuanxiang Jin , Guiling Yang , Quanbin Zhang , Zhengshun Wen","doi":"10.1016/j.carbpol.2025.124473","DOIUrl":"10.1016/j.carbpol.2025.124473","url":null,"abstract":"<div><div>Marine polysaccharides have emerged as promising immunomodulators. However, conventional analytical approaches have failed to elucidate their activation mechanisms from a global perspective. In this study, we isolated a highly branched glycogen (GCEP2a) from eggs of the sea urchin <em>Glyptocidaris crenularis</em>. Structural characterization revealed that GCEP2a possesses a backbone composed of →4)-α-D-Glc<em>p</em>-(1 → residues, with one C6-branch per five residues, and a molecular weight of 8.06 × 10<sup>3</sup> kDa. Employing nascent-proteome bioorthogonal non-canonical amino acid tagging (BONCAT) enrichment followed by DIA-FAIMS, we unraveled the global immunostimulatory mechanisms of GCEP2a in RAW264.7 macrophages. This advanced approach enabled dynamic profiling of nascent protein synthesis, uncovering a multi-receptor and multi-pathway regulatory network. Specifically, GCEP2a activates signaling consistent with engagement of the toll-like receptors (TLRs), C-type lectin receptors (CLRs), and RIG-I-like receptors (RLRs), thereby triggering downstream signaling cascades including the NF-κB, MAPK, and PI3K-AKT pathways. Additionally, GCEP2a downregulates the biosynthesis of lacto- and neolacto-series glycosphingolipids, indicating metabolic reprogramming associated with M1 polarization. These findings not only suggest that GCEP2a exhibits potential as an immune adjuvant, but also provide initial insights into the application of BONCAT-based nascent proteomics for investigating the multi-modal immunostimulatory mechanisms of marine polysaccharides.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124473"},"PeriodicalIF":12.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural mechanism study on the retention and slow release of aroma molecules by starch in the form of V6-type crystals 淀粉以v6型晶体形式保留和缓释香气分子的结构机理研究

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-26 DOI: 10.1016/j.carbpol.2025.124476

Yushen Liang , Fan Wang , Rongrong Ma , Yaoqi Tian

{"title":"Structural mechanism study on the retention and slow release of aroma molecules by starch in the form of V6-type crystals","authors":"Yushen Liang , Fan Wang , Rongrong Ma , Yaoqi Tian","doi":"10.1016/j.carbpol.2025.124476","DOIUrl":"10.1016/j.carbpol.2025.124476","url":null,"abstract":"<div><div>The structural evolution of V6-type starches was analyzed from the microscopic level—single-helix conformation, unit cell structure, and lamellar structure—to the macroscopic level—crystalline structure and crystal properties. It also identified the mechanisms by which the structure of V-type starch affected aroma retention. Three V6-type starches, i.e. V6I-, V6II-, and V6III-type, with different structural characteristics, were prepared using 1-octanol, 1-octen-3-ol, and γ-octalactone, respectively. V6I-type starch, with its higher content of single helices and greater structural variability in both unit cell and lamellar structures, showed a significant increase in aroma retention at 12–20 h, resulting in a high retention rate (<em>R</em> = 59 %). In contrast, V6II- and V6III-type starches, with lower structural variability and less dense V-type crystals, exhibited higher initial retention rates (<em>t</em> ≤ 12 h) but lower final retention rates of 46 % and 35 %, respectively. Correlation analysis indicated that the microstructure had a cumulative effect on the macroscopic crystalline structure, with the highest positive correlation between aroma retention rate and crystalline structure (relative crystallinity) as well as crystal performance (short-range order and structural stability). V6III-type starch showed the best slow-release effect, with a value of 39.02 %. These findings illuminate structure-driven strategies for tailoring aroma retention and release in V6-type starch.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124476"},"PeriodicalIF":12.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation and characterization of soy protein isolate-chitosan-epigallocatechin gallate ternary complexes: Molecular interactions and functional properties 大豆分离蛋白-壳聚糖-表没食子儿茶素没食子酸酯三元配合物的形成和表征：分子相互作用和功能特性

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-26 DOI: 10.1016/j.carbpol.2025.124474

Imane Bourouis , Mengya Sun , He Li , Zhihua Pang , Xinqi Liu

{"title":"Formation and characterization of soy protein isolate-chitosan-epigallocatechin gallate ternary complexes: Molecular interactions and functional properties","authors":"Imane Bourouis , Mengya Sun , He Li , Zhihua Pang , Xinqi Liu","doi":"10.1016/j.carbpol.2025.124474","DOIUrl":"10.1016/j.carbpol.2025.124474","url":null,"abstract":"<div><div>In this study, ternary complexes using soy protein isolate (SPI), chitosan (CS), and epigallocatechin gallate (EGCG) were prepared, and the non-covalent interaction mechanisms between SPI-CS and EGCG were explored through multispectral techniques. The impact of varying EGCG concentrations (0.1–0.5 mg/mL, corresponding to approximately 0.22–1.09 mmol/L) on the properties of SPI-CS complexed microgels was studied under different pH (3.0–7.0) and NaCl (0–400 mM) conditions. The findings confirmed the successful formation of a new ternary complex, as shown by structural alterations in the SPI-CS binary complexes upon the addition of EGCG, as evidenced by quenched intrinsic fluorescence and a red shift in the maximum fluorescence emission peak. The secondary structure analysis revealed a reduction in β-sheet content accompanied by an increase in α-helix structures. FTIR results indicated that electrostatic interactions, hydrogen bonding, and hydrophobic interactions played key roles in the interactions between SPI-CS and EGCG. These structural changes also influenced the thermal stability of the complexes. Furthermore, EGCG increased the apparent viscosity, yield stress, and viscoelastic moduli (G′ and G″), while also improving the tribological performance of the SPI-CS systems. Overall, this study offers foundational insight into the potential utilization of SPI-CS-EGCG complexes in food applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124474"},"PeriodicalIF":12.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of cellulose nanocrystals with epoxidized canola oil for enhancing interfacial compatibility with poly(lactic acid) 环氧菜籽油改性纤维素纳米晶增强与聚乳酸的界面相容性

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-25 DOI: 10.1016/j.carbpol.2025.124471

Mohamed Wahbi, Yidan Wen, Marianna Kontopoulou, Kevin J. De France

{"title":"Modification of cellulose nanocrystals with epoxidized canola oil for enhancing interfacial compatibility with poly(lactic acid)","authors":"Mohamed Wahbi, Yidan Wen, Marianna Kontopoulou, Kevin J. De France","doi":"10.1016/j.carbpol.2025.124471","DOIUrl":"10.1016/j.carbpol.2025.124471","url":null,"abstract":"<div><div>Herein, we investigate a sustainable hydrophobic modification of cellulose nanocrystals (CNCs) with epoxidized canola oil (ECO) via an oxirane ring-opening reaction, in order to improve compatibility with poly(lactic acid) (PLA). The modified CNCs (CNC-g-ECO) exhibited improved hydrophobicity, as evidenced by their lack of colloidal stability in water and an increase in water contact angle from 33° to 73°. Importantly, XRD analysis indicated that the modification did not disrupt the crystalline structure of the CNCs. Neat and modified CNCs were compounded with PLA at 1 wt% using multiple processing protocols. Polarized optical microscopy revealed that the modified CNCs exhibited significantly improved dispersion and distribution within the PLA matrix across all processing methods. Additionally, the modified CNCs acted as effective nucleating agents for PLA, leading to an increase in its degree of crystallinity. Notably, we found that CNC modification with ECO enhanced thermal stability and completely mitigated discoloration or thermal aging, which is a common occurrence in CNC-based composites, typically caused by CNC degradation and oxidation of carboxyl groups during processing. Overall, our approach gives CNC an expanded thermal processing window and improves dispersion in polymer matrices, facilitating the development of high-performance composites for a number of different applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124471"},"PeriodicalIF":12.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of conditioning baths on the structure and properties of fibers spun from cellulose with low alpha content 调质浴对低含量纤维素纺成纤维结构和性能的影响

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-25 DOI: 10.1016/j.carbpol.2025.124472

Igor Makarov , Markel Vinogradov , Ekaterina Palchikova , Yuriy Kulanchikov , Ivan Levin , Alexander Procko , Konstantin Sinyaev , Stanislav Ermakov , Valery Kulichikhin , Elena Fedorova , Igor Govyazin

{"title":"The influence of conditioning baths on the structure and properties of fibers spun from cellulose with low alpha content","authors":"Igor Makarov , Markel Vinogradov , Ekaterina Palchikova , Yuriy Kulanchikov , Ivan Levin , Alexander Procko , Konstantin Sinyaev , Stanislav Ermakov , Valery Kulichikhin , Elena Fedorova , Igor Govyazin","doi":"10.1016/j.carbpol.2025.124472","DOIUrl":"10.1016/j.carbpol.2025.124472","url":null,"abstract":"<div><div>For many years, the production of artificial cellulose fibers has been associated with the viscose process, which is inherently environmentally hazardous and unacceptable in modern conditions. The NMMO process is an alternative in which cellulose solutions are obtained using a direct solvent, <em>N</em>-methylmorpholine-N-oxide (NMMO). Spinning solutions in NMMO can be made from cellulose with a high concentration of impurities (lignin, hemicellulose, etc.). Metals that affect solvent and polymer stability are an exception; their content should not exceed the acceptable levels. Conditioning fibers in baths of diverse compositions is one of the most important stages of structure formation. Keeping fibers made from paper-grade pulp in conditioning baths causes changes in not only the size of crystallites and the degree of crystallinity, but also in mechanical characteristics. Thus, after completely removing the solvent and immersing the fibers in alcohol, the crystallinity rises as compared to fibers that have just received water baths. Strength and elastic modulus attain their peak values, while relative elongation falls to 3–6 %. Regardless of the structural alteration, all corrugated fibers keep their crimp, color, and organoleptic qualities.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124472"},"PeriodicalIF":12.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-function relationships of edible and medicinal mushroom polysaccharides: Structural analysis, target molecules and signaling pathways 食用菌和药用菌多糖的结构-功能关系：结构分析、靶分子和信号通路

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-25 DOI: 10.1016/j.carbpol.2025.124463

Jun-Ying Zhao , Jie Guo , Hui-Yu Ye , Peng-Wei Luo , Qian Zhu , Huan Xu , Ying Zhou , Yu-Jing Wang

{"title":"Structure-function relationships of edible and medicinal mushroom polysaccharides: Structural analysis, target molecules and signaling pathways","authors":"Jun-Ying Zhao , Jie Guo , Hui-Yu Ye , Peng-Wei Luo , Qian Zhu , Huan Xu , Ying Zhou , Yu-Jing Wang","doi":"10.1016/j.carbpol.2025.124463","DOIUrl":"10.1016/j.carbpol.2025.124463","url":null,"abstract":"<div><div>Edible and medicinal mushrooms have attracted attention for their abundant resources, distinctive flavors, and health-enhancing properties. Polysaccharides are the most abundant and widely studied macromolecules in these mushrooms. They exhibit various bioactivities, including immunostimulation, antioxidant, antitumor, hypoglycemic, and lipid metabolism regulation. Edible and medicinal mushroom polysaccharides (EMMPs), as naturally derived “biological response modifiers”, are essential for maintaining host health owing to their unique chemical structures and diverse biological functions. However, current structural analysis techniques still face challenges in characterizing the highly heterogeneous polysaccharides. Meanwhile, the multi-target and multi-pathway interaction effects between polysaccharides and organisms remain incompletely elucidated, which severely restricts the development and application of EMMPs. In light of these challenges, this paper reviews the latest advances concerning the structural features and bioactivities of EMMPs. The structure-function relationships of EMMPs are elucidated through synthesizing structural analysis strategies and integrating target molecules and signaling pathways related to health benefits. This provides a scientific basis for establishing structure-guided bioactivity modulation strategies and lays a theoretical foundation for the development of functional factors derived from EMMPs and the intervention of precise nutrition.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124463"},"PeriodicalIF":12.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical, clinical, and commercialization of chitosan in the biomedical space 壳聚糖在生物医学领域的临床前、临床和商业化

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-25 DOI: 10.1016/j.carbpol.2025.124456

Maame Abena O. Afrifa , Samuel G. Awuah

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All-cellulose-based solar evaporators with improved wet mechanical integrity via mercerization 全纤维素基太阳能蒸发器，通过丝光改善湿机械完整性

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-25 DOI: 10.1016/j.carbpol.2025.124470

Soojin Kwon , Jung-soo Han , Sangyun Kim , Kyudeok Oh

{"title":"All-cellulose-based solar evaporators with improved wet mechanical integrity via mercerization","authors":"Soojin Kwon , Jung-soo Han , Sangyun Kim , Kyudeok Oh","doi":"10.1016/j.carbpol.2025.124470","DOIUrl":"10.1016/j.carbpol.2025.124470","url":null,"abstract":"<div><div>With rising demand for sustainable technologies, renewable energy–driven water purification and desalination have gained increasing attention. Here, we present a newly developed all-cellulose interfacial solar evaporator system with enhanced wet mechanical integrity through mercerization. The devices consist of a porous microfibrillated cellulose supporting layer and a cellulose nanofibril photothermal layer integrated with carbon nanotubes. Post-fabrication mercerization, an alkali treatment using sodium hydroxide, induced a crystalline transformation from cellulose I to cellulose II, resulting in improved fiber entanglement and structural integrity. Systematic characterization revealed a robust structure and outstanding performance, with solar-to-vapor energy conversion efficiencies up to 95 % and evaporation rates of 15 kg·m<sup>−2</sup>·h<sup>−1</sup> under high-intensity simulated sunlight (5–10 kW·m<sup>−2</sup>), as well as the highest efficiencies reported to date at 3 and 5 kW·m<sup>−2</sup>. It also demonstrates >99.9 % rejection of common salts and toxic heavy-metal ions, exhibiting self-regenerating behavior, highlighting their suitability for long-term field use. These results demonstrate that mercerization, a relatively mild chemical treatment, is effective in overcoming the intrinsic wet strength limitations of cellulose-based devices, thereby enabling their practical application in sustainable water purification. Our study highlights the potential of all-cellulose, biodegradable solar evaporators for scalable, eco-friendly water treatment solutions.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"370 ","pages":"Article 124470"},"PeriodicalIF":12.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schizophyllum commune polysaccharide ameliorates diet-induced obesity by regulating the Faecalibaculum rodentium/indole-3-lactic acid/microRNA axis 裂肉多糖通过调节粪足菌/吲哚-3-乳酸/microRNA轴改善饮食诱导的肥胖

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-09-24 DOI: 10.1016/j.carbpol.2025.124436

Chaomin Yin , Chen Li , Xiuzhi Fan , Defang Shi , Jiangtao Li , Jianhui Qiu , Fen Yao , Wei Yu , Hong Gao

{"title":"Schizophyllum commune polysaccharide ameliorates diet-induced obesity by regulating the Faecalibaculum rodentium/indole-3-lactic acid/microRNA axis","authors":"Chaomin Yin , Chen Li , Xiuzhi Fan , Defang Shi , Jiangtao Li , Jianhui Qiu , Fen Yao , Wei Yu , Hong Gao","doi":"10.1016/j.carbpol.2025.124436","DOIUrl":"10.1016/j.carbpol.2025.124436","url":null,"abstract":"<div><div>Diet-induced metabolic disorder is a global health concern, and bioactive polysaccharides have been shown to mitigate metabolic disorder by modifying gut microbiota. Polysaccharides from <em>Schizophyllum commune</em> have shown excellent anti-obesity effects, but the specific regulatory mechanisms remain unclear. Herein, we reported that SCP could effectively inhibit 3 T3-L1 preadipocyte differentiation in vitro and supplementation with SCP alleviated obesity in HFD-fed mice. SCP treatment significantly enriched <em>Faecalibaculum rodentium</em> and ILA and increased the expression levels of several lipid metabolism-related genes including <em>AMPKα</em>, <em>PGC-1α</em> and <em>PPARγ</em>. The anti-obesogenic effects of SCP can be transferred by FMT. SCP supplementation and FMT significantly increased the ILA levels in serum and feces. Moreover, FMT significantly increased the levels of miR-144-5p, miR-142a-5p and miR-150-5p; these miRNAs were enriched in the phosphatidylinositol signaling pathway and were positively correlated with the content of ILA. The lipogenesis-related gene <em>Nr2F6</em> was coregulated by the above miRNAs, and its expression level significantly increased in FMT mice. These results indicate that SCP ameliorates diet-induced obesity by increasing the abundance of <em>F. rodentium</em> and ILA as well as the expression levels of certain miRNAs. Our study may provide a new reference for understanding the anti-obesogenic effects of natural polysaccharides.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124436"},"PeriodicalIF":12.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0