Carbohydrate Polymers最新文献

{"title":"RGD-Alginate beads as scaffolds for culturing primary human dermal and pulmonary fibroblasts","authors":"M.C. Stahl ,&nbsp;K.G. Bergendahl ,&nbsp;D. Zaytseva-Zotova ,&nbsp;K.R. Rytterager ,&nbsp;C.T. Nordgård ,&nbsp;J.S. Kjesbu ,&nbsp;H. Haslene-Hox ,&nbsp;Ø. Halaas ,&nbsp;P. Sætrom ,&nbsp;A.S. Chahal ,&nbsp;B.L. Strand","doi":"10.1016/j.carbpol.2026.124913","DOIUrl":"10.1016/j.carbpol.2026.124913","url":null,"abstract":"<div><div>The use of hydrogel microparticles as granular hydrogels is an emerging approach in tissue engineering, where microparticles offer printability, injectability, and serve as scaffolds for cell culture. While culturing dermal fibroblasts for tissue engineering applications is well reported, there is limited research on culturing primary human pulmonary fibroblasts on granular hydrogels. In this study, we grafted RGD-peptides to alginate, formed microbeads, and investigated the ability of granular hydrogels to support the adhesion and growth of primary normal human dermal fibroblasts (NHDFs) and human pulmonary fibroblasts (HPFa). NHDFs adhered to linear RGD (linRGD)-alginate microbeads and spread on the bead surfaces with increased adhesion with increased peptide concentration (0.3–1.3 mM). In contrast, HPFa did not adhere to the linRGD-alginate microbeads. However, HPFa adhered and spread on flat linRGD-alginate gels, indicating that HPFa do respond to linRGD as an adhesion ligand. Supplementation of <span><math><mrow><mi>M</mi><msup><mrow><mi>n</mi></mrow><mrow><mn>2</mn><mo>+</mo></mrow></msup></mrow></math></span> resulted in cell adhesion to linRGD-alginate microbeads. Enhanced adhesion and spreading of HPFa to RGD-alginate microbeads were observed when using cyclic RGD. Hence, RGD-alginate microbeads is a promising material for structuring primary human dermal and pulmonary fibroblasts, showing the relevance of using alginate microbeads as scaffolds for 3D cultures with fibroblasts.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124913"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wine processing induced structural modification of Polygonati Rhizoma polysaccharide and their enhancement of Tc1 cell immunomodulatory activity via microbiota-mediated butyrate metabolism","authors":"Fenghe Yang ,&nbsp;Chun Wang ,&nbsp;Zhiqian Song ,&nbsp;Shitao Peng ,&nbsp;Ziqi Tian ,&nbsp;Wenjie Lu ,&nbsp;Tao Lin ,&nbsp;Qiao He ,&nbsp;Aiping Lyu ,&nbsp;Zhangchi Ning","doi":"10.1016/j.carbpol.2026.124935","DOIUrl":"10.1016/j.carbpol.2026.124935","url":null,"abstract":"<div><div>The herb Polygonati Rhizoma is highly esteemed for its immune regulatory therapeutic and nutritive properties, with polysaccharide identified as the principal components that play a pivotal role in immune response modifying. In China, the immunomodulatory effects of Polygonati Rhizoma polysaccharide (PRP) are believed to enhanced after wine processing. However, the structural changes and underlying mechanisms remain insufficiently elucidated. We isolated and purified PRP and wine processing PRP (WPRP) for structural and functional analysis. Structural analysis showed a processing-driven shift from a low-molecular-weight fructo-glucosyl fructan in PRP (1.85 kDa) to a higher-molecular-weight, pectin-type polysaccharide in WPRP (7.31 kDa) enriched in arabinose, galactose and galacturonic acid. The precise structural transition was from <em>α</em>-D-Glc<em>p</em> → [2)-<em>β</em>-D-Fru<em>f</em>-(1]₃ → 2)-<em>β</em>-D-Fru<em>f</em>-(1 → 6)-<em>α</em>-D-Glc<em>p</em>-(1 → 2)-<em>β</em>-D-Fru<em>f</em> → in PRP to → 4)-<em>β</em>-D-Gal<em>p</em>-(1 → 4)-<em>β</em>-D-Gal<em>p</em>-(1 → 4)-<em>α</em>-D-GalA<em>p</em>-(1 → 5)-<em>α</em>-L-Ara<em>f</em>-(1 → [5)-<em>α</em>-L-Ara<em>f</em>-(1]₃ → 4)-<em>α</em>-D-GalA<em>p</em>-(1 → 4)-<em>α</em>-D-GalA<em>p</em>-(1 → in WPRP. WPRP exhibited stronger immunomodulatory activity than PRP in immunosuppressed mice. Mechanistically, galacturonic acid-rich pectins and arabinan driven by wine processing are preferential fermentable substrates for butyrate-producing gut bacteria, which promoted Tc1 cell activation/differentiation, and preserved intestinal epithelial integrity. These findings reveal that PRP drives structural remodeling after wine processing, modulating microbial butyrate metabolism and promoting Tc1 activation, which provide novel insights into the modern medical value of traditional dietary resources.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124935"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flame-retardant and electromagnetic-interference-shielding silver nanowire/silicon dioxide/aramid nanofiber/sodium alginate lightweight porous composite for wearable sensors","authors":"Xinxin Cai ,&nbsp;Hui Liu ,&nbsp;Wen Li ,&nbsp;Jiwen Hu ,&nbsp;Xiaobin Li ,&nbsp;Shudong Lin","doi":"10.1016/j.carbpol.2026.125034","DOIUrl":"10.1016/j.carbpol.2026.125034","url":null,"abstract":"<div><div>With the rapid advancement of wearable electronics and smart devices, multifunctional wearable sensors have gained increasing attention. Therefore, a multifunctional silver nanowire/silicon dioxide/aramid nanofiber/sodium alginate (AgNWs/SiO₂/ANF/SA) porous composite was fabricated via liquid‑nitrogen freeze-drying, combining lightweight structure, electromagnetic interference (EMI) shielding, flame retardancy, and sensing. The porous composite was crosslinked through dual interactions of calcium ions (Ca²⁺) coordination and hydrogen bonding, forming a layered porous structure. The incorporation of AgNWs remarkably improved the electrical conductivity and EMI shielding capability of the porous composite. In particular, the AgNWs/SiO₂/ANF/SA composite containing 40% AgNWs (40Ag-A) achieved a low density of 44.01 kg/m³ together with outstanding EMI shielding effectiveness. Moreover, Ca²⁺ crosslinking with ANF and SA, combined with the synergistic reinforcement of SiO₂, enhanced the flame-retardant and smoke-suppression properties, lowering the heat release rate (PHRR), total heat release (THR), total smoke production (TSP), and carbon monoxide production rate (COP) of 40Ag-A to 41.64 kW/m², 2.98 MJ/m², 0.12 m², and 2.00 × 10⁻³ g/s. The wearable strain sensor fabricated using the 40Ag-A demonstrated outstanding sensitivity (S = 7.40, 19.45, and 40.23) and fast response/recovery characteristics (36 ms), allowing real-time detection of human joint movements. Therefore, the porous composite achieved synergistic enhancement in lightweight structure, electromagnetic shielding, flame retardancy, and sensing performance, showing great potential for wearable electronics, safety protection, and Smart Internet of Things applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125034"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A starch from Spirulina subsalsa: structural characterization and anti-photoaging activity","authors":"Yang Zhao ,&nbsp;Qianchen Sun ,&nbsp;Kexin Pei ,&nbsp;Haiyan Pei","doi":"10.1016/j.carbpol.2026.125001","DOIUrl":"10.1016/j.carbpol.2026.125001","url":null,"abstract":"<div><div><em>Spirulina subsalsa</em> is a filamentous cyanobacterium with great potential as a source of functional polysaccharides, but the structural characteristics of these polysaccharides and their potential role in skin photoaging protection remain largely unexplored. In this study three polysaccharide fractions (SPS-1, SPS-2, &amp; SPS-3) were isolated from the aqueous extract of <em>Spirulina subsalsa</em>, among which SPS-1 was further investigated due to its structural homogeneity and superior yield. SPS-1 was a homogeneous neutral polysaccharide composed mainly of glucose (98.9%), with a molecular mass of 2.89 × 10⁵ g/mol and a relatively low polydispersity index (PDI = 2.22). NMR and methylation analyses confirmed that it had a semi-rigid starch structure, characterized by a backbone of repeating →4)-α-<span>d</span>-Glc<em>p</em>-(1 → residues with limited branching. In UVB-irradiated HaCaT cells, SPS-1 exhibited anti-photoaging effects by attenuating oxidative stress, suppressing inflammation, and restoring extracellular matrix homeostasis through inhibition of the MAPK/NF-κB pathways. In vivo evaluation demonstrated its efficacy in enhancing skin barrier function, with limited skin permeation promoting surface retention and sustained activity that improved hydration and reduced water loss. These results indicate that SPS-1 has potential natural anti-photoaging activity and provide a theoretical basis for the structure–function study and skincare application of <em>Spirulina subsalsa</em> polysaccharides.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125001"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-engineering chitin: From poor processability to functional hydrogels via ketone modification and dynamic crosslinking","authors":"Rafael F.N. Quadrado ,&nbsp;Chisom Friday ,&nbsp;Atanur Satir ,&nbsp;Charles E. Frazier ,&nbsp;Kevin J. Edgar ,&nbsp;André R. Fajardo","doi":"10.1016/j.carbpol.2026.125048","DOIUrl":"10.1016/j.carbpol.2026.125048","url":null,"abstract":"<div><div>Chitin remains underutilized in hydrogel systems due to its low solubility and chemical inertness compared to its deacetylated derivative, chitosan. In this work, we report the design of a novel ketone-functionalized hydroxypropyl chitin (Ox-HPChit), obtained via selective oxidation using sodium hypochlorite, enabling dynamic covalent gelation through Schiff base formation with carboxymethyl chitosan (CMCs). This fully biopolymeric system forms injectable, self-healing hydrogels under mild conditions, without the need for synthetic crosslinkers or initiators. The optimized Ox-HPChit/CMCs hydrogel (Gel(1:2)) exhibited rapid gelation (24 min), high swelling capacity (2350%) and robust mechanical recovery, with over 85% of the storage modulus restored after high-strain cycles. Macroscopic injectability, as well as self-healing and adhesion to surfaces, were visually demonstrated. Furthermore, methotrexate-loaded hydrogels showed pH-responsive release, with 79.2% released at pH 5.5 after 24 h, due to the reversible nature of the imine crosslinks that form the hydrogel network. These findings demonstrate the successful development of a new functional chitin derivative and highlight its ability to act as a reactive precursor for dynamic, all-polysaccharide hydrogel networks formed via reversible imine chemistry. This work expands the chemical versatility of chitin and underscores its potential as a carbohydrate platform for the rational design of advanced polysaccharide-based materials, including drug delivery systems.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125048"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural characterization of Taiwanofungus camphoratus polysaccharide and its ameliorative effects on myelosuppression and immunosuppression by regulating macrophage activation","authors":"Yawen Wang ,&nbsp;Jianbin Wang ,&nbsp;Hang Lian ,&nbsp;Xueting Liu ,&nbsp;Jiahao Zheng ,&nbsp;Leyi Wang ,&nbsp;Juan Liang ,&nbsp;Xinyue Wei ,&nbsp;Yange Liu","doi":"10.1016/j.carbpol.2026.125020","DOIUrl":"10.1016/j.carbpol.2026.125020","url":null,"abstract":"<div><div>Chemotherapy-induced myelosuppression and immunosuppression impair anticancer efficacy, while macrophages maintain hematopoietic and immune homeostasis. The potential of <em>Taiwanofungus camphoratus</em> polysaccharides to alleviate these two conditions through macrophage modulation remains unexplored. This study focuses on a bioactive polysaccharide from <em>Taiwanofungus camphoratus</em> mycelium, aiming to characterize it and explore its molecular mechanism in alleviating myelosuppression and immunosuppression. Using advanced purification and analytical techniques, we identified a <em>Taiwanofungus camphoratus</em> polysaccharide (ACPSA) which has two structural domains: a heteroglucan constructed with →4) -α-D-Glc<em>p</em> -(1→ and →6)-α-D-Gal<em>p</em>-(1→ backbone linkages; and, β-glucan constituents featuring linear →6)-β-D-Glc<em>p</em>-(1→ and →3)-β-D-Glc<em>p</em>-(1→ polymeric frameworks. Using mouse models of myelosuppression and immunosuppression, along with macrophage models, we found that ACPSA alleviates damage to the bone marrow and immune organs, restores hematopoietic stem/progenitor cell differentiation, normalizes leukocyte depletion, and corrects macrophage abnormalities by upregulating classical activation markers. Morphometric and immunoblot analyses demonstrated that ACPSA enhances classical macrophage activation and phagocytic capacity in vitro. ACPSA promoted macrophage reconstitution and activation in vivo. This study employs proteomics to explore the molecular mechanisms of ACPSA's biological functions. It has been verified that ACPSA enhances classical macrophage activation and phagocytic function by suppressing macrophage autophagy. This mechanism highlights its therapeutic potential in addressing chemotherapy-induced complications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125020"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-based advanced biomaterials and stimuli-responsive systems for diabetic ulcer management: From principles to translational potential","authors":"Girish Kumar ,&nbsp;Tarun Virmani ,&nbsp;Abhishek Sharma ,&nbsp;Bhawna Goel ,&nbsp;Nitin Chitranshi ,&nbsp;Md Sayeed Akhtar ,&nbsp;Khalid Orayj ,&nbsp;Joana Galvão Duarte ,&nbsp;Filipa Mascarenhas-Melo","doi":"10.1016/j.carbpol.2026.125005","DOIUrl":"10.1016/j.carbpol.2026.125005","url":null,"abstract":"<div><div>Diabetic ulcers remain a significant clinical concern because of their poor healing, persistent inflammation, and increased infection risk. Chitosan and its derivatives have emerged as promising biomaterials for ulcer management due to their biocompatibility, biodegradability, mucoadhesiveness, pH responsiveness, and intrinsic properties, including hemostatic effects, antibacterial activity, anti-inflammatory properties, antioxidant capabilities, and self-healing capabilities. This review provides a comprehensive and current overview of chitosan-based approaches for diabetic ulcer management, focusing on both conventional and advanced biomaterials, including nanoparticles, hydrogels, nanofibers, microneedles, sponges, and 3D scaffolds. Special attention is given to stimuli-responsive chitosan systems designed to adjust drug release in response to specific cues, such as pH, reactive oxygen species, temperature, enzymes, or glucose levels. To underscore the translation potential, the review compiles commercialized products, recent patents, and clinical trials related to the management of diabetic ulcers based on chitosan formulations. Finally, the integration of AI-driven design with smart chitosan systems is proposed as a future direction towards personalized and predictive diabetic ulcer management.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125005"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ultra-expansible chitosan-silk fibroin miniaturized sponge loaded with tranexamic acid modified gelatin for coagulation abnormalities","authors":"Yuxiang Wang ,&nbsp;Haizhou Qiu ,&nbsp;Birui Yang ,&nbsp;Yang Li ,&nbsp;Wentao Wang ,&nbsp;Yujiang Fan ,&nbsp;Li Jiang ,&nbsp;Yong Sun","doi":"10.1016/j.carbpol.2026.125032","DOIUrl":"10.1016/j.carbpol.2026.125032","url":null,"abstract":"<div><div>The coagulation abnormalities, including complex and irregular bleeding surfaces and underlying coagulopathies in patients, are significant clinical cause of uncontrollable hemorrhage and death in accidental trauma. Herein, we have developed an ultra-expansible chitosan-silk fibroin miniaturized sponge (MS-GT) for delivering antifibrinolytic drug — tranexamic acid (TXA) to achieve <em>in situ</em> hemostasis of the first-aid wounds. TXA-modified gelatin was combined with the highly compressed functional chitosan-based sponge through strong hydrogen bonds, which stabilized sponge's compression state and made it easier to undergo thermosensitive dissolution to release its expansion potential. The MS-GT (∼ 3 mm³, thickness &lt; 1 mm) could achieve a volume expansion of over 11 times within five seconds to seal complex and irregular deep wounds without the need for additional specialized instruments. In addition, the loaded TXA promoted the formation of fibrin to enhance hemostatic efficacy for overcoming the bleeding in coagulation disorders, including disseminated intravascular coagulation (DIC) and hemophilia B model, with significantly superior hemostatic effect comparing with bulk sponge and clinical collagen sponge. This chitosan-based MS-GT alleviated the formation of fibrous capsules in the liver during the post-hemostasis regeneration process, offering new insights for the development of emergency hemostatic materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125032"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stretch-oriented chitosan/PVA-based anisotropic double network hydrogel curing by annealing and rehydration for wearable strain sensors","authors":"Zijian Gao ,&nbsp;Wenjun Kang ,&nbsp;Xin Guan ,&nbsp;Honglei Liu ,&nbsp;Yihan Guo ,&nbsp;Zichun Zhao ,&nbsp;Yongqi Yang ,&nbsp;Jian Sun ,&nbsp;Hailun Ren ,&nbsp;Zhaohui Jin","doi":"10.1016/j.carbpol.2026.125014","DOIUrl":"10.1016/j.carbpol.2026.125014","url":null,"abstract":"<div><div>Conductive hydrogel is considered as ideal candidates for flexible electronic devices. However, the limited toughness, flexibility and swelling behavior of conductive hydrogel hinder their application in various environments. In this work, an anisotropic and swelling resistant hydrogel is developed by stretching and reorienting polymer chains by combining with annealing and rehydration process, which is inspired by hierarchical structure of natural tissues. As a result, this hydrogel exhibits significant variability in mechanical properties along and perpendicular to the orientation direction. The toughness along the orientation direction is 1018.5 ± 35.6 kJ·m⁻³ and the tearing energy is 0.56 ± 0.03 kJ·m⁻². The toughness perpendicular to the orientation direction is 483.4 ± 18.6 kJ·m⁻³ and the tearing energy is 2.24 ± 0.07 kJ·m⁻². The hydrophobic interactions of 2-hydroxyethyl methacrylate, in conjunction with the dense polymer network contribute to swelling resistant of the hydrogel. The anisotropic hydrogel is further integrated into flexible sensors, which could be capable of monitoring human motion in amphibious environments, providing distinctly different feedback signals in the directions parallel and perpendicular to the orientation. This work provides a promising strategy to prepare diverse anisotropic materials, offering new solutions for sensor technology.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125014"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep eutectic hydrogel with polyphenol metal coordination and size reduced cellulose for high performance strain sensing","authors":"Kunpeng Qian ,&nbsp;Yu Sun ,&nbsp;Wenya Ma ,&nbsp;Xuliang Wang ,&nbsp;Huanhuan Liu ,&nbsp;Yijie Li ,&nbsp;Li Li","doi":"10.1016/j.carbpol.2026.124998","DOIUrl":"10.1016/j.carbpol.2026.124998","url":null,"abstract":"<div><div>Deep eutectic solvent (DES)-based hydrogels are environmentally friendly and structurally tunable, yet their applications are often limited by poor conductivity, weak resilience and rigidity. Herein, a multifunctional hydrogel (DC-TAZn) was developed by reinforcing a choline chloride-polyacrylic acid (ChCl-PAA) matrix with size-reduced cellulose nanofibers (CNF) and dynamic tannic acid-Zn²⁺ coordination. The hydrogel exhibits high ionic conductivity (0.34 S/m), excellent stretchability (up to 807%), remarkable resilience (&gt;99.89%), and a reliable gauge factor (1.99) for strain sensing. Additionally, DC-TAZn hydrogel shows strong adhesion, self-healing ability and antibacterial activity, while maintaining functionality under extreme conditions. This multi-synergistic hydrogel provides a sustainable strategy for designing next-generation smart hydrogels with integrated mechanical, conductive, and sensing functionalities, advancing applications in wearable electronics and intelligent human-machine interfaces.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124998"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}