Carbohydrate Polymers最新文献_第6页

Next-generation chitosan biodegradable films reinforced with bioactive acid-DES: A sustainable solution for improved mechanical, antibacterial, and anti-browning properties 用生物活性酸- des增强的下一代壳聚糖可生物降解薄膜：一种改善机械、抗菌和抗褐变性能的可持续解决方案

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-01-31 DOI: 10.1016/j.carbpol.2026.125006

Dehong Lu , Huimin Yao , Nouman Ali Shah , Sajid Ali , Li-Yan Zeng , Ping Shi , Yuan-Sen Liu , Ziru Dai , Hafiz Umer Javed

{"title":"Next-generation chitosan biodegradable films reinforced with bioactive acid-DES: A sustainable solution for improved mechanical, antibacterial, and anti-browning properties","authors":"Dehong Lu , Huimin Yao , Nouman Ali Shah , Sajid Ali , Li-Yan Zeng , Ping Shi , Yuan-Sen Liu , Ziru Dai , Hafiz Umer Javed","doi":"10.1016/j.carbpol.2026.125006","DOIUrl":"10.1016/j.carbpol.2026.125006","url":null,"abstract":"<div><div>The growing demand for sustainable and active food-packaging materials has increased interest in biodegradable biopolymers with improved functional performance. This study developed multifunctional chitosan (CS) films incorporating deep eutectic solvents (DESs) as green bioactive plasticizers to improve antioxidant, antibacterial, and mechanical properties. DESs were prepared using choline chloride with five organic acids, including citric (CA), malic (MA), oxalic (OA), lactic (LA), and ascorbic acids (AA), and the resulting DESs were evaluated for antioxidant and antibacterial activities. AA-DES and OA-DES showed the highest activities and were incorporated into CS films individually and combined (CS-AA-OA) at 1% concentration. Structural characterization (FTIR, XRD, SEM, TGA) and functional assessments were conducted to evaluate mechanical, thermal, and bioactive performance. The CS-OA film exhibited superior mechanical strength (56.42 MPa; 9.10% EB), while CS-AA-OA achieved the highest radical-scavenging activity (DPPH 88.15%, ABTS 98.44%) and strong antibacterial efficacy against <em>E. coli</em> (24.7 ± 0.34 mm) and <em>S. aureus</em> (22.8 ± 0.52 mm). The soil burial test confirmed excellent biodegradability, and coating applications on mushrooms and bananas effectively reduced browning, weight loss, and firmness degradation. The combined incorporation of AA-DES and OA-DES enhanced CS film structure and bioactivity, providing a sustainable, high-performance material for active food packaging.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125006"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Starch as a designable platform for oral drug delivery: From structural modulation to application in inflammatory bowel disease 淀粉作为可设计的口服给药平台：从结构调节到炎症性肠病的应用

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-01-26 DOI: 10.1016/j.carbpol.2026.125019

Mengyuan Qin , Feng Jiang , Yan Hong , Lingjin Li , Yongmin Cui , Canran Jin , Zhengbiao Gu , Li Cheng , Zhaofeng Li , Caiming Li , Xiaofeng Ban

{"title":"Starch as a designable platform for oral drug delivery: From structural modulation to application in inflammatory bowel disease","authors":"Mengyuan Qin , Feng Jiang , Yan Hong , Lingjin Li , Yongmin Cui , Canran Jin , Zhengbiao Gu , Li Cheng , Zhaofeng Li , Caiming Li , Xiaofeng Ban","doi":"10.1016/j.carbpol.2026.125019","DOIUrl":"10.1016/j.carbpol.2026.125019","url":null,"abstract":"<div><div>The effective management of inflammatory bowel disease (IBD) remains constrained by a central pharmaceutical challenge: achieving site-specific drug delivery to inflamed colonic mucosa while minimizing systemic exposure. Conventional oral formulations often suffer from off-target release and poor bioavailability, leading to suboptimal efficacy and systemic side effects. This review addresses this challenge by focusing on starch, a natural, biodegradable, and structurally versatile polysaccharide, as a foundational material for engineering intelligent colon-targeted carriers. It examines how the hierarchical architecture and tunable chemistry of starch enable the rational design of delivery systems capable of navigating the gastrointestinal tract. Specifically, it discusses chemical, physical, and enzymatic modification strategies that impart starch-based carriers with microenvironment-responsive behavior and active targeting toward overexpressed receptors. Beyond sophisticated targeting, the review critically analyzes how these designed starch-based oral delivery systems exert multi-mechanistic therapeutic effects, including reinforcing the epithelial barrier, restoring microbial homeostasis, and recalibrating immune responses. By synthesizing recent advances through a “structure-to-function” perspective, this work provides a strategic rationale for developing next-generation starch-based oral platforms aimed at precise, localized, and effective intervention in IBD.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125019"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation and utilization of chondroitin sulfate with different molecular weights by the gut microbiota from four midlife women: Role of Bacteroides ovatus AP1 4名中年女性肠道微生物群对不同分子量硫酸软骨素的降解和利用：卵形拟杆菌AP1的作用

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-02 DOI: 10.1016/j.carbpol.2026.125049

Junpeng Huang , Xinmiao Ren , Yaxue Liu , Mengshi Xiao , Yuhong Gao , Wen-Can Huang , Haijin Mou , Changliang Zhu

{"title":"Degradation and utilization of chondroitin sulfate with different molecular weights by the gut microbiota from four midlife women: Role of Bacteroides ovatus AP1","authors":"Junpeng Huang , Xinmiao Ren , Yaxue Liu , Mengshi Xiao , Yuhong Gao , Wen-Can Huang , Haijin Mou , Changliang Zhu","doi":"10.1016/j.carbpol.2026.125049","DOIUrl":"10.1016/j.carbpol.2026.125049","url":null,"abstract":"<div><div>Chondroitin sulfate (CS) is a glycosaminoglycan that plays essential roles in physiological functions. However, the relationship between CS and the intestines of midlife women remains unclear. This study investigated the degradation and utilization of low-molecular-weight CS (LMWCS) and high-molecular-weight CS (HMWCS) using an <em>in</em> <em>vitro</em> fermentation model with fecal samples from four midlife women. The result showed that 51% of LMWCS and 41% of HMWCS were degraded within 48 h, with interindividual variation. Both CS forms were ultimately degraded to an unsaturated disaccharide (udp2), while LMWCS was metabolized more efficiently. This result in higher production of short-chain fatty acids, particularly acetate and propionate. Fermentation of both CS forms increased <em>Bacteroides</em> abundance, with LMWCS more effectively promoting beneficial bacteria and reducing <em>Klebsiella</em>. <em>Bacteroides ovatus</em> AP1 was identified as a key CS-degrading species, efficiently utilizing both LMWCS (87%) and HMWCS (58%), producing udp2 and propionate. Whole-genome sequencing of <em>B. ovatus</em> AP1 revealed 649 carbohydrate-active enzyme genes, including multiple polysaccharide lyases involved in CS depolymerization. qPCR confirmed the upregulation of CS-metabolism-related genes during fermentation. These findings highlight the potential of LMWCS as a prebiotic for modulating gut microbiota and provide insights into the metabolism of CS by the gut microbiota.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125049"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NaBr-free TEMPO-catalyzed oxidation of cellulose with sodium dichloroisocyanurate in water at pH 9 在pH为9的水中，二氯异氰尿酸钠催化纤维素无nabr的tempo氧化

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-09 DOI: 10.1016/j.carbpol.2026.125080

Akira Isogai , Korawit Chitbanyong , Pavitra Thevi Arnandan , Runqing Hou , Izumi Shibata , Miyuki Takeuchi , Masato Saito , Hiroyuki Fukasawa

{"title":"NaBr-free TEMPO-catalyzed oxidation of cellulose with sodium dichloroisocyanurate in water at pH 9","authors":"Akira Isogai , Korawit Chitbanyong , Pavitra Thevi Arnandan , Runqing Hou , Izumi Shibata , Miyuki Takeuchi , Masato Saito , Hiroyuki Fukasawa","doi":"10.1016/j.carbpol.2026.125080","DOIUrl":"10.1016/j.carbpol.2026.125080","url":null,"abstract":"<div><div>The conventional TEMPO/NaBr/NaOCl oxidation of cellulose in water at pH ~10 is an established method for preparing TEMPO-oxidized cellulose nanofibrils (TEMPO: 2,2,6,6-tetramethylpiperidine-1-oxyl radical). However, significant depolymerization, the formation of sodium polyglucuronate homopolymers, and other side reactions are unavoidable, resulting in the formation of oxidation products with heterogeneous chemical structures or low mass-recovery ratios. In this study, NaBr-free TEMPO/sodium dichloroisocyanurate (NaDCC) oxidation of cellulose in water at pH 9 was developed, which is advantageous in terms of process controls, mass recovery ratios, constant carboxy group contents, and maintenance of the original fiber morphologies, even under harsh oxidation conditions. This is probably because the oxidation of C6–OH groups into sodium C6-carboxylate groups occurred selectively on the cellulose microfibril surfaces, with less depolymerization or side reactions. TEMPO/NaDCC-oxidized microcrystalline cellulose and cotton linters cellulose were converted into cellulose nanocrystals and microfibrillated cellulose, respectively, by mechanical disintegration in water. In water at pH 9, the new TEMPO/NaDCC oxidation system can be used to oxidize various cellulose, pulp, and plant samples, or to produce TEMPO-oxidized cellulose fibers and nanomaterials with the benefits of lower cost, ease of handling, less depolymerization or fewer side reactions, higher mass recoveries, and lower environmental impact.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125080"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoscale insights into cellulose–imidazolium ionic liquid interactions via atomic force microscopy 纳米级洞察纤维素-咪唑离子液体相互作用通过原子力显微镜

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-06 DOI: 10.1016/j.carbpol.2026.125073

Ruimei Cao , Hongshuai Gao , Wanxue Lv , Yuting Song , Yan Long , Min Yu , Baozeng Ren , Yi Nie , Suojiang Zhang

{"title":"Nanoscale insights into cellulose–imidazolium ionic liquid interactions via atomic force microscopy","authors":"Ruimei Cao , Hongshuai Gao , Wanxue Lv , Yuting Song , Yan Long , Min Yu , Baozeng Ren , Yi Nie , Suojiang Zhang","doi":"10.1016/j.carbpol.2026.125073","DOIUrl":"10.1016/j.carbpol.2026.125073","url":null,"abstract":"<div><div>The interaction force of cellulose is a key contributing factor to the mechanical properties and functionality of cellulose-based products, while quantitative understanding the nanoscale interaction of cellulose is challenging through experimentation. Herein, atomic force microscope (AFM) force spectroscopy was innovatively used to quantitatively measure the intermolecular forces of cellulose in air/water/ionic liquids (ILs), respectively. The results showed that the intermolecular forces were reduced by 60.3% and 34.0%, when the hydroxy groups of cellulose were replaced by methyl and hydroxyethyl groups, demonstrating the dominance of hydrogen bond and van der Waals forces in cellulose cohesion. Meanwhile, cation-anion of ILs cooperativity significantly decreased the interaction forces with 84.5% (39.13 nN → 6.08 nN), further demonstrating that the hydrogen bond formation ability, hydrophobic and van der Waals forces play significant roles in cellulose dissolution. Additionally, a dual-site interaction mechanism was proposed by combining the results of NMR and molecular dynamics simulations. Furthermore, the swelling to single-chain stripping evolution of fiber in ILs was visualized by in-situ AFM, and used as the spinning solution to successfully prepare regenerated cellulose fibers with good mechanical properties. Therefore, this work not only provided important guidance for new insights into the interaction mechanism of cellulose at the nanoscale, but also for screening and designing ILs for cellulose dissolution.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125073"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-phase reinforcement of chitin nanocrystals in bicontinuous bigels: a strategy for high-precision 3D food printing 双连续凝胶中几丁质纳米晶体的相内增强：高精度3D食品打印的一种策略

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2026-01-16 DOI: 10.1016/j.carbpol.2026.124948

Erpeng Chao , Qun Yu , Jieying Li , Liuping Fan , Yulin Zhou

{"title":"Intra-phase reinforcement of chitin nanocrystals in bicontinuous bigels: a strategy for high-precision 3D food printing","authors":"Erpeng Chao , Qun Yu , Jieying Li , Liuping Fan , Yulin Zhou","doi":"10.1016/j.carbpol.2026.124948","DOIUrl":"10.1016/j.carbpol.2026.124948","url":null,"abstract":"<div><div>This study introduced an intra-phase reinforcement strategy utilizing chitin nanocrystals (ChNCs) to enhance the structural stability and 3D printability of bicontinuous bigels (BCBG). Varying ChNCs concentrations significantly influenced the gel network, rheological behavior, textural attributes, and oil/water distribution, thereby influencing their performance as edible inks for 3D food printing. Notably, the 1% ChNCs-BCBG exhibited the highest creep recovery rate (60.15 ± 0.08%), maximum thixotropic recovery rate (69.63 ± 0.06%), longest delay time (λ<sub><em>ret</em></sub> = 13.42 ± 0.43 s), greatest cohesiveness (1.53 ± 0.14). Additionally, it significantly improved water retention, as evidenced by a reduction in the <em>T₂₃</em> relaxation time from 938.49 ms (0% ChNCs) to 335.94 ms (1% ChNCs). These improvements induced superior printing performance, reducing deformation rates to 1.34 ± 0.14% for the starfish model and 2.16 ± 0.13% for the Superman model. Correlation analysis further confirmed strong relationships between rheological and textural properties, water/oil distribution, and 3D printing precision. This study underscores the potential of ChNCs-reinforced BCBG in 3D food printing.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124948"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional starch-based eutectogels with high mechanical properties, adhesion, self-healing, fatigue resistance and degradability for flexible wearable sensing 多功能淀粉基共凝胶，具有高机械性能，粘附性，自愈性，抗疲劳性和可降解性，用于柔性可穿戴传感

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2026-01-26 DOI: 10.1016/j.carbpol.2026.125018

Dadong Sun , Zhihua Xu , Li Guo , Bin Yu , Lu Lu , Bo Cui , Xuemin Kang , Zhijun Zhang , Fanfu Meng , Chenghai Li , Guowei Cai

{"title":"Multifunctional starch-based eutectogels with high mechanical properties, adhesion, self-healing, fatigue resistance and degradability for flexible wearable sensing","authors":"Dadong Sun , Zhihua Xu , Li Guo , Bin Yu , Lu Lu , Bo Cui , Xuemin Kang , Zhijun Zhang , Fanfu Meng , Chenghai Li , Guowei Cai","doi":"10.1016/j.carbpol.2026.125018","DOIUrl":"10.1016/j.carbpol.2026.125018","url":null,"abstract":"<div><div>Flexible wearable sensors have developed rapidly due to the urgent demands for human motion monitoring. Eutectogel-based soft materials have exhibited great potential for wearable sensing applications. However, it is still a challenge to develop multifunctional eutectogels with excellent mechanical properties, adhesion, self-healing, fatigue resistance and degradability. In this work, a multifunctional starch-based eutectogel was developed by a one-pot and in-situ photo-polymerization method. The eutectogel had excellent stretchability (2710%), high strength (5.43 MPa), toughness (94.38 MJ/m<sup>3</sup>), Young's modulus (10.23 MPa), adhesion, fatigue resistance (1000 cycles), degradability and a certain degree of self-healing ability. These properties were closely correlated to the synergistic effect among the amylopectin, polyacrylic acid and choline chloride via hydrogen-bond and electrostatic interactions. The mechanical properties of eutectogel can be adjusted by changing the starch content. A wearable sensor based on the eutectogel was realized accurate and stable monitoring of human joint motions. This study addressed the limitations of the dehydration and single function of the traditional hydrogels, and provides a novel way for the development of the multifunctional bio-based gels for next-generation flexible wearable devices.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125018"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into the mechanism of gellan gum enhancing stability of high internal phase Pickering emulsions based on egg yolk granules: Intermolecular interaction and network structure 结冷胶增强蛋黄颗粒高内相皮克林乳稳定性的机理：分子间相互作用和网络结构

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2026-01-21 DOI: 10.1016/j.carbpol.2026.124979

Yue Huang , Dekun Meng , Nan Zhang , Huajiang Zhang , Lina Xu , Yunhe Xu , Hanyu Li , Ning Xia , Mohamed Ghamry , Ahmed M. Rayan

{"title":"Insight into the mechanism of gellan gum enhancing stability of high internal phase Pickering emulsions based on egg yolk granules: Intermolecular interaction and network structure","authors":"Yue Huang , Dekun Meng , Nan Zhang , Huajiang Zhang , Lina Xu , Yunhe Xu , Hanyu Li , Ning Xia , Mohamed Ghamry , Ahmed M. Rayan","doi":"10.1016/j.carbpol.2026.124979","DOIUrl":"10.1016/j.carbpol.2026.124979","url":null,"abstract":"<div><div>The integration of polysaccharides into high internal phase Pickering emulsions (HIPPEs) has been recognized as an innovative approach to improving their stability. To reveal the enhancing mechanisms of gellan gum (GG) on the stability of HIPPEs based on egg yolk granules (EYGs), this study systematically investigated the effect of GG concentration on the molecular structure, interfacial properties, and emulsion stability of EYGs-GG complexes. The results showed that HIPPEs stabilized by EYGs-0.3%GG complex exhibited the highest stability. In this complex, GG bound to the surface of EYGs particles via electrostatic attractions and hydrophobic interactions, leading to a 60.0% higher surface charge and a 59.2% lower surface hydrophobicity compared with those of EYGs particles. While the interaction reduced the penetration of EYGs particles at the oil-water interface, it increased the diffusion rate and molecular rearrangement behavior, facilitating the formation of the stable elastic interfacial film. Moreover, adding 0.3% GG formed denser 3D network structures in the aqueous phase, which inhibited oil droplet coalescence and further enhanced the structural strength of the HIPPEs. These findings provided theoretical insights into the mechanism by which GG enhanced the stability of emulsions based on EYGs, offering a rational design strategy for developing high-performance systems of HIPPEs.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124979"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold plasma-assisted processing: A sustainable route to high-quality chitosan from crab shells 冷等离子体辅助加工：从蟹壳中获得高质量壳聚糖的可持续途径

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2026-01-25 DOI: 10.1016/j.carbpol.2026.125008

Zhicheng Cai , Jianfeng Lu , Qiang Li , Qingli Han , Yuan Song , Lin Lin , Chenghui Wang , Bin Zheng , Xiangzhao Mao , Changhu Xue

{"title":"Cold plasma-assisted processing: A sustainable route to high-quality chitosan from crab shells","authors":"Zhicheng Cai , Jianfeng Lu , Qiang Li , Qingli Han , Yuan Song , Lin Lin , Chenghui Wang , Bin Zheng , Xiangzhao Mao , Changhu Xue","doi":"10.1016/j.carbpol.2026.125008","DOIUrl":"10.1016/j.carbpol.2026.125008","url":null,"abstract":"<div><div>Traditional chitosan production, involving chitin extraction and deacetylation, relies on harsh high-alkali chemical processing, which raises safety and sustainability concerns. This study proposes an atmospheric-pressure plasma pretreatment strategy to enhance deacetylation efficiency and structural quality during the alkaline deacetylation of chitin extracted from crab shells to produce chitosan. Comprehensive characterisation using Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy and molecular weight analysis reveal that plasma selectively etches the amorphous domains and weakens glycosidic linkages, thereby improving mass-transfer efficiency during deacetylation. Under 40–50% NaOH, plasma-treated samples achieve markedly higher deacetylation degrees (PAW post-processing: 65–74%) than those of the conventional method (traditional chemical method: 58–67%), together with higher crystallinity (up to 31.18%) and enhanced thermal stability. These molecular and interfacial modifications collectively enhance antibacterial performance, enlarging inhibition zones against <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em> to 14.57 ± 0.45 mm and 14.16 ± 0.06 mm, respectively. Overall, plasma pretreatment is an environmentally benign and structurally beneficial approach for producing high-performance chitosan from crab shells.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125008"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular alginate-based hydrogels embedding multilayer nanofibers: A synergistic strategy for hemostasis, antibacterial, and immunomodulatory therapy 模块化海藻酸盐基水凝胶包埋多层纳米纤维：止血、抗菌和免疫调节治疗的协同策略

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2026-01-27 DOI: 10.1016/j.carbpol.2026.124977

Hao Liu , Yujie Lv , Jiawang Li , Le Kang , Menghui Chen , Langqun Tan , Xiaoshun Yao , Huipeng Wang , Minyue Zhang , Jianxiang Li , Jie Zhu , Chenggong Zhang , Jianyong Yu , Dequn Wu

{"title":"Modular alginate-based hydrogels embedding multilayer nanofibers: A synergistic strategy for hemostasis, antibacterial, and immunomodulatory therapy","authors":"Hao Liu , Yujie Lv , Jiawang Li , Le Kang , Menghui Chen , Langqun Tan , Xiaoshun Yao , Huipeng Wang , Minyue Zhang , Jianxiang Li , Jie Zhu , Chenggong Zhang , Jianyong Yu , Dequn Wu","doi":"10.1016/j.carbpol.2026.124977","DOIUrl":"10.1016/j.carbpol.2026.124977","url":null,"abstract":"<div><div>Non-compressible hemorrhage remains a leading cause of trauma mortality, with ineffective management triggering infection, dysregulated inflammation, and multi-organ dysfunction. Herein, we report a multilayer nanofiber-reinforced alginate hydrogel (GT-F) combining rapid hemostasis, strong tissue adhesion, high mechanical resilience, and wound healing. The hydrogel matrix, composed of dopamine-modified methacrylate alginate (AMD) and gelatin methacryloyl (GelMA), was incorporated with tranexamic acid (TAX). The biomimetic multilayer nanofiber framework is constructed from hydrophobic polycaprolactone (PCL) and simultaneously encapsulates both the natural medicinal compound curcumin (Cur) and the quaternary ammonium antibacterial agent (HDEAB). Experimental results indicate that, within an optimal range, increasing AMD content enhances hydrogel crosslinking density, reducing pore size and equilibrium swelling. Compared to conventional GelMA hydrogel, compressive strength was nearly quadrupled, and tensile strength increased over threefold. In vitro and in vivo studies confirm that GT-F hydrogels exhibit excellent biocompatibility, degradability, rapid hemostasis (<30 s), and robust antimicrobial and antioxidant properties. In a rat liver puncture model, GT-F hydrogels markedly outperformed commercial gauze in hemostasis, reduced macrophage inflammatory infiltration, promoted proliferating cell nuclear antigen (PCNA) expression, accelerated wound repair, and exhibited anti-adhesion effects. Collectively, this study offers a promising hydrogel-based adhesive strategy for clinical management of non-compressible hemorrhage and tissue repair.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124977"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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