{"title":"Lotus seed starch-chlorogenic acid complexes alleviated chronic colitis and linked cognitive dysfunction via gut microbiota regulation: gut-brain-axis interaction.","authors":"Xiaoying Wang, Shiqi Wang, Baodong Zheng, Zebin Guo","doi":"10.1016/j.carbpol.2025.124158","DOIUrl":null,"url":null,"abstract":"<p><p>This study aims to reveal the protective mechanism of lotus seed starch-chlorogenic acid complexes (A-LS-CA) at different doses on chronic colitis and cognitive dysfunction induced by Dextran sulfate sodium. Here, A-LS-CA alleviated the pathological symptoms of mice chronic colitis in a dose-dependent manner, including improving the disease activity index, the colon length and tissue damage. It was remarkable that 2 g/kg A-LS-CA reduced the mRNA expressions and protein levels of TNF-α, IL-6, IL-1β, NF-κB and TLR4 of the colon tissue in DSS-induced chronic colitis mice. In addition, 2 g/kg A-LS-CA enhanced the level of ZO-1 and Claudin-1, which were 1.75 and 1.63 folds higher than that of the model group, respectively. In particular, A-LS-CA reshaped the gut microbiota of mice with chronic colitis and promoted the production of key metabolites, including short-chain fatty acids and tryptamine. Therefore, we speculated that A-LS-CA has a positive effect on gut microbiota and its metabolites, thereby alleviating behavioral disorders of mice with chronic colitis. In conclusion, these findings provide a research basis for starch-polyphenol complex to improve chronic colitis and cognitive dysfunction via gut-brain-axis balance.</p>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"368 Pt 2","pages":"124158"},"PeriodicalIF":12.5000,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Polymers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.carbpol.2025.124158","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
This study aims to reveal the protective mechanism of lotus seed starch-chlorogenic acid complexes (A-LS-CA) at different doses on chronic colitis and cognitive dysfunction induced by Dextran sulfate sodium. Here, A-LS-CA alleviated the pathological symptoms of mice chronic colitis in a dose-dependent manner, including improving the disease activity index, the colon length and tissue damage. It was remarkable that 2 g/kg A-LS-CA reduced the mRNA expressions and protein levels of TNF-α, IL-6, IL-1β, NF-κB and TLR4 of the colon tissue in DSS-induced chronic colitis mice. In addition, 2 g/kg A-LS-CA enhanced the level of ZO-1 and Claudin-1, which were 1.75 and 1.63 folds higher than that of the model group, respectively. In particular, A-LS-CA reshaped the gut microbiota of mice with chronic colitis and promoted the production of key metabolites, including short-chain fatty acids and tryptamine. Therefore, we speculated that A-LS-CA has a positive effect on gut microbiota and its metabolites, thereby alleviating behavioral disorders of mice with chronic colitis. In conclusion, these findings provide a research basis for starch-polyphenol complex to improve chronic colitis and cognitive dysfunction via gut-brain-axis balance.
期刊介绍:
Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience.
The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.