莲子淀粉-绿原酸复合物通过肠道菌群调节缓解慢性结肠炎和相关的认知功能障碍:肠-脑轴相互作用。

IF 12.5 1区 化学 Q1 CHEMISTRY, APPLIED
Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-07-30 DOI:10.1016/j.carbpol.2025.124158
Xiaoying Wang, Shiqi Wang, Baodong Zheng, Zebin Guo
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引用次数: 0

摘要

本研究旨在揭示不同剂量莲子淀粉-绿原酸复合物(A-LS-CA)对硫酸葡聚糖钠诱导的慢性结肠炎和认知功能障碍的保护机制。在这里,a - ls - ca以剂量依赖的方式缓解了小鼠慢性结肠炎的病理症状,包括改善疾病活动性指数、结肠长度和组织损伤。2 g/kg A-LS-CA显著降低dss诱导的慢性结肠炎小鼠结肠组织中TNF-α、IL-6、IL-1β、NF-κB和TLR4 mRNA表达和蛋白水平。此外,2 g/kg A-LS-CA可提高大鼠ZO-1和Claudin-1水平,分别比模型组高1.75倍和1.63倍。特别是,A-LS-CA重塑了慢性结肠炎小鼠的肠道微生物群,促进了关键代谢物的产生,包括短链脂肪酸和色胺。因此,我们推测a - ls - ca对肠道菌群及其代谢物具有积极作用,从而缓解慢性结肠炎小鼠的行为障碍。本研究结果为淀粉-多酚复合物通过肠-脑-轴平衡改善慢性结肠炎和认知功能障碍提供了研究基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lotus seed starch-chlorogenic acid complexes alleviated chronic colitis and linked cognitive dysfunction via gut microbiota regulation: gut-brain-axis interaction.

This study aims to reveal the protective mechanism of lotus seed starch-chlorogenic acid complexes (A-LS-CA) at different doses on chronic colitis and cognitive dysfunction induced by Dextran sulfate sodium. Here, A-LS-CA alleviated the pathological symptoms of mice chronic colitis in a dose-dependent manner, including improving the disease activity index, the colon length and tissue damage. It was remarkable that 2 g/kg A-LS-CA reduced the mRNA expressions and protein levels of TNF-α, IL-6, IL-1β, NF-κB and TLR4 of the colon tissue in DSS-induced chronic colitis mice. In addition, 2 g/kg A-LS-CA enhanced the level of ZO-1 and Claudin-1, which were 1.75 and 1.63 folds higher than that of the model group, respectively. In particular, A-LS-CA reshaped the gut microbiota of mice with chronic colitis and promoted the production of key metabolites, including short-chain fatty acids and tryptamine. Therefore, we speculated that A-LS-CA has a positive effect on gut microbiota and its metabolites, thereby alleviating behavioral disorders of mice with chronic colitis. In conclusion, these findings provide a research basis for starch-polyphenol complex to improve chronic colitis and cognitive dysfunction via gut-brain-axis balance.

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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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