Bioelectrochemistry最新文献

{"title":"Electrochemiluminescent detection of glucose by employing a cobalt-based stainless steel electrode","authors":"Fathimath Abbas ,&nbsp;Zhiyong Dong ,&nbsp;Ala'a Mhmoued Abdllh Alboull ,&nbsp;Hongzhan Liu ,&nbsp;Tadele Eticha ,&nbsp;Wenyue Gao ,&nbsp;Yu Tian ,&nbsp;Guobao Xu","doi":"10.1016/j.bioelechem.2025.109061","DOIUrl":"10.1016/j.bioelechem.2025.109061","url":null,"abstract":"<div><div>Electrodes employed in the detection of glucose are commonly fabricated from conductive substances, including platinum, gold, or carbon, often modified with enzymes such as glucose oxidase, and are designed to promote electrochemical interactions that precisely quantify glucose levels in biological specimens. Cobalt-based stainless steel exhibits excellent biocompatibility and corrosion resistance and has been using in various advanced applications, such as medical devices. Herein, we demonstrate the first electroanalytical application of cobalt-based stainless steel electrode through its application for luminol electrochemiluminescence (ECL) detection of hydrogen peroxide and glucose. Luminol‑hydrogen peroxide shows intense ECL at cobalt-based stainless steel electrode, enabling the detection of H₂O₂ in the concentration range of 0.01 μM to 20 μM with a limit of detection of 1.25 nM. Moreover, intense ECL of luminol‑hydrogen peroxide at cobalt-based stainless steel electrode was used to develop an ECL glucose detection method by coupling with the enzymatic conversion of glucose to hydrogen peroxide in the presence of glucose oxidase. The developed ECL glucose detection method shows a wide linear range of 0.005 to 5 mM with a limit of detection of 0.005 mM and a limit of quantification as 0.016 mM, with excellent reproducibility (3.7 % RSD). This method was further validated through its application to real honey samples, and the results were compared by the HPLC method, showcasing its potential for glucose detection. This study implies significant potential of cobalt-based stainless steel electrode across various electroanalytical applications due to its sensitivity, wide detection range, and robustness.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109061"},"PeriodicalIF":4.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical regulation of mitochondrial respiratory chain protein redox states using transmembrane copper peptides for myocardial infarction risk assessment","authors":"Panpan Hao ,&nbsp;Yanping Liu ,&nbsp;Ping Wang ,&nbsp;Min Li ,&nbsp;Xiaomei Li","doi":"10.1016/j.bioelechem.2025.109071","DOIUrl":"10.1016/j.bioelechem.2025.109071","url":null,"abstract":"<div><div>Detecting mitochondrial Complex I protein glutathionylation in peripheral blood is crucial for preventing myocardial infarction, highlighting its role as a key oxidative stress biomarker in cardiovascular disease. Our study introduces a novel molecular probe for quantitative analysis, enhancing early diagnosis and treatment strategies. This probe integrates a mitochondrial targeting sequence for heightened sensitivity, ensuring precise detection. Leveraging Complex I's redox catalytic activity enables signal amplification, facilitating robust detection in complex clinical matrices. It represents a promising step in cardiovascular disease management, offering early identification of pathophysiological markers relevant to myocardial infarction risk assessment and prevention. Our approach focuses on respiratory chain Complex I proteins and their oxidative modifications, providing insights into oxidative stress levels and myocardial infarction risk. The peptide-based molecular probe integrates functional sequences targeting Complex I and copper ions for effective interaction and immobilization on a conductive substrate. By harnessing Complex I's redox activity and employing catalytic cycles with nicotinamide adenine dinucleotide, our method enhances sensitivity and specificity in detecting pathological glutathionylation under oxidative stress, validated with clinical samples demonstrating robust detection capabilities for clinical diagnostics and risk assessment.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109071"},"PeriodicalIF":4.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing electrolytic ablation therapy: Effects of electrode polarization modes through in silico and in vitro studies","authors":"Enaide Maine Calzado ,&nbsp;Nahuel Olaiz ,&nbsp;Luis Enrique Bergues Cabrales ,&nbsp;Pablo Turjanski","doi":"10.1016/j.bioelechem.2025.109062","DOIUrl":"10.1016/j.bioelechem.2025.109062","url":null,"abstract":"<div><div>Electrolytic ablation is an emerging cancer therapy that induces tumor necrosis by applying direct electrical current through electrodes inserted locally into the tissue. The extreme cathodic and anodic pH fronts induced by the electrolytic ablation are the main cause of tumor necrosis. This study investigates how different electrode polarization modes influence the distribution of extreme pH areas, ionic species concentrations, tissue permeabilization, and overall efficacy of Electrolytic ablation therapy. Using <em>in silico</em> modeling, which solves the Nernst-Planck equations, and <em>in vitro</em> experiments on potato tubers (<em>Solanum tuberosum</em> L.) as a biological surrogate, two electrode configurations are analyzed: Configuration Ia (one anode and four cathodes) and Configuration Ib (four anodes and one cathode).</div><div>The results demonstrate that Configuration Ib produces broader extreme pH areas, larger tissue damage zones, and greater permeabilization compared to Configuration Ia. This behavior is attributed to the enhanced migration and diffusion of H⁺ ions under the Configuration Ib polarization strategy.</div><div>These findings underscore the importance of selecting the electrode polarization mode in optimizing Electrolytic ablation therapy parameters. The broader ablation areas and higher efficacy observed with Configuration Ib suggest its potential to improve tumor treatment outcomes, particularly when combined with electroporation-based therapies.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109062"},"PeriodicalIF":4.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive detection of miR-31 using a signal-on electrochemiluminescence biosensor based on CRISPR/Cas12a and MXene nanocomposites","authors":"Ze Ji ,&nbsp;Suhang Cheng ,&nbsp;Wensi Li ,&nbsp;Yufei Xing ,&nbsp;Zhichao Tang ,&nbsp;Xiang Zhu ,&nbsp;Dan Wang ,&nbsp;Chunyan Hao ,&nbsp;Beijuan Wang ,&nbsp;Minhua Shi","doi":"10.1016/j.bioelechem.2025.109059","DOIUrl":"10.1016/j.bioelechem.2025.109059","url":null,"abstract":"<div><div>MicroRNAs (miRNAs) have emerged as critical biomarkers for early cancer diagnosis due to their high specificity and stability in biological fluids. In this study, we report a highly sensitive and specific electrochemiluminescence (ECL) biosensor for the detection of miR-31, a miRNA closely associated with non-small cell lung cancer. The sensing platform integrates a PEI-Ru@Ti₃C₂@AuNPs-modified electrode with a ferrocene-labeled DNA probe (DNA1-Fc) to construct a target-responsive signal-on system. Upon recognition of miR-31, an isothermal strand displacement amplification (ISDA) reaction is initiated, producing abundant double-stranded DNA (dsDNA) that activates the CRISPR/Cas12a complex. The trans-cleavage activity of Cas12a then cleaves the DNA1-Fc probes on the electrode surface, removing the quenching ferrocene moiety and restoring the Ru-based ECL signal. Under optimized conditions, the biosensor exhibited a wide dynamic range from 10 aM to 100 pM and a remarkably low detection limit of 1.67 aM. The system also showed excellent specificity against homologous miRNAs, and its applicability was successfully validated in spiked human serum samples, achieving high recovery and reproducibility. The synergistic combination of nanomaterial-enhanced ECL emission, isothermal nucleic acid amplification, and CRISPR-based enzymatic cleavage provides a powerful strategy for ultrasensitive nucleic acid detection. This work offers a promising approach for early cancer diagnosis and has great potential for clinical translation and point-of-care testing.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109059"},"PeriodicalIF":4.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical biosensor constructed using dual-signal amplification techniques (PER-HCR) for the ultrasensitive trace detection of ctDNA BRAF mutation","authors":"Aiting Cai ,&nbsp;Qingping Fu ,&nbsp;Mingzhong Sun ,&nbsp;Hongmei Chen ,&nbsp;Yungang Wang ,&nbsp;Huixiang Ju","doi":"10.1016/j.bioelechem.2025.109058","DOIUrl":"10.1016/j.bioelechem.2025.109058","url":null,"abstract":"<div><div>The detection of BRAF mutations in circulating tumor DNA is beneficial for early diagnosis and personalized therapeutic approaches of melanoma. However, the sensitive and reliable trace detection of BRAF mutations remains a major challenge. Therefore, in this study, the combination of two isothermal signal amplification techniques (primer exchange reaction (PER) and hybridization chain reaction (HCR)) was proposed to construct an electrochemical biosensor for the efficient and sensitive detection of BRAF mutations. The presence of target triggered PER and HCR sequentially to achieve dual-cascade amplification of positive electrochemical signal feedback. Compared to the detection limit (1.27 pM or 0.23 pM) of single-signal amplification technology (PER or HCR), the detection limit of dual-signal amplification techniques was significantly lower (0.34 fM). In addition, the dual-signal amplification strategy exhibited other excellent sensing properties, such as a wide linear detection range (0.01 pM to 1 nM), excellent specificity, satisfactory reproducibility and stability, and the ability to achieve low-level target detection in diluted serum samples. Based on all of these features, the proposed strategy indicate broad application prospects for detecting low-abundance nucleic acid targets in clinical samples.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109058"},"PeriodicalIF":4.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An electrochemical biosensor for detecting pathogenic bacteria based on hybrid nanocomposites","authors":"Jiaqi Wei ,&nbsp;Chunye Wang ,&nbsp;TianYu Zhang ,&nbsp;Zhuo Hao ,&nbsp;Guijuan Qu ,&nbsp;Jiayu Wan","doi":"10.1016/j.bioelechem.2025.109057","DOIUrl":"10.1016/j.bioelechem.2025.109057","url":null,"abstract":"<div><div>Prevention and control of foodborne pathogens are essential for public health safety. This study integrates organic-inorganic hybrid nanocomposites, lateral flow immunochromatography, and screen-printed electrodes to develop an innovative electrochemical biosensor for detecting foodborne pathogens. Two types of organic-inorganic hybrid nanocomposites incorporated onto a conjugate pad or nitrocellulose membrane support were used. In the presence of foodborne pathogens, a sandwich immune complex structure forms on the detection line. Ferrocene within the sandwich structure is detected using differential pulse voltammetry. The biosensor specifically detects foodborne pathogens with a minimum detection limit of 25 CFU·mL⁻¹ and a detection linear range of 10² to 10⁸ CFU·mL⁻¹, demonstrating excellent specificity and sensitivity. This biosensor can be integrated with smartphones, enhancing the intelligence and miniaturization of biosensors.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109057"},"PeriodicalIF":4.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on inhibition of sulfate-reducing bacteria corrosion by synergistic action of corrosion inhibitors and biological mineralization","authors":"Ting Xu,&nbsp;Guannan Li,&nbsp;Min Du,&nbsp;Jian Wang","doi":"10.1016/j.bioelechem.2025.109056","DOIUrl":"10.1016/j.bioelechem.2025.109056","url":null,"abstract":"<div><div>A study investigated the corrosion inhibition efficacy of a composite formulation comprising zinc sulfate (ZnSO₄), calcium gluconate (CaGlu), and sodium tripolyphosphate (Na₅P₃O₁₀) on X80 steel in the presence of sulfate-reducing bacteria (SRB). This formulation was found to act synergistically with SRB-induced biomineralization, proposing a novel approach utilizing extracellular polymeric substances (EPS) in concert with corrosion inhibitors for corrosion mitigation. The results demonstrated that zinc ions exhibited bactericidal properties, significantly reducing the microbial population in the solution. Under the influence of EPS secreted by metabolically active SRB, the inhibitor components facilitated the formation of an inorganic-organic heterogeneous composite film on the steel surface. This film exhibited excellent crack-resistant and spallation-resistant properties, demonstrating high stability. It synergistically inhibited the corrosion process of X80 steel. This work presents a new strategy for controlling microbiologically influenced corrosion (MIC) in the oil and gas industry.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"166 ","pages":"Article 109056"},"PeriodicalIF":4.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectroelectrochemical analysis of membrane permeation mechanisms of cell-penetrating peptide-modified fluorescent proteins","authors":"Hiroki Sakae ,&nbsp;Kaho Takada ,&nbsp;Chitose Maruyama ,&nbsp;Yoshimitsu Hamano ,&nbsp;Hirohisa Nagatani","doi":"10.1016/j.bioelechem.2025.109054","DOIUrl":"10.1016/j.bioelechem.2025.109054","url":null,"abstract":"<div><div>Cell penetrating peptides (CPPs) can translocate substances into cells and have potential as molecular carriers in drug delivery system (DDS). In order to elucidate the cellular internalization mechanism of cargoes utilizing CPPs, the interfacial behavior of fluorescent protein, monomeric Azami-Green (mAG) modified with two types of CPPs, ε-poly-<span>l</span>-lysine (εPL) and octa-arginine (R8), was studied at the liquid|liquid interface as a model of biomembrane surfaces. CPP-unmodified mAG and R8-mAG showed the aqueous adsorption process at the water|1,2-dichloroethane interface. On the other hand, εPL-mAG was transferred across the interface accompanied by the adsorption steps at both sides of the interface. Spectroelectrochemical analysis indicated that the adsorption of mAG was facilitated at the phospholipid-modified biomimetic interface. In the presence of CPPs, the adsorption of mAG on the membrane surface was inhibited by competitive adsorption with εPL, whereas the phase transfer of mAG readily occurred due to the disturbance of the membrane structure by R8. Although the R8-mAG behaves in a similar membrane reaction mechanism to the unmodified mAG, the phase transfer efficiency of εPL-mAG was improved by suppressing the interaction with the phospholipid membrane. Therefore, the membrane permeation of mAG was successfully achieved by the modification with εPL. Present findings demonstrated that εPL is a promising CPP for the membrane permeation of proteins with a high hydrophilicity and molecular weight.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"166 ","pages":"Article 109054"},"PeriodicalIF":4.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-Azido-4-nitrophenol is a light-sensitive antibacterial protonophore","authors":"Alexander M. Firsov ,&nbsp;Ljudmila S. Khailova ,&nbsp;Pavel A. Nazarov ,&nbsp;Maxim Ukraintsev ,&nbsp;Roman S. Kirsanov ,&nbsp;Sergei I. Kovalchuk ,&nbsp;Konstantin G. Lyamzaev ,&nbsp;Alisa A. Panteleeva ,&nbsp;Galina A. Korshunova ,&nbsp;Elena A. Kotova ,&nbsp;Yuri N. Antonenko","doi":"10.1016/j.bioelechem.2025.109055","DOIUrl":"10.1016/j.bioelechem.2025.109055","url":null,"abstract":"<div><div>The azide-containing analogue 2-azido-4-nitrophenol (NPA) of the classical mitochondrial uncoupler 2,4-dinitrophenol (DNP) was actively used in 1970s as a tool for searching the binding sites of OxPhos uncouplers on mitochondrial proteins. Here, we report data on the protonophoric, uncoupling and cytotoxic activity of this compound. Artificial bilayer lipid membrane (BLM) experiments revealed much higher potency of NPA compared to DNP in the induction of proton-selective transmembrane electric current. Accordingly, NPA was more effective than DNP in both decreasing membrane potential and stimulating respiration of isolated rat liver mitochondria. NPA also exhibited higher depolarizing and cytotoxic activity towards mammalian cell culture, and was more potent than DNP in suppressing growth of both gram-negative (<em>Escherichia coli</em>) and gram-positive (<em>Bacillus subtilis</em>) bacteria. In all these systems, the activity of NPA but not that of DNP was abolished upon UV illumination. As shown by capillary electrophoresis and LC-MS analysis, UV light induced degradation of NPA to products lacking protonophoric activity, unlike DNP, which appeared to be light-insensitive. Therefore, NPA can be considered as a light-sensitive protonophore that is able to inhibit bacterial growth and promote mitophagy in mammalian cells.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"167 ","pages":"Article 109055"},"PeriodicalIF":4.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-doped-diamond coupling with gold nanoparticles to prepare a simple and highly rigid aptasensor for detection of bleomycin","authors":"Yilin Liu ,&nbsp;Lingfeng Wan ,&nbsp;Danhong Zhang ,&nbsp;Yibo Ma ,&nbsp;Danni Hu ,&nbsp;Hongdong Li ,&nbsp;Chunli Yao","doi":"10.1016/j.bioelechem.2025.109052","DOIUrl":"10.1016/j.bioelechem.2025.109052","url":null,"abstract":"<div><h3>Background</h3><div>Bleomycin (BLM), an essential antitumour medication in clinical applications, has detrimental effects on human health when it appears in an ecological environment, even at trace concentrations. It is desirable to detect trace amounts of BLM by a fast, simple, and efficient method, however, the traditional technologies (e.g., high-performance liquid chromatography, enzyme-linked immunosorbent assay, etc.) generally require expensive equipment and a complicated process, and/or have the disadvantages of long-time running times and poor repeatability. Electrochemical biosensors have been proposed as a fast, easy, sensitive, and cost-effective method for the detection of BLM, and finding a suitable work electrode plays a crucial role in realizing highly performance detection.</div></div><div><h3>Results</h3><div>In this work, based on a boron-doped diamond (BDD) electrode, coupling with gold (Au) nanoparticles, we design an electrochemical aptasensor for sensitive and specific detection of BLM, featuring a synergistic assembly of aptamers, Au nanoparticle<strong>s</strong>, and BDD film. The BLM aptasensor presents a wide linear range in 1.0 × 10⁻¹⁷-1.0 × 10⁻⁸ mol L⁻¹, and achieves a limit of detection as low as 8.5 × 10⁻¹⁸ mol L⁻¹. The examinations of trace BLM serum also present a large region of 1.0 × 10⁻¹³-1.0 × 10⁻⁹ mol L⁻¹. Besides, the interfering tests exibit that the relative responses (RR, %) are ranged from −4.1 % to 6.4 % in five similar structure interfer, and the daily RRs varies between between −3.3 % and 7.3 % in comparison to the 100 % for the first day, which domenstrating the high stability and repeatability and accuracy of the aptasensor.</div></div><div><h3>Significance</h3><div>The innovative aptasensor consisting of β-mercaptohexanol (MCH), Aptamers, Au-NPs, and BDD (MAA-BDD) for the electrochemical detection of trace BLM is of excellent sensitivity, specificity, rigidity, and repeatability, which is suitable for further practical applications on trace BLM detection in various environments.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"166 ","pages":"Article 109052"},"PeriodicalIF":4.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}