Bioelectrochemistry最新文献_第10页

Biocorrosion studies on borated and non-borated 304 L stainless steel using Bacillus subtilis SNF-1, a bacterial isolate from SNF pool 利用枯草芽孢杆菌SNF-1对含硼和非含硼304 L不锈钢的生物腐蚀研究

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-09-09 DOI: 10.1016/j.bioelechem.2025.109106

Namrata Upadhyay , Sudhir K. Shukla , N. Malathy , Y.V. Nancharaiah , A. Ravi Shankar , S. Ningshen

{"title":"Biocorrosion studies on borated and non-borated 304 L stainless steel using Bacillus subtilis SNF-1, a bacterial isolate from SNF pool","authors":"Namrata Upadhyay , Sudhir K. Shukla , N. Malathy , Y.V. Nancharaiah , A. Ravi Shankar , S. Ningshen","doi":"10.1016/j.bioelechem.2025.109106","DOIUrl":"10.1016/j.bioelechem.2025.109106","url":null,"abstract":"<div><div>This study investigates microbiologically-influenced corrosion (MIC) aspects of borated and non-borated 304 L- stainless-steel using <em>Bacillus subtilis</em> SNF-1, which was isolated from the spent nuclear fuel pool (SNF). Over 28 days, electrochemical analyses revealed distinct corrosion behaviours: borated 304 L SS exhibited a more pronounced decrease in open circuit potential (from 0.03 to −0.35 V vs. Ag/AgCl) as compared to non-borated 304 L SS (from 0.05 to −0.10 V vs. Ag/AgCl) indicating higher susceptibility to MIC. Potentiodynamic polarization studies revealed an increase in passive current density (from 1.5 to 2.4 μA.cm<sup>−2</sup> for non-borated 304 L SS and from 2.4 to 3.4 μA.cm<sup>−2</sup> for borated 304 L SS), along with a lower pitting potential indicating the role of <em>B. subtilis</em> SNF-1 in MIC. Electrochemical impedance spectroscopy confirmed accelerated degradation, with polarization resistance (R<sub>p</sub>) dropping by 69 % in borated 304 L SS and 86 % in non-borated 304 L SS. Despite higher absolute corrosion rates in borated 304 L SS, non-borated 304 L SS experienced a greater relative increase in corrosion (3.8-fold vs. 2.3-fold) due to denser biofilm coverage (95 % vs. 74 %). Surface analysis identified localized pitting beneath biofilms, exacerbated by boride-induced micro-galvanic effects. These findings underscore the dual role of alloy microstructure and biofilm dynamics in MIC severity.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109106"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigations of potential therapeutic targets from high-throughput, label-free, quantitative proteomic studies in MDA-MB-468 cells treated with metformin and electrical pulses 二甲双胍和电脉冲处理MDA-MB-468细胞的高通量、无标记、定量蛋白质组学研究的潜在治疗靶点研究。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-10-24 DOI: 10.1016/j.bioelechem.2025.109153

Praveen Sahu , Ignacio G. Camarillo , Raji Sundararajan

{"title":"Investigations of potential therapeutic targets from high-throughput, label-free, quantitative proteomic studies in MDA-MB-468 cells treated with metformin and electrical pulses","authors":"Praveen Sahu , Ignacio G. Camarillo , Raji Sundararajan","doi":"10.1016/j.bioelechem.2025.109153","DOIUrl":"10.1016/j.bioelechem.2025.109153","url":null,"abstract":"<div><div>High-throughput, label-free quantitative proteomic analyses, along with cell viability and reactive oxygen species (ROS) studies, were performed on MDA-MB-468 human triple-negative breast cancer (TNBC) cells, to gain mechanistic insights into therapeutic actions. TNBC was chosen as it is the most lethal subtype of breast cancer, highly aggressive, prone to recurrence and metastasis, with the highest prevalence in black women. The absence of specific biomarkers limits targeted therapies. This unmet need was studied using proteomics, after treating the cells with electrical pulses (EP) combined with metformin (met). With the EP + met treatment (1000 V/cm, 1 mM), cell viability dropped to 25.6 % after 24 h and ROS increased to 179 %, compared to control at 100 %. Proteomics revealed 125 upregulated and 37 downregulated proteins in EP + met, compared to met alone, involving enzymes, proliferation markers, and kinases. Key gene changes included upregulation of ALAD, MKI67, and LRCH4, and downregulation of EIF1AX, NSUN5, and GNS. LRCH4 and GNS are suggested to be potential novel therapeutic targets, as LRCH4 upregulation links to inhibition of the mTOR/PI3K/Akt pathway, reducing proliferation, while GNS downregulation suppresses tumor growth and metastasis. Overall, proteomics-based preliminary findings suggest that EP + met modulate TNBC pathways, identifying potential biomarkers and providing a foundation for future validation</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109153"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectricity generation via biodegradation of pharmaceutical wastewater using MnCo2O4-CV coated electrodes in dual-chamber microbial fuel cells 利用MnCo2O4-CV包覆电极在双室微生物燃料电池中生物降解制药废水产生生物电。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-11-11 DOI: 10.1016/j.bioelechem.2025.109165

A.D. Ettiyan , Tamilarasan K , Siva P.R. Muppala

{"title":"Bioelectricity generation via biodegradation of pharmaceutical wastewater using MnCo2O4-CV coated electrodes in dual-chamber microbial fuel cells","authors":"A.D. Ettiyan , Tamilarasan K , Siva P.R. Muppala","doi":"10.1016/j.bioelechem.2025.109165","DOIUrl":"10.1016/j.bioelechem.2025.109165","url":null,"abstract":"<div><div>This study presents an innovative and environmentally sustainable approach for treating pharmaceutical wastewater (PWW) using a dual-chamber microbial fuel cell (DMFC) that simultaneously generates bioelectricity. The DMFC system incorporates manganese cobalt oxide-coated carbon veil (MnCo<sub>2</sub>O<sub>4</sub>-CV) electrodes to optimize organic pollutant removal and enhance power production from PWW. The novel MnCo<sub>2</sub>O<sub>4</sub>-CV electrode coating represents a significant advancement, offering superior chemical stability, electrical conductivity, durability, large surface area, and enhanced absorption capacity. Following a systematic acclimatization, various organic loadings were investigated to identify optimal operating conditions. Results demonstrated peak performance at an organic loading of 2.0 g COD/L. Under these conditions, the system exhibited remarkable removal efficiencies for total chemical oxygen demand (TCOD), soluble chemical oxygen demand (SCOD), and total suspended solids (TSS), while generating electrical output. Performance evaluation encompassed maximum voltage, current density, power density, coulombic efficiency, and pollutant removal metrics. Microbial community analysis via 16S rRNA gene sequencing revealed a diverse bacterial community in the anodic biofilm that contributed to improved system performance.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109165"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical sensor for urinary H2O2 detection to aid AKI diagnosis and treatment evaluation 电化学传感器尿液H2O2检测辅助AKI诊断和治疗评价。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-11-16 DOI: 10.1016/j.bioelechem.2025.109173

Cheng Huang , Haowen Liu , Bao Jiang , Guoli Li , Xinlu Qin , Yinan Hua , Yongming Deng , Yicheng Wang , Lin Zhou

引用次数: 0

Carboxyl-functionalized covalent organic framework with precisely matched pore size achieving effective loading of cytochrome C for electrochemical biosensors 具有精确匹配孔径的羧基功能化共价有机骨架实现了电化学生物传感器细胞色素C的有效负载。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-11-14 DOI: 10.1016/j.bioelechem.2025.109169

HaoXian He , JianBing Li , JianMing Liu, LongSheng Pei, LongFei Miao, YongHai Song, LiMin Liu, Li Wang

{"title":"Carboxyl-functionalized covalent organic framework with precisely matched pore size achieving effective loading of cytochrome C for electrochemical biosensors","authors":"HaoXian He , JianBing Li , JianMing Liu, LongSheng Pei, LongFei Miao, YongHai Song, LiMin Liu, Li Wang","doi":"10.1016/j.bioelechem.2025.109169","DOIUrl":"10.1016/j.bioelechem.2025.109169","url":null,"abstract":"<div><div>The immobilization of enzymes is crucial for enhancing their catalytic activity and stability. Covalent organic frameworks (COF), with abundant active sites and tunable pore structures, enable effective immobilization of enzymes. Here, we designed carboxyl-functionalized COF (COF-COOH) to immobilize Cytochrome C (Cyt C), aiming to regulate the perfect pairing of the COF pore (3.67 nm) and the Cyt C dimension (2.6 nm × 3.2 nm × 3.3 nm). Meanwhile, the large amount of -COOH can increase the electrostatic and hydrogen bonding forces between COF-COOH and Cyt C. Thus, the Cyt C was efficiently loaded into COF-COOH through the post-modification method (loading efficiency = 62.37 %). The catalytic activity (<em>k</em><sub><em>cat</em></sub><em>/K</em><sub><em>m</em></sub>) of Cyt C@COF-COOH toward H<sub>2</sub>O<sub>2</sub> was significantly enhanced to 309.96 s<sup>−1</sup> M<sup>−1</sup> as compared to free Cyt C of 105.55 s<sup>−1</sup> M<sup>−1</sup>. The catalytic activity of Cyt C@COF-COOH toward H<sub>2</sub>O<sub>2</sub> still exceeds 80 % in some harsh environments (acetonitrile, dimethyl sulfoxide, tetrahydrofuran and 60 °C). The detection range of electrochemical H<sub>2</sub>O<sub>2</sub> biosensor based on Cyt C@COF-COOH is as wide as 2.0–80 μM, and the sensitivity is as high as 0.373 μA μM<sup>−1</sup> cm<sup>−2</sup>.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109169"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The assessment of interaction kinetics between specific monoclonal antibody and immobilized SARS-CoV-2 nucleoprotein 特异性单克隆抗体与固定化SARS-CoV-2核蛋白相互作用动力学评价

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-08-25 DOI: 10.1016/j.bioelechem.2025.109090

Yana Karnitskaya , Maryia Drobysh , Almira Ramanaviciene , Agne Rimkute , Indre Kucinskaite-Kodze , Greta Zvirzdine , Rimantas Slibinskas , Oksana Pogorielova , Viktoriia Korniienko , Arunas Ramanavicius

{"title":"The assessment of interaction kinetics between specific monoclonal antibody and immobilized SARS-CoV-2 nucleoprotein","authors":"Yana Karnitskaya , Maryia Drobysh , Almira Ramanaviciene , Agne Rimkute , Indre Kucinskaite-Kodze , Greta Zvirzdine , Rimantas Slibinskas , Oksana Pogorielova , Viktoriia Korniienko , Arunas Ramanavicius","doi":"10.1016/j.bioelechem.2025.109090","DOIUrl":"10.1016/j.bioelechem.2025.109090","url":null,"abstract":"<div><div>The emergence of SARS-CoV-2 has posed significant global health challenges. The nucleocapsid protein (N-protein) is a structural part of the SARS-CoV-2 virus and an important immunogenic target of specific antibodies, which are developed in the organism during the infection by this virus. Artificially designed specific (monoclonal and polyclonal) antibodies are also used for therapeutic and bioanalytical purposes, therefore, the assessment and characterization of newly designed antibodies is an important analytical issue. This study reports an electrochemical biosensing system for the assessment of the interaction between newly designed specific antibody and SARS-CoV-2 recombinant N-protein, against which the antibody was designed, and which was used as a target in biological recognition part of the biosensing system. The biosensing system was applied for the determination of the interaction kinetics between immobilized N-protein and a newly derived monoclonal antibody (mAb) 16D9 (mAb-16D9). Cyclic voltammetry was employed to evaluate the kinetics of the interaction between the recombinant N-protein and mAb-16D9. The binding constant (<em>K</em>c) was determined to be 50.99 μg/mL, demonstrating a strong affinity, while the limit of detection was 4.3 × 10<sup>−4</sup> μg/mL, highlighting sufficient affinity of mAb-16D9 towards N-protein, which determined good sensitivity of the developed biosensors. These findings highlight the potential application of the here-reported electrochemical biosensor for rapid testing of antigen-antibody interaction kinetics and the characterization of newly designed antibody.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109090"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of aptamer – carbon hybrid materials for electrochemical detection of wound healing biomarker – TNF-α protein 适体-碳杂化材料在伤口愈合生物标志物TNF-α蛋白电化学检测中的应用

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-10-28 DOI: 10.1016/j.bioelechem.2025.109152

Julia Czopinska , Filip Budny , Andrzej Peplowski , Anna Sobiepanek , Marta Jarczewska

{"title":"Application of aptamer – carbon hybrid materials for electrochemical detection of wound healing biomarker – TNF-α protein","authors":"Julia Czopinska , Filip Budny , Andrzej Peplowski , Anna Sobiepanek , Marta Jarczewska","doi":"10.1016/j.bioelechem.2025.109152","DOIUrl":"10.1016/j.bioelechem.2025.109152","url":null,"abstract":"<div><div>Carbon – based surfaces are becoming attractive alternative to gold transducers, which are commonly applied for development of nucleic acid sensors. However, one of the challenges is the necessity of elaboration of carbon transducers modification methods, yielding stable receptor layers that are capable of binding to target analytes. Herein, we present the studies on the elaboration of aptamer layers aimed for electrochemical detection of cytokine - tumor necrosis factor-alpha (TNF-α). This protein can serve as biomarker of wound healing processes that might be the answer to need for rapid determination of the stage of the wound that can result in selection of proper diagnosis as well as treatment strategy. We aimed on functionalization of edge – plane pyrolytic graphite as well as planar screen – printed electrodes. The aptamer layers were formed through one-step procedure using pyrene and anthracene anchor groups conjugated with aptamers. The research enabled to choose ferri/ferrocyanide redox indicator that was the source of electrochemical signal, determine the range of linear response (5–200 ng/L) with LOD of 5.07 ng/L and test the sensor against complex samples of serum or simulated wound exudate. The developed aptasensor proved to be promising solution towards non-invasive monitoring of wound healing.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109152"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nafion-stabilized silver nanoparticles modified glassy carbon electrode for ultrasensitive detection of alpha-1-acid glycoprotein 钠稳定的纳米银修饰玻碳电极用于α -1-酸性糖蛋白的超灵敏检测

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-09-19 DOI: 10.1016/j.bioelechem.2025.109112

Gulam Rabbani , Akbar Mohammad , Mohammad Ehtisham Khan , Waleed Zakri , Mohsin Vahid Khan , Khurshid Ahamd , Wahid Ali , Syed Kashif Ali , Nazim Hasan , Abdulrahman Khamaj , Jintae Lee

{"title":"Nafion-stabilized silver nanoparticles modified glassy carbon electrode for ultrasensitive detection of alpha-1-acid glycoprotein","authors":"Gulam Rabbani , Akbar Mohammad , Mohammad Ehtisham Khan , Waleed Zakri , Mohsin Vahid Khan , Khurshid Ahamd , Wahid Ali , Syed Kashif Ali , Nazim Hasan , Abdulrahman Khamaj , Jintae Lee","doi":"10.1016/j.bioelechem.2025.109112","DOIUrl":"10.1016/j.bioelechem.2025.109112","url":null,"abstract":"<div><div>In this study, alpha-1-acid glycoprotein (AGP), a crucial biomarker associated with various diseases and physiological conditions, was selected for detection using the developed immunosensor. The immunosensor was fabricated by depositing a synthesized Nafion/silver nanoparticles (AgNPs) nanocomposite on the glassy carbon electrode as the substrate material. The changes in the physicochemical properties after Nafion/AgNPs nanocomposite deposition were analyzed through SEM and XPS measurements. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to analyze the immunosensor fabrication's electrochemical performance. AGP was detected through the immobilized anti-AGP on the electrode surface. The developed immunosensor exhibited a wide linear detection range from 0.05 to 3.2 mg/mL and a LOD of 0.17 mg/mL. The developed immunosensor showed excellent selectivity and repeatability when subjected to different kinds of interfering proteins. The recovery of AGP ranged from 101.7 to 103.7 % and RSD was <4 %, indicating high accuracy in real samples detection. The immunosensor developed for AGP detection showed a number of beneficial characteristics, including low cost and small volume sample requirements, making it highly suitable for point-of-care applications. This study provides new insights into the precise fabrication and affordable immunosensors for diverse clinical diagnostic applications.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109112"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal exopolysaccharides as a bio-binder for conductive pigment/reduced graphene oxide/nano‑cobalt composite: an eco-friendly solution for anode rechargeable batteries 真菌胞外多糖作为导电颜料/还原氧化石墨烯/纳米钴复合材料的生物粘合剂：阳极可充电电池的环保解决方案

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-09-04 DOI: 10.1016/j.bioelechem.2025.109094

Nashwa.M. Yousif , Reham M.M. AbdelKader , Ola.M. Gomaa

{"title":"Fungal exopolysaccharides as a bio-binder for conductive pigment/reduced graphene oxide/nano‑cobalt composite: an eco-friendly solution for anode rechargeable batteries","authors":"Nashwa.M. Yousif , Reham M.M. AbdelKader , Ola.M. Gomaa","doi":"10.1016/j.bioelechem.2025.109094","DOIUrl":"10.1016/j.bioelechem.2025.109094","url":null,"abstract":"<div><div>The rapid increase in population has driven the demand for fossil fuel energy, contributing to increased carbon emissions that ultimately accelerate global warming and climate change. Battery storage systems have many advantages over conventional energy sources. However, they face limitations such as energy storage, cost, and environmental hazards that come with the use of chemical binders. This study presents a novel application of <em>Talaromyces atroroseus</em> co-produced exopolysaccharides (EPS)-pigment complex for their bio-binding and conductivity properties that can replace chemical binders in the preparation of rechargeable anode batteries. The EPS–pigment complex was combined with reduced graphene oxide (rGO) and nano‑cobalt (CoNPs) to fabricate a hybrid conductive composite on nickel foam mesh. The composite was characterized using Energy Dispersive X-ray (EDX) and X-ray diffraction (XRD), both confirmed the presence of C, O, and Co. Electrochemical characterization of the composite elements showed a cathodic peak at 0.2 V and an anodic peak at 0.414 V. At the same time, the specific capacitance reached 400 F/g for the composite. The results also demonstrated a good rate of charge and discharge. Compared to chemical binders, fungal EPS showed good binding strength and environmental benefits due to its bio-based nature.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109094"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired electrochemical supercapacitor: peptide-driven osteosarcoma detection via hydroxyapatite formation and ferroptosis modulation 生物激发的电化学超级电容器：肽驱动的骨肉瘤检测通过羟基磷灰石形成和铁下垂调节。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-03-01 Epub Date: 2025-11-03 DOI: 10.1016/j.bioelechem.2025.109160

Pengwei Jing , Xinhua Yang , Haokang Zhang , Guishi Li , Zengliang Wang

{"title":"Bioinspired electrochemical supercapacitor: peptide-driven osteosarcoma detection via hydroxyapatite formation and ferroptosis modulation","authors":"Pengwei Jing , Xinhua Yang , Haokang Zhang , Guishi Li , Zengliang Wang","doi":"10.1016/j.bioelechem.2025.109160","DOIUrl":"10.1016/j.bioelechem.2025.109160","url":null,"abstract":"<div><div>Osteosarcoma, a prevalent age-related condition, often goes undiagnosed due to expensive and invasive detection methods. This study presents a novel, cost-effective, non-invasive electrochemical sensor for Osteosarcoma detection, leveraging peptide probes to selectively recognize key biomarkers like iron ions and osteocalcin. Using a phospholipid monolayer and a conductive substrate, the sensor utilizes peptide probes containing a tripeptide iron-binding sequence and an osteocalcin sequence to detect ferroptosis-induced iron ions and elevated osteocalcin levels, both indicative of early-stage Osteosarcoma. Electrochemical modulation facilitates the covalent assembly of osteocalcin into nanoscale aggregates, significantly amplifying the sensor's signal. This design avoids the need for complex antibodies or nanomaterials, enhancing affordability and simplicity. By integrating everyday components like toothpaste to form a low baseline signal and utilizing saliva as the sample, the sensor offers high sensitivity and a low-cost alternative to traditional diagnostic methods. This innovative approach combines bioinspired materials and electrochemical techniques to provide a promising solution for early Osteosarcoma detection, addressing the pressing need for accessible diagnostics in aging populations.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109160"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145547454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0