Zhongguo yao li xue bao = Acta pharmacologica Sinica最新文献_第6页

Flutamide suppressed prostate hypertrophy in rats and mice. 氟他胺抑制大鼠和小鼠前列腺肥大。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

Y Y Zhang, P F Li, B L Chen, D Li

引用次数: 0

Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells. 亮氨酸-2-丙氨酸脑啡肽诱导δ阿片受体内化在CHO细胞中的稳定表达。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

C H Wang, D H Zhou, J Chen, Z Q Chi

{"title":"Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells.","authors":"C H Wang, D H Zhou, J Chen, Z Q Chi","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To characterize the internalization of delta opioid receptors (DOR) stably expressed in Chinese hamster ovary (CHO) cells and the role of the C-terminal in this process.Methods: Receptor membrane anchoring was shown by immunofluorescence microscopy. Receptor internalization was assessed by measuring the radioligand binding resistant to the acid-buffer wash.Results: Originally, all the wild-type (CHO-W) and C-truncated (CHO-T) DOR expressed were localized to the membrane. Agonist [3H] leucine-2-alanine enkephalin (LAE) but not the antagonist [3H]diprenorphine (Dip) induced rapid receptor internalization. The internalization of C-truncated DOR in CHO-T was similar to that of the wild-type in maximal level, but climbed up more slowly. DOR internalization was extracellular osmolarity- and temperature-sensitive. Pertussis toxin and universal protein kinase inhibitor staurosporine had no effect on it.Conclusion: DOR internalization is an agonist and clathrin-coated pits dependent, but post-receptor cellular signal transduction independent process; moreover, the C-terminal of DOR, not engaged in membrane anchoring, affects the initialization of DOR internalization.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21531672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dauricine suppressed CsCl-induced early afterdepolarizations and triggered arrhythmias in rabbit heart in vivo. 尿嘧啶在体内抑制氯化铅诱导的兔心脏早期后去极化和诱发心律失常。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

J S Xia, H Tu, Z Li, F D Zeng

{"title":"Dauricine suppressed CsCl-induced early afterdepolarizations and triggered arrhythmias in rabbit heart in vivo.","authors":"J S Xia, H Tu, Z Li, F D Zeng","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To study the effect of dauricine on CsCl-induced early afterdepolarizations (EAD) and ventricular arrhythmias in rabbits.Methods: Monophasic action potentials (MAP) of the left ventricle of the rabbit heart in situ were recorded with MAP recording technique. CsCl 1-2 mmol.kg-1 i.v. was used to induce EAD and ventricular arrhythmias.Results: CsCl resulted in decrease of MAP amplitude (MAPA, P < 0.05) and prolongation of MAP duration at 90% repolarization (MAPD90, P < 0.01), QRS, and R-R duration (P < 0.05) compared with those before CsCl in the dauricine and control group. CsCl injection induced EAD that appeared within about 30 s and disappeared 5-15 min thereafter. EAD always preceded ventricular arrhythmias including ventricular premature beats and paroxysmal ventricular tachycardia. The EAD amplitude (EADA) in the dauricine group (26% +/- 9% of MAPA) was smaller than that in the control group (52% +/- 5% of MAPA, P < 0.05) and the incidence of arrhythmias in dauricine group (28%) was lower than that in control group (80%, P < 0.05).Conclusion: Dauricine exerted an antagonistic effect on EAD and suppressed triggered ventricular arrhythmias by decreasing EADA.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21531677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dauricine inhibits redistribution of platelet membrane glycoprotein IV and release of intracellular alpha-granule thrombospondin induced by thrombin. 尿嘧啶抑制血小板膜糖蛋白IV的再分配和凝血酶诱导的细胞内α -颗粒血栓反应蛋白的释放。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

T Guo, Y Z Zhang, D X Liu, P Zou, D Shen

引用次数: 0

Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. 治疗阿尔茨海默病患者的石杉碱- a胶囊和片剂。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

S S Xu, Z Y Cai, Z W Qu, R M Yang, Y L Cai, G Q Wang, X Q Su, X S Zhong, R Y Cheng, W A Xu, J X Li, B Feng

{"title":"Huperzine-A in capsules and tablets for treating patients with Alzheimer disease.","authors":"S S Xu, Z Y Cai, Z W Qu, R M Yang, Y L Cai, G Q Wang, X Q Su, X S Zhong, R Y Cheng, W A Xu, J X Li, B Feng","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To compare the efficacy and safety between huperzine-A (Hup) in capsules and tablets for treating patients with Alzheimer disease (AD).Methods: Using multicenter, prospective, double-blind, double-mimic, parallel, positive controlled and randomized methods, 60 patients meeting with the NINCDS-ARDRA criteria of AD were divided into 2 equal groups. Patients in the capsule group received 4 capsules of Hup (each contains 50 micrograms) and 4 tablets of placebo (lactose and starch inside); while the tablet group received 4 tablets of Hup (each contains 50 micrograms) and 4 capsules of placebo, p.o., twice a day for 60 d. All the patients were evaluated with a lot of related ranting scales, and physiological and laboratory examination.Results: There were significant differences (P < 0.01) on all the psychological evaluations between 'before' and 'after' the 60-d trial of 2 groups, but there was no significant difference between 2 groups by group t test (P > 0.05). The changes of oxygen free radicals in 2 groups showed marked improvement. No severe side effect besides moderate to mild nausea was found in both groups.Conclusion: There is equal efficacy and safety between Hup in capsule and tablet for treating patients with AD, and Hup can reduce the pathological changes of the oxygen free radicals in the plasma and erythrocytes of patients with AD.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21531671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory effects of total saponins of Panax notoginseng. 三七总皂苷的抗炎作用。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

S H Li, Y Chu

引用次数: 0

Water-retention effect of suberogorgin was due to secretion of antidiuretic hormone in rat. 牛皮甙的保水作用主要是由于其在大鼠体内分泌抗利尿激素所致。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

W D Peng

{"title":"Water-retention effect of suberogorgin was due to secretion of antidiuretic hormone in rat.","authors":"W D Peng","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To study the mechanism of antidiuretic effect of suberogorgin (Sub).Methods: Conscious rat was given i.g. Sub 3.16 mg.kg-1 20 min after water-loaded treatment and then urine was collected in metabolic cage. Ion excretion was determined in atomic emission spectrometry. Urinary prostaglandin E (PGE), plasma PGE, antidiuretic hormone (ADH), and aldosterone were measured with RIA. Sub vs pituitrin or DOCA effects were carried out in hypophysectomized or adrenalectomized rats.Results: The urine volume and the excretions of urinary sodium and potassium were decreased, maximally by 91%, 76%, and 86%, during the 24-h period after Sub. This antidiuretic effect possessed a progressive weakening with time. The concentrations of urinary PGE, plasma PGE, and ADH were increased by 25%, 212%, and 538%, respectively, but plasma aldosterone was not significantly influenced, 2 h after Sub dosing. The response of urine-excretion of rat to Sub was almost resisted by hypophysectomy but not by adrenalectomy.Conclusion: Sub decreased the urine excretion by, at least in part, accelerating the secretion of ADH but neither by PGE nor by aldosterone.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21532725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice. 有氧运动和人参皂苷对饮食性高脂血症小鼠脂质代谢的影响。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

Y Yang, T Wu, K He, Z G Fu

{"title":"Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice.","authors":"Y Yang, T Wu, K He, Z G Fu","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To study the effect of aerobic exercise and its combination with Gin (ginsenosides from stems and leaves of ginseng) on lipid metabolism in diet-induced hyperlipidemia mice.Methods: The mouse hyperlipidemia model was set up by feeding high cholesterol diet. Unloaded swimming was designed to be a manner of aerobic exercise. The effects of aerobic exercise and its combination with Gin on total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-c) in serum, malondialdehyde (MDA), and superoxide dismutase (SOD) in liver tissue were measured; the thymus and liver were weighed.Results: (1) The mouse hyperlipidemia model was set up successfully: TC and MDA increased (P < 0.05) but HDL-c and SOD decreased (P < 0.05); the liver weight increased and the thymus weight reduced; fatty liver was found; (2) aerobic exercise reduced TC but increased MDA and HDL-c in cholesterol-rich diet mice; the liver weight did not reduce, and fatty liver did not clear up; and (3) when aerobic exercise combined with Gin, TC and TG decreased markedly (P < 0.01), and MDA also decreased (P < 0.05); SOD and HDL-c increased markedly (P < 0.01); the thymus weight increased and the liver weight decreased to normal level; fatty liver cleared up.Conclusion: Aerobic exercise could lower serum lipid to some extent but could not satisfactorily regulate lipid metabolism. When combined with Gin, aerobic exercise could better lower serum lipid, regulate lipid metabolism, promote antioxidation, and enhance immune activity.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21532726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction. 雷米普利对心肌梗死后血管紧张素II受体基因转录水平的影响。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

Y C Zhu, Y Z Zhu, J Li, H Schäfer, W E Schmidt, T Unger, T Yao

{"title":"Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction.","authors":"Y C Zhu, Y Z Zhu, J Li, H Schäfer, W E Schmidt, T Unger, T Yao","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To study the early changes of cardiac angiotensin (Ang) II receptor gene transcription after myocardial infarction (MI) in rats chronically treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril.Methods: MI was induced by left anterior descending coronary artery ligation in rats and sham-operated rats were used as control. Rats were treated daily with ramipril (1 mg.kg-1) or water, initiated 1 wk before surgery. Quantitative RT-PCR was applied to determine the Ang II receptors AT1, AT2 receptor gene mRNA levels in the non-infarcted myocardium.Results: AT1 and AT2 mRNA levels increased time point-dependently in the cardiac septum after MI reaching a peak on d 1. There was no significant difference of the myocardial AT1 and AT2 receptor mRNA levels between the ramipril-treated and water-treated rats after MI.Conclusion: The AT1 and AT2 receptor gene transcription in the non-infarcted myocardium was associated with the process of cardiac remodeling after MI but not affected by ACE inhibition.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21531670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion. 5-HT1P受体介导的豚鼠肠系膜下神经节神经元缓慢去极化。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

L C Wang, S R Cai, Z X Huang, Q L Shao, R C Ma

引用次数: 0