5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

L C Wang, S R Cai, Z X Huang, Q L Shao, R C Ma

引用次数: 0

Abstract

Aim: To study the effects of several 5-hydroxytryptamine (5-HT) receptor subtype antagonists on 5-HT-induced depolarization and the effects of 5-HT1P receptor agonist on the membrane potential in the neurons of guinea pig inferior mesenteric ganglion (IMG).

Methods: Intracellular recordings were made from neurons of the isolated guinea pig IMG.

Results: Cyproheptadine (5-HT1/2 antagonist 10 mumol.L-1, n = 7) and BRL 24924 (5-HT1P antagonist 10 mumol.L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP (5-HT1P agonist 10 mmol.L-1) induced a slow depolarization in most of 5-HT sensitive neurons (10/14).

Conclusion: 5-HT-induced slow depolarization is mediated by 5-HT1P receptor.

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5-HT1P受体介导的豚鼠肠系膜下神经节神经元缓慢去极化。

目的:研究几种5-羟色胺(5-HT)受体亚型拮抗剂对豚鼠肠系膜下神经节(IMG)神经元去极化的影响及5-羟色胺受体激动剂对神经元膜电位的影响。方法:对离体豚鼠IMG神经元进行细胞内记录。结果:赛庚啶(5-HT1/2拮抗剂)10mumol;L-1, n = 7)和BRL 24924 (5-HT1P拮抗剂10 μ mol)。L-1, n = 19)可逆抑制5-HT慢反应;MCPP (5-HT1P激动剂10 mmol.L-1)的压力射血诱导大多数5-HT敏感神经元缓慢去极化(10/14)。结论:5-HT1P受体介导5-HT1P诱导的慢去极化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhongguo yao li xue bao = Acta pharmacologica Sinica

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