Dauricine suppressed CsCl-induced early afterdepolarizations and triggered arrhythmias in rabbit heart in vivo.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

J S Xia, H Tu, Z Li, F D Zeng

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Abstract

Aim: To study the effect of dauricine on CsCl-induced early afterdepolarizations (EAD) and ventricular arrhythmias in rabbits.

Methods: Monophasic action potentials (MAP) of the left ventricle of the rabbit heart in situ were recorded with MAP recording technique. CsCl 1-2 mmol.kg-1 i.v. was used to induce EAD and ventricular arrhythmias.

Results: CsCl resulted in decrease of MAP amplitude (MAPA, P < 0.05) and prolongation of MAP duration at 90% repolarization (MAPD90, P < 0.01), QRS, and R-R duration (P < 0.05) compared with those before CsCl in the dauricine and control group. CsCl injection induced EAD that appeared within about 30 s and disappeared 5-15 min thereafter. EAD always preceded ventricular arrhythmias including ventricular premature beats and paroxysmal ventricular tachycardia. The EAD amplitude (EADA) in the dauricine group (26% +/- 9% of MAPA) was smaller than that in the control group (52% +/- 5% of MAPA, P < 0.05) and the incidence of arrhythmias in dauricine group (28%) was lower than that in control group (80%, P < 0.05).

Conclusion: Dauricine exerted an antagonistic effect on EAD and suppressed triggered ventricular arrhythmias by decreasing EADA.

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尿嘧啶在体内抑制氯化铅诱导的兔心脏早期后去极化和诱发心律失常。

目的:研究水杨碱对家兔镉致早期去极化(EAD)和室性心律失常的影响。方法:采用MAP记录技术，原位记录兔左心室单相动作电位(MAP)。CsCl 1-2 mmol。kg-1静脉注射诱导EAD和室性心律失常。结果:与CsCl前相比，CsCl组MAP振幅(MAPA, P < 0.05)降低，90%复极MAP持续时间(MAPD90, P < 0.01)延长，QRS和R-R持续时间(P < 0.05)延长。CsCl注射诱导EAD在30 s内出现，5 ~ 15 min后消失。EAD常先于室性心律失常，包括室性早搏和阵发性室性心动过速。尿嘧啶组EAD振幅(EADA)(26% +/- 9%的MAPA)小于对照组(52% +/- 5%的MAPA, P < 0.05)，心律失常发生率(28%)低于对照组(80%，P < 0.05)。结论:丹参碱对EAD具有拮抗作用，可通过降低EADA来抑制诱发性室性心律失常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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