Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

Y C Zhu, Y Z Zhu, J Li, H Schäfer, W E Schmidt, T Unger, T Yao

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Abstract

Aim: To study the early changes of cardiac angiotensin (Ang) II receptor gene transcription after myocardial infarction (MI) in rats chronically treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril.

Methods: MI was induced by left anterior descending coronary artery ligation in rats and sham-operated rats were used as control. Rats were treated daily with ramipril (1 mg.kg-1) or water, initiated 1 wk before surgery. Quantitative RT-PCR was applied to determine the Ang II receptors AT1, AT2 receptor gene mRNA levels in the non-infarcted myocardium.

Results: AT1 and AT2 mRNA levels increased time point-dependently in the cardiac septum after MI reaching a peak on d 1. There was no significant difference of the myocardial AT1 and AT2 receptor mRNA levels between the ramipril-treated and water-treated rats after MI.

Conclusion: The AT1 and AT2 receptor gene transcription in the non-infarcted myocardium was associated with the process of cardiac remodeling after MI but not affected by ACE inhibition.

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雷米普利对心肌梗死后血管紧张素II受体基因转录水平的影响。

目的:研究血管紧张素转换酶(ACE)抑制剂雷米普利长期治疗大鼠心肌梗死(MI)后心肌血管紧张素(Ang) II受体基因转录的早期变化。方法:采用冠状动脉左前降支结扎术诱导大鼠心肌梗死，假手术大鼠为对照。大鼠术前1周开始每日服用雷米普利(1 mg.kg-1)或水。采用定量RT-PCR检测非梗死心肌中Ang II受体AT1、AT2受体基因mRNA表达水平。结果:心肌梗死后心间隔内AT1和AT2 mRNA水平呈时间点依赖性升高，在第1天达到峰值。结论:心肌梗死后非梗死心肌中AT1和AT2受体基因转录与心肌重构过程相关，但不受ACE抑制的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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