ACS Photonics最新文献

{"title":"Proton pump inhibitors and the risk of inflammatory bowel disease: a Mendelian randomisation study.","authors":"Hongjin An, Min Zhong, Huatian Gan","doi":"10.1136/gutjnl-2024-331904","DOIUrl":"10.1136/gutjnl-2024-331904","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e35"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating early-onset OSCC in Africa: findings of minimal cumulative incidence.","authors":"Mohamed Noureldin, Joel H Rubenstein, Brooke Kenney, Akbar K Waljee","doi":"10.1136/gutjnl-2023-331687","DOIUrl":"10.1136/gutjnl-2023-331687","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e33"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecystectomy following EUS-guided gallbladder drainage in patients with acute cholecystitis at high surgical risk: friend or foe?","authors":"Alberto Larghi, Roy L J van Wanrooij, Michiel Bronswijk, Giuseppe Vanella, Rastislav Kunda, Manuel Pérez-Miranda, Jeanin E Van-Hooft, Marc A Barthet, Paolo Giorgio Arcidiacono, Schalk Willem Van der Merwe","doi":"10.1136/gutjnl-2024-332273","DOIUrl":"10.1136/gutjnl-2024-332273","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e40"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microscopic pathology assessment of colorectal polyp size is less accurate than intracolonoscopic assessment.","authors":"Maurice B Loughrey","doi":"10.1136/gutjnl-2024-332206","DOIUrl":"10.1136/gutjnl-2024-332206","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e37"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting treatment response in ASUC: do we measure systemic severity, organ response or both?","authors":"Pernille D Ovesen, Johan Fredrik Kristoffer Fremberg Ilvemark, Rune Wilkens, Casper Steenholdt, Jakob Seidelin","doi":"10.1136/gutjnl-2023-331793","DOIUrl":"10.1136/gutjnl-2023-331793","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e38"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical consequences of computer-aided colorectal polyp detection.","authors":"Pieter Sinonquel, Tom Eelbode, Oliver Pech, Dominiek De Wulf, Pieter Dewint, Helmut Neumann, Giulio Antonelli, Federico Iacopini, David Tate, Arnaud Lemmers, Nastazja Dagny Pilonis, Michal Filip Kaminski, Philip Roelandt, Cesare Hassan, Demedts Ingrid, Frederik Maes, Raf Bisschops","doi":"10.1136/gutjnl-2024-331943","DOIUrl":"10.1136/gutjnl-2024-331943","url":null,"abstract":"<p><strong>Background and aim: </strong>Randomised trials show improved polyp detection with computer-aided detection (CADe), mostly of small lesions. However, operator and selection bias may affect CADe's true benefit. Clinical outcomes of increased detection have not yet been fully elucidated.</p><p><strong>Methods: </strong>In this multicentre trial, CADe combining convolutional and recurrent neural networks was used for polyp detection. Blinded endoscopists were monitored in real time by a second observer with CADe access. CADe detections prompted reinspection. Adenoma detection rates (ADR) and polyp detection rates were measured prestudy and poststudy. Histological assessments were done by independent histopathologists. The primary outcome compared polyp detection between endoscopists and CADe.</p><p><strong>Results: </strong>In 946 patients (51.9% male, mean age 64), a total of 2141 polyps were identified, including 989 adenomas. CADe was not superior to human polyp detection (sensitivity 94.6% vs 96.0%) but outperformed them when restricted to adenomas. Unblinding led to an additional yield of 86 true positive polyp detections (1.1% ADR increase per patient; 73.8% were <5 mm). CADe also increased non-neoplastic polyp detection by an absolute value of 4.9% of the cases (1.8% increase of entire polyp load). Procedure time increased with 6.6±6.5 min (+42.6%). In 22/946 patients, the additional detection of adenomas changed surveillance intervals (2.3%), mostly by increasing the number of small adenomas beyond the cut-off.</p><p><strong>Conclusion: </strong>Even if CADe appears to be slightly more sensitive than human endoscopists, the additional gain in ADR was minimal and follow-up intervals rarely changed. Additional inspection of non-neoplastic lesions was increased, adding to the inspection and/or polypectomy workload.</p>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1974-1983"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengths and limitations of AlphaMissense in <i>CPA1</i> missense variant classification.","authors":"Ya-Hui Wang, Emmanuelle Masson, Zhuan Liao, Claude Férec, Wen-Bin Zou, Jian-Min Chen","doi":"10.1136/gutjnl-2024-332120","DOIUrl":"10.1136/gutjnl-2024-332120","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e42"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon nanotube/polyvinylidene fluoride flexible composite material with low percolation threshold and adjustable negative permittivity","authors":"Zuxiang Mu,&nbsp;Yinuo Sun,&nbsp;Zhaocun Shen,&nbsp;Gemeng Liang,&nbsp;Jinshuo Zou,&nbsp;Peitao Xie","doi":"10.1007/s42114-024-01049-4","DOIUrl":"10.1007/s42114-024-01049-4","url":null,"abstract":"<div><p>In the interdisciplinary fields of materials science, electromagnetics, and optics, the negative dielectric constant, as a unique physical property, is gradually attracting widespread attention from the academic and industrial communities. Materials with negative dielectric constant impose strict requirements on the value and flexibility of the negative dielectric constant in today’s diverse development. In this study, a flexible carbon nanotube (CNTs)/polyvinylidene fluoride (PVDF) composite film with a low percolation threshold of negative dielectric constant was prepared using a casting method, with a percolation threshold of only 9 wt%. By varying the CNTs content, the intensity of both positive and negative dielectric constant responses can be tuned. The research revealed that the conduction mechanism involves both hopping conduction and metal-like conduction. Notably, at the CNTs content of 11 wt%, a negative dielectric constant was observed across the entire frequency range, showing a Drude-Lorentz-type dispersion. The composite materials with lower CNTs content exhibited dielectric loss primarily at low frequencies, while those with higher CNTs content showed dielectric loss across the full frequency range. This work demonstrates a cost-effective and straightforward approach for controlling negative dielectric constants, which holds promise for applications in electronic devices and electromagnetic shielding.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":"7 6","pages":""},"PeriodicalIF":23.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis.","authors":"Mohamed G Shiha, Annalisa Schiepatti, Stiliano Maimaris, NIcoletta Nandi, Hugo A Penny, David S Sanders","doi":"10.1136/gutjnl-2024-333110","DOIUrl":"10.1136/gutjnl-2024-333110","url":null,"abstract":"<p><strong>Objective: </strong>Potential coeliac disease (PCD) is characterised by positive serological and genetic markers of coeliac disease with architecturally preserved duodenal mucosa. The clinical outcomes and rates of progression to overt coeliac disease in patients with PCD remain uncertain. In this systematic review and meta-analysis, we aimed to evaluate the clinical outcomes of patients with PCD.</p><p><strong>Design: </strong>We searched Medline, Embase, Scopus and Cochrane Library from 1991 through May 2024 to identify studies evaluating the clinical outcomes of patients with PCD. The progression rates to villous atrophy, seroconversion and response to a gluten-free diet (GFD) were analysed. A random-effect meta-analysis was performed, and the results were reported as pooled proportions with 95% CIs.</p><p><strong>Results: </strong>Seventeen studies comprising 1010 patients with PCD were included in the final analyses. The pooled prevalence of PCD among patients with suspected coeliac disease was 16% (95% CI 10% to 22%). The duration of follow-up in most of the studies was at least 1 year, with follow-up periods within individual studies ranging from 5 months to 13 years. During follow-up, 33% (95% CI 18% to 48%; I²=96.4%) of patients with PCD on a gluten-containing diet developed villous atrophy, and 33% (95% CI 17% to 48%; I²=93.0%) had normalisation of serology. Among those who adhered to a GFD, 88% (95% CI 79% to 97%; I²=93.2%) reported symptomatic improvement.</p><p><strong>Conclusion: </strong>Almost a third of patients with PCD develop villous atrophy over time, whereas a similar proportion experience normalisation of serology despite a gluten-containing diet. Most symptomatic patients benefit from a GFD. These findings highlight the importance of structured follow-up and individualised management for patients with PCD.</p>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1944-1952"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD64⁺ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8⁺ T cells.","authors":"Tianxing Zhou, Xupeng Hou, Jingrui Yan, Lin Li, Yongjie Xie, Weiwei Bai, Wenna Jiang, Yiping Zou, Xueyang Li, Ziyun Liu, Zhaoyu Zhang, Bohang Xu, Guohua Mao, Yifei Wang, Song Gao, Xiuchao Wang, Tiansuo Zhao, Hongwei Wang, Hongxia Sun, Xiufeng Zhang, Jun Yu, Chongbiao Huang, Jing Liu, Jihui Hao","doi":"10.1136/gutjnl-2024-332371","DOIUrl":"10.1136/gutjnl-2024-332371","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to improve the efficacy of CLDN18.2/CD3 bispecific T-cell engagers (BiTEs) as a promising immunotherapy against pancreatic ductal adenocarcinoma (PDAC).</p><p><strong>Design: </strong>Humanised hCD34⁺/hCD3e⁺, Trp53^R172HKras^G12DPdx1-Cre (KPC), pancreas-specific Cldn18.2 knockout (KO), fibroblast-specific Fcgr1 KO and patient-derived xenograft/organoid mouse models were constructed. Flow cytometry, Masson staining, Cell Titer Glo assay, virtual drug screening, molecular docking and chromatin immunoprecipitation were conducted.</p><p><strong>Results: </strong>CLDN18.2 BiTEs effectively inhibited early tumour growth, but late-stage efficacy was significantly diminished. Mechanically, the Fc fragment of BiTEs interacted with CD64⁺ cancer-associated fibroblasts (CAFs) via activation of the SYK-VAV2-RhoA-ROCK-MLC2-MRTF-A-α-SMA/collagen-I pathway, which enhanced desmoplasia and limited late-stage infiltration of T cells. Molecular docking analysis found that vilanterol suppressed BiTEs-induced phosphorylation of VAV2 (Y172) in CD64⁺ CAFs and weakened desmoplasia. Additionally, decreased cyclic guanosine-adenosine monophosphate synthase/stimulator of interferon genes (STING) activity reduced proliferation of TCF-1⁺PD-1⁺ stem-like CD8⁺ T cells, which limited late-stage effects of BiTEs. Finally, vilanterol and the STING agonist synergistically boosted the efficacy of BiTEs by inhibiting the activation of CD64⁺ CAFs and enriching proliferation of stem-like CD8⁺ T cells, resulting in sustained anti-tumour activity.</p><p><strong>Conclusion: </strong>Vilanterol plus the STING agonist sensitised PDAC to CLDN18.2 BiTEs and augmented efficacy as a potential novel strategy.</p>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1984-1998"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}