ACS Photonics最新文献

{"title":"Recent advances in clinical practice: mastering the challenge—managing IBS symptoms in IBD","authors":"Judith Wellens, João Sabino, Tim Vanuytsel, Jan Tack, Séverine Vermeire","doi":"10.1136/gutjnl-2024-333565","DOIUrl":"https://doi.org/10.1136/gutjnl-2024-333565","url":null,"abstract":"Many patients with IBD report persisting symptoms, despite resolution of the inflammatory process. Although by definition, a diagnosis of IBS cannot be made, the prevalence of ‘IBS in IBD’ surpasses the rate of IBS in the global population by fivefold. Because IBS-like symptoms are associated with a decreased quality of life and increased healthcare utilisation in IBD, diagnosis and treatment are necessary. In this review, we summarise the current knowledge on IBS-like symptoms in IBD. A pathophysiological common ground is present, which includes genetic susceptibility, environmental triggers, gut microbial dysbiosis, increased intestinal permeability, visceral hypersensitivity and involvement of brain–gut interaction. When symptoms persist after resolution of inflammation, other GI diseases should be excluded based on the chief complaint, considering any possible psychological co-morbidity early in the diagnostic work-up. Subsequent treatment should be initiated that is evidence-based and often multimodal, including classical and non-classical pharmacological agents as well as lifestyle and microbiota-based approaches, spanning the breadth of the gut, brain and its interaction. Treatment goals in this substantial part of the IBD population should be adapted to not only focus on treating the inflammation but taking care of the patient.","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":"10 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mechanical strategy of surface anchoring to enhance the electrochemical performance of ZnO/NiCo2O4@nickel foam self-supporting anode for lithium-ion batteries","authors":"Yanbin Xu,&nbsp;Xingang Liu,&nbsp;Shuai Wang,&nbsp;Zhenyu Fu,&nbsp;Lixiang Sun,&nbsp;Wenfan Feng,&nbsp;Zhiqiang Lv,&nbsp;Yuming Cui,&nbsp;Xiao Li,&nbsp;Ping Yin,&nbsp;Ashely DeMerle,&nbsp;Ethan Burcar,&nbsp;Zhe Wang,&nbsp;Zhenglong Yang","doi":"10.1007/s42114-024-01058-3","DOIUrl":"10.1007/s42114-024-01058-3","url":null,"abstract":"<div><p>NiCo₂O₄ has the advantages of high energy density, low cost, and environment-friendly as the anode materials of lithium-ion batteries. However, NiCo₂O₄ is adversely affected by the slow transmission rate of lithium-ion, and the collapse of its three-dimensional loose and porous nano-flake structure causes its poor cycling performance. In this study, in order to address this issue, the NiCo₂O₄ @ Nickel Foam (NF) composite was formed by depositing ZIF-67 on nickel foam through room temperature standing and 350 ℃ treatment, and then short ZnO nanorods with an anchoring structure were grown on its surface through heat treatment and hydrothermal treatment to obtain ZnO/NiCo₂O₄@NF compound materials. The nano-rod structure of ZnO material increases the contact between the electrode material and electrolyte and reduces the charge transfer resistance, and its anchoring structure stabilizes the porous sheet architecture of NiCo₂O₄@NF. After 100 cycles (100 mA∙g⁻¹), the discharge capacity of the ZnO/NiCo₂O₄@NF composite electrode remained at 475.2 mAh∙g⁻¹, which is significantly higher than 313.8 mAh∙g⁻¹ of NiCo₂O₄@NF electrode and 245.4 mAh∙g⁻¹ of ZnO@NF electrode.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":"7 6","pages":""},"PeriodicalIF":23.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large proximal gastric GIST tumours: downsizing by imatinib and subsequent endoresection","authors":"Ayimukedisi Yalikong, Baohui Song, Dongli He, Enpan Xu, Zhipeng Qi, Yunshi Zhong","doi":"10.1136/gutjnl-2024-332993","DOIUrl":"https://doi.org/10.1136/gutjnl-2024-332993","url":null,"abstract":"Surgical removal is recommended for gastrointestinal stromal tumours (GISTs) larger than 3 cm due to their potential for malignancy but limited wedge resection is not possible in the proximal stomach. Endoscopic removal of larger lesions has been technically limited in complex anatomical regions such as cardia. We report two cases of large proximal (cardia/fundus) GIST tumours (51 and 60 mm) which were downsized (to 26 and 36 mm) by 3–7 months of imatinib therapy followed by transmural endoscopic resection. Follow-up of 23 and 16 months including endoscopy and CT was unremarkable. GISTs commonly occur in the stomach.1 2 Due to their malignant potential, surgery is generally recommended.3–5 Recently, endoscopic resection of submucosal tumours (SMTs) has made significant progress.6 The European Society of Gastrointestinal Endoscopy recommended endoscopic resection for gastric GISTs<35 mm projecting into the lumen.3 Endoscopic full-thickness resection (EFTR), an extension of submucosal dissection, has shown promising results for SMTs arising from the deep muscularis propria (MP), particularly in the gastric fundus.7 However, achieving R0 resection in GISTs>35 mm remains challenging.8 Large GISTs in anatomically complex areas such as the cardia and fundus may still necessitate surgical resection.2 Radical surgery, however, poses risks to cardia function and patient quality of life.9 Preoperative imatinib can shrink tumours, reduce mitotic activity and lower recurrence risk.9 10 The American College of Gastroenterology guidelines suggested neoadjuvant imatinib to facilitate tumour reduction in large GISTs, enhancing the feasibility of minimally invasive endoscopic resection. Hence, in this context, we explored the combination of preoperative imatinib with EFTR as a novel, minimally invasive strategy for treating large gastric GISTs. Our primary outcomes suggested this approach may be a viable alternative for GISTs in gastric anatomical complex regions. Case 1 was a 65-year-old woman with abdominal distension and belching for several months. Gastroscopy revealed …","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":"159 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases","authors":"Yuanfang Li, Yongqiang Zheng, Jiaqian Huang, Run-Cong Nie, Qi-Nian Wu, Zhijun Zuo, Shuqiang Yuan, Kai Yu, Cheng-Cai Liang, Yi-Qian Pan, Bai-Wei Zhao, Yuhong Xu, Qihua Zhang, Yashang Zheng, Junquan Chen, Zhao-Lei Zeng, Wei Wei, Ze-Xian Liu, Rui-Hua Xu, Hui-Yan Luo","doi":"10.1136/gutjnl-2024-333617","DOIUrl":"https://doi.org/10.1136/gutjnl-2024-333617","url":null,"abstract":"Background Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer peritoneal metastasis (GCPM) have a poor prognosis and respond poorly to conventional treatments. Recently, immune checkpoint blockade (ICB) has demonstrated favourable efficacy in the treatment of GCPM. Stratification of best responders and elucidation of resistance mechanisms of ICB therapies are highly important and remain major clinical challenges. Design We performed a phase II trial involving patients with GCPM treated with ICB (sintilimab) combined with chemotherapy. The samples of primary tumours, GCPMs and peripheral blood from patients were collected for single-cell sequencing to comprehensively interpret the tumour microenvironment of GCPM and its impacts on immunotherapy efficacy. Results The GCPM ecosystem coordinates a unique immunosuppressive pattern distinct from that of primary GC, which is dominated by a stroma-myeloid niche composed of SPP1+tumour-associated macrophages (TAMs) and Thrombospondin 2 (THBS2)+matrix cancer-associated fibroblasts (mCAFs). Consequently, this stroma-myeloid crosstalk is the major mediator of ICB resistance in patients with GCPM. Mechanistically, the accumulated THBS2+mCAFs facilitate the recruitment of peritoneum-specific tissue-resident macrophages and their transformation into SPP1+TAMs via the complement C3 and its receptor C3a receptor 1 (C3AR1), thereby forming a protumoral stroma-myeloid niche. Blocking the C3-C3AR1 axis disrupts the stroma-myeloid crosstalk and thereby significantly improves the benefits of ICB in in vivo models. Conclusion Our findings provide a new molecular portrait of cell compositions associated with ICB resistance in patients with GCPM and aid in the prioritisation of therapeutic candidates to potentiate immunotherapy. Data are available in a public, open access repository. Data are available on reasonable request. The sample information is listed in online supplemental table S1. The 10X genomics raw data of this study are deposited in the Genome Sequence Archive for Human database (ID: HRA009064; link: [https://ngdc.cncb.ac.cn/gsa-human/browse/HRA009064][1]). Additionally, the GEXSCOPE single-cell matrix data are deposited in the Mendeley repository (ID: jwkc5t6r55). Previously published scRNA-seq data that were reanalysed and integrated into this study are available in the Gene Expression Omnibus database under accession code GSE183904. All the data that support the findings of this study are available from the corresponding author on reasonable request. [1]: https://ngdc.cncb.ac.cn/gsa-human/browse/HRA009064)","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":"196 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?","authors":"Fons F van den Berg, Marc G Besselink, Hjalmar van Santvoort","doi":"10.1136/gutjnl-2024-332129","DOIUrl":"10.1136/gutjnl-2024-332129","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"e34"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent intestinal ulcers and perforations complicated with pigmentation.","authors":"Junfeng Guo, Linxi Su, Guangsheng Du, Yuyang Chen, Cheng Liu, Bing Wang, Yangfan Lv, Shiming Yang, Xia Xie","doi":"10.1136/gutjnl-2024-332057","DOIUrl":"10.1136/gutjnl-2024-332057","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1964-1983"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Puerarin alleviates atherosclerosis via the inhibition of <i>Prevotella copri</i> and its trimethylamine production.","authors":"","doi":"10.1136/gutjnl-2024-331880","DOIUrl":"10.1136/gutjnl-2024-331880","url":null,"abstract":"<p><strong>Objective: </strong>Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, the precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate the effects of PU and its mechanisms in mitigating AS in both mice and humans.</p><p><strong>Design: </strong>The impact of PU on AS was examined in <i>ApoE</i> ^-/- mice fed a high-fat diet (HFD) and in human patients with carotid artery plaque. To explore the causal link between PU-associated gut microbiota and AS, faecal microbiota transplantation (FMT) and mono-colonisation of mice with <i>Prevotella copri</i> (<i>P. copri</i>) were employed.</p><p><strong>Results: </strong>PU alleviated AS by modulating the gut microbiota, as evidenced by alterations in gut microbiota composition and the amelioration of AS following FMT from PU-treated mice into <i>ApoE^-/-</i> mice fed HFD. Specifically, PU reduced the abundance of <i>P. copri</i>, which exacerbated AS by producing trimethylamine (TMA). Prolonged mono-colonisation of <i>P. copri</i> undermines the beneficial effects of PU on AS. In clinical, the plaque scores of AS patients were positively correlated with the abundance of <i>P. copri</i> and plasma trimethylamine-N-oxide (TMAO) levels. A 1-week oral intervention with PU effectively decreased <i>P. copri</i> levels and reduced TMAO concentrations in patients with carotid artery plaque.</p><p><strong>Conclusion: </strong>PU may provide therapeutic benefits in combating AS by targeting <i>P. copri</i> and its production of TMA.</p><p><strong>Trial registration number: </strong>ChiCTR1900022488.</p>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1934-1943"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohn's disease stopping infliximab.","authors":"Nicolas Pierre, Vân Anh Huynh-Thu, Dominique Baiwir, Gabriel Mazzucchelli, Maximilien Fléron, Lisette Trzpiot, Gauthier Eppe, Edwin De Pauw, David Laharie, Jack Satsangi, Peter Bossuyt, Lucine Vuitton, Sophie Vieujean, Jean-Frédéric Colombel, Marie-Alice Meuwis, Edouard Louis","doi":"10.1136/gutjnl-2024-332648","DOIUrl":"10.1136/gutjnl-2024-332648","url":null,"abstract":"<p><strong>Objective: </strong>In patients with Crohn's disease (CD) on combination therapy (infliximab and immunosuppressant) and stopping infliximab (cohort from the study of infliximab diSconTinuation in CrOhn's disease patients in stable Remission on combined therapy with Immunosuppressors (STORI)), the risk of short-term (≤6 months) and mid/long-term relapse (>6 months) was associated with distinct blood protein profiles. Our aim was to test the external validity of this finding in the SPARE cohort (A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy).</p><p><strong>Design: </strong>In SPARE, patients with CD in sustained steroid-free clinical remission and on combination therapy were randomly allocated to three arms: continuing combination therapy, stopping infliximab or stopping immunosuppressant. In the baseline serum of the STORI and SPARE (arm stopping infliximab) cohorts, we studied 202 immune-related proteins. The proteins associated with time to relapse (univariable Cox model) were compared between STORI and SPARE. The discriminative ability of biomarkers (individually and combined in pairs) was evaluated by the c-statistic (concordance analysis) which was compared with C-reactive protein (CRP), faecal calprotectin and a previously validated model (CEASE).</p><p><strong>Results: </strong>In STORI and SPARE, distinct blood protein profiles were associated with the risk of short-term (eg, high level: CRP, haptoglobin, interleukin-6, C-type lectin domain family 4 member C) and mid/long-term relapse (eg, low level: Fms-related tyrosine kinase 3 ligand, kallistatin, fibroblast growth factor 2). At external validation, the top 10 biomarker pairs showed a higher c-statistic than the CEASE model, CRP and faecal calprotectin in predicting short-term (0.76-0.80 vs 0.74 vs 0.71 vs 0.69, respectively) and mid/long-term relapse (0.66-0.68 vs 0.61 vs 0.52 vs 0.59, respectively).</p><p><strong>Conclusion: </strong>In patients with CD stopping infliximab, we confirm that the risk of short-term and mid/long-term relapse is associated with distinct blood protein profiles showing the potential to guide infliximab withdrawal.</p><p><strong>Trial registration number: </strong>NCT00571337 and NCT02177071.</p>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1965-1973"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulation and entry inhibition: selgantolimod's double punch against hepatitis B virus.","authors":"Thomas Baumert, Melanie Urbanek-Quaing, Markus Cornberg","doi":"10.1136/gutjnl-2024-332679","DOIUrl":"10.1136/gutjnl-2024-332679","url":null,"abstract":"","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":" ","pages":"1925-1926"},"PeriodicalIF":23.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the structural, magnetic, and electrical properties of epsilon-negative Bamboo/NiS2/(MnFe2O4)x/PVC metacomposites","authors":"Sakineh Karimi,&nbsp;Reza Gholipur","doi":"10.1007/s42114-024-01012-3","DOIUrl":"10.1007/s42114-024-01012-3","url":null,"abstract":"<div><p>Considerable attention has been focused on the unique and unexpected properties of lightweight, broad-spectrum, and high reflection loss (RL) metacomposites with adjustable electromagnetic characteristics. This research project aimed to investigate the structural, magnetic, and electrical attributes of Bamboo/NiS₂/(MnFe₂O₄)_x/PVC metacomposites, which display negative permittivity behavior as a novel material. When the mole value of MnFe₂O₄ was 0.0027 or lower, the presence of negative permittivity was detected at frequencies between 0–100 MHz and higher. The main reason for this was the easy creation of electrical percolation through the processed bamboo structure, which is crucial for achieving negative permittivity and high AC conductivity. The frequency-dependent variations in permittivity were in agreement with the Lorentz model. By altering the mole fraction of MnFe₂O₄ to adjust impedance, the electromagnetic absorption capabilities of the metacomposites were improved to − 25.87878 dB for a thickness of 1 mm. The findings presented in this study have the potential to pave the way for innovative developments in the field of negative permittivity metacomposites, facilitating the practical implementation of epsilon-negative materials and lightweight absorption properties in electromagnetic devices such as memristors, light-dependent resistors (LDRs), and low-frequency reflectors.</p></div>","PeriodicalId":23,"journal":{"name":"ACS Photonics","volume":"7 6","pages":""},"PeriodicalIF":23.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}