Veterinary Research Forum最新文献_第4页

Studies on syndemic infection of porcine reproductive and respiratory syndrome virus with porcine circovirus 2 in backyard pigs of Mizoram, India. 印度米佐拉姆省散养猪群猪繁殖与呼吸综合征病毒与猪圆环病毒 2 综合感染研究。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-02-15 DOI: 10.30466/vrf.2024.2023688.4187

Amitava Paul, Tridib Kumar Rajkhowa, Kiran Jayappa

{"title":"Studies on syndemic infection of porcine reproductive and respiratory syndrome virus with porcine circovirus 2 in backyard pigs of Mizoram, India.","authors":"Amitava Paul, Tridib Kumar Rajkhowa, Kiran Jayappa","doi":"10.30466/vrf.2024.2023688.4187","DOIUrl":"10.30466/vrf.2024.2023688.4187","url":null,"abstract":"Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus 2 (PCV2) are among one of the most prevalent and important infectious agents, which cause a severe economic impact on pig farming worldwide. Circulation of these viruses together in the same pig population may lead to the syndemic infection with altered pathogenicity and thereby pathology and clinical manifestation of the diseases. The present study evaluated syndemic infection between PRRSV and PCV2 in the pig population reared in the backyard farms in Mizoram state of India. The syndemicity between PRRSV and PCV2 was confirmed by clinico-pathological studies followed by simultaneous detection of both the viruses in tissue samples by polymerase chain reaction (PCR) and reverse transcription-PCR (RT-PCR), immunohisto-chemistry and SYBR green-based real-time PCR / RT- PCR. The syndemicity resulted to a more severe respiratory disease in affected pigs. Pathological studies on affected pigs revealed a combined picture of hemorrhagic lesions with lymphadenopathy. The SYBR green-based absolute quantification assay estimated the PCV2 load in more quantities than that of PRRSV in all the tissues. The highest PRRSV load was detected in the lungs, while the highest PCV2 load was detected in mesenteric and inguinal lymph nodes. The co-circulation of different pathogenic viruses and their persistent infections in a population is always a matter of great concern to pig producers across the world. The present findings highlighted the similar situation with syndemic infection of PRRSV with PCV2 for the first time in Mizoram, India, that caused severe respiratory disease in affected pigs.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 2","pages":"81-88"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An outbreak of Fusobacterium necrophorum associated foot rot in a herd of four-horned antelope (Tetracerus quadricornis) in India. 印度一群四角羚羊（四角羚羊）爆发与坏死性梭杆菌相关的足腐病。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.30466/vrf.2024.2028598.4269

Susitha Rajkumar, Loveleen Maria Vaz, Mathavan Anandhi, Karikalan Mathesh, Shivasharanappa Nayakvadi, Solomon Rajkumar, Shirish Dadarao Narnaware

{"title":"An outbreak of Fusobacterium necrophorum associated foot rot in a herd of four-horned antelope (Tetracerus quadricornis) in India.","authors":"Susitha Rajkumar, Loveleen Maria Vaz, Mathavan Anandhi, Karikalan Mathesh, Shivasharanappa Nayakvadi, Solomon Rajkumar, Shirish Dadarao Narnaware","doi":"10.30466/vrf.2024.2028598.4269","DOIUrl":"https://doi.org/10.30466/vrf.2024.2028598.4269","url":null,"abstract":"An outbreak of contagious foot rot due to Fusobacterium necrophorum infection was reported in a herd of four-horned antelopes (Tetracerus quadricornis) in a wildlife sanctuary at Goa, India. The infected animals showed signs of anorexia, limping and foot lesions, like erosions and sloughing of hooves. Mortality was recorded in two antelopes in which gross lesions, like generalized congestion of skeletal muscles and internal organs, and multi-focal to coalescing abscesses in lung, pleura, and diaphragm were observed. Histopathological evaluation of interdigital skin showed zones of coagulative necrosis, infiltration of mononuclear inflammatory cells, congestion, hemorrhage, and thrombosis in the dermis. Lung showed extensive areas of consolidation with alveolar edema, hyperemic alveolar capillaries, hemorrhage, and infiltration of inflammatory cells. The bacterial culture from heart blood, lung, liver, and kidney tissues revealed isolation of F. necrophorum being also confirmed by polymerase chain reaction (PCR) using amplification of lktA gene of F. necrophorum. In addition, the PCR also confirmed the presence of F. necrophorum DNA in the interdigital skin, lung, and liver tissues. Phylogenetic analysis showed that the F. necrophorum isolate from the present study grouped closely with isolates from Australia, China, Pakistan, and Iraq, as well as an Indian isolate from goat. The affected live animals were treated with oral antibiotics, anti-inflammatory medicines, and vitamin supplements for seven days, and recovered. This study confirmed the first outbreak of contagious foot rot and systemic infection with F. necrophorum in a herd of four-horned antelopes in India.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 1","pages":"51-56"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic profiling of pseudorabies virus-infected PK-15 cells based on 4D label free analysis. 伪狂犬病毒感染PK-15细胞的蛋白质组学分析

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-03-15 DOI: 10.30466/vrf.2024.2026963.4239

Shuaiwei Wang, Xiaoyong Chen, Houqiang Luo, Meng Wang, Junyu Liu, Qingsong Han

{"title":"Proteomic profiling of pseudorabies virus-infected PK-15 cells based on 4D label free analysis.","authors":"Shuaiwei Wang, Xiaoyong Chen, Houqiang Luo, Meng Wang, Junyu Liu, Qingsong Han","doi":"10.30466/vrf.2024.2026963.4239","DOIUrl":"10.30466/vrf.2024.2026963.4239","url":null,"abstract":"Pseudorabies virus (PRV) heavily depends on host machinery to support its life cycle. Investigating the interaction between PRV and host could aid in the understandings of viral pathogenesis. In this study, we performed a 4D label free proteomic method to examine the differentially expressed proteins in porcine kidney PK-15 cells with PRV infection. The results showed that the levels of 661 proteins were significantly elevated and 693 proteins were markedly reduced. Furthermore, these altered proteins were primarily enriched in spliceosome, protein processing in endoplasmic reticulum (ER), RNA transport, and protein export. To ensure the reliability of the proteomic results, the protein levels of formin binding protein 11 and wolfram syndrome 1as components of spliceosome and ER were verified via western blotting and the results were consistent. Together, our data shed light on a new protein profiling induced by PRV infection and highlighted the importance of spliceosome and ER in PRV replication which could promote understandings of host-PRV interplay.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 3","pages":"141-147"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of using a Rovabio^® Plus multi-enzyme on production and incubation performance, blood parameters and duodenum morphology of broiler breeders at age of 45 - 60 weeks. Rovabio®Plus复合酶对45 ~ 60周龄肉种鸡产量、孵化性能、血液参数和十二指肠形态的影响

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.30466/vrf.2024.2033379.433

Payam Panahi Moghaddam, Yahya Ebrahimnezhad, Naser Maheri-Sis, Habib Aghdam Shahryar, Abolfazl Aghajanzadeh-Golshani, Abolfazl Gorbani

{"title":"The effects of using a Rovabio® Plus multi-enzyme on production and incubation performance, blood parameters and duodenum morphology of broiler breeders at age of 45 - 60 weeks.","authors":"Payam Panahi Moghaddam, Yahya Ebrahimnezhad, Naser Maheri-Sis, Habib Aghdam Shahryar, Abolfazl Aghajanzadeh-Golshani, Abolfazl Gorbani","doi":"10.30466/vrf.2024.2033379.433","DOIUrl":"10.30466/vrf.2024.2033379.433","url":null,"abstract":"The aim of this study was to investigate the effects of using a Rovabio® Plus multi-enzyme on production and reproductive performance, duodenum morphology and biochemical parameters in 45 - 60 weeks old broiler breeders. For this purpose, 260 broiler breeders of Ross 308 strain were used in a completely randomized design with four treatments and five replications (13 hens and one rooster in each replication). Experimental treatments included: 1) Positive control diet (diet with standard energy and phosphorus and without multi-enzyme), 2) Negative control diet (diet in terms of energy 5.00% and phosphorus 50.00% less than the positive control diet, 3) Negative control diet with 1.00 g kg-1 Rovabio® Plus multi-enzyme and 4) Positive control diet with 1.00 g kg-1 Rovabio® Plus multi-enzyme. The results showed that negative control diet caused a significant decrease in the egg production percentage, egg weight, egg mass, settable eggs, fertile eggs, hatchability and one grade chickens, increased the feed conversion ratio and embryonic losses. Addition of 1.00 g kg-1 of multi-enzyme to negative control diet made the above parameters similar to the positive control treatment, however, the positive control treatment supplemented with multi-enzyme had a better performance compared to other treatments. This research showed that dietary supplementation of Rovabio® Plus multi-enzyme in broiler breeders at the age of 45 - 60 weeks led to the improvement of productive performance and incubation in negative control diet.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 4","pages":"245-252"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immuno-chromatography based rapid detection of canine distemper in dogs and its comparison with RT-PCR. 基于免疫层析的犬犬瘟热快速检测及其与RT-PCR的比较。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.30466/vrf.2024.2030571.4301

Jharna Koul, Divya Agnihotri, Ricky Jhambh, Tarun Kumar, Gaurav Charaya

{"title":"Immuno-chromatography based rapid detection of canine distemper in dogs and its comparison with RT-PCR.","authors":"Jharna Koul, Divya Agnihotri, Ricky Jhambh, Tarun Kumar, Gaurav Charaya","doi":"10.30466/vrf.2024.2030571.4301","DOIUrl":"10.30466/vrf.2024.2030571.4301","url":null,"abstract":"The present study was planned to confirm the clinical diagnosis of canine distemper in dogs with reverse transcriptase polymerase chain reaction (RT-PCR) and its comparison with lateral flow assay based immuno-chromatographic (IC) technique. Fifty clients owned dogs having clinical signs suggestive of respiratory, skin or nervous form of canine distemper were included in the study. An immuno-chromatography-based test was applied using serum to screen each of the suspected dog. In addition to serum, nasal discharges of 15 cases and ocular discharges of 10 samples were used to diagnose canine distemper. Screening with IC kit revealed 72.00% serum samples positive, 66.66% ocular and 50.00% nasal samples were found positive for antigen. The RT-PCR targeting N gene of canine distemper virus was used for the molecular diagnosis of canine distemper. Out of 50 blood samples tested with RT-PCR assay, 38 (76.00%) samples were positive showing characteristics band of 287bp. Statistical comparison of IC Kit (serum samples) results with RT-PCR results comparison showed that IC kit was 52.00% accurate with 36.84% sensitivity, 100% specificity, positive predictive value of 93.33% and negative predictive value of 31.43%. In the current study it was observed that the IC test was rapid, quick and specific but was found to be less sensitive compared to RT-PCR.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 5","pages":"261-265"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Gundelia tournefortii extract on diabetic gastropathy: involvement of inflammation, apoptosis, oxidative stress, and histopathology. 金针藤提取物对糖尿病胃病的影响：炎症、细胞凋亡、氧化应激和组织病理学的参与。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-03-15 DOI: 10.30466/vrf.2024.2027690.4249

Muhammet Bahaeddin Dörtbudak, Uğur Şeker, Muhammet Demircioğlu, Ismail Demircioğlu

{"title":"Effect of Gundelia tournefortii extract on diabetic gastropathy: involvement of inflammation, apoptosis, oxidative stress, and histopathology.","authors":"Muhammet Bahaeddin Dörtbudak, Uğur Şeker, Muhammet Demircioğlu, Ismail Demircioğlu","doi":"10.30466/vrf.2024.2027690.4249","DOIUrl":"10.30466/vrf.2024.2027690.4249","url":null,"abstract":"In this study, the effect of Gundelia tournefortii (GT) extract against diabetic gastropathy was investigated by pathological methods. The animal groups were designed as the control, diabetes, diabetes + GT50, diabetes + GT100, and diabetes + GT200 groups. No treatment was applied to the control group. The other groups received 45.00 mg kg-1 streptozotocin intraperitoneally on the experimental day. The treatment groups were also given 50.00, 100, and 200 mg kg-1 of GT extract daily by gavage for 21 days. Tissues were stained with Hematoxylin and Eosin for histopathological examination. Immunohistochemical staining was performed to reveal the presence of inflammation (tumor necrosis factor alpha), apoptosis (cysteine aspartate specific proteases-3), and oxidative stress (heat shock protein-27). Histopathological examination revealed no pathological lesion in the control group. In the diabetes group, mucosal tissue damage, and vascular and inflammatory changes were observed. In the treatment groups, GT decreased histopathological findings in parallel with the dose increase. Immunohistochemical examination revealed no immunopositivity in the control group, while severe immunopositivity was observed in the diabetes groups in terms of inflammation, apoptosis, and oxidative stress. In the treatment groups, there was a decrease in the severity of immunopositivity's depending on the dose increase. As a result of this study, which has not been done before, GT was found to have a protective effect against gastropathy, being an important complication of diabetes, and this study is thus an important reference point for future research and promises new hope for the patients.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 3","pages":"133-139"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of the effect of Tarantula cubensis alcoholic extract on cadmium embryotoxicity. 狼蛛酒精提取物对镉胚胎毒性影响的测定。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.30466/vrf.2024.2031444.4313

Rahmi Canbar, Gokhan Akcakavak, Muhittin Uslu, Mustafa Sedat Arslan, Harun Kizilay

{"title":"Determination of the effect of Tarantula cubensis alcoholic extract on cadmium embryotoxicity.","authors":"Rahmi Canbar, Gokhan Akcakavak, Muhittin Uslu, Mustafa Sedat Arslan, Harun Kizilay","doi":"10.30466/vrf.2024.2031444.4313","DOIUrl":"10.30466/vrf.2024.2031444.4313","url":null,"abstract":"Tarantula cubensis alcoholic extract (TCAE) is a homeopathic product used in the veterinary field. This study aimed to determine the effects of TCAE on cadmium (Cd) toxicity in the embryo. The study used 220 fertile, incubated chicken eggs divided into 11 equal groups on the 7th day of incubation. The groups comprised untreated and physiological saline control groups, a group with TCAE alone, four groups with varying doses of Cd alone and four groups with the same doses of Cd plus TCAE. At the end of the incubation period, the eggs were opened, kidney and liver tissue samples were taken for histopathology and the number of dead and living embryos were recorded. In the prsent study, the median lethal dose of Cd was determined to be 0.029 mg per egg and the median lethal dose of Cd plus TCAE was determined to be 0.020 mg per egg. The histopathological examinations determined that kidney and liver damage were increased when TCAE and Cd were administered together, that was higher than when Cd was given alone. Thus, TCAE, which had no toxic effect on the embryo when used alone, might increase the embryotoxic activity of Cd. However, more detailed studies are needed.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 4","pages":"203-208"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of cage density and meat storage period on some meat quality parameters in brown and white spent hens. 笼密度和肉贮藏期对褐白花母鸡部分肉品质参数的影响。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-02-15 DOI: 10.30466/vrf.2024.2025425.4210

Uğur Özentürk, Ayşe Uysal, Ekrem Laçin, Soner Uysal, Sevda Urçar Gelen, Hayrunnisa Özlü

{"title":"The effect of cage density and meat storage period on some meat quality parameters in brown and white spent hens.","authors":"Uğur Özentürk, Ayşe Uysal, Ekrem Laçin, Soner Uysal, Sevda Urçar Gelen, Hayrunnisa Özlü","doi":"10.30466/vrf.2024.2025425.4210","DOIUrl":"10.30466/vrf.2024.2025425.4210","url":null,"abstract":"This study was conducted to determine the effect of different cage densities and meat storage periods on some meat quality parameters in drumstick and breast meat of brown and white spent hens. The study used three different cage densities as low (5 hens per cage), normal (seven hens per cage) and high (10 hens per cage) including 396 hens as 198 Hy-Line Brown (HB) and 198 Isa Tinted (IT). The feeding of chickens was ad libitum (20 - 60 weeks). At the end of the study, a total number of 54 chickens (27 HB and 27 IT) were slaughtered. Some chemical and microbiological analyses were carried out by separating the drumstick and breast area of the slaughtered chickens. According to the results of the research, the redness and yellowness values of the breast area were higher in the ITs. The effect of cage density was significant only for yellowness in the drumstick area. The effects of storage time, lightness and yellowness in the drumstick area and lightness value in the breast area were found to be significant. Bacterial density and thiobarbituric acid reactive substances values of both breast and drumstick regions of spent hens were higher in HBs, while pH values were higher in ITs. The bacterial density in the meat was increased during the storage period. In conclusion, cage density, genotype and storage time affected the microbiological and chemical quality of spent chicken meat. With this result, it can be said that meat quality studies, which mostly focus on broilers, are also important in spent hens.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 2","pages":"71-79"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of erythropoietin on cardiac morphometry in exercised male and female adolescent rats. 促红细胞生成素对运动后雌雄大鼠心脏形态的影响。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.30466/vrf.2024.2035267.4360

Mehmet Burak Ateş, Gokhan Akcakavak, Ozgur Ozdemir, Mehmet Ozdemir, Ibrahim Bozkurt

{"title":"Effects of erythropoietin on cardiac morphometry in exercised male and female adolescent rats.","authors":"Mehmet Burak Ateş, Gokhan Akcakavak, Ozgur Ozdemir, Mehmet Ozdemir, Ibrahim Bozkurt","doi":"10.30466/vrf.2024.2035267.4360","DOIUrl":"10.30466/vrf.2024.2035267.4360","url":null,"abstract":"Erythropoietin (EPO) is a glycoprotein hormone predominantly produced in the kidneys, primarily stimulating erythroid cell proliferation in the bone marrow. The present study investigated the impact of EPO combined with swimming exercise on cardiac morphometry in adolescent male and female rats. The 4-week study involved 48 rats (24 males and 24 females), which were divided into four main groups of six males and six females each. The control group was administered intraperitoneal saline four times a week. The swimming exercise group also received intraperitoneal saline, followed by 30 min of swimming exercise, four times a week. The drug control group was given 50.00 IU kg-1 epoetin alfa intraperitoneally, four times a week. Lastly, the Swimming + Drug group received 50.00 IU kg-1 epoetin alfa intraperitoneally, four times a week, followed by 30 min of swimming exercise. The post-study measurements demonstrated that EPO administration did not result in notable alterations in crucial parameters, including the left ventricular mass index, left ventricular mass, and left ventricular posterior wall in the context of left ventricular hypertrophy in both genders. However, in female rats, EPO-only group and the combined EPO and exercise group showed significant thinning of the right ventricular wall and interventricular septum indicating potential cardiac dilatation. The results highlight the necessity of considering gender-specific responses when evaluating EPO's cardiovascular effects, particularly concerning the right ventricle, and suggest further investigation into the long-term consequences of these observed changes.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 4","pages":"189-194"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of effects of vancomycin/polycaprolactone nanocomposite in comparison with curcumin/polycaprolactone on the healing of experimental osteomyelitis in rabbit tibia. 万古霉素/聚己内酯纳米复合材料与姜黄素/聚己内酯纳米复合材料对兔胫骨实验性骨髓炎愈合的影响。

IF 0.8 4区农林科学

Veterinary Research Forum Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.30466/vrf.2024.2028501.4268

Amirreza Hajati Ziabari, Alireza Jahandideh, Abolfazl Akbarzadeh, Pejman Mortazavi

{"title":"Evaluation of effects of vancomycin/polycaprolactone nanocomposite in comparison with curcumin/polycaprolactone on the healing of experimental osteomyelitis in rabbit tibia.","authors":"Amirreza Hajati Ziabari, Alireza Jahandideh, Abolfazl Akbarzadeh, Pejman Mortazavi","doi":"10.30466/vrf.2024.2028501.4268","DOIUrl":"10.30466/vrf.2024.2028501.4268","url":null,"abstract":"Osteomyelitis is caused by the local spread of an infected source adjacent to the infection following trauma, bone surgery or joint replacement. The present study aimed to evaluate the effect of vancomycin (Van)/polycaprolactone (PCL) nanocomposite in comparison with curcumin (Cur)/PCL on the healing of experimental osteomyelitis in tibia in rabbits. After induction of osteomyelitis forty adult male New Zealand white rabbits were randomly divided into four groups. Control group: The animals were considered as controls and no scaffolds were used. In PCL/Van group, the created bone defects were filled with the combination of PCL and Van. In PCL/Cur, the created bone defects were filled with the combination of PCL and Cur. Polycaprolactone/Cur/Van group: The created bone defects were filled with the combination of PCL, Cur and Van. Bone samples were taken for histopathological evaluation on the 30th and 60th days. For radiological evaluations of the osteomyelitis, radiographs were prepared at time intervals zero (day of surgery), 15, 30, 45, and 60 days after surgery. In order to evaluate hematology, blood was taken on days 0 (day of surgery), 15, 30, 45, and 60. The results of the present study showed that Cur nanocomposite significantly improved the healing process of the rabbit tibia experimental osteomyelitis model compared to the control group. Also, the PCL/Cur/Van group showed the best healing results. In conclusion, PCL/Cur/Van nanocomposite scaffold showed positive effects on the healing process.","PeriodicalId":23989,"journal":{"name":"Veterinary Research Forum","volume":"16 4","pages":"235-243"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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