Veterinary Medicine and Science最新文献

{"title":"Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus.","authors":"Hong Zou, Zheng Niu, Peng Cheng, Chunxia Wu, Wenjie Li, Gan Luo, Shilei Huang","doi":"10.1002/vms3.70182","DOIUrl":"10.1002/vms3.70182","url":null,"abstract":"<p><p>Peste des petits ruminants virus (PPRV), a single-stranded negative-sense RNA virus with an envelope, belongs to the Morbillivirus in the Paramyxoviridae family and is prevalent worldwide. PPRV infection causes fever, stomatitis, diarrhoea, pneumonia, abortion and other symptoms in small ruminants, with a high mortality rate that poses a significant threat to the sustainability and productivity of the small ruminant livestock sector. The PPRV virus particles have a diameter of approximately 400-500 nm and are composed of six structural proteins: nucleocapsid protein (N), phosphoprotein (P), envelope matrix protein (M), fusion protein (F), haemagglutinin protein (H) and large protein (L). Each protein has a distinct role in the virus's life cycle. Although the life cycle activities of PPRV have been widely reported, they are still limited. Research has demonstrated that PPRV has distinct adhesion factors on various cell surfaces, such as the epithelial cell adhesion factor nectin-4 or the lymphocyte adhesion factor SLAM. After attaching to the cell, the F and H proteins on the PPRV membrane interact with each other, resulting in a conformational change in the F protein. This change allows the F protein to enter the cell through direct fusion with the host cell membrane. The virus enters the host cell via the outer vesicle endocytosis strategy and replicates and proliferates through the role of caveolin, actin, dynein and cholesterol on the host cell membrane. This review summarises the viral structure, attachment mechanism and transmembrane internalisation mechanism of PPRV. The aim of this review is to provide theoretical support for the development of PPRV inhibitors and the prevention and control of PPR.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70182"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Variability of Pestivirus A (BVDV-1) Circulating in Cattle From Eastern Turkey.","authors":"Fatima Abounaaja, Ali Riza Babaoglu","doi":"10.1002/vms3.70127","DOIUrl":"10.1002/vms3.70127","url":null,"abstract":"<p><strong>Background: </strong>Bovine viral diarrhoea virus (BVDV) infection, caused by Pestiviruses A and B, with various clinical findings and causes significant economic losses. This disease is common in Turkey as well as in other countries, especially in European countries.</p><p><strong>Objective: </strong>This study was designed to determine the genotypes of BVDVs and their variability among cattle in eastern Turkey.</p><p><strong>Methods: </strong>A total of 110 samples from 85 cattle suspected of BVDV infection were tested using RT-PCR with primers targeting the 5'UTR, autoprotease (N^pro) and E2 gene regions of pestiviruses. Sequence and phylogenetic analyses were performed on the 5'UTR and N^pro gene regions of these samples.</p><p><strong>Results: </strong>Analysis of 15 sequences obtained from 13 cattle revealed that Pestivirus A (BVDV-1) was responsible for the infection. In addition, the study identified subgenotypes BVDV-1a (n = 5), 1b (n = 5), 1d (n = 1), 1f (n = 1), 1l (n = 1) and 1r (n = 2). No evidence of infection with Pestivirus B (BVDV-2), Pestivirus D (Border disease virus) or Pestivirus H (HoBi-like virus/BVDV-3) was found.</p><p><strong>Conclusion: </strong>The significance of pestiviruses in causing genital and respiratory problems is once again emphasised, underscoring the necessity of including them in herd screening. Identifying BVDV genetic diversity both in Turkey and worldwide is crucial for developing effective protection, control and eradication strategies, particularly for vaccination programs. As a conclusion, the identification of BVDV-1a, 1b, 1d, 1f, 1l and 1r in the eastern provinces of Turkey points to an increase in BVDV-1 genetic diversity.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70127"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Evidence for the Preventive Role of Vaccinium macrocarpon Aiton in Indomethacin-Induced Gastric Ulcer: Focusing on Antioxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms.","authors":"Ismail Cagri Aydin, Irmak Ferah Okkay, Ufuk Okkay, Mustafa Ozkaraca, Fatma Yesilyurt, Aysegul Yilmaz, Betul Cicek, Ozhan Karatas, Hilal Kadioglu Kalkandelen, Bilge Aydin, Ahmet Hacimuftuoglu, Songul Karakaya, Zuhal Güvenalp, A M Abd El-Aty","doi":"10.1002/vms3.70048","DOIUrl":"10.1002/vms3.70048","url":null,"abstract":"<p><p>The present study aimed to unveil the gastroprotective potential of Vaccinium macrocarpon (VM) extract and its mechanism of action against indomethacin (INDO)-induced gastric ulcers in rats. To achieve this goal, rats were pretreated with either omeprazole (20 mg/kg) or VM (100 mg/kg) orally for 14 consecutive days. Gastric tissue samples were collected and various parameters were evaluated to understand the mechanism of VM's action, including the levels of superoxide dismutase, malondialdehyde, glutathione, CAT and transforming growth factor beta (TGF-β), as well as the mRNA expression levels of tumour necrosis factor alpha, interleukin 1 beta, nuclear factor kappa B (NF-κB) and inhibitor kappa B (IκB). Additionally, the immunopositivity of cyclooxygenase (COX)-1, COX-2, PGE2, proliferating cell nuclear antigen (PCNA) and caspase-3 was assessed. The total amount of phenolic compounds present in the VM extract was high (58.08 µg/mL gallic acid equivalent/mg extract). The healing effect of VM was demonstrated by an increase in the expression of PCNA. Furthermore, the level of TGF-β was found to increase upon treatment with VM. Analyses of COX-1, COX-2 and PGE2 expression in gastric tissue confirmed the gastroprotective effect of VM. Notably, the expression of NF-κB was markedly reduced, whereas that of IκB was substantially increased. Overall, the findings of this study demonstrate that VM extract has gastroprotective and curative effects against INDO-induced ulcers through its antioxidant, anti-inflammatory, mucosal regenerative and anti-apoptotic activities. Therefore, VM may serve as a useful adjuvant treatment for nonsteroidal anti-inflammatory drugs-induced gastric ulcer disease.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70048"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Anaerobic Culture Methods for Detecting Clostridioides difficile in Bovine Faeces.","authors":"Laurel E Redding, Scott G Daniel, Alexander Smith, Orlaith Keenan, Denise Barnhart, Joseph P Zackular","doi":"10.1002/vms3.70085","DOIUrl":"10.1002/vms3.70085","url":null,"abstract":"<p><strong>Background: </strong>The study of the epidemiology of Clostridioides difficile in populations is greatly facilitated by the ability to isolate and further characterize individual organisms, which requires effective culture protocols. In cattle, where little is known about the epidemiology of C. difficile, no studies have assessed or compared the performance of different assays for detecting C. difficile.</p><p><strong>Objectives: </strong>This study compared two culture protocols for detecting C. difficile in bovine faeces from 121 gestating cows and 70 of their neonatal calves, while situating results obtained with each protocol relative to those obtained with shotgun metagenomic sequencing.</p><p><strong>Methods: </strong>Protocol 1 involved direct plating enrichment onto taurocholine-cycloserine-cefoxitin-fructose agar (TCCFA), while Protocol 2 included an ethanol shock step before plating on CCFA/ChromID agar. For both protocols, one aliquot underwent broth enrichment prior to plating, while the other aliquot did not.</p><p><strong>Results: </strong>Clostridioides difficile was detected following broth enrichment in two of the same calf samples using both protocols, and an additional cow sample was found to be positive with Protocol 2, though the difference in detection rates was not statistically significant (p = 1.0).</p><p><strong>Conclusions: </strong>The detection of C. difficile in a much high number of these samples by shotgun metagenomics, albeit at low levels of relative abundance, suggests that neither of these culture protocols is sensitive when levels of abundance are low.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70085"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Freestyle Optium Neo H and Centrivet GK Device in the Diagnosis of Hypoglycaemia and Hyperketonaemia in Dairy Goats: A Field Study.","authors":"Murat Uztimür, Cennet Nur Ünal, Abdülkerim Deniz, Aytaç Pekmezci","doi":"10.1002/vms3.70159","DOIUrl":"10.1002/vms3.70159","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of data on the validation and diagnostic performance of the Freestyle Optium Neo-H (Freestyle) and Centrivet GK (Centrivet) devices for the diagnosis of hypoglycaemia, hyperglycaemia and hyperketonaemia in goats.</p><p><strong>Objectives: </strong>The aim of the present study was to validate the Freestyle and Centrivet for the analysis of whole blood beta-hydroxybutyric acid (BHBA) and to validate the Freestyle for the analysis of whole blood glucose concentrations using the reference method (RM) in goat blood collected from the jugular and ear veins.</p><p><strong>Methods: </strong>Venous blood samples were utilised to assess glucose and BHBA concentrations using the Freestyle, Centrivet and RM. The cut-off point of BHBA was ≥ 0.8 mmol/L for hyperketonaemia. A total of 198 paired blood samples (vena jugularis and ear vein) were collected from 99 hair goats. The cut-off point for hypoglycaemia diagnosis was < 49 mg/dL.</p><p><strong>Results: </strong>There were proportional but no constant errors between RM and Freestyle and Centrivet for BHBA, and both proportional and constant errors were observed for glucose analysis. The mean bias for BHBA analysis was 0.14 and 0.06 mmol/L (Freestyle-RM) 0.51 and 0.16 mmol/L (Centrivet-RM) for jugular and ear veins, respectively. The mean bias for blood glucose analysis was 0.0 and 5.6 mg/L between Freestyle and RM in the jugular and ear veins, respectively. The sensitivity (Centrivet: 50%-61.3%; Freestyle: 93.6%-75.8%) and specificity (Centrivet GK: 75.7%-73%; Freestyle: 37.8%-70.3%) were determined in jugular and ear vein blood for hyperketonaemia diagnostics, respectively. The AUC of Freestyle was 0.89 and 0.95 in the jugular and ear vein for hypoglycaemia, respectively. The sensitivity of Freestyle was 60.3% and 96.8% in the jugular and ear vein for hypoglycaemia. The specificity of Freestyle was 100.0% and 76.7% for hypoglycaemia in jugular and ear veins, respectively.</p><p><strong>Conclusions: </strong>Freestyle demonstrated acceptable diagnostic performance for hypoglycaemia in ear veins, but neither Freestyle nor Centrivet showed sufficient diagnostic performance for hyperketonaemia. Both analysers were not interchangeable with RM in BHBA and glucose analysis.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70159"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Inhibitory Effects of Flunixin Meglumine and Meloxicam on the Smooth Muscles Motility of the Gastrointestinal Tract of Cattle.","authors":"Saima Mushtaq, Yavuz Kursad Das, Abdurrahman Aksoy","doi":"10.1002/vms3.70190","DOIUrl":"10.1002/vms3.70190","url":null,"abstract":"<p><p>This study aimed to compare the inhibitory effect of flunixin meglumine and meloxicam on the smooth muscles of the gastrointestinal tract in male cattle. Tissue samples, including the abomasum, ileum, proximal loop and centripetal gyri of the ascending colon, were collected from routinely slaughtered male cattle. These samples were sectioned into strips and mounted in an isolated tissue bath system. Smooth muscle contractions were evoked using carbachol, and cumulative doses of atropine, flunixin meglumine and meloxicam were administered to assess smooth muscle activity. Atropine, used as a positive control, did not abolish contractions in the abomasum and centripetal gyri tissues, even at a high concentration of 10 µM. Based on area-under-curve values, flunixin meglumine demonstrated a greater inhibitory effect than meloxicam by factors of 8.57, 4.28, 12.44 and 3.93 in the abomasum, ileum, proximal loop and centripetal gyri tissues, respectively. For beats-per-minute values, flunixin meglumine exhibited a stronger inhibitory effect than meloxicam by factors of 7.22, 3.88, 7.03 and 3.35 in the abomasum, ileum, proximal loop and centripetal gyri tissues, respectively. Finally, based on peak maximum values, flunixin meglumine's inhibitory effect was 6.13, 4.43, 7.07 and 7.02 times greater than that of meloxicam in the abomasum, ileum, proximal loop and centripetal gyri tissues, respectively. In conclusion, flunixin meglumine was more potent than meloxicam in inhibiting smooth muscle activity. Conversely, meloxicam is associated with fewer adverse effects due to its selective action on the cyclooxygenase-2 enzyme. However, flunixin meglumine may be more advantageous than meloxicam for applications in beef and milk production due to its shorter residue elimination time.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70190"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Maropitant, Ondansetron and Metoclopramide on Dexmedetomidine-Induced Vomiting in Cats.","authors":"Ayşe Gölgeli Bedir, Latif Emrah Yanmaz, Sıtkıcan Okur, Mümin Gökhan Şenocak, Ferda Turgut, Yakup Kocaman, Ömer Tarık Orhun, Uğur Ersöz, Büşra Baykal","doi":"10.1002/vms3.70152","DOIUrl":"10.1002/vms3.70152","url":null,"abstract":"<p><strong>Objectives: </strong>Vomiting is frequently observed in cats after dexmedetomidine administration. This study aimed to compare the efficacy of different antiemetics in preventing vomiting in cats after dexmedetomidine administration.</p><p><strong>Methods: </strong>Sixty-four cats were randomly allocated to receive saline solution (0.9% NaCl, 0.1 mL/kg, SC), maropitant (1 mg/kg, SC), ondansetron (0.22 mg/kg, IM) or metoclopramide (1 mg/kg, IM) 30 min before the intramuscular administration of dexmedetomidine (25 µg/kg). Duration of vomiting, severity of vomiting and nausea signs (sialorrhoea, lip licking, retching and vomiting) was recorded for 30 min after dexmedetomidine administration.</p><p><strong>Results: </strong>The duration and severity of vomiting were significantly reduced in groups that received maropitant, ondansetron or metoclopramide compared to the saline group. Although differences were observed in retching and vomiting between the saline and other groups (p < 0.001), there were no significant differences in sialorrhoea or lip licking (p = 0.34 and p = 0.12, respectively).</p><p><strong>Conclusions: </strong>Maropitant, ondansetron and metoclopramide were found to significantly reduce retching and vomiting compared to the control group. In conclusion, no significant difference was found among maropitant, ondansetron and metoclopramide groups in the prevention of dexmedetomidine-induced vomiting in cats.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70152"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Multiple Perianal Apocrine Hamartomas in a Poodle Dog Using Carbon Dioxide Laser.","authors":"Minjeong Kang, Hyeona Bae, DoHyeon Yu","doi":"10.1002/vms3.70168","DOIUrl":"10.1002/vms3.70168","url":null,"abstract":"<p><p>Hamartoma is characterized by the abnormal proliferation of cells and tissues within the originating organ. Apocrine hamartoma (AH) affecting the skin, especially in the perianal area, has not yet been reported in dogs. A 7-year-old neutered male Poodle presented with multiple perianal papules and pruritus. Histopathological examination revealed significant enlargement of the apocrine glands and ducts, accompanied by mononuclear cell infiltration that extended into the subcutis. Given the location, number, depth and extent of the lesion, CO₂ laser ablation was chosen over surgical resection. Complete recovery was observed at the surgical site 1 month after treatment, and pruritic symptoms were markedly reduced. CO₂ laser ablation is a relatively safe and effective palliative treatment for perianal AH in dogs.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70168"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Susceptibility of Zoonotic Bacteria Isolated From Oral Cavities of Indigenous Dogs From Semi-Urban Areas in Uganda.","authors":"Paul Mukasa, Patrick Engeu Ogwang, Richard Oriko Owor, Julius B Lejju, Hannington Gumisiriza, Ibrahim Ntulume, Christopher Adaku","doi":"10.1002/vms3.70169","DOIUrl":"10.1002/vms3.70169","url":null,"abstract":"<p><p>Dog bites are a source of zoonotic infections to humans, such as pasteurellosis and meningitis. Zoonotic bacterial identification and their antibiotic susceptibility assessment are key towards the successful management of such infections. This study isolated and identified zoonotic bacterial species from the oral cavities of indigenous dogs and also determined their antibiotic susceptibility profile. Oral swab samples collected from 54 indigenous dogs (domestic [36] and stray [18]) were cultured on agar media, and then on selective-differential media. The colony morphology and conventional biochemical tests were used to identify the bacterial isolates. Antibiotic susceptibility was evaluated using the Kirby-Bauer disk diffusion method. A total of 232 bacterial isolates were obtained, from which 29 bacteria species (18 Gram-negative and 11 Gram-positive) belonging to 19 genera and 13 families were identified. Aerobic and anaerobic bacteria species constituted 69% and 31%, respectively. The most prevalent bacteria species was Staphylococcus aureus (10.8%) followed by Escherichia coli (9.5%), while Yersinia enterocolitica (0.4%) was the least common. Most bacteria species belonged to family Enterobacteriaceae (11) followed by Vibrionaceae (04). All the sampled dogs had a number of multi-drug-resistant superbugs in their oral cavities. However, all the tested bacterial isolates were only susceptible to imipenem and chloramphenicol. All the identified bacteria species were resistant to metronidazole, amoxicillin-clavulanic acid and ceftazidime. Therefore, antibiotics such as imipenem and chloramphenicol could be of better choice for managing dog bite infections compared to the antibiotics recommended by Uganda Clinical Guidelines, such as metronidazole and amoxicillin-clavulanic acid.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70169"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Economic Significance of Fasciolosis among Cattle Slaughtered at Municipal Abattoirs in Ethiopia from 2010 to 2023: A Systematic Review and Meta-Analysis.","authors":"Abayeneh Girma, Amere Genet, Kasaye Teshome, Indiris Abdu, Dessalew Tamir","doi":"10.1002/vms3.70186","DOIUrl":"10.1002/vms3.70186","url":null,"abstract":"<p><strong>Background: </strong>Fasciolosis is a prevalent disease that significantly impairs the health and productivity of cattle and causes significant economic damage. Beyond the individually available studies with varying prevalence rates, there are no pooled national prevalence studies on bovine fasciolosis. Therefore, the current study aims to determine the pooled prevalence and economic significance of fasciolosis among cattle in Ethiopia.</p><p><strong>Methods: </strong>Cochrane's Q, inverse variance (I²), sensitivity analysis, funnel plots, Begg's and Egger's regression tests were used to assess heterogeneity and publication bias. A random-effects model was used to calculate the pooled burden of fasciolosis among cattle.</p><p><strong>Results: </strong>The pooled prevalence of fasciolosis among cattle was 28.02% (7626/27,604) with (95% CI: 24.77%-31.26%). About 25.58% (3200/12,639) with (95% CI: 20.89, 30.27) and 30.45% (4426/14,965) with (95% CI: 26.05, 34.85) were found to harbour Fasciola through coprological inspection and post-mortem examination, respectively. Among a total of 14,965 livers of slaughtered cattle examined in municipal abattoirs, Fasciola hepatica (54.43%) was the predominant fluke identified compared to Fasciola gigantica (23.21%). Mixed infections of both species and unidentified immature flukes were detected in 15.04% and 7.02% of the affected livers, respectively. Regarding the severity of the pathological lesions observed, 35.08%, 49.31% and 15.61% of the livers were mildly, moderately and seriously infested, respectively. The total annual economic significance of fasciolosis among cattle from 21 reported studies was approximately 43,240,653.2 ETB (US$4,069,100.649). Increasing and decreasing trends of pooled fasciolosis prevalence were observed from 2010 to 2023 in coprological examination and post-partum inspection, respectively.</p><p><strong>Conclusion: </strong>Therefore, bovine fasciolosis requires integrated control methods to address its influence on animal health and economic impact.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70186"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}