Veterinary Medicine and Science最新文献

{"title":"More Timely Response to Outbreaks of Zoonotic Compared to Non-Zoonotic Diseases in Animals in Tanzania.","authors":"Esron Karimuribo, Veronica Masawe, Lars Eik Olav, Doreen Ndossi, Ann-Katrin Llarena, Calvin Sindato","doi":"10.1002/vms3.70483","DOIUrl":"10.1002/vms3.70483","url":null,"abstract":"<p><p>Timeliness metrics analysis is a useful approach for tracking speed in actions and identifying gaps during disease outbreaks. There is limited information on the time taken for preventing, controlling and containing disease outbreaks in human and animal populations in Tanzania. We conducted timeliness metrics analysis on zoonotic and non-zoonotic disease outbreaks which occurred between May 2019 and April 2023 in 10 selected districts within four regions located in the Northern (Arusha and Kilimanjaro regions) and Southern Highlands zones (Mbeya and Songwe regions) of Tanzania. Field-based outbreak milestones for selected zoonotic diseases, namely rabies and anthrax and non-zoonotic diseases, African swine fever (ASF), contagious caprine pleuropneumonia and Peste des petits ruminants, were recorded. Modified metrics for One Health Surveillance were employed to estimate the time used for disease outbreak detection, notification, verification, risk assessment, laboratory confirmation, inter-sectoral sharing of information (for zoonotic diseases only), response and public communication. A total of 98 disease outbreaks, of which 63 were zoonotic (64.3%) and 35 were non-zoonotic (35.7%), were recorded. These outbreaks were distributed across the Northern (68/98) and Southern Highlands (30/98) zones. The time taken to detect zoonotic disease outbreaks was significantly shorter (median = 2 days, range = 1-48 days) than the time taken to detect non-zoonotic disease outbreaks (median = 3 days, range = 1-40 days) (p = 0.0485). Furthermore, the time taken to detect disease outbreaks in the Northern zone was significantly shorter (median = 2 days, range = 1-48 days) than the time taken in the Southern Highlands zone (median = 7 days, range = 1-40 days) (p = 0.0010). Variation between geographical locations was observed where in the Northern zone, a shorter time was taken to verify (median = 1 day, range = 1-14 days) and to respond (median = 1 day, range = 1-30 days) to disease outbreaks than in the Southern Highlands (verification time: median = 3 days, range = 1-30 days and response time: median = 30 days, range = 1-60 days). Such differences could be due to resource disparities in the two zones and shorter distance to access diagnostic facilities in the Northern zone. This is the first field-based timeliness metrics analysis study carried out in Tanzania. Findings of this study may be utilised to guide animal and public health interventions for effective and efficient surveillance and control of emerging and re-emerging infectious diseases. It is recommended that more investment is carried out in emergency preparedness for the timely management of zoonotic and non-zoonotic diseases in Tanzania.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70483"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Green Cobalt Nanoparticles in the Diet of Broiler Chickens to Improve Sustainable Production and Health.","authors":"Fayiz M Reda, Abdullah S Alawam, Hemat K Mahmoud, Mohamed T El-Saadony, Ayman S Salah, Hassan A Rudayni, Ahmed A Allam, Karima El-Naggar, Mahmoud Alagawany, Most Khairunnesa","doi":"10.1002/vms3.70508","DOIUrl":"10.1002/vms3.70508","url":null,"abstract":"<p><strong>Background: </strong>Nanoparticles (NPs), such as green cobalt NPs (CoNPs), are easier to pass through cell membranes in animals and interact rapidly with biological systems. Therefore, using green CoNPs is one of the recommendations for enhancing the bioavailability of cobalt, thereby improving its absorption.</p><p><strong>Objectives: </strong>The goal of this study was to explore the influences of biological nano-cobalt (BNCo) as a feed supplement on broiler growth performance, haematology, blood chemistry, antioxidant activities, immunological status, digestive enzymes and carcass characteristics.</p><p><strong>Methods: </strong>A total of 300 Arbour Acre broiler chicks, all unsexed, were distributed into 5 treatment groups, each containing 60 chicks, at random. Five replications of each group were formed, each containing 12 chicks. The first group received a control diet free of BNCo, whereas the second, third, fourth and fifth groups were administered diets fortified with BNCo at concentrations of 100, 200, 300 and 400 ppm, respectively.</p><p><strong>Results: </strong>The results illustrated a significant increase in body weight (p < 0.001), body weight gain (p < 0.001) and improvement in feed conversion ratio (p < 0.01) in comparison to the control diet. BNCo supplementation significantly increased the percentage of immune organs, especially the spleen and thymus (p < 0.05, p < 0.01). Moreover, BNCo supplementation significantly increased haemoglobin (Hb) (p < 0.01), red blood cells (RBCs) (p < 0.05) and white blood cells (WBCs) (p < 0.05). In broiler chickens, BNCo supplementation increased serum levels of total protein, albumin and globulin significantly (p < 0.05) and reduced serum levels of aspartate aminotransferase (AST) activity (p < 0.001) and alanine aminotransaminase (ALT) (p < 0.01). The BNCo in feed supplementation raised blood levels of cobalt and markedly improved lipid markers, immunological and antioxidant status (p < 0.05). Furthermore, digestive enzymes were significantly boosted (p < 0.05) by BNCo treatments.</p><p><strong>Conclusion: </strong>The results indicated that BNCo supplementation at 200 ppm/kg diet produced the best overall performance, demonstrating its potential as an innovative additive for broiler diets.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70508"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Aspects of Letrozole Effect on Metabolism, Bone Health, Oxidative Stress and Prostate in the Intact Adult Dog.","authors":"Zahra Dadvand, Dorsa Zahedtalab, Maryam Barzegar Bafruei, Nooshin Derakhshandeh, Asghar Mogheiseh, Saeed Nazifi, Mohammad Reza Divar, Mahboobeh Ashrafi","doi":"10.1002/vms3.70467","DOIUrl":"10.1002/vms3.70467","url":null,"abstract":"<p><p>Letrozole enhances male fertility by balancing oxidative stress and altering the hormonal regulation of spermatogenesis. The study aimed to determine the effect of short-term letrozole administration on the concentration of canine prostatic-specific esterase, parathormone, insulin-like growth factor, vitamin D, alkaline phosphatase, lactate dehydrogenase, creatinine kinase, calcium, magnesium, cholesterol, and triglyceride in the serum of dogs. Moreover, total antioxidant capacity and lipid peroxidation were detected in intact adult dogs^, serum, and seminal plasma. Seven intact adult male mixed-breeds were given 0.25 mg/kg of letrozole orally daily for four weeks. Blood samples and sperm were collected on days 0 (pretreatment), 14 (treatment), 28 (treatment), and 42 (post-treatment). During the trial, malondialdehyde concentrations in serum and seminal plasma dropped considerably between day 0 and days 28 and 42 and between day 14 and days 28 and 42. The calcium concentration fell considerably on day 42 compared to days 0, 14 and 28. The reduction in 1,25-dihydroxy vitamin D concentration was significantly different on days 14 and 42. The concentration of parathormone and alkaline phosphatase rose during and after treatment. However, the insulin-like growth factor diminished during letrozole administration. According to the current research, oral administration of letrozole has been demonstrated to have a negative impact on bone health, leading to elevated levels of parathormone and alkaline phosphatase, as well as reduced levels of serum IGF-1, calcium, and 1,25-dihydroxy vitamin D. Serum levels of canine lipid markers, including cholesterol and triglycerides, and creatine kinase and lactate dehydrogenase levels were unaffected. The low number of dogs and the brief observation period limit the validity of the results and the inferences that can be drawn from the study.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70467"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrosing Mediastinitis in a 5-Year-Old Labrador Retriever.","authors":"Kyle L Granger, Julien Guillaumin, Kurt Williams, Sarah Shropshire, Alex Ohlendorf, Kelly E Hall","doi":"10.1002/vms3.70472","DOIUrl":"10.1002/vms3.70472","url":null,"abstract":"<p><strong>Background: </strong>Fibrosing mediastinitis (FM) is a rare but serious condition characterized by excessive fibrous tissue proliferation in the mediastinum, often leading to compression of vital structures. Although considered benign, in people, clinical manifestations of FM can range from asymptomatic incidental findings on imaging studies to severe respiratory compromise and hemodynamic instability. While documented in people, FM has not yet been reported in dogs.</p><p><strong>Case presentation: </strong>A 5-year-old male neutered Labrador Retriever presented with progressive respiratory distress, leading to pleural effusion and facial swelling. Thoracic radiographs revealed mediastinal mass-like structures and pleural effusion. Computed tomography demonstrated a mediastinal mass-like structure, enlarged tracheobronchial lymph nodes, multifocal narrowing of lobar bronchi and pulmonary veins and compression of the oesophagus and trachea. The dog was humanely euthanized due to poor response to empiric therapy and the owner's perception of suffering. A post-mortem examination confirmed severe chronic mediastinal inflammation with fibrosis and vasculitis consistent with fibrosing mediastinitis.</p><p><strong>Conclusions: </strong>This report presents a unique case of FM in a dog.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70472"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the Technique for Order Preference by Similarity to Ideal Solution to Determine the Best Level of Hydrolysed Feather Powder in Broilers Diet.","authors":"Hosna Hajati, Amir Hossein Alizadeh-Ghamsari, Seied Abdoluah Hoseeini, Houshang Lotfollahian","doi":"10.1002/vms3.70478","DOIUrl":"10.1002/vms3.70478","url":null,"abstract":"<p><strong>Background: </strong>Feathers constitute about 5-7 percent of broilers live body weight, and they are bulky waste in poultry slaughterhouses. These wastes are a serious issue that can cause environmental pollution. On the other hand, poultry feathers can be considered as a dietary ingredient to decrease the competition between humans and poultry in consuming corn and soybeans.</p><p><strong>Objectives: </strong>The aim of this study was to determine the best level of hydrolysed feather powder inclusion in broilers diet by using TOPSIS.</p><p><strong>Methods: </strong>A total of five hundred Arian broiler chicks were used in a completely randomised design with 4 treatments, 5 replicates, and 25 chicks per replicate. Experimental treatments included four levels of hydrolysed feather powder as 0, 3, 6, or 9 % of the diet. The experiment lasted for 42 days. After recording parameters relating to the birds growth performance, carcass characteristics, production index, humoral immunity, heterophil to lymphocyte ratio, multiple attribute decision making (MADM), and the technique for order of preference by similarity to ideal solution (TOPSIS) were used.</p><p><strong>Results: </strong>Considering the closeness coefficient, hydrolysed feather at the level of 3 % had the highest coefficient (0.8038); however, hydrolysed feather at the level of 9 % had the lowest coefficient (0.7364).</p><p><strong>Conclusions: </strong>Hydrolysed feather can be considered as a protein source in broilers diet that is not used as food for humans, and it will help the circular feed economy. With regard to the multi-attribute decision-making (MADM) method, it is recommended to use 3 % hydrolysed feather in the broilers diet.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70478"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic Measurement of the Renal Cortical Thickness-to-Abdominal Aortic Ratio in Healthy Rabbits.","authors":"Zahra Sadat Yousefsani, Ali Mirshahi, Mohammad Azizzadeh, Amir Nadimi Khorasani","doi":"10.1002/vms3.70455","DOIUrl":"10.1002/vms3.70455","url":null,"abstract":"<p><strong>Background: </strong>Ultrasonography is a preferred diagnostic tool for renal disease in clinical practice. Kidney size is a commonly used morphological parameter in renal assessment; however, it lacks sensitivity for early disease detection. Cortical parameters, particularly cortical thickness, correlate more strongly with early renal disease, as the cortex plays a key role in filtration and is highly vulnerable to injury. Rabbits, widely kept as pets, have distinct renal anatomy and are prone to kidney diseases, making them a relevant model for renal studies. Previous studies have shown that ultrasonography can effectively measure kidney size in rabbits, correlating with body weight.</p><p><strong>Objectives: </strong>This study aimed to establish a normative ratio of renal cortical thickness to the internal diameter of the abdominal aorta in healthy rabbits.</p><p><strong>Methods: </strong>Sixty healthy adult male mixed-breed rabbits underwent ultrasonographic evaluation. Renal cortical thickness and abdominal aortic diameter were measured, ensuring that only rabbits without clinical or ultrasonographic signs of kidney disease were included.</p><p><strong>Results: </strong>Pearson correlation analysis revealed a positive correlation between renal cortical thickness, aortic diameter and body weight. However, the ratio of renal cortical thickness to aortic diameter remained independent of body weight.</p><p><strong>Conclusions: </strong>This study established a normative reference range for renal cortical thickness relative to aortic diameter in rabbits, providing a novel diagnostic parameter for renal assessment. The confidence intervals for the ratio were 0.82 (0.77-0.87) to 1.35 (1.30-1.40) for the left kidney and 0.79 (0.74-0.84) to 1.33 (1.27-1.38) for the right kidney, marking the first report of this method in the literature.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70455"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Epidemiology and Molecular Investigation of Protoparvovirus carnivoran1 Infection in Naturally Infected Domestic Cats in Bangladesh.","authors":"Sanjida Ali Sani, Chandan Nath, Md Moktadir Billah Reza, Jannatul Naima, Partha Samanta, Md Saddam Hossain, Md Rayhan Faruque, Md Ahaduzzaman","doi":"10.1002/vms3.70480","DOIUrl":"10.1002/vms3.70480","url":null,"abstract":"<p><strong>Background: </strong>The infection of cats with Protoparvovirus carnivoran1 is a global concern due to the likelihood of infection from multiple genetically similar viruses.</p><p><strong>Objectives: </strong>The present study was undertaken to investigate the clinico-molecular epidemiology of Protoparvovirus carnivoran1 infection in naturally infected domestic cats in Bangladesh.</p><p><strong>Methods: </strong>Rectal swabs (N = 100) were collected from cats manifesting clinical signs and screened for the presence of Protoparvovirus carnivoran1 using polymerase chain reaction (PCR). Selected positive samples (n = 38) were partially sequenced for molecular analysis. A structured questionnaire was developed to estimate potential risk factors for Protoparvovirus carnivoran1 infection, clinical and therapeutic outcomes and overall associations among the variables. Data were analysed using descriptive, univariable and multivariable statistical techniques.</p><p><strong>Results: </strong>The overall PCR detection rate of the targeted Protoparvovirus carnivoran1 virus was 99% (99/100). Young and non-vaccinated animals were mostly infected (p < 0.05). The mortality and case fatality of infected cats were 10% and 45%, respectively. The clinical outcomes did not vary between animals receiving different therapeutic groups (p = 0.19). The phylogenetic analysis suggests that Protoparvovirus carnivoran1 isolates share a common ancestor with isolates from different global regions.</p><p><strong>Conclusions: </strong>The findings indicate that Protoparvovirus carnivoran1 is circulating in Bangladesh. The clinico-epidemiological and evolutionary outcomes can be used as a guide for future preventive and control measures against parvovirus infection, both locally and internationally.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70480"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, Identification, and Antibiogram Characteristics of Staphylococcus aureus From Dairy Cows Kept Under Extensive Management System, in the Uba DebreTsehay District of Southern Ethiopia.","authors":"Mabure Shille, Fitsum Dulo, Shubisa Abera, Seblewongel Ayechew","doi":"10.1002/vms3.70503","DOIUrl":"10.1002/vms3.70503","url":null,"abstract":"<p><p>Bovine mastitis is a widespread and important disease of cows that affects the global production and quality of milk in the dairy industry. A cross-sectional study conducted from February to August 2022 in the Uba Debretsehay District aimed to determine the prevalence of bovine mastitis, assess the associated risk factors and the antibiotic susceptibility profiles of Staphylococcus aureus isolates from mastitis-positive cows. A total of 432 cows were screened through clinical examinations and the California mastitis test to determine the occurrence of clinical and sub-clinical mastitis respectively. A milk sample was collected from mastitis-positive cows and standard microbiological procedures were used to identify S. aureus. Antimicrobial susceptibility testing was performed using 10 antimicrobials following the Kirby-Bauer disc diffusion method. The overall prevalence of mastitis was 44.2% (191/432; 95% CI = 0.37-0.51) and 41% (702/1728) at the cow and quarter level respectively. The odds for the occurrence of mastitis significantly decreased without tick infestation and or injury (OR = 0.15; 95% CI = 0.07-0.28), and the previous history of mastitis (OR = 0.28; 95% CI = 0.17-0.47). Cows in mid-stage lactation were 2.13 times more likely to develop mastitis than early-stage lactating cows. Additionally, cows kept with in larger herds were 1.57 times more prone to mastitis than those on small herd size. Out of the 191 mastitis-positive milk samples, S. aureus was isolated in 2.6% (5/191) of these samples using the BioLog microbial identification system. S. aureus isolates showed no susceptibility (0%) to penicillin G or tetracycline, but exhibited 100% susceptibility to amoxicillin-clavulanate, cefoxitin, ciprofloxacin, chloramphenicol, oxacillin, trimethoprim-sulphamethoxazole, and gentamicin. Mastitis is a severe problem for dairy production in the study area, and the resistance of S. aureus to commonly used antibiotics was observed. Therefore, proactive management strategies including adequate sanitation of the dairy environment, regular screening of animals, and rational use of antibiotic agents were recommended to maintain the productivity and well-being of dairy cows in the study areas.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70503"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Naringin on Bisphenol A-Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens.","authors":"Leah Oluwaseyanu Esuola, Oluwaseun Olarenwaju Esan, Adamu Shafiu Maikifi, Temitayo Olabisi Ajibade, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Ademola Adetokunbo Oyagabemi, Temidayo Olutayo Omobowale, Omolade Abodunrin Oladele, Evaristus Nwulia, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju","doi":"10.1002/vms3.70322","DOIUrl":"10.1002/vms3.70322","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is an endocrine-disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic properties.</p><p><strong>Objective: </strong>The aim of this study was to determine the protective effect of naringin against the damage induced by BPA in the brain and testes of commercial chicken.</p><p><strong>Methods: </strong>Thirty-day-old cockerel chickens were purchased and reared for 6 weeks and subsequently divided into six groups: group A (control), group B (100 ppm BPA-treated), group C (BPA and 100 mg/kg naringin-treated), Group D (BPA and 200 mg/kg naringin-treated), group E (100 mg/kg naringin-treated), and group F (200 mg/kg naringin-treated). BPA was administered via drinking water, while naringin was administered via oral gavage. Analyses such as biochemical assays, hormonal assays, histopathology, and immunohistochemistry were done.</p><p><strong>Results: </strong>The results showed a decrease in the level of LH, FSH, and testosterone, an increase in the level of oxidative stress markers (MDA and H₂O₂), and alteration in the levels of enzymatic and non-enzymatic antioxidants (GSH, GST, SOD, GPx) in the brain and testes of the BPA-intoxicated group. Histologically, neuronal necrosis and degeneration were observed in the brain, and degeneration of testicular cells was seen in the testes of BPA-intoxicated chickens. Immunohistochemical evaluation revealed low expression of myelin basic protein in the brain and increased expression of caspase 3 in the testes of the BPA-intoxicated group.</p><p><strong>Conclusions: </strong>Naringin reversed the neurotoxicity and reproductive toxicity of BPA by normalizing the values of the altered parameters. Hence, naringin ameliorated the deleterious effects caused by BPA in both the brain and testes by enhancing the antioxidant defence mechanism.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70322"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis, Surgical Treatment and Postoperative Outcome of Rabbits (Oryctolagus cuniculus) With Intraabdominal Abscess: 12 Cases (2017-2023).","authors":"Iori Koizumi, Hirotaka Kondo","doi":"10.1002/vms3.70506","DOIUrl":"10.1002/vms3.70506","url":null,"abstract":"<p><strong>Background: </strong>The precise pathogenesis of intraabdominal abscess in pet rabbits remains unclear and descriptions of clinical findings are scant.</p><p><strong>Objectives: </strong>The objective of this retrospective study was to describe the clinical findings, possible pathogeneses and surgical treatments with long-term outcomes of rabbits presenting with intraabdominal abscess.</p><p><strong>Methods: </strong>Medical records of rabbits that underwent surgical excision and were diagnosed with intraabdominal abscess between 2017 and 2023 in a first-opinion hospital were retrospectively evaluated.</p><p><strong>Results: </strong>Medical records were available for a total of 2128 rabbits, with 13 confirmed cases of intraabdominal abscess. Twelve cases considered eligible for this study were reviewed. Median age of the rabbits at onset was 18 months. Rabbits comprised 7 males (1 castrated) and 5 females (3 spayed), with 9 Lop-eared, 2 Netherland Dwarf and 1 Mini Rex. Common clinical signs were anorexia, decreased activity and abnormality of fecal production. Abdominal ultrasound and radiography revealed intraabdominal lesions in 12 and 7 cases, respectively. Exploratory laparotomy revealed intraabdominal abscess in all cases. Abscesses arose from the vermiform appendix in 6 cases and were associated with previous gastrointestinal perforation in 3 cases. The abscess was excised or incised with irrigation of the intraabscess cavity and administration of antibiotics. Nine cases showed an uneventful outcome (median survival time, 1044 days), including five cases showing growth of residual intraabdominal abscess.</p><p><strong>Conclusions: </strong>Intraabdominal abscess in rabbits is commonly associated from the vermiform appendix and previous gastrointestinal perforation. Surgical intervention for intraabdominal abscess along with antibiotic therapy appears effective.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70506"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}