{"title":"Clinical Epidemiology and Molecular Investigation of Protoparvovirus carnivoran1 Infection in Naturally Infected Domestic Cats in Bangladesh.","authors":"Sanjida Ali Sani, Chandan Nath, Md Moktadir Billah Reza, Jannatul Naima, Partha Samanta, Md Saddam Hossain, Md Rayhan Faruque, Md Ahaduzzaman","doi":"10.1002/vms3.70480","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The infection of cats with Protoparvovirus carnivoran1 is a global concern due to the likelihood of infection from multiple genetically similar viruses.</p><p><strong>Objectives: </strong>The present study was undertaken to investigate the clinico-molecular epidemiology of Protoparvovirus carnivoran1 infection in naturally infected domestic cats in Bangladesh.</p><p><strong>Methods: </strong>Rectal swabs (N = 100) were collected from cats manifesting clinical signs and screened for the presence of Protoparvovirus carnivoran1 using polymerase chain reaction (PCR). Selected positive samples (n = 38) were partially sequenced for molecular analysis. A structured questionnaire was developed to estimate potential risk factors for Protoparvovirus carnivoran1 infection, clinical and therapeutic outcomes and overall associations among the variables. Data were analysed using descriptive, univariable and multivariable statistical techniques.</p><p><strong>Results: </strong>The overall PCR detection rate of the targeted Protoparvovirus carnivoran1 virus was 99% (99/100). Young and non-vaccinated animals were mostly infected (p < 0.05). The mortality and case fatality of infected cats were 10% and 45%, respectively. The clinical outcomes did not vary between animals receiving different therapeutic groups (p = 0.19). The phylogenetic analysis suggests that Protoparvovirus carnivoran1 isolates share a common ancestor with isolates from different global regions.</p><p><strong>Conclusions: </strong>The findings indicate that Protoparvovirus carnivoran1 is circulating in Bangladesh. The clinico-epidemiological and evolutionary outcomes can be used as a guide for future preventive and control measures against parvovirus infection, both locally and internationally.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70480"},"PeriodicalIF":1.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244267/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Medicine and Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1002/vms3.70480","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The infection of cats with Protoparvovirus carnivoran1 is a global concern due to the likelihood of infection from multiple genetically similar viruses.
Objectives: The present study was undertaken to investigate the clinico-molecular epidemiology of Protoparvovirus carnivoran1 infection in naturally infected domestic cats in Bangladesh.
Methods: Rectal swabs (N = 100) were collected from cats manifesting clinical signs and screened for the presence of Protoparvovirus carnivoran1 using polymerase chain reaction (PCR). Selected positive samples (n = 38) were partially sequenced for molecular analysis. A structured questionnaire was developed to estimate potential risk factors for Protoparvovirus carnivoran1 infection, clinical and therapeutic outcomes and overall associations among the variables. Data were analysed using descriptive, univariable and multivariable statistical techniques.
Results: The overall PCR detection rate of the targeted Protoparvovirus carnivoran1 virus was 99% (99/100). Young and non-vaccinated animals were mostly infected (p < 0.05). The mortality and case fatality of infected cats were 10% and 45%, respectively. The clinical outcomes did not vary between animals receiving different therapeutic groups (p = 0.19). The phylogenetic analysis suggests that Protoparvovirus carnivoran1 isolates share a common ancestor with isolates from different global regions.
Conclusions: The findings indicate that Protoparvovirus carnivoran1 is circulating in Bangladesh. The clinico-epidemiological and evolutionary outcomes can be used as a guide for future preventive and control measures against parvovirus infection, both locally and internationally.
期刊介绍：
Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science.
Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell.
Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
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