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Measurement of Insulin Resistance in Cats With Chronic Kidney Disease. 慢性肾病猫胰岛素抵抗的测量。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70383
Idil Bastan, Cem Turker Cayiroglu, Yeliz Kaya Kartal, Tevhide Sel
{"title":"Measurement of Insulin Resistance in Cats With Chronic Kidney Disease.","authors":"Idil Bastan, Cem Turker Cayiroglu, Yeliz Kaya Kartal, Tevhide Sel","doi":"10.1002/vms3.70383","DOIUrl":"10.1002/vms3.70383","url":null,"abstract":"<p><strong>Background: </strong>Chronic renal failure in cats is frequently associated with several well-known consequences, including uremia, hypertension, anaemia and secondary hyperparathyroidism. In contrast to extensive studies on insulin resistance and impaired glucose homeostasis in humans with chronic kidney disease (CKD), there is a lack of research addressing these metabolic alterations in cats with CKD. Understanding the metabolic changes associated with CKD in cats is essential for effective clinical management and for enhancing our knowledge of the disease's pathophysiology. Therefore, this study aimed to evaluate insulin secretion, glucose concentrations and homoeostasis model assessment of insulin resistance (HOMA-IR) in non-diabetic cats diagnosed with stage 3-4 CKD.</p><p><strong>Methods: </strong>Ten clinically healthy cats (healthy controls) and fifteen non-diabetic cats with CKD) were included in the study. Fasting blood glucose, insulin, urea, creatinine, phosphor, calcium, sodium, chlorine, potassium, albumin and total protein levels were analysed in all the patients. The HOMA-IR index was calculated to show the existence of insulin resistance.</p><p><strong>Results: </strong>Serum samples from 25 cats were analysed, including 15 with CKD and 10 healthy controls. Cats with CKD exhibited significantly lower serum insulin concentrations (6.05 ± 2.45pg/mL) compared to healthy cats (19.08 ± 5.01pg/mL; p < 0.001). Glucose concentrations in cats with CKD (149.89 ± 61.49) were notably higher than those in healthy controls (93.02 ± 7.39; p < 0.001). The HOMA-IR score was significantly lower in cats with CKD (0.31 ± 0.15) compared to the control group (0.62 ± 0.16; p < 0.001).</p><p><strong>Limitations: </strong>The limitations of this study include a small sample size, the absence of histopathological assessments and the failure to fully characterise the inflammatory status of the subjects.</p><p><strong>Conclusion: </strong>Our findings indicate that, unlike in humans, insulin levels and HOMA-IR are lower in cats with CKD, suggesting a potential mechanism of β-cell dysfunction and reduced insulin secretion contributing to hyperglycaemia. Future research focused on oxidative stress in conjunction with pro-inflammatory cytokines, inflammatory mediators and serum fPLI concentrations may be crucial for understanding the pathogenesis of hypoinsulinaemia in cats with CKD.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70383"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Ram Semen Low Cryotolerance by Replacing the Seminal Plasma With That of High-Cryotolerant Rams or Extender. 用高低温耐受性公羊或增种公羊的精浆代替精浆改善低低温耐受性公羊精液。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70381
Cemal Dayanıklı, Bülent Bülbül, Şükrü Doğan, Ebru Şengül, Mesut Kırbaş, Yavuz Kal, Mehmet Bozkurt Ataman
{"title":"Improving Ram Semen Low Cryotolerance by Replacing the Seminal Plasma With That of High-Cryotolerant Rams or Extender.","authors":"Cemal Dayanıklı, Bülent Bülbül, Şükrü Doğan, Ebru Şengül, Mesut Kırbaş, Yavuz Kal, Mehmet Bozkurt Ataman","doi":"10.1002/vms3.70381","DOIUrl":"10.1002/vms3.70381","url":null,"abstract":"<p><p>Ram semen cryotolerance problem continues despite intensive research. This study aimed to evaluate the effect of replacing total seminal plasma (SP) with that of high-cryotolerant rams or extender on semen quality parameters in low-cryotolerant rams. Rams previously determined as low (n = 6) and high-cryotolerant (n = 5) were used in the breeding season. High-cryotolerant rams were only included with their SP in the SP+ group. Each normospermic fresh ejaculate from low-cryotolerant rams was split into three aliquots to form the groups. The control aliquot was diluted using a two-step process. Centrifugation removed SP from the second aliquot (SP- group), and the sperm pellet was rediluted with a Tris-based extender using the same amount of SP removed. The third aliquot's SP was removed as in the SP- group, but the remaining sperm pellet was rediluted with fresh SP harvested from high-cryotolerant rams using the same amounts of removed SP in the SP+ group. Semen was rediluted with a Tris-based extender in the SP- and SP+ groups using a two-step process as in the control group. Sperm quality was similar between the groups after dilution and equilibration. However, the post-thaw semen quality was higher in the SP- (one parameter) and SP+ (four parameters) groups than in the control group (p < 0.05). Additionally, these parameters were similar in the SP- and SP+ groups. This study showed that, although an adequate extender had positive effects, replacing the whole SP with that of high-cryotolerant rams may better solve the low cryotolerance problem in ram semen.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70381"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report. 静脉脂质乳成功治疗意外过量金刚烷胺1例。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70402
Brett Hogberg, Kristen Marshall, Mark Vardanega
{"title":"Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report.","authors":"Brett Hogberg, Kristen Marshall, Mark Vardanega","doi":"10.1002/vms3.70402","DOIUrl":"10.1002/vms3.70402","url":null,"abstract":"<p><p>A 2.5-year-old, 4.9 kg, Chinese Crested was accidentally administered a dose of 43.5 mg/kg of amantadine, resulting in the rapid onset of tremors, agitation, vertical nystagmus, and lack of pupillary light reflex in one eye. After unsuccessful treatment with methocarbamol, a 1.5 mL/kg bolus of 20% intravenous lipid emulsion therapy was initiated followed by a 0.25 mL/kg/min continuous rate infusion. All clinical signs secondary to the amantadine toxicity resolved following intravenous lipid emulsion therapy and remained normal on 24 h, day 5, day 18, and day 50. This represents the first report of amantadine toxicity in a clinical setting and is the first case showing that intravenous lipid emulsion therapy could be an effective treatment for amantadine toxicity.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70402"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Victory and Defeat on the Correlations of Stress Parameters Between the Horse and Rider in Kök-Börü Equestrian Teams. 胜利与失败对Kök-Börü马术队马与骑手压力参数相关性的影响。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70356
Ali Rişvanli, İsmail Şen, Kanat Canuzakov, Askarbek Tulobayev, Abuzer Taş, Ruslan Salykov, Nezahat Ceylan, Ünal Türkçapar, Ulanbek Alimov, Arina Kazakbayeva, Ayday Cunuşova, Nur Abdimnap Uulu, Burak Fatih Yuksel, Mert Turanli, Muhammed Uz, Metin Bayraktar, Nuriddin Ruzikulov
{"title":"The Effect of Victory and Defeat on the Correlations of Stress Parameters Between the Horse and Rider in Kök-Börü Equestrian Teams.","authors":"Ali Rişvanli, İsmail Şen, Kanat Canuzakov, Askarbek Tulobayev, Abuzer Taş, Ruslan Salykov, Nezahat Ceylan, Ünal Türkçapar, Ulanbek Alimov, Arina Kazakbayeva, Ayday Cunuşova, Nur Abdimnap Uulu, Burak Fatih Yuksel, Mert Turanli, Muhammed Uz, Metin Bayraktar, Nuriddin Ruzikulov","doi":"10.1002/vms3.70356","DOIUrl":"10.1002/vms3.70356","url":null,"abstract":"<p><p>The presented study outlines a research plan aimed at determining the effects of winning and losing situations on the relationship levels between the rider and horse's stress, metabolic, and physiological parameters in Kök-Börü, a traditional equestrian team game. For this purpose, blood samples were collected from both the horses and riders of four different teams participating in two different Kök-Börü games before and after the games. Cortisol, ACTH, beta-endorphin, epinephrine, norepinephrine, T3 and T4 analyses were performed on the collected blood samples using species-specific commercial ELISA kits. Additionally, biochemical and haematological parameters in the same blood samples were tested using an autoanalyser. Based on the obtained data, it was found that there were both positive and negative correlations between most biochemical and haematological parameters of the winning teams' horses and riders before and after the game. However, when examining the correlations between the hormonal parameters of the winning teams' horses and riders before the game, only a negative correlation was found between ACTH and T4 (-0.529, p < 0.05), and no positive correlation was identified among any hormonal parameters. In conclusion, it was interpreted that in the equestrian team sport of Kök-Börü, there are significant changes in the hormonal parameters, especially before and after the game, between the horses and riders of the losing teams. Furthermore, it was concluded that winning and losing situations in Kök-Börü games did not have a significant impact on the correlations between haematological and biochemical parameters before and after the game for both the horses and riders.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70356"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic Antifungal Efficacy of Eugenol-Loaded Nanocapsules Combined With Itraconazole Against Trichophyton mentagrophytes. 载丁香酚纳米胶囊联合伊曲康唑协同抑菌效果研究。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70352
Javad Malakootikhah, Aghil Sharifzadeh, Mohana Rastegar, Alireza Khosravi, Donya Nikaein
{"title":"Synergistic Antifungal Efficacy of Eugenol-Loaded Nanocapsules Combined With Itraconazole Against Trichophyton mentagrophytes.","authors":"Javad Malakootikhah, Aghil Sharifzadeh, Mohana Rastegar, Alireza Khosravi, Donya Nikaein","doi":"10.1002/vms3.70352","DOIUrl":"10.1002/vms3.70352","url":null,"abstract":"<p><strong>Background and objectives: </strong>The increasing prevalence of dermatophyte infections and the emergence of antifungal resistance highlight the urgent need for novel treatment approaches. Trichophyton mentagrophytes, a common dermatophyte, often resists standard antifungal therapies, necessitating alternative solutions. Eugenol, a natural compound with potent antifungal properties, has gained attention for its synergistic effects with conventional antifungal agents. However, its clinical application is limited by poor bioavailability and stability. Nanoencapsulation of eugenol offers a promising strategy to enhance its antifungal efficacy and address these limitations. This study aims to evaluate the antifungal efficacy of eugenol and nanoencapsulated eugenol in combination with Itraconazole against T. mentagrophytes isolates.</p><p><strong>Methods: </strong>Eugenol-loaded nanocapsules were fabricated using the nanoprecipitation method and subsequently evaluated. The antifungal activity of eugenol, nano-eugenol and Itraconazole-individually and in combination-was assessed against clinical isolates of T. mentagrophytes derived from animal and human sources, using minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) determinations. The chequerboard assay evaluated the synergistic effects.</p><p><strong>Results: </strong>Scanning electron microscopy (SEM) and dynamic light scattering (DLS) analyses showed that eugenol nanocapsules have a uniform, spherical morphology with an average size of 150.9 nm and moderate polydispersity (polydispersity index [PDI] = 0.531), whereas a slight negative zeta potential (-0.1 mV) contributes to suspension stability by minimizing aggregation. The geometric mean MIC of eugenol was 119.3 µg/mL, significantly lower than that of nano-eugenol (477.4 µg/mL), whereas Itraconazole had the lowest MIC at 11 µg/mL. Eugenol demonstrated a more potent fungicidal effect than its nanoencapsulated form, though nanoencapsulation improved stability and bioavailability. Combining Itraconazole with nano-eugenol showed synergy in 73.3% of T. mentagrophytes isolates, reducing Itraconazole's MIC by up to 1/2 or 1/4. Both forms of eugenol exhibited effective anti-dermatophytic activity.</p><p><strong>Conclusion: </strong>The findings suggest that nanoencapsulated eugenol, in combination with Itraconazole, provides a potent and synergistic antifungal approach against T. mentagrophytes, potentially reducing the dosage and resistance risks associated with Itraconazole. These results underscore the potential of nano-enhanced plant extracts in developing effective, sustainable antifungal therapies.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70352"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Dietary Melatonin on Heart and Lung Telomere Length and Shelterin Protein Gene Expression of Pulmonary Hypertensive Broiler Chickens. 饲粮中添加褪黑素对肺动脉高压肉鸡心肺端粒长度和庇护蛋白基因表达的影响
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70355
Peyman Gheytaspour, Shahab Bahadoran, Hossein Hassanpour
{"title":"The Impact of Dietary Melatonin on Heart and Lung Telomere Length and Shelterin Protein Gene Expression of Pulmonary Hypertensive Broiler Chickens.","authors":"Peyman Gheytaspour, Shahab Bahadoran, Hossein Hassanpour","doi":"10.1002/vms3.70355","DOIUrl":"10.1002/vms3.70355","url":null,"abstract":"<p><strong>Objectives: </strong>Pulmonary hypertension syndrome (PHS) is a common metabolic disease in broiler chickens linked to oxidative stress. This study explored the potential of melatonin, an antioxidant, to improve PHS response and telomere structure in chickens with cold-induced PHS.</p><p><strong>Methods: </strong>We investigated the effects of dietary melatonin supplementation on telomere length and the expression of genes related to telomere protection (shelterin genes) in the heart and lungs of broiler chickens with PHS.</p><p><strong>Results: </strong>Melatonin supplementation improved telomere length in the heart tissue of chickens with PHS. We also observed changes in the expression of genes (TRF1, RAP1, and TPP1) responsible for protecting telomeres, suggesting a potential mechanism for melatonin's beneficial effects. Melatonin's impact was more pronounced in the heart than in the lungs.</p><p><strong>Conclusions: </strong>Melatonin may help protect cardiac cells during PHS by improving telomere length and influencing the activity of genes involved in telomere protection. These findings suggest that melatonin could be a valuable tool in managing heart cell dysfunction associated with PHS in poultry.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70355"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Some Morphological Characteristics of the Kyrgyz Taigan Dog Breed. 吉尔吉斯太干犬品种若干形态特征的测定。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70409
Hasan Hüseyin Arı, Abuzer Taş, İsmail Şen, Metin Bayraktar, Mustafa Garip, Aziz Begaliev, Ruslan Salykov
{"title":"Determination of Some Morphological Characteristics of the Kyrgyz Taigan Dog Breed.","authors":"Hasan Hüseyin Arı, Abuzer Taş, İsmail Şen, Metin Bayraktar, Mustafa Garip, Aziz Begaliev, Ruslan Salykov","doi":"10.1002/vms3.70409","DOIUrl":"10.1002/vms3.70409","url":null,"abstract":"<p><p>This study involved morphological measurements of the body and head of 77 male and female Kyrgyz Taigans aged 12-16, 24-30 and 36+ months (denoted as groups 1, 2 and 3, respectively). Length measurements (head, face and ear) were obtained using an electronic calliper; width measurements (head, face and pinna) and circumference measurements (head, neck, chest, waist and front and rear shins) were taken using a measuring tape; and height measurements (withers and rump) were obtained using a measuring stick. IBM SPSS 22 was used for statistical analysis, and descriptive statistics of the groups were obtained. Student's t-test was used for between-group comparisons (gender), ANOVA for multiple-group comparisons (age), and the Tukey test for post hoc analysis. The average measurements for face, ear, tail, head, neck, front and rear shins, body length, and height were compared, and significant differences (p < 0.05) were observed between the male and female dogs in the three groups. Significant differences in neck, waist and chest circumferences and chest width and depth were also observed (p < 0.05). The Kyrgyz Taigan is a medium-sized dog breed in terms of body weight, is long-headed (dolichocephalic), exhibits a rectangular body shape similar to other greyhound breeds, and has a rump and withers that are of similar heights. Compared with other greyhound breeds, the Kyrgyz Taigan has greater values for head length, withers and rump heights, chest circumference and chest depth.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70409"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Comparison of Ketamine-Dexmedetomidine With Ketamine-Propofol During Canine Orchiectomy: A Randomized Study. 氯胺酮-右美托咪定与氯胺酮-异丙酚在犬睾丸切除术中的临床比较:一项随机研究。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70412
Mumin Gokhan Senocak
{"title":"Clinical Comparison of Ketamine-Dexmedetomidine With Ketamine-Propofol During Canine Orchiectomy: A Randomized Study.","authors":"Mumin Gokhan Senocak","doi":"10.1002/vms3.70412","DOIUrl":"10.1002/vms3.70412","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of two different protocols, ketamine with dexmedetomidine (ketamine-dexmedetomidine [KD]) and ketamine with propofol (ketamine-propofol [KP]), on intubation time, selected cardiopulmonary parameters, and anaesthesia maintenance during canine orchiectomy in a clinical setting.</p><p><strong>Study design: </strong>Randomized clinical trial.</p><p><strong>Animals: </strong>Twenty-six healthy dogs were undergoing orchiectomy.</p><p><strong>Methods: </strong>Dogs were randomly assigned to the KD group [n = 13; single intravenous bolus of ketamine (5 mg kg<sup>-1</sup>) combined with dexmedetomidine (10 µg kg<sup>-1</sup>)], or KP group [n = 13, an intravenous bolus of ketamine combined with propofol at a 1:2 concentration ratio and infused at a 0.2 mL kg<sup>-1</sup> min<sup>-1</sup> rate for 120 s until jaw relaxation and the consumed amount recorded]. Orotracheal intubation followed the induction of anaesthesia. The cardiopulmonary variables were assessed at baseline and 5-min intervals up to 30 min. A 20% increase in at least two variables, such as heart rate (HR), mean arterial pressure (MAP) and respiratory rate, prompted the administration of top-ups. Following surgery, the recovery time and quality were assessed.</p><p><strong>Results: </strong>There was no significant difference in intubation time between KD (3.3 ± 0.8) and KP (2.7 ± 0.9, p = 0.121). Over time, HR and MAP significantly increased in the KP group compared to the KD group (p < 0.001). The haemoglobin oxygen saturation was higher in the KD group (97.7% ± 2.1%) compared to the KP (95.3% ± 2.2%, p = 0.015). The duration of the top-up requirement was longer in the KD group as compared to a single bolus of KP, with a mean difference of 31.2 min (95% CI 20.80-41.51) (p < 0.01).</p><p><strong>Conclusions and clinical relevance: </strong>Both KP and KD combinations effectively maintain anaesthesia during canine castration surgery, demonstrating comparable intubation times. Although KP requires additional top-ups, it potentially offers enhanced cardiovascular stability compared to KD. However, the use of KP necessitates support of body temperature and oxygenation.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70412"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Antimicrobial and Antibiofilm Efficacy of Lavender Essential Oil and Linalool on Dual Candida albicans Biofilms With Staphylococcus aureus and Staphylococcus epidermidis From Canine External Otitis. 薰衣草精油和芳樟醇对犬外耳炎金黄色葡萄球菌和表皮葡萄球菌双重白色念珠菌生物膜的抑菌和抗菌效果评价。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70407
Navid Neisari, Aghil Sharifzadeh, Bahar Nayeri Fasaei, Sepideh Asadi, Alireza Khosravi, Abolfazl Rafati Zomorodi, Javad Malakootikhah
{"title":"Evaluating the Antimicrobial and Antibiofilm Efficacy of Lavender Essential Oil and Linalool on Dual Candida albicans Biofilms With Staphylococcus aureus and Staphylococcus epidermidis From Canine External Otitis.","authors":"Navid Neisari, Aghil Sharifzadeh, Bahar Nayeri Fasaei, Sepideh Asadi, Alireza Khosravi, Abolfazl Rafati Zomorodi, Javad Malakootikhah","doi":"10.1002/vms3.70407","DOIUrl":"10.1002/vms3.70407","url":null,"abstract":"<p><strong>Background: </strong>Biofilm formation significantly contributes to the rise of antimicrobial resistance, treatment failures and recurrent infections. Essential oils (EOs), particularly lavender EO (LEO), have gained attention for their antimicrobial and antibiofilm activities. This study investigates the effects of LEO and linalool on Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), and Candida albicans (C. albicans) isolates.</p><p><strong>Materials and methods: </strong>The chemical composition of LEO was analysed using gas chromatography-mass spectrometry (GC-MS). Eight clinical and reference microorganisms were tested, including four C. albicans, three S. aureus, and three S. epidermidis isolates, to assess their biofilm-producing potential with the tissue microtiter plate method. Antimicrobial and antibiofilm activities of LEO and linalool were evaluated in planktonic, single-biofilm, and dual-biofilm phases through microbroth dilution and scanning electron microscopy (SEM).</p><p><strong>Results: </strong>The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) of LEO in the planktonic phase were 1250 µg/mL and 2500 µg/mL against Staphylococcus isolates, respectively, while the corresponding value for C. albicans isolates was 5000 µg/mL. 90% biofilm inhibition was achieved at concentrations of 5000 µg/mL and 40,000 µg/mL for Staphylococcus and C. albicans, respectively. LEO completely inhibited dual biofilms formed by C. albicans/S. aureus and C. albicans/S. epidermidis at 20,000 µg/mL, whereas linalool attained 100% inhibition at 40,000 µg/mL.</p><p><strong>Conclusion: </strong>LEO demonstrates significant antimicrobial and antibiofilm activity against Staphylococcus and C. albicans isolates, effective in both planktonic and biofilm phases.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70407"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Fattening Performance, Slaughter, Carcass, and Some Meat Quality Characteristics of Imported Simmental, Charolaise, and Belgian Blue × Holstein F1 Bulls. 进口西蒙塔尔公牛、夏洛莱斯公牛和比利时蓝×荷斯坦F1公牛增肥性能、屠宰性能、胴体及部分肉品质的研究。
IF 1.8 3区 农林科学
Veterinary Medicine and Science Pub Date : 2025-05-01 DOI: 10.1002/vms3.70219
Necmettin Ünal, Mustafa Polat, Akın Yakan
{"title":"Investigation of Fattening Performance, Slaughter, Carcass, and Some Meat Quality Characteristics of Imported Simmental, Charolaise, and Belgian Blue × Holstein F<sub>1</sub> Bulls.","authors":"Necmettin Ünal, Mustafa Polat, Akın Yakan","doi":"10.1002/vms3.70219","DOIUrl":"10.1002/vms3.70219","url":null,"abstract":"<p><p>This research was carried out to examine the fattening performance, slaughter, carcass, and some meat quality characteristics under intensive fattening conditions of Simmental, Charolaise, and Belgian Blue × Holstein F<sub>1</sub> (BB×H F<sub>1</sub>) bullocks imported from Europe to Türkiye. The animal material of the study consisted of 13 Simmental, 14 Charolaise, and 15 Belgian Blue × Holstein F<sub>1</sub> (BB×H F<sub>1</sub>) bullocks, in a total of 42 heads. The fattening period of the Simmental, Charolaise, and BB×H F<sub>1</sub> bullocks was started at 11 months of age with a live weight of 405-434 kg and finished at 19 months of age with a live weight of 648-742 kg. While Charolais had better values than other genotypes in terms of daily live weight gain and FCR, Simmentals had the highest carcass-meat ratio. The meat quality traits of longissimus thoracic muscle ascertained at 24th hours after slaughter in the genotypes were obtained among 5.54-5.65 for pH and 13.72-16.45% for water holding capacity; 18.37-26.28% for cooking loss. It was determined that the fattening performances of imported Simmental, Charolaise, and BB×H F<sub>1</sub> bullocks under intensive fattening conditions were acceptable, and the best in Charolaise bullocks compared with the other genotypes. While the ratios of the valuable cuts in the whole carcass, and selected meat quality characteristics were the lowest in Charolaise, it was determined that the ratios of various bones in the whole carcass were higher in the Simmental bullock compared with the other genotypes.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 3","pages":"e70219"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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