Measurement of Insulin Resistance in Cats With Chronic Kidney Disease.

IF 1.8 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Medicine and Science Pub Date : 2025-05-01 DOI:10.1002/vms3.70383

Idil Bastan, Cem Turker Cayiroglu, Yeliz Kaya Kartal, Tevhide Sel

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引用次数: 0

Abstract

Background: Chronic renal failure in cats is frequently associated with several well-known consequences, including uremia, hypertension, anaemia and secondary hyperparathyroidism. In contrast to extensive studies on insulin resistance and impaired glucose homeostasis in humans with chronic kidney disease (CKD), there is a lack of research addressing these metabolic alterations in cats with CKD. Understanding the metabolic changes associated with CKD in cats is essential for effective clinical management and for enhancing our knowledge of the disease's pathophysiology. Therefore, this study aimed to evaluate insulin secretion, glucose concentrations and homoeostasis model assessment of insulin resistance (HOMA-IR) in non-diabetic cats diagnosed with stage 3-4 CKD.

Methods: Ten clinically healthy cats (healthy controls) and fifteen non-diabetic cats with CKD) were included in the study. Fasting blood glucose, insulin, urea, creatinine, phosphor, calcium, sodium, chlorine, potassium, albumin and total protein levels were analysed in all the patients. The HOMA-IR index was calculated to show the existence of insulin resistance.

Results: Serum samples from 25 cats were analysed, including 15 with CKD and 10 healthy controls. Cats with CKD exhibited significantly lower serum insulin concentrations (6.05 ± 2.45pg/mL) compared to healthy cats (19.08 ± 5.01pg/mL; p < 0.001). Glucose concentrations in cats with CKD (149.89 ± 61.49) were notably higher than those in healthy controls (93.02 ± 7.39; p < 0.001). The HOMA-IR score was significantly lower in cats with CKD (0.31 ± 0.15) compared to the control group (0.62 ± 0.16; p < 0.001).

Limitations: The limitations of this study include a small sample size, the absence of histopathological assessments and the failure to fully characterise the inflammatory status of the subjects.

Conclusion: Our findings indicate that, unlike in humans, insulin levels and HOMA-IR are lower in cats with CKD, suggesting a potential mechanism of β-cell dysfunction and reduced insulin secretion contributing to hyperglycaemia. Future research focused on oxidative stress in conjunction with pro-inflammatory cytokines, inflammatory mediators and serum fPLI concentrations may be crucial for understanding the pathogenesis of hypoinsulinaemia in cats with CKD.

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慢性肾病猫胰岛素抵抗的测量。

背景：猫的慢性肾衰竭通常与几个众所周知的后果有关，包括尿毒症、高血压、贫血和继发性甲状旁腺功能亢进。与对慢性肾脏疾病（CKD）患者胰岛素抵抗和葡萄糖稳态受损的广泛研究相反，缺乏针对CKD猫的这些代谢改变的研究。了解与猫慢性肾病相关的代谢变化对于有效的临床管理和增强我们对疾病病理生理学的认识至关重要。因此，本研究旨在评估诊断为3-4期CKD的非糖尿病猫的胰岛素分泌、葡萄糖浓度和胰岛素抵抗（HOMA-IR）的稳态模型评估。方法：选取10只临床健康猫（健康对照）和15只未患糖尿病的CKD猫作为研究对象。分析所有患者的空腹血糖、胰岛素、尿素、肌酐、磷、钙、钠、氯、钾、白蛋白和总蛋白水平。计算HOMA-IR指数，显示胰岛素抵抗的存在。结果：分析了25只猫的血清样本，其中15只患有CKD， 10只健康对照。与健康猫（19.08±5.01pg/mL）相比，CKD猫的血清胰岛素浓度显著降低（6.05±2.45pg/mL）；P < 0.001)。CKD猫的葡萄糖浓度（149.89±61.49）明显高于健康对照组(93.02±7.39；P < 0.001)。CKD猫的HOMA-IR评分（0.31±0.15）明显低于对照组(0.62±0.16；P < 0.001)。局限性：本研究的局限性包括样本量小，缺乏组织病理学评估，未能充分表征受试者的炎症状态。结论：我们的研究结果表明，与人类不同，CKD猫的胰岛素水平和HOMA-IR较低，这表明β细胞功能障碍和胰岛素分泌减少导致高血糖的潜在机制。未来的研究重点是氧化应激与促炎细胞因子、炎症介质和血清fPLI浓度的结合，这可能对了解CKD猫低胰岛素血症的发病机制至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Medicine and Science Veterinary-General Veterinary

CiteScore

3.00

自引率

0.00%

发文量

296

期刊介绍： Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.