{"title":"柚皮苷对双酚a诱导的公鸡神经和生殖系统氧化应激损伤的治疗作用。","authors":"Leah Oluwaseyanu Esuola, Oluwaseun Olarenwaju Esan, Adamu Shafiu Maikifi, Temitayo Olabisi Ajibade, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Ademola Adetokunbo Oyagabemi, Temidayo Olutayo Omobowale, Omolade Abodunrin Oladele, Evaristus Nwulia, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju","doi":"10.1002/vms3.70322","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is an endocrine-disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic properties.</p><p><strong>Objective: </strong>The aim of this study was to determine the protective effect of naringin against the damage induced by BPA in the brain and testes of commercial chicken.</p><p><strong>Methods: </strong>Thirty-day-old cockerel chickens were purchased and reared for 6 weeks and subsequently divided into six groups: group A (control), group B (100 ppm BPA-treated), group C (BPA and 100 mg/kg naringin-treated), Group D (BPA and 200 mg/kg naringin-treated), group E (100 mg/kg naringin-treated), and group F (200 mg/kg naringin-treated). BPA was administered via drinking water, while naringin was administered via oral gavage. Analyses such as biochemical assays, hormonal assays, histopathology, and immunohistochemistry were done.</p><p><strong>Results: </strong>The results showed a decrease in the level of LH, FSH, and testosterone, an increase in the level of oxidative stress markers (MDA and H<sub>2</sub>O<sub>2</sub>), and alteration in the levels of enzymatic and non-enzymatic antioxidants (GSH, GST, SOD, GPx) in the brain and testes of the BPA-intoxicated group. Histologically, neuronal necrosis and degeneration were observed in the brain, and degeneration of testicular cells was seen in the testes of BPA-intoxicated chickens. Immunohistochemical evaluation revealed low expression of myelin basic protein in the brain and increased expression of caspase 3 in the testes of the BPA-intoxicated group.</p><p><strong>Conclusions: </strong>Naringin reversed the neurotoxicity and reproductive toxicity of BPA by normalizing the values of the altered parameters. Hence, naringin ameliorated the deleterious effects caused by BPA in both the brain and testes by enhancing the antioxidant defence mechanism.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 4","pages":"e70322"},"PeriodicalIF":1.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183602/pdf/","citationCount":"0","resultStr":"{\"title\":\"Therapeutic Effects of Naringin on Bisphenol A-Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens.\",\"authors\":\"Leah Oluwaseyanu Esuola, Oluwaseun Olarenwaju Esan, Adamu Shafiu Maikifi, Temitayo Olabisi Ajibade, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Ademola Adetokunbo Oyagabemi, Temidayo Olutayo Omobowale, Omolade Abodunrin Oladele, Evaristus Nwulia, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju\",\"doi\":\"10.1002/vms3.70322\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Bisphenol A (BPA) is an endocrine-disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic properties.</p><p><strong>Objective: </strong>The aim of this study was to determine the protective effect of naringin against the damage induced by BPA in the brain and testes of commercial chicken.</p><p><strong>Methods: </strong>Thirty-day-old cockerel chickens were purchased and reared for 6 weeks and subsequently divided into six groups: group A (control), group B (100 ppm BPA-treated), group C (BPA and 100 mg/kg naringin-treated), Group D (BPA and 200 mg/kg naringin-treated), group E (100 mg/kg naringin-treated), and group F (200 mg/kg naringin-treated). BPA was administered via drinking water, while naringin was administered via oral gavage. Analyses such as biochemical assays, hormonal assays, histopathology, and immunohistochemistry were done.</p><p><strong>Results: </strong>The results showed a decrease in the level of LH, FSH, and testosterone, an increase in the level of oxidative stress markers (MDA and H<sub>2</sub>O<sub>2</sub>), and alteration in the levels of enzymatic and non-enzymatic antioxidants (GSH, GST, SOD, GPx) in the brain and testes of the BPA-intoxicated group. Histologically, neuronal necrosis and degeneration were observed in the brain, and degeneration of testicular cells was seen in the testes of BPA-intoxicated chickens. Immunohistochemical evaluation revealed low expression of myelin basic protein in the brain and increased expression of caspase 3 in the testes of the BPA-intoxicated group.</p><p><strong>Conclusions: </strong>Naringin reversed the neurotoxicity and reproductive toxicity of BPA by normalizing the values of the altered parameters. Hence, naringin ameliorated the deleterious effects caused by BPA in both the brain and testes by enhancing the antioxidant defence mechanism.</p>\",\"PeriodicalId\":23543,\"journal\":{\"name\":\"Veterinary Medicine and Science\",\"volume\":\"11 4\",\"pages\":\"e70322\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183602/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Medicine and Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1002/vms3.70322\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Medicine and Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1002/vms3.70322","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Therapeutic Effects of Naringin on Bisphenol A-Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens.
Background: Bisphenol A (BPA) is an endocrine-disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic properties.
Objective: The aim of this study was to determine the protective effect of naringin against the damage induced by BPA in the brain and testes of commercial chicken.
Methods: Thirty-day-old cockerel chickens were purchased and reared for 6 weeks and subsequently divided into six groups: group A (control), group B (100 ppm BPA-treated), group C (BPA and 100 mg/kg naringin-treated), Group D (BPA and 200 mg/kg naringin-treated), group E (100 mg/kg naringin-treated), and group F (200 mg/kg naringin-treated). BPA was administered via drinking water, while naringin was administered via oral gavage. Analyses such as biochemical assays, hormonal assays, histopathology, and immunohistochemistry were done.
Results: The results showed a decrease in the level of LH, FSH, and testosterone, an increase in the level of oxidative stress markers (MDA and H2O2), and alteration in the levels of enzymatic and non-enzymatic antioxidants (GSH, GST, SOD, GPx) in the brain and testes of the BPA-intoxicated group. Histologically, neuronal necrosis and degeneration were observed in the brain, and degeneration of testicular cells was seen in the testes of BPA-intoxicated chickens. Immunohistochemical evaluation revealed low expression of myelin basic protein in the brain and increased expression of caspase 3 in the testes of the BPA-intoxicated group.
Conclusions: Naringin reversed the neurotoxicity and reproductive toxicity of BPA by normalizing the values of the altered parameters. Hence, naringin ameliorated the deleterious effects caused by BPA in both the brain and testes by enhancing the antioxidant defence mechanism.
期刊介绍：
Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science.
Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell.
Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
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