IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-09 DOI: 10.3390/toxics13070577

Zhiwei Li, Jingxin Huang, Weizhen Zhang, Hao Yu, Yin Wang

{"title":"Simultaneous Decontamination for Ammonia Nitrogen and Phosphate Efficiently by Crystal Morphology MgO-Coated Functional Biochar Derived from Sludge and Sunflower Stalk.","authors":"Zhiwei Li, Jingxin Huang, Weizhen Zhang, Hao Yu, Yin Wang","doi":"10.3390/toxics13070577","DOIUrl":"https://doi.org/10.3390/toxics13070577","url":null,"abstract":"Eutrophication driven by nitrogen and phosphorus discharge remains a critical global environmental challenge. This study developed a sustainable strategy for synergistic nutrient removal and recovery by fabricating MgO-coated biochar (Mg-MBC600) through co-pyrolysis of municipal sludge and sunflower stalk (300-700 °C). Systematic investigations revealed temperature-dependent adsorption performance, with optimal nutrient removal achieved at 600 °C pyrolysis. The Mg-MBC600 composite exhibited enhanced physicochemical properties, including a specific surface area of 156.08 m2/g and pore volume of 0.1829 cm3/g, attributable to magnesium-induced structural modifications. Advanced characterization confirmed the homogeneous dispersion of MgO nanoparticles (~50 nm) across carbon matrices, forming active sites for chemisorption via electron-sharing interactions. The maximum adsorption capacities of Mg-MBC600 for nitrogen and phosphorus reached 84.92 mg/L and 182.27 mg/L, respectively. Adsorption kinetics adhered to the pseudo-second-order model, indicating rate-limiting chemical bonding mechanisms. Equilibrium studies demonstrated hybrid monolayer-multilayer adsorption. Solution pH exerted dual-phase control: acidic conditions (pH 3-5) favored phosphate removal through Mg3(PO4)2 precipitation, while neutral-alkaline conditions (pH 7-8) promoted NH4+ adsorption via MgNH4PO4 crystallization. XPS analysis verified that MgO-mediated chemical precipitation and surface complexation dominated nutrient immobilization. This approach establishes a circular economy framework by converting waste biomass into multifunctional adsorbents, simultaneously addressing sludge management challenges and enabling eco-friendly wastewater remediation.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Aluminum Exposure Is More Closely Linked to Antioxidant Dynamics than to Body Mass Index. 膳食铝暴露与抗氧化动力学的关系比与体重指数的关系更密切。

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-09 DOI: 10.3390/toxics13070578

Ozge Yesildemir, Ceren Filiz Ozsoz, Mensure Nur Celik, Ozge Aydin Guclu, Anil Ozgur, Duygu Ağagündüz, Ferenc Budán

{"title":"Dietary Aluminum Exposure Is More Closely Linked to Antioxidant Dynamics than to Body Mass Index.","authors":"Ozge Yesildemir, Ceren Filiz Ozsoz, Mensure Nur Celik, Ozge Aydin Guclu, Anil Ozgur, Duygu Ağagündüz, Ferenc Budán","doi":"10.3390/toxics13070578","DOIUrl":"https://doi.org/10.3390/toxics13070578","url":null,"abstract":"The association between aluminum exposure and obesity remains uncertain. This study investigated whether aluminum exposure (dietary, serum, and urinary) is linked to obesity and whether dietary antioxidant capacity moderates this relationship. A total of 54 adult women (26 obese, 28 normal weight) were recruited from a private weight loss clinic in Türkiye. Dietary aluminum exposure was estimated using 24 h dietary recalls and literature values, and antioxidant capacity was calculated through a food frequency questionnaire. Serum and spot urine samples were collected, and aluminum levels were measured using inductively coupled plasma optical emission spectrometry. No significant differences were observed between normal weight and obese groups in serum aluminum (127.7 ± 102.42 vs. 122.9 ± 88.37 µg/L, p > 0.05), urinary aluminum (28.1 ± 12.73 vs. 14.1 ± 10.77 µg/L, p > 0.05), or weekly dietary aluminum exposure (0.61 ± 0.45 vs. 0.45 ± 0.24 mg/kg bw/week, p > 0.05). Dietary aluminum exposure correlated positively with total antioxidant capacity (r = 0.665, p < 0.001). Regression analysis revealed that dietary aluminum exposure was inversely associated with body mass index (β = -0.27, p < 0.05), while antioxidant capacity did not moderate this relationship, nor did the age difference. These results suggest dietary aluminum exposure reflects diet quality and/or food preparation methods, etc., rather than directly influencing obesity.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonicotinoid-Induced Cytotoxicity: Insights into Cellular Mechanisms and Health Risks. 新烟碱诱导的细胞毒性：对细胞机制和健康风险的见解。

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-09 DOI: 10.3390/toxics13070576

Yuqing Ma, Qiangwei Wang

引用次数: 0

Accumulation of Mixed Heavy Metals in Maternal Hair and Risk of Pre-Eclampsia: A Prospective Nested Case-Control Study. 母亲头发中混合重金属的积累与先兆子痫的风险：一项前瞻性巢式病例对照研究

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-08 DOI: 10.3390/toxics13070575

Thi Ha Luu, Gege Ma, Ming Jin, Xiaojing Liu, Mengyuan Ren, Suhong Gao, Jiamei Wang, Rongwei Ye, Xiaohong Liu, Nan Li

{"title":"Accumulation of Mixed Heavy Metals in Maternal Hair and Risk of Pre-Eclampsia: A Prospective Nested Case-Control Study.","authors":"Thi Ha Luu, Gege Ma, Ming Jin, Xiaojing Liu, Mengyuan Ren, Suhong Gao, Jiamei Wang, Rongwei Ye, Xiaohong Liu, Nan Li","doi":"10.3390/toxics13070575","DOIUrl":"https://doi.org/10.3390/toxics13070575","url":null,"abstract":"Heavy metals (lead [Pb], cadmium [Cd], arsenic [As], mercury [Hg], manganese [Mn], copper [Cu], zinc [Zn], and iron [Fe]) might be risk factors for pre-eclampsia (PE), whereas their joint effect remains unclear. To address this issue, we conducted a nested case-control study consisting of 49 PE cases and 329 controls from a Chinese prospective birth cohort and divided the participants into low/high and quartile groups based on hair metal concentrations. We used logistic regression models and a weighted quantile sum (WQS) model to investigate the independent and mixed associations between these eight heavy metals in maternal hair and the risk of PE. After multivariable adjustment, high hair Pb was associated with a 2.53-fold increased risk of PE, and significantly higher risks of PE were also observed in quartiles 2 to 4 of Pb and quartiles 3 to 4 of Fe. The WQS model revealed a statistically significant association between maternal co-exposure to all eight heavy metals and the risk of PE, with Pb, As, and Fe presenting the biggest risk. Therefore, high maternal exposure to heavy metals may increase the risk of PE. It is crucial to consider co-exposure to multiple heavy metals throughout pregnancy in future research endeavors.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-Curcumin Mitigates Doxorubicin-Induced Reproductive Toxicity via Antioxidant, Anti-Apoptosis, and SIRT1-Modulating Effects in Rat Model. 纳米姜黄素通过抗氧化、抗凋亡和sirt1调节作用减轻阿霉素诱导的大鼠生殖毒性

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-08 DOI: 10.3390/toxics13070574

Noha A Alshuwayer, Qamraa H Alqahtani, Marwa H Hussein, Raeesa Mohammed, Abdulaziz Siyal, Iman H Hasan

{"title":"Nano-Curcumin Mitigates Doxorubicin-Induced Reproductive Toxicity via Antioxidant, Anti-Apoptosis, and SIRT1-Modulating Effects in Rat Model.","authors":"Noha A Alshuwayer, Qamraa H Alqahtani, Marwa H Hussein, Raeesa Mohammed, Abdulaziz Siyal, Iman H Hasan","doi":"10.3390/toxics13070574","DOIUrl":"https://doi.org/10.3390/toxics13070574","url":null,"abstract":"Background: Doxorubicin (DOX) is a potent anti-cancer agent that is widely described in cancer treatment. However, its administration is often limited by its adverse effects, particularly its testicular toxicity, which can induce infertility in male patients. DOX-induced testicular damage is due to oxidative stress, apoptosis, and inflammation. Nanocurcumin (NCR) is a nano-formulated edition of curcumin with a higher therapeutic potential. NCR has demonstrated antioxidant and anti-inflammatory properties.Methods: This study is designed to inspect the potential validity of NCR on DOX-induced testicular damage in male rats. We used thirty-two Wistar albino rats (150-200 g) and divided them into four groups. NCR (80 mg/kg/ dissolved in 1% CMC) was given orally by oral gavage for 14 days. A single dose of DOX (15 mg/kg) (i.p.) was injected on the 7th day of the experiment.Results: DOX treatment reduced the sperm viability and motility rate, cellular antioxidants, and gonadal hormones; it led to higher levels of inflammatory mediators, necrosis, and sloughing in seminiferous tubules. Conversely, NCR treatment significantly alleviated these side effects by improving sperm count/motility and reducing sperm abnormalities. The testicular function recovery was likely driven by stimulating the cytoprotective SIRT1/NF-κB pathway, depressing the testicular level of oxidative indicators such as MDA, TNF-α, iNOS, IL-1β, and NO, and increasing levels of antioxidants such as GSH and SOD. In addition, NCR contradicted the apoptotic changes by downregulating the pro-apoptotic signals Bax and caspase-3, while inducing Bcl-2 upregulation. Moreover, NCR increased levels of gonadal hormones, attenuated histological abnormalities, and preserved testicular structure when compared with the DOX group.Conclusions: NCR treatment can effectively ameliorate DOX-induced testicular toxicity.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA-Seq Analysis of Mouse Hepatocytes AML12 Exposed to Neodymium Nitrate. 硝酸钕作用下小鼠肝细胞AML12的RNA-Seq分析

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-07 DOI: 10.3390/toxics13070573

Ning Wang, Jing Leng, Yaxin Han, Gonghua Tao, Jingqiu Sun, Cheng Dong, Kelei Qian, Xiuli Chang, Ping Xiao, Xinyu Hong

{"title":"RNA-Seq Analysis of Mouse Hepatocytes AML12 Exposed to Neodymium Nitrate.","authors":"Ning Wang, Jing Leng, Yaxin Han, Gonghua Tao, Jingqiu Sun, Cheng Dong, Kelei Qian, Xiuli Chang, Ping Xiao, Xinyu Hong","doi":"10.3390/toxics13070573","DOIUrl":"https://doi.org/10.3390/toxics13070573","url":null,"abstract":"Objective: Neodymium nitrate (Nd(NO3)3) is widely used globally, raising concerns about its occupational and environmental safety. It enters the human body via the digestive system, accumulates in organs, and causes toxicity, including potential hepatotoxicity. However, the role of non-coding RNAs (ncRNAs) in Nd(NO3)3-induced liver injury remains unclear. This study aimed to identify key genes and regulatory pathways involved in Nd(NO3)3-induced hepatic injury using RNA sequencing (RNA-seq) and differential gene expression analysis.Methods: Mouse hepatocytes (AML12 cells) were exposed to Nd(NO3)3, and RNA-seq was performed to analyze the expression profiles of miRNA, lncRNA, circRNA, and mRNA. qPCR was used to validate the RNA-seq results. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to explore the functions and pathways associated with differentially expressed genes (DEGs).Results: Nd(NO3)3 exposure altered the expression of ferroptosis-related genes and induced significant changes in mRNA, miRNA, circRNA, and lncRNA expression levels. GO and KEGG analyses revealed that DEGs were closely related to cellular ferroptosis pathways. Specific miRNAs, lncRNAs, and circRNAs were significantly upregulated, suggesting their potential as biomarkers for Nd(NO3)3-induced ferroptosis and liver injury.Conclusion: This study provides the first comprehensive transcriptome database for Nd(NO3)3-induced liver injury, highlighting the involvement of ncRNAs in hepatotoxicity. These findings offer valuable insights for developing biomarkers and understanding the mechanisms underlying Nd(NO3)3-induced hepatic injury.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personal Exposure Assessment of Respirable Particulate Matter Among University Students Across Microenvironments During the Winter Season Using Portable Monitoring Devices. 利用便携式监测装置评估冬季微环境下大学生可吸入颗粒物的个人暴露

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-07 DOI: 10.3390/toxics13070571

Muhammad Jahanzaib, Sana Iqbal, Sehrish Shoukat, Duckshin Park

{"title":"Personal Exposure Assessment of Respirable Particulate Matter Among University Students Across Microenvironments During the Winter Season Using Portable Monitoring Devices.","authors":"Muhammad Jahanzaib, Sana Iqbal, Sehrish Shoukat, Duckshin Park","doi":"10.3390/toxics13070571","DOIUrl":"https://doi.org/10.3390/toxics13070571","url":null,"abstract":"Respirable particulate matter (RPM) is a major indoor environment concern posing direct health risks. Localized data on RPM exposure remains scarce across different microenvironments in occupational and educational settings. Students in educational settings are increasingly vulnerable to RPM, specifically in the winter season when more activities are carried out indoors and meteorological conditions elevate the PM levels. This study was conducted to assess the personal exposure of university students to RPM within their frequently visited microenvironments (MEs). Forty volunteers were selected, and their exposure to RPM was measured by specifically monitoring their particle mass count (PMC) and particle number count (PNC) in commonly identified MEs. Calibrated air pumps with nylon cyclones and a Dylos DC 1100 Pro were used for this purpose. We found that the mean RPM concentration for personal exposure was 251 µg/m3, significantly exceeding the prescribed National Environmental Quality Standards (NEQS) limit of 35 µg/m3. We also observed a significant correlation between the PNC and PMC in the microenvironments. The assessment of personal exposure to RMP in this study highlights the urgent need for mitigation strategies in educational settings to reduce the personal exposure of students to RMP to reduce their health-related risks.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aurelia aurita as a Model for Ecotoxicologically Assessing Food Additives: 2-Methyl-1-phenylpropan-2-ol and 1-Phenylethan-1-ol. 作为食品添加剂2-甲基-1-苯丙醇和1-苯基比-1-醇生态毒理学评价模型的auria。

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-07 DOI: 10.3390/toxics13070572

Borja Mercado, Borja Vila, Luis Roca-Pérez, Neus Duran-Giner, Rafael Boluda-Hernández, Oscar Andreu-Sánchez

{"title":"Aurelia aurita as a Model for Ecotoxicologically Assessing Food Additives: 2-Methyl-1-phenylpropan-2-ol and 1-Phenylethan-1-ol.","authors":"Borja Mercado, Borja Vila, Luis Roca-Pérez, Neus Duran-Giner, Rafael Boluda-Hernández, Oscar Andreu-Sánchez","doi":"10.3390/toxics13070572","DOIUrl":"https://doi.org/10.3390/toxics13070572","url":null,"abstract":"Industry currently generates numerous substances, such as food additives, whose environmental impacts, particularly in marine environments, remain inadequately assessed. This study employed Aurelia aurita for the first time as a model organism to evaluate the toxicity of such compounds. The main goal was to evaluate the toxicity of two food additives, 2-methyl-1-phenylpropan-2-ol (S1) and 1-phenylethan-1-ol (S2), on A. aurita ephyrae, comparing the results with other organisms representing different trophic levels, specifically the alga Phaeodactylum tricornutum and the crustacean Artemia salina. Acute toxicity tests were conducted on each organism. In A. aurita, S1 exhibited high toxicity (LC50 ≈ 10 mg/L), while S2 had lower toxicity (LC50 ≈ 80 mg/L). The pulsation frequency data for A. aurita revealed that S1 initially increased the pulsation rates at lower concentrations (maximum at 10 mg/L), followed by a significant decrease at higher concentrations. Conversely, S2 showed a steady decrease in pulsation rates up to 10 mg/L, with a slight increase at concentrations of 15, 20, and 25 mg/L. The results demonstrate varying sensitivities to the toxic effects of the two compounds across different trophic levels, with A. aurita ephyrae being the most sensitive. This suggests the potential efficacy of jellyfish as novel ecotoxicological models due to their heightened sensitivity, enabling the detection of lower contaminant concentrations in test samples. Further research is required to enhance the efficiency of ecotoxicological assays using this model.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial for the Special Issue "Editorial Board Members' Collection Series: Aerosol Particles". 《编委会成员文集系列：气溶胶粒子》特刊社论。

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-05 DOI: 10.3390/toxics13070568

Matthias Karl, Yuan Cheng

引用次数: 0

Innovative Strategies to Decompose Pollutants. 分解污染物的创新策略。

IF 3.9 3区环境科学与生态学

Toxics Pub Date : 2025-07-05 DOI: 10.3390/toxics13070569

Fabrizio Olivito, Pravin Jagdale

引用次数: 0

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