Toxics最新文献

{"title":"Improved Prediction of Hourly PM_2.5 Concentrations with a Long Short-Term Memory Optimized by Stacking Ensemble Learning and Ant Colony Optimization.","authors":"Zuhan Liu, Xianping Hong","doi":"10.3390/toxics13050327","DOIUrl":"https://doi.org/10.3390/toxics13050327","url":null,"abstract":"<p><p>To address the performance degradation in existing PM_2.5 prediction models caused by excessive complexity, poor spatiotemporal efficiency, and suboptimal parameter optimization, we employ stacking ensemble learning for feature weighting analysis and integrate the ant colony optimization (ACO) algorithm for model parameter optimization. Combining meteorological and collaborative pollutant data, a model (namely the stacking-ACO-LSTM model) with a much shorter consuming time than that of only long short-term memory (LSTM) networks suitable for PM_2.5 concentration prediction is established. It can effectively filter out feature variables with higher weights, thereby reducing the predictive power of the model. The prediction of hourly PM_2.5 concentration of the model is trained and tested using real-time monitoring data in Nanchang City from 2017 to 2019. The results show that the established stacking-ACO-LSTM model has high accuracy in predicting PM_2.5 concentration, and compared to the same model without considering time and space efficiency and defective parameter optimization, the mean square error (MSE) decreases by about 99.88%, and the coefficient of determination (R²) increases by about 2.39%. This study provides a new idea for predicting PM_2.5 concentration in cities.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Nutrition and Fine Particulate Matter (PM2.5) on Inflammatory Responses in Individuals with Metabolic Syndrome: A Paired Case Study from Chiang Mai, Thailand.","authors":"Wason Parklak, Hataichanok Chuljerm, Sawaeng Kawichai, Puriwat Fakfum, Putita Jiraya, Praporn Kijkuokool, Wiritphon Khiaolaongam, Pakaphorn Ngamsang, Sakaewan Ounjaijean, Kittipan Rerkasem, Kanokwan Kulprachakarn","doi":"10.3390/toxics13050325","DOIUrl":"https://doi.org/10.3390/toxics13050325","url":null,"abstract":"<p><p>Exposure to fine particulate matter (PM2.5) is linked to increased systemic inflammation, particularly in individuals with metabolic syndrome (MS). This study assessed the impact of nutrition and PM2.5 exposure on inflammatory markers in individuals with MS. A total of 50 participants (25 with MS, 25 healthy controls) were monitored during a high-PM2.5 exposure period (HEP) and a low-PM2.5 exposure period (LEP). Dietary intake, health assessments, and inflammatory markers-TNF-α, IL-6, and CRP-were evaluated. The MS group had significantly higher BMI, fasting blood glucose, and triglyceride levels and lower HDL-C than the healthy group (<i>p</i> < 0.01), but these parameters did not change significantly between the HEP and LEP. Notably, dietary fiber intake increased in the MS group during the LEP (<i>p</i> < 0.05). CRP levels were higher in the MS group and significantly decreased in both groups during the LEP (<i>p</i> < 0.05). IL-6 was higher in the MS group during the HEP but did not significantly change across periods. TNF-α showed no differences. Dietary fiber intake was inversely correlated with IL-6 and CRP in the healthy group and strongly correlated with CRP in the MS group (<i>r</i> = -0.403, <i>p</i> < 0.01). Antioxidant vitamins were inversely correlated with inflammation only in healthy participants. These findings suggest that an increased dietary fiber intake may help reduce PM2.5-induced inflammation, particularly in individuals with MS.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-Friendly Synthesis of Zirconia Nanoparticles Using <i>Sonchus asper</i> Extract: A Sustainable Approach to Enhancing Chinese Cabbage Growth and Remediating Chromium-Contaminated Soil.","authors":"Guojie Weng, Weidong Li, Fengyue Qin, Menglu Dong, Shuangqi Yue, Sajid Mehmood, Xu Wang","doi":"10.3390/toxics13050324","DOIUrl":"https://doi.org/10.3390/toxics13050324","url":null,"abstract":"<p><p>Chromium (Cr) contamination poses severe risks to plant health and soil quality, requiring sustainable remediation methods. This study explored the synthesis of zirconia nanoparticles (PF-ZrO₂ NPs) from <i>Sonchus asper</i> extract and assessed their potential to alleviate Cr toxicity in Chinese cabbage (<i>Brassica rapa</i> var. pekinensis). The characterization of nanoparticles was performed through XRD, SEM, and FTIR analyses, confirming their crystalline nature, structure, and surface chemistry. The results indicated significant declines in plant growth, chlorophyll content, biomass, and nutrient uptake under Cr stress (treatments T2 and T4), accompanied by elevated oxidative stress indicators (H₂O₂, MDA) and Cr accumulation. The application of PF-ZrO₂ NPs (T3 and T5) notably reduced shoot Cr concentrations (by 58.94% and 35.90%) and improved the chlorophyll level (by 5.41% and 14.41%). Additionally, nanoparticles increased antioxidant enzyme activity (SOD, POD, CAT) and improved soil properties (pH, cation exchange capacity, nutrient retention). These findings suggest green-synthesized PF-ZrO₂ NPs are effective, environmentally friendly candidates for Cr remediation in contaminated soils.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Sensitization Testing Using New Approach Methodologies.","authors":"Judy Strickland","doi":"10.3390/toxics13050326","DOIUrl":"https://doi.org/10.3390/toxics13050326","url":null,"abstract":"<p><p>Chemical regulatory authorities require skin sensitization information for a number of chemical sectors, such as cosmetics, pesticides, newly marketed chemicals, household products, and topical pharmaceuticals [...].</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanisms Contributing to the Impairment of Steroid Hormones, Sperm Characteristics, and Testicular Architecture in Male Rabbits After Chronic Exposure to Cadmium: Role of Gallic Acid and Selenium as Antioxidants.","authors":"Salah A Sheweita, Saleh M Al-Qahtani, Rofida M Ahmed, Mohamed S Sheweita, Ahmed Atta","doi":"10.3390/toxics13040323","DOIUrl":"https://doi.org/10.3390/toxics13040323","url":null,"abstract":"&lt;p&gt;&lt;p&gt;One hazardous material that occurs naturally in the environment and induces oxidative stress is cadmium (Cd). Epidemiological data revealed that exposure to cadmium in the workplace and environment might be linked to many illnesses and serious testicular injuries.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;It is taught that antioxidants can protect different organs against environmental toxic compounds. Therefore, the current investigation aims to show the role of antioxidants (gallic acid and selenium) in the protection against cadmium toxicity, including the architecture of the testes, semen properties, steroid hormones, protein expression of cytochrome P450 [CYP 19 and 11A1] contributing to the production of steroid hormones, and antioxidant enzyme activities, in male rabbits.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Male rabbits were given cadmium orally three times/week [1 mg/kg BW] for twelve weeks. In addition, gallic acid (20 mg/kg) or selenium (1 mg/kg BW) was administered two hours before cadmium treatment. This investigation included a spectrophotometer, histopathology, and Western immunoblotting techniques.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Cadmium treatment significantly reduced sperm counts, testosterone, and estrogen levels after four, eight, and twelve weeks of treatment. In addition, after a 12-week treatment of rabbits with cadmium, the activity of 17β-hydroxysteroid dehydrogenase and antioxidant enzymes, including catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, and glutathione S-transferase, as well as the glutathione levels, were inhibited in the testes tissue. On the other hand, following cadmium treatment, rabbit's testes showed a discernible increase in free radical levels. Interestingly, the activity of antioxidant enzymes and level of free radicals were recovered in rabbits treated with gallic acid or selenium before cadmium treatment. In addition, after 12 weeks of cadmium treatment, the steroidogenic protein expressions of CYP 11A1 and CYP 19 were upregulated and downregulated in the testes, respectively. Interestingly, after pretreatment of rabbits with either gallic acid or selenium for two hours before cadmium administration, the downregulated CYP11A1 was restored to normal levels. In the histopathological investigation, immature spermatozoids and sloughed spermatogonium cells were observed in cadmium-treated rabbits' testes. On the other hand, pretreatments of rabbits with gallic acid or selenium mitigated and alleviated the adverse effects of cadmium on testes architecture and increased the production of healthy sperm.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The lower levels of steroid hormones could be due to the downregulation of CYP11A1, inhibition of 17β-hydroxysteroid dehydrogenase, antioxidant enzyme activities, and the induction of free radical levels. Furthermore, the pretreatment of rabbits with gallic acid or selenium mitigated the adverse effects of cadmium on the tissue architecture of testes an","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanism of Perfluorooctane Sulfonate-Induced Lung Injury Mediated by the Ras/Rap Signaling Pathway in Mice.","authors":"Jianhao Peng, Jinfei He, Chenglong Ma, Jiangdong Xue","doi":"10.3390/toxics13040320","DOIUrl":"https://doi.org/10.3390/toxics13040320","url":null,"abstract":"<p><p>Perfluorooctane sulfonate (PFOS), a persistent organic pollutant, has raised significant public health concerns because of its widespread environmental presence and potential toxicity. Epidemiological studies have linked PFOS exposure to respiratory diseases, but the underlying molecular mechanisms remain poorly understood. Male C57 BL/6J mice were divided into a control group receiving Milli-Q water, a low-dose PFOS group (0.2 mg/kg/day), and a high-dose PFOS group (1 mg/kg/day) administered via intranasal instillation for 28 days. Lung tissue transcriptome sequencing revealed significantly enriched differentially expressed genes in the Ras and Rap signaling pathways. Key genes including Rap1b, Kras, and BRaf as well as downstream genes, such as MAPK1 and MAP2K1, exhibited dose-dependent upregulation in the high-dose PFOS exposure group. Concurrently, the downstream effector proteins MEK, ERK, ICAM-1, and VEGFa were significantly elevated in bronchoalveolar lavage fluid (BALF). These alterations are mechanistically associated with increased oxidative stress, inflammatory cytokine release, and pulmonary tissue damage. The results indicated that PFOS-induced lung injury is likely predominantly mediated through the activation of the Rap1b- and Kras-dependent BRaf-MEK-ERK axis. These findings highlight the critical role of Ras/Rap signaling pathways in PFOS-associated respiratory toxicity and underscore the need to develop therapeutic interventions targeting these pathways to mitigate associated health risks.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12030834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Ecotoxicological Impacts.","authors":"Pedro J Berríos-Rolón, María C Cotto, Francisco Márquez","doi":"10.3390/toxics13040321","DOIUrl":"https://doi.org/10.3390/toxics13040321","url":null,"abstract":"<p><p>This comprehensive review offers new perspectives on the distribution, sources, and ecotoxicological impacts of polycyclic aromatic hydrocarbons (PAHs) in freshwater systems. Unlike previous reviews, this work integrates recent findings on PAH dynamics within environmental matrices and emphasizes spatiotemporal variability across geographic regions. It critically examines both anthropogenic and natural sources, as well as the physical, chemical, and biological mechanisms driving PAH transport and fate. Special attention is given to the ecotoxicological effects of PAHs on freshwater organisms, including bioaccumulation, endocrine disruption, and genotoxicity. Notably, this review identifies key knowledge gaps and proposes an interdisciplinary framework to assess ecological risk and guide effective monitoring and management strategies for the protection of freshwater ecosystems.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient Air Pollution and Semen Quality in China: A Nationwide Case-Control Study of 27,014 Males with Biomarker-Confirmed Semen Pathology.","authors":"Jianfeng Liu, Zhixiang Fang, Dongyue Chai, Zhipeng Zhu, Qunshan Shen, Xiaojin He","doi":"10.3390/toxics13040322","DOIUrl":"https://doi.org/10.3390/toxics13040322","url":null,"abstract":"<p><p>Amidst China's rapid industrialization and deteriorating air quality, emerging evidence suggests a parallel decline in male reproductive health. However, large-scale assessments of pollution-semen quality associations remain scarce. This nationwide multicenter study investigated these relationships among 27,014 Chinese men using high-resolution satellite-derived exposure estimates (PM_2.5, PM₁₀, NO₂, O₃, CO, and SO₂) and generalized linear mixed models (GLMM), adjusting for key demographic confounders. A case-control study involving 5256 cases and 21758 controls used the exposure values of air pollutants 90 days prior to sperm collection for epidemiological exposure analysis reactions to obtain the association between sperm quality and air pollution. This study demonstrates significant associations between increased exposure to regional air pollutants and the risk of substandard semen quality in China. Key findings reveal NO₂'s potential reproductive toxicity, showing a 79.7% increased risk of semen volume abnormalities per 11.34 µg/m³ exposure (OR = 1.797, 95% CI: 1.402-2.302). Susceptibility disparities emerged, with 16.4-fold greater PM_2.5 sensitivity in obese individuals (OR = 1.121 vs. 1.007) and 133% higher PM₁₀ risk in urban residents (OR = 1.342 vs. 1.006). Strikingly, SO₂ exposure at 15% of the WHO 24 h average guideline (6.16 µg/m³) was associated with a 3.8% increase in abnormalities, indicating the challenge of the current safety thresholds. These findings highlight the need for policy reforms, including (1) incorporating reproductive health endpoints into air quality standards, (2) implementing antioxidant interventions for high-risk groups, and (3) strengthening traffic emission controls in urban planning. This study underscores the need for comprehensive strategies to mitigate the impact of air pollution on male reproductive health.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Synthesis of Silica-Based Hybrid Sorbents and Their Application in Radionuclide Separation and Removal via Chromatographic Technique.","authors":"Xiangbiao Yin, Fan Wang, Qi Zheng, Shunyan Ning, Lifeng Chen, Yuezhou Wei","doi":"10.3390/toxics13040319","DOIUrl":"https://doi.org/10.3390/toxics13040319","url":null,"abstract":"<p><p>The efficient separation and removal of key nuclides is important for the nuclear fuel cycle from the aspects of radioactivity reduction and potential resource recycling. The urgent objective is to design and develop functional materials for the separation and removal of important nuclides. Porous silicon-based adsorbents are considered highly advantageous materials for separating and removing radioactive nuclides in complex environments due to their excellent mechanical properties, high porosity, and functionalization ability. In this review, we compiled the applications of porous silica-based materials in recent years in the separation and removal of key nuclides, such as actinides, lanthanides, strontium, cesium, iodine, and platinum group metals; discussed their separation and removal performances; analyzed the constitutive relationship between key radionuclides and porous silica-based adsorbents; and systematically described the properties and mechanisms of different types of porous silica-based adsorbents. This article aims to provide some ideas for the design of an advanced separation process in the nuclear fuel cycle.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollution Characterization and Environmental Impact Evaluation of Atmospheric Intermediate Volatile Organic Compounds: A Review.","authors":"Yongxin Yan, Yan Nie, Xiaoshuai Gao, Xiaoyu Yan, Yuanyuan Ji, Junling Li, Hong Li","doi":"10.3390/toxics13040318","DOIUrl":"https://doi.org/10.3390/toxics13040318","url":null,"abstract":"<p><p>Atmospheric intermediate volatile organic compounds (IVOCs) are important precursors of secondary organic aerosols (SOAs), and in-depth research on them is crucial for atmospheric pollution control. This review systematically synthesizes global advancements in understanding IVOC sources, emissions characterization, compositional characteristics, ambient concentrations, SOA contributions, and health risk assessments. IVOCs include long-chain alkanes (C₁₂~C₂₂), sesquiterpenes, polycyclic aromatic hydrocarbons, monocyclic aromatic hydrocarbons, phenolic compounds, ketones, esters, organic acids, and heterocyclic compounds, which originate from primary emissions and secondary formation. Primary emissions include direct emissions from anthropogenic and biogenic sources, while secondary formation mainly results from radical reactions or particulate surface reactions. Recently, the total IVOC emissions have decreased in some countries, while emissions from certain sources, such as volatile chemical products, have increased. Ambient IVOC concentrations are generally higher in urban rather than in rural areas, higher indoors than outdoors, and on land rather than over oceans. IVOCs primarily generate SOAs via oxidation reactions with hydroxyl radicals, nitrate radicals, the ozone, and chlorine atoms, which contribute more to SOAs than traditional VOCs, with higher SOA yields. SOA tracers for IVOC species like naphthalene and β-caryophyllene have been identified. Integrating IVOC emissions into regional air quality models could significantly improve SOA simulation accuracy. The carcinogenic risk posed by naphthalene should be prioritized, while benzo[a]pyrene requires a combined risk assessment and hierarchical management. Future research should focus on developing high-resolution online detection technologies for IVOCs, clarifying the multiphase reaction mechanisms involved and SOA tracers, and conducting comprehensive human health risk assessments.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}