Toxics最新文献

{"title":"RETRACTED: Di Paola et al. Environmental Risk Assessment of Dexamethasone Sodium Phosphate and Tocilizumab Mixture in Zebrafish Early Life Stage (<i>Danio rerio</i>). <i>Toxics</i> 2022, <i>10</i>, 279.","authors":"Davide Di Paola, Jessica Maria Abbate, Carmelo Iaria, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Salvatore Cuzzocrea, Nunziacarla Spanò, Enrico Gugliandolo, Alessio Filippo Peritore","doi":"10.3390/toxics13020085","DOIUrl":"https://doi.org/10.3390/toxics13020085","url":null,"abstract":"<p><p>The journal retracts the article \"Environmental risk assessment of mixture of COVID-19 treating pharmaceutical drugs in zebrafish early life stage (<i>Danio rerio</i>)\" [...].</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Paola et al. Environmental Impact of Pharmaceutical Pollutants: Synergistic Toxicity of Ivermectin and Cypermethrin. <i>Toxics</i> 2022, <i>10</i>, 388.","authors":"Davide Di Paola, Carmelo Iaria, Fabio Marino, Enrico Gugliandolo, Cristian Piras, Rosalia Crupi, Salvatore Cuzzocrea, Nunziacarla Spanò, Domenico Britti, Alessio Filippo Peritore","doi":"10.3390/toxics13020072","DOIUrl":"10.3390/toxics13020072","url":null,"abstract":"<p><p>The journal retracts the article entitled \"Environmental Impact of Pharmaceutical Pollutants: Synergistic Toxicity of Ivermectin and Cypermethrin\" [...].</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Di Paola et al. Combined Effects of Potassium Perchlorate and a Neonicotinoid on Zebrafish Larvae (<i>Danio rerio</i>). <i>Toxics</i> 2022, <i>10</i>, 203.","authors":"Davide Di Paola, Fabiano Capparucci, Sabrina Natale, Rosalia Crupi, Salvatore Cuzzocrea, Nunziacarla Spanò, Enrico Gugliandolo, Alessio Filippo Peritore","doi":"10.3390/toxics13020074","DOIUrl":"10.3390/toxics13020074","url":null,"abstract":"<p><p>The journal retracts the article, \"Combined Effects of Potassium Perchlorate and a Neonicotinoid on Zebrafish Larvae (<i>Danio rerio</i>)\" [...].</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subchronic Exposure to Low-Dose Chlorfenapyr and Emamectin Benzoate Disrupts Kidney Metabolism in Rats.","authors":"Di Zhang, Xiao-Hua Song, Dan Yang, Mu-Zi Ge, Jun Qiu, Han-Qing Jiang, Yan-Yan Sun, Xiang-Dong Li, Yi-Jun Wu","doi":"10.3390/toxics13010065","DOIUrl":"https://doi.org/10.3390/toxics13010065","url":null,"abstract":"<p><p>Residues of the pesticides chlorfenapyr (CFP) and emamectin benzoate (EMB) often coexist in the environment and can be accumulated in the body. To understand the impact of these two chemicals on health, we investigated their effect on the kidneys. In this study, rats were treated with CFP and/or EMB at low/medium/high doses of 1/3/9 mg/kg/day and 0.2/0.6/1.8 mg/kg/day, respectively, via oral gavage for 60 days. Kidneys and serum samples were collected and serum biochemistry and kidney histopathological changes were analyzed and examined. Kidney metabolome alterations were analyzed by using gas chromatography-mass spectrometry. The results showed that combined exposure to CFP and EMB elevated BUN levels and induced pathological damage, which presented as thinner renal tubular epithelial cells, an abnormal glomerular morphology, and an increased fibrotic area. CFP and/or EMB disrupted glutathione metabolism and carbohydrate metabolism, resulting in the alteration of kidney metabolomes and inducing oxidative stress in the cells of kidney tissues. In addition, CFP decreased ATP content and inhibited pyruvate PDH activity in the kidneys. These findings suggest that long-term exposure to CFP and EMB at environmentally relevant levels induce alterations in the renal metabolome, oxidative stress, and an insufficient energy supply, which may contribute to renal histopathological damage.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Activity as a Growing Threat to Marine Ecosystems: Plastic and Temperature Effects on the Sponge <i>Sarcotragus spinosulus</i>.","authors":"Jessica Lombardo, Maria Del Mar Ribas-Taberner, Maria Magdalena Quetglas-Llabrés, Samuel Pinya, Llorenç Gil, Silvia Tejada, Antoni Sureda, Montserrat Compa","doi":"10.3390/toxics13010066","DOIUrl":"https://doi.org/10.3390/toxics13010066","url":null,"abstract":"<p><p>Human activities increasingly threaten marine ecosystems through rising waste and temperatures. This study investigated the role of plastics as vectors for <i>Vibrio</i> bacteria and the effects of temperature on the marine sponge <i>Sarcotragus spinosulus</i>. Samples of plastics and sponges were collected during July, August (high-temperature period), and November (lower-temperature period). Bacterial growth and sponge responses were analysed using biochemical biomarkers. The results revealed a peak in colony-forming units (CFU), particularly of <i>Vibrio alginolyticus</i>, on plastics and sponges in August, followed by a decrease in November. In August, CFU counts of <i>Vibrio</i> spp. were significantly higher in sponges with poor external appearance (characterized by dull coloration and heavy epiphytic growth) but returned to levels observed in healthy sponges by November. Microplastics were detected in the tissues of both sponge groups, with higher concentrations found in affected specimens. Biomarker analyses revealed increased lysozyme, glutathione S-transferase, catalase, and superoxide dismutase activities in healthy sponges during August, while malondialdehyde levels, indicating oxidative damage, were higher in affected sponges. In conclusion, affected sponges exhibited elevated CFU counts of <i>Vibrio</i> spp. and reduced antioxidant and detoxification responses under elevated temperatures. These findings suggest that combined impacts of plastics and warming may pose significant risks to <i>S. spinosulus</i> in the context of global climate change.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Disinfection Byproduct 2,6-Dichloro-1,4-benzoquinone on the Cyanobacterium <i>Microcystis aeruginosa</i>: From the Perspectives of Biochemistry and Non-Targeted Metabolomics.","authors":"Tianqi Zhang, Zhaoyang Wang, Liang Wu, Chaonan Liu, Liang Meng, Fuxiang Tian, Meifang Hou, Haizhuan Lin, Jing Ye","doi":"10.3390/toxics13010064","DOIUrl":"https://doi.org/10.3390/toxics13010064","url":null,"abstract":"<p><p>2,6-Dichloro-1,4-benzoquinone (2,6-DCBQ) is an emerging chlorinated disinfection byproduct (DBP) in bodies of water. However, this compound poses an unknown toxic effect on cyanobacteria. In this study, the toxicological mechanisms of 2,6-DCBQ in <i>Microcystis aeruginosa</i> (<i>M. aeruginosa</i>) were investigated through physiological and nontargeted metabolomic assessments. The results show that 2,6-DCBQ inhibited the growth of <i>M. aeruginosa</i>, reduced its photosynthetic pigment and protein contents, increased the levels of reactive oxygen species, damaged the antioxidant defense system, and aggravated the cytomembrane. Meanwhile, 2,6-DCBQ stimulated the production and release of microcystin-LR (MC-LR) and altered the transcripts of genes associated with its synthesis (<i>mcyA</i>, <i>mcyD</i>) and transport (<i>mcyH</i>). In addition, nontargeted metabolomics of <i>M. aeruginosa</i> cells exposed to 0.1 mg/L 2,6-DCBQ identified 208 differential metabolites belonging to 10 metabolic pathways and revealed the considerable interference caused by 2,6-DCBQ among ABC transporters, the two-component system, and folate biosynthesis. This study deepens the understanding of the physiological and nontargeted metabolomic responses of <i>M. aeruginosa</i> exposed to 2,6-DCBQ, offers insights into the toxic effect of 2,6-DCBQ on <i>M. aeruginosa</i>, and provides a theoretical basis for the ecological risk assessment of emerging DBPs in accordance with water quality criteria.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Autophagy in Copper-Induced Apoptosis and Developmental Neurotoxicity in SH-SY5Y Cells.","authors":"Lu Lu, Ying Zhang, Wei Shi, Qian Zhou, Zhuoqi Lai, Yuepu Pu, Lihong Yin","doi":"10.3390/toxics13010063","DOIUrl":"https://doi.org/10.3390/toxics13010063","url":null,"abstract":"<p><p>Copper (Cu) is a global environmental pollutant that poses a serious threat to humans and ecosystems. Copper induces developmental neurotoxicity, but the underlying molecular mechanisms are unknown. Neurons are nonrenewable, and they are unable to mitigate the excessive accumulation of pathological proteins and organelles in cells, which can be ameliorated by autophagic degradation. In this study, we established an in vitro model of Cu²⁺-exposed (0, 15, 30, 60 and 120 μM) SH-SY5Y cells to explore the role of autophagy in copper-induced developmental neurotoxicity. The results showed that copper resulted in the reduction and shortening of neural synapses in differentiated cultured SH-SY5Y cells, a downregulated Wnt signaling pathway, and nuclear translocation of β-catenin. Exposure to Cu²⁺ increased autophagosome accumulation and autophagic flux blockage in terms of increased sequestosome 1 (p62/SQSTM1) and microtubule-associated protein 1 light chain 3B (LC3B) II/LC3BI expressions and inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway. Furthermore, copper induced apoptosis, characterized by increased expressions of Bcl2 X protein (Bax), caspase 3, and Poly (ADP-ribose) polymerase (PARP) and decreased expression of B-cell lymphoma 2 (Bcl2). Compared with the 120 μM Cu²⁺ exposure group alone, autophagy activator rapamycin pretreatment increased expression of Wnt and β-catenin nuclear translocation, decreased expression of LC3BII/LC3BI and p62, as well as upregulated expression of Bcl2 and downregulated expressions of caspase 3 and PARP. In contrast, after autophagy inhibitor chloroquine pretreatment, expressions of Wnt and β-catenin nuclear translocation were decreased, expression levels of LC3BII/LC3BI and p62 were upregulated, expression of Bcl2 was decreased, while expression levels of caspase 3, Bax, and PARP were increased. In conclusion, the study demonstrated that autophagosome accumulation and autophagic flux blockage were associated with copper-induced developmental neurotoxicity via the Wnt signaling pathway, which might deepen the understanding of the developmental neurotoxicity mechanism of environmental copper exposure.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondhand Smoke Exposure and Brain Health Indicators in Cuban Preschoolers.","authors":"Yaser Ramírez Benítez, Miriela Díaz Bringas, Rodneys Mauricio Jiménez-Morales, Ijang Bih Ngyah-Etchutambe, Linda S Pagani","doi":"10.3390/toxics13010062","DOIUrl":"https://doi.org/10.3390/toxics13010062","url":null,"abstract":"<p><p>Secondhand smoke affects nearly 40% of children worldwide, leading to serious health and behavioral problems. Being neurotoxic, it poses potential risks for child health and learning. In Cuba, there is limited research on the association of secondhand smoke with children's brain health, especially in vulnerable populations like young children at home. The overall purpose of this study is two-fold. First, we determined the relationship between household smoke exposure and risks to brain health in Cuban children. Second, we analyzed the role of family environment factors, such as socio-economic status, in our estimates. Although this research represents the first investigation of its kind in Cuba, we expect to find evidence of neurotoxic associations with household smoke. We collected data between 2015 and 2018 using the medical records of 627 Cuban preschool children to explore the link between brain health indicators and exposure to tobacco smoke at home. We assessed archival reports on parental smoking, duration and frequency of exposure, and several indicators of brain health, including executive function, language development, sleep quality, and fluid intelligence. The findings indicate that exposure to tobacco smoke at home has a negative association with children's brain health, affecting both the cognitive (executive and linguistic functions) and non-cognitive aspects (sleep quality) of child development. Continuous exposure (five to seven times per week) and transient exposure (two to three times per week) were found to be more negatively related to sleep quality than in cognitive functions, particularly in children of middle socio-economic status. This highlights the need to implement parental information campaigns in Cuba.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Trihalomethanes and Human Cancer: A Systematic Review and Meta-Analysis.","authors":"Miaomiao Fu, Pengyu Xue, Zhuorong Du, Jingsi Chen, Xiaojun Liang, Jiafu Li","doi":"10.3390/toxics13010060","DOIUrl":"https://doi.org/10.3390/toxics13010060","url":null,"abstract":"<p><p>The control of waterborne diseases through water disinfection is a significant advancement in public health. However, the disinfection process generates disinfection by-products (DBPs), including trihalomethanes (THMs), which are considered to influence the occurrence of cancer. This analysis aims to quantitatively evaluate the relationship between blood concentrations of THMs and cancer. Additionally, the relationship between blood chloroform concentration and cancer is analyzed separately. Following PRISMA guidelines, we conducted a thorough search in the PubMed, Web of Science, and CNKI databases. Statistical analysis was performed using Review Manager 5.4 software. After screening, seven studies meeting the evaluation criteria were included. A total of 1027 blood samples from patients with cancer and 7351 blood samples from the control group were collected. The average concentration of THMs in the blood of the experimental group was 46.71 pg/mL, while it was 36.406 pg/mL in the control group. The difference between the two groups was statistically significant (SMD = -0.36, 95% CI: -0.45 to -0.27, <i>p</i> < 0.00001). However, due to the limited research data on the relationship between blood THMs and cancer, the conclusions drawn exhibit high heterogeneity. Additionally, we discussed the carcinogenic mechanisms of THMs, which involve multiple biological pathways such as oxidative stress, DNA adduct formation, and endocrine disruption, with variations in accumulation and target sites potentially leading to different cancer types, for which evidence is currently lacking. In the future, further epidemiological and animal model studies on THMs should be conducted to obtain more accurate conclusions.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-Induced Adverse Reactions: A Review of Physiological Food Quality Control, Mucosal Defense Mechanisms, and Gastrointestinal Physiology.","authors":"Dongdong Guo, Chang Liu, Hongkang Zhu, Yuliang Cheng, Xiang Huo, Yahui Guo, He Qian","doi":"10.3390/toxics13010061","DOIUrl":"https://doi.org/10.3390/toxics13010061","url":null,"abstract":"<p><p>Although food is essential for the survival of organisms, it can also trigger a variety of adverse reactions, ranging from nutrient intolerances to celiac disease and food allergies. Food not only contains essential nutrients but also includes numerous substances that may have positive or negative effects on the consuming organism. To protect against potentially harmful components, all animals have evolved defense mechanisms, which are similar to antimicrobial defenses but often come at the cost of the organism's health. When these defensive responses are exaggerated or misdirected, they can lead to adverse food reactions, where the costs outweigh the benefits. Furthermore, due to the persistent toxicity of harmful food components, the failure of defense mechanisms can also result in pathological effects triggered by food. This article review presents a food quality control framework that aims to clarify how these reactions relate to normal physiological processes. Organisms utilize several systems to coexist with symbiotic microbes, regulate them, and concurrently avoid, expel, or neutralize harmful pathogens. Similarly, food quality control systems allow organisms to absorb necessary nutrients while defending against low-quality or harmful components in food. Although many microbes are lethal in the absence of antimicrobial defenses, diseases related to microbiome dysregulation, such as inflammatory bowel disease, have significantly increased. Antitoxin defenses also come with costs and may fail due to insufficiencies, exaggerations, or misdirected actions, ultimately leading to adverse food reactions. With the changes in human diet and lifestyle, the failure of defense mechanisms has contributed to the rising incidence of food intolerances. This review explores the mechanisms of antitoxin defenses and analyzes how their failure can lead to adverse food reactions, emphasizing the importance of a comprehensive understanding of food quality control mechanisms for developing more effective treatments for food-triggered diseases.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}