Toxics最新文献

{"title":"Influence and Mechanism of Solid-Phase Particle Factors on Oil-Solid Separation of Oily Sludge Treated by Flotation Method.","authors":"Shuhui Wu, Xue Yao, Xiao Wang, Wenyan Yuan, Qiuhong Li, Xiaoyin Niu, Yanfei Ma","doi":"10.3390/toxics12120880","DOIUrl":"https://doi.org/10.3390/toxics12120880","url":null,"abstract":"<p><p>The solid phase composition in oily sludge (OS) is a key factor affecting the oil-solid separation of OS. In this paper, the effects and mechanisms of solid-phase particle factors on the oil content of residue phase were investigated in order to improve the oil-solid separation efficiency. Flotation experiments were carried out on single-size sand and mixed-size sand OS consisting of three particle sizes at room temperature without adding flotation reagents. The effects of different-size particles as solid phase composition of OS and flotation parameter settings such as flotation temperature (Tp), flotation time (Tt), impeller speed (Rs) and liquid-solid ratio (L/OS) on the oil-solid separation efficiency were investigated. The experimental results showed that the oil content of residue phase decreased with the increasing of solid-phase particle size for single-size sand OS, and the optimal flotation conditions were Tp of 50 °C, Tt of 25 min, Rs of 1450 r/min and L/OS of 12:1. The oil-solid separation was more pronounced for mixed-size sand OS with a complex particle composition, while different particle compositions of the solid phase in OS promoted oil-solid separation. Scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FT-IR) characterisation of OS before and after flotation confirmed the relative advantage of coarse particle OS in the oil-solid separation process. The classical first-order model was well fitted to the flotation kinetic process of single-size sand and mixed-size sand OS. The response surface methodology (RSM) method was used to determine the Rs as the main control factor of the flotation process, and the oil content of residue phase in mixed-size sand OS was optimised to 2.63%. This study provides important process parameters and theoretical basis for the efficient treatment of OS.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Combined Effect of Metals Exposure and Behavioral Factors on Depressive Symptoms in Women.","authors":"Olamide Ogundare, Emmanuel Obeng-Gyasi","doi":"10.3390/toxics12120879","DOIUrl":"https://doi.org/10.3390/toxics12120879","url":null,"abstract":"<p><p>This study investigates the combined effects of environmental pollutants (lead, cadmium, total mercury) and behavioral factors (alcohol consumption, smoking) on depressive symptoms in women. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 cycle, specifically exposure levels of heavy metals in blood samples, were used in this study. The analysis of these data included the application of descriptive statistics, linear regression, and Bayesian Kernel Machine Regression (BKMR) to explore associations between environmental exposures, behavioral factors, and depression. The PHQ-9, a well-validated tool that assesses nine items for depressive symptoms, was used to evaluate depression severity over the prior two weeks on a 0-3 scale, with total scores ranging from 0 to 27. Exposure levels of heavy metals were measured in blood samples. BKMR was used to estimate the exposure-response relationship, while posterior inclusion probability (PIP) in BKMR was used to quantify the likelihood that a given exposure was included in the model, reflecting its relative importance in explaining the outcome (depression) within the context of other predictors in the mixture. A descriptive analysis showed mean total levels of lead, cadmium, and total mercury at 1.21 µg/dL, 1.47 µg/L, and 0.80 µg/L, respectively, with a mean PHQ-9 score of 5.94, which corresponds to mild depressive symptoms based on the PHQ-9 scoring. Linear regression indicated positive associations between depression and lead as well as cadmium, while total mercury had a negative association. Alcohol and smoking were also positively associated with depression. These findings were not significant, but limitations in linear regression prompted a BKMR analysis. BKMR posterior inclusion probability (PIP) analysis revealed alcohol and cadmium as significant contributors to depressive symptoms, with cadmium (PIP = 0.447) and alcohol (PIP = 0.565) showing notable effects. Univariate and bivariate analyses revealed lead and total mercury's strong relationship with depression, with cadmium showing a complex pattern in the bivariate analysis. A cumulative exposure analysis of all metals and behavioral factors concurrently demonstrated that higher quantile levels of combined exposures were associated with an increased risk of depression. Finally, a single variable-effects analysis in BKMR revealed lead, cadmium, and alcohol had a stronger impact on depression. Overall, the study findings suggest that from exposure to lead, cadmium, mercury, alcohol, and smoking, cadmium and alcohol consumption emerge as key contributors to depressive symptoms. These results highlight the need to address both environmental and lifestyle choices in efforts to mitigate depression.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Genotoxic and Environmentally Relevant Lower Molecular Weight Polycyclic Aromatic Hydrocarbons Significantly Increase Tumorigenicity of Benzo[<i>a</i>]pyrene in a Lung Two-Stage Mouse Model.","authors":"Alison K Bauer, Deedee Romo, Finnegan Friday, Kaila Cho, Kalpana Velmurugan, Brad L Upham","doi":"10.3390/toxics12120882","DOIUrl":"https://doi.org/10.3390/toxics12120882","url":null,"abstract":"<p><p>The World Health Organization has classified air pollution as a carcinogen, and polycyclic aromatic hydrocarbons (PAHs) are major components of air particulates of carcinogenic concern. Thus far, most studies focused on genotoxic high molecular weight PAHs; however, recent studies indicate potential carcinogenicity of the non-genotoxic lower molecular weight PAHs (LMW PAHs) that are found in indoor and outdoor air pollution as well as secondhand cigarette smoke. We hypothesize that LMW PAHs contribute to the promotion stage of cancer when combined with benzo[<i>a</i>]pyrene (B[<i>a</i>]P), a legacy PAH. We specifically determined the effects of an LMW PAH mixture containing 1-methylanthracene (1MeA), fluoranthene (Flthn), and phenanthrene (Phe) combined with B[<i>a</i>]P on lung tumor promotion. To test this hypothesis, we used a two-stage, initiation/promotion BALB/ByJ female lung tumor mouse model. The mice were initiated with 3-methylcholanthrene followed by exposures to B[<i>a</i>]P, the LMW PAH mixture, and the combination of the LMW PAH mixture plus B[<i>a</i>]P, all at 10 mg/kg. The LMW PAHs combined with B[<i>a</i>]P significantly increased the promotion and incidence of lung tumors over that of B[<i>a</i>]P alone. The LMW PAHs in the absence of B[<i>a</i>]P did not significantly promote tumors, indicating strong co-promotional activities. We further assessed the effects of these PAHs on other hallmarks of cancer, namely, bronchoalveolar lavage fluid inflammatory infiltrates, pro-inflammatory transcripts, KC protein content, and mRNA expression of the gap junction (<i>Gja1</i>) and epiregulin (<i>Ereg</i>) genes. The LMW PAHs increased the biomarkers of inflammation, decreased <i>Gja1</i> expression, and increased <i>Ereg</i> expression, all consistent with tumor promotion. This study indicates that non-genotoxic LMW PAHs can contribute to the cancer process and warrants further studies to assess the carcinogenic risks of other LMW PAHs.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM_2.5 Exposure Induces Glomerular Hyperfiltration in Mice in a Gender-Dependent Manner.","authors":"Hao Wang, Li Ma, Yuqiong Guo, Lingyu Ren, Guangke Li, Nan Sang","doi":"10.3390/toxics12120878","DOIUrl":"https://doi.org/10.3390/toxics12120878","url":null,"abstract":"<p><p>As one of the most common air pollutants, fine particulate matter (PM_2.5) increases the risk of diseases in various systems, including the urinary system. In the present study, we exposed male and female C57BL/6J mice to PM_2.5 for 8 weeks. Examination of renal function indices, including creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA), and urinary microalbumin, indicated that the kidneys of female mice, not male mice, underwent early renal injury, exhibiting glomerular hyperfiltration. Meanwhile, pathological staining showed that the kidneys of female mice exhibited enlarged glomerulus that filled the entire Bowman's capsule in the female mice. Afterward, we explored the potential causes and mechanisms of glomerular hyperfiltration. Variations in mRNA levels of key genes involved in the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) demonstrated that PM_2.5 led to elevated glomerular capillary hydrostatic pressure in female mice by disturbing the balance between the RAS and KKS, which in turn increased the glomerular filtration rate (GFR). In addition, we found that PM_2.5 increased blood glucose levels in the females, which enhanced tubular reabsorption of glucose, attenuated macular dense sensory signaling, induced renal hypoxia, and affected adenosine triphosphate (ATP) synthesis, thus attenuating tubuloglomerular feedback (TGF)-induced afferent arteriolar constriction and leading to glomerular hyperfiltration. In conclusion, this study indicated that PM_2.5 induced glomerular hyperfiltration in female mice by affecting RAS/KKS imbalances, as well as the regulation of TGF; innovatively unveiled the association between PM_2.5 subchronic exposure and early kidney injury and its gender dependence; enriched the toxicological evidence of PM_2.5 and confirmed the importance of reducing ambient PM_2.5 concentrations.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Environmental Risks of Local Contamination of Garden Urban Soils with Heavy Metals Using Ecotoxicological Tests.","authors":"Dariusz Gruszka, Iwona Gruss, Katarzyna Szopka","doi":"10.3390/toxics12120873","DOIUrl":"https://doi.org/10.3390/toxics12120873","url":null,"abstract":"<p><p>Heavy metal soil contamination in urban areas poses a significant environmental hazard, particularly in regions with historical or ongoing industrial activities. These areas are often polluted with metals such as Pb, Cu, Cd, and Zn, which can be absorbed by plants and pose risks to both ecosystems and human health. This study investigates soil contamination in urban gardens in Wroclaw, Poland, where elevated levels of trace elements were detected. Standard soil analyses, including macroelement content, granulometry, and trace element concentrations, were performed alongside an ecotoxicological evaluation using an Ostracodtoxkit test. The test evaluates the impact of contaminants on organism growth. An uncontaminated urban garden soil served as a reference. This study revealed that Zn, Cu, Pb, and Cd concentrations in soils exceeded limits permitted by Polish regulations in several soil samples. Despite the high concentrations of total metals, the bioavailable forms of these metals (measured by extraction of 1 M NH₄NO₃ extraction) were significantly lower, highlighting that the total metal content may not fully reflect the environmental risk. Pb was identified as the primary contributor to growth inhibition of test organisms, showing a particularly strong correlation with ecotoxicity. These findings underscore the importance of using ecotoxicological tests to evaluate soil contamination risks.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Perfluoroalkyl Substance Exposure in Association with Global Histone Post-Translational Methylation in 2-Year-Old Children.","authors":"Wan-Ju Tsai, Wu-Shiun Hsieh, Pau-Chung Chen, Chen-Yu Liu","doi":"10.3390/toxics12120876","DOIUrl":"https://doi.org/10.3390/toxics12120876","url":null,"abstract":"<p><p>Perfluoroalkyl substances (PFASs) have elimination half-lives in years in humans and are persistent in the environment. PFASs can cross the placenta and impact fetal development. Exposure to PFASs may lead to adverse effects through epigenetic mechanisms. This study aimed to investigate whether prenatal exposure to perfluorooctyl sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) was associated with global histone methylation level changes among the 130 2-year-old children followed-up in a birth cohort study in Taiwan. PFOS, PFOA, PFNA, and PFUA were measured by UHPLC/MS/MS in cord blood. Global histone methylation levels were measured from the blood leukocytes of 2-year-old children by Western blotting. Multivariable regression analyses were applied to adjust for potential confounding effects. Among the 2-year-old children, an IQR increase in the natural log-transformed PFUA exposure was associated with an increased H3K4me3 level by 2.76-fold (95%CI = (0.79, 4.73), <i>p</i> = 0.007). PFOA and PFNA exposures was associated with a decreased H3K27me3 level by 2.35-fold (95%CI = (-4.29, -0.41), <i>p</i> = 0.01) and 2.01-fold (95%CI = (-4.00, -0.03), <i>p</i> = 0.04), respectively. Our findings suggest that prenatal PFAS exposure affected histone post-translational modifications.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Substituent Groups on the Adsorption Efficiency of Phenols by Activated Carbon Developed by Hydrothermally Treated Phyllanthus Emblica Fruit Stone.","authors":"Suhas, Sarita Kushwaha, Monika Chaudhary, Shubham Chaudhary, Vaishali Tyagi, Isabel Pestana da Paixão Cansado, Mohammad Hadi Dehghani","doi":"10.3390/toxics12120874","DOIUrl":"https://doi.org/10.3390/toxics12120874","url":null,"abstract":"<p><p>In this study, the novel activated carbon developed from <i>Phyllanthus emblica</i> fruit stone, through hydrothermal treatment at low pressure and temperature, was utilized for the removal of 4-nitrophenol, 4-chlorophenol, and phenol from water. The activated carbon produced (AC-HTPEFS) showed a well-developed porosity with a surface area of 569 m² g^-1 and a total pore volume of 0.342 cm³ g^-1. The adsorption process was explored and efficiently applied regarding the removal of phenols and substituted phenols from wastewater. Thermodynamic analyses indicated that the adsorption process was endothermic and spontaneous. To analyze the equilibrium data, different isotherm models were employed. The Langmuir model applied best, with maximum adsorption capacities of 0.463, 0.434, and 0.387 mmol g^-1 at 25 °C for 4-nitrophenol (4-NP), 4-chlorophenol (4-CP), and phenol, respectively, regarding the AC-HTPEFS. The adsorption was mainly an endothermic process, and the results achieved were slightly higher than those obtained with a commercial activated carbon commonly used for this purpose.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence, Bioaccumulation, and Trophic Transfer of Short-Chain Chlorinated Paraffins (SCCPs) in a Marine Food Web from Laizhou Bay, Bohai Sea (Eastern China).","authors":"Min Song, Dianfeng Han, Shunxin Hu, Qingkui Cui, Huanjun Li, Fan Li, Jianbai Zhang, Yongchun Liu, Mei Zhao, Cunxin Zhang, Yingjiang Xu","doi":"10.3390/toxics12120877","DOIUrl":"https://doi.org/10.3390/toxics12120877","url":null,"abstract":"<p><p>Short-chain chlorinated paraffins (SCCPs) are a persistent organic pollutant, and limited information is available on their bioaccumulation and trophic transfer, which would be affected by carbon chain length, chlorine content, and hydrophobicity. In this study, relevant data on SCCPs in water, sediments, and organisms collected from Laizhou Bay were analyzed to investigate the specific distribution of SCCPs and their bioaccumulation and trophic transfer. In water and sediments, the average SCCP concentrations (ΣSCCPs) were 362.23 ± 81.03 ng/L and 609.68 ± 90.28 ng/g d.w., respectively. In 28 species of organisms, the ΣSCCPs varied from 70.05 to 47,244.13 ng/g l.w. (average = 648 ± 7360) and the predominant homologs were C₁₃ (average = 34.91%) and Cl_5-7 (average = 93.13%), differing from those in water (average = C₁₁ 32.75% and average = Cl_5-7 88%) and sediments (average = C₁₃ 31.60% and average = Cl_6-8 87.16%). The logarithm bioaccumulation factors (BAFs) of ΣSCCPs were 1.18-2.74 and were positively correlated with the log K_ow. A significant negative linear relationship was observed between biota-sediment accumulation factors (BSAFs) and log K_ow. It is suggested that the hydrophobicity may affect the bioaccumulation of SCCPs. SCCPs demonstrated a trophic magnification factor (TMF) ranging from 2.19 to 3.00 (average = 2.51) and exhibited a significant linear correlation with carbon chain length (<i>p</i> < 0.05) and log K_ow values (<i>p</i> < 0.05), suggesting that SCCPs have biomagnification potential in Laizhou Bay that is affected by hydrophobicity and carbon chain length.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanisms of Cadmium Toxicity in Living Organisms.","authors":"Slavena Davidova, Viktor Milushev, Galina Satchanska","doi":"10.3390/toxics12120875","DOIUrl":"https://doi.org/10.3390/toxics12120875","url":null,"abstract":"<p><p>Cadmium (Cd) is a toxic metal primarily found as a by-product of zinc production. Cd was a proven carcinogen, and exposure to this metal has been linked to various adverse health effects, which were first reported in the mid-19th century and thoroughly investigated by the 20th century. The toxicokinetics and dynamics of Cd reveal its propensity for long biological retention and predominant storage in soft tissues. Until the 1950s, Cd pollution was caused by industrial activities, whereas nowadays, the main source is phosphate fertilizers, which strongly contaminate soil and water and affect human health and ecosystems. Cd enters the human body mainly through ingestion and inhalation, with food and tobacco smoke being the primary sources. It accumulates in various organs, particularly the kidney and liver, and is known to cause severe health problems, including renal dysfunction, bone diseases, cardiovascular problems, and many others. On a cellular level, Cd disrupts numerous biological processes, inducing oxidative stress generation and DNA damage. This comprehensive review explores Cd pollution, accumulation, distribution, and biological impacts on bacteria, fungi, edible mushrooms, plants, animals, and humans on a molecular level. Molecular aspects of carcinogenesis, apoptosis, autophagy, specific gene expression, stress protein synthesis, and ROS formation caused by Cd were discussed as well. This paper also summarizes how Cd is removed from contaminated environments and the human body.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titanium Dioxide Nanoparticles-Induced Genotoxic Effects in Mosquito <i>Culex quinquefaciatus</i>.","authors":"Aastha Saini, Kanwaljit Kaur Ahluwalia, Amrik Singh Ahluwalia, Neelam Thakur, Puneet Negi, Abeer Hashem, Khalid F Almutairi, Elsayed Fathi Abd Allah","doi":"10.3390/toxics12120871","DOIUrl":"https://doi.org/10.3390/toxics12120871","url":null,"abstract":"<p><p>Titanium dioxide (TiO₂) nanoparticles are being extensively used in a wide range of industrial applications for producing a variety of different consumer products, including medicines and even food items. The consumption of these products is increasing at an alarming rate, and this results in the release of these nanoparticles in the environment, causing a threat to organisms thriving in aquatic as well as terrestrial ecosystems. That is why screening such materials for their genotoxic effects, if any, becomes essential. A toxicity assay was performed to determine the LD₂₀ of these nanoparticles for the mosquito <i>Culex quinquefaciatus</i> by Probit analysis. Early fourth instar larvae were exposed to the selected dose of 50 µg/mL, which is <LD₂₀ value, for 24 h treatment. Chromosomal slides were prepared from lacto-aceto-orcein-stained gonads of adult mosquitoes developed from treated and control larvae. These nanoparticles were reported cytotoxic as a statistically significant decline in mitotic index in treated mosquitoes than controls were observed. The nanoparticles were also found to induce various structural and numerical chromosomal aberrations in the treated lot. In the end, it can be concluded that these nanoparticles do have a genotoxic effect. The present study provides a caution against further use of these nanoparticles. There must be the development of strategies for the safe, sustainable use as well as proper disposal of these nanoparticles so as to protect both biotic and non-biotic components of the environment.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}