新烟碱诱导的细胞毒性：对细胞机制和健康风险的见解。

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2025-07-09 DOI:10.3390/toxics13070576

Yuqing Ma, Qiangwei Wang

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引用次数: 0

摘要

新烟碱类在农业生产中广泛使用，但越来越多的证据表明其对各种细胞类型的细胞毒性作用。研究表明，这些农药会显著损害生殖细胞、脂肪细胞、神经细胞、免疫细胞和上皮细胞的活力和功能。潜在的机制包括代谢紊乱、线粒体功能障碍和氧化应激。这些细胞效应引起了人们对新烟碱类杀虫剂对人类健康和环境构成的潜在风险的严重关切。进一步的调查对于充分了解其毒理学影响并为更安全的农药管理和使用提供信息至关重要。

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Neonicotinoid-Induced Cytotoxicity: Insights into Cellular Mechanisms and Health Risks.

Neonicotinoids are extensively used in agricultural production, yet increasing evidence highlights their cytotoxic effects on various cell types. Research has demonstrated that these pesticides can significantly impair the viability and function of reproductive, adipose, neural, immune, and epithelial cells. The underlying mechanisms involve metabolic disturbances, mitochondrial dysfunction, and oxidative stress. These cellular effects raise serious concerns about the potential risks neonicotinoids pose to both human health and the environment. Further investigation is essential to fully understand their toxicological impact and to inform safer pesticide regulation and use.

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.