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Distinct Impacts of Prenatal and Postnatal Phthalate Exposure on Behavioral and Emotional Development in Children Aged 1.5 to 3 Years. 产前和产后接触邻苯二甲酸盐对 1.5 至 3 岁儿童行为和情感发育的不同影响。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-31 DOI: 10.3390/toxics12110795
Yi-Siang Huang, Pi-Lien Hung, Liang-Jen Wang, Chih-Min Tsai, Chang-Ku Tsai, Mao-Meng Tiao, Hong-Ren Yu
{"title":"Distinct Impacts of Prenatal and Postnatal Phthalate Exposure on Behavioral and Emotional Development in Children Aged 1.5 to 3 Years.","authors":"Yi-Siang Huang, Pi-Lien Hung, Liang-Jen Wang, Chih-Min Tsai, Chang-Ku Tsai, Mao-Meng Tiao, Hong-Ren Yu","doi":"10.3390/toxics12110795","DOIUrl":"10.3390/toxics12110795","url":null,"abstract":"<p><p>Development is a continuous process, but few studies have assessed the simultaneous impact of prenatal and postnatal phthalate exposure on children's behavioral and emotional development. A total of 491 mother-child pairs from the general population in southern Taiwan were studied from 2021 to 2022. Urinary concentrations of bisphenol A (BPA) and phthalate metabolites-mono-ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-benzyl phthalate (MBzP), and mono-2-ethylhexyl phthalate (MEHP)-were measured in pregnant mothers during the second trimester and in their corresponding children aged 1.5 to 3 years. Behavioral symptoms in children were evaluated using the Child Behavior Checklist (CBCL). Odds ratios (ORs) represent a 1-unit increase in log10-transformed creatinine-corrected maternal urine concentrations. Prenatal maternal urinary MnBP levels were associated with total problems (OR = 19.32, 95% CI: 1.80-43.13, <i>p</i> = 0.04), anxiety (OR = 33.58, 95% CI: 2.16-521.18, <i>p</i> = 0.01), and sleep problems (OR = 41.34, 95% CI: 1.04-1632.84, <i>p</i> = 0.04) in children. Additionally, urinary MnBP levels in children correlated with total problems (OR = 7.06, 95% CI: 1.01-49.05, <i>p</i> = 0.04) and internalizing problems (OR = 11.04, 95% CI: 1.27-95.72, <i>p</i> = 0.01). These findings suggest that prenatal and postnatal exposure to dibutyl phthalate (DBP), metabolized as MnBP, distinctly affects children's behavioral development.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis. 长期暴露于环境空气污染与空腹血糖之间的关系:系统回顾与元分析》。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-30 DOI: 10.3390/toxics12110792
Tong Wu, Yang Lan, Ge Li, Kai Wang, Yu You, Jiaqi Zhu, Lihua Ren, Shaowei Wu
{"title":"Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis.","authors":"Tong Wu, Yang Lan, Ge Li, Kai Wang, Yu You, Jiaqi Zhu, Lihua Ren, Shaowei Wu","doi":"10.3390/toxics12110792","DOIUrl":"10.3390/toxics12110792","url":null,"abstract":"<p><p>Increasing studies are indicating a potential association between ambient air pollution exposure and fasting blood glucose (FBG), an indicator of prediabetes and diabetes. However, there is inconsistency within the existing literature. The aim of this study was to summarize the associations of exposures to particulate matters (PMs) (with aerodynamic diameters of ≤1 μm (PM<sub>1</sub>), ≤2.5 μm (PM<sub>2.5</sub>), and ≤10 μm (PM<sub>10</sub>), respectively) and gaseous pollutants (sulfur dioxide (SO<sub>2</sub>), nitrogen dioxide (NO<sub>2</sub>) and ozone (O<sub>3</sub>)) with FBG based on the existing epidemiological research for a better understanding of the relationship between air pollution and diabetes. Up to 2 July 2024, we performed a comprehensive literature retrieval from various electronic databases (PubMed, Web of Science, Scopus, and Embase). Random-effect and fixed-effect models were utilized to estimate the pooled percent changes (%) and 95% confidence intervals (CIs). Then, subgroup meta-analyses and meta-regression analyses were applied to recognize the sources of heterogeneity. There were 33 studies eligible for the meta-analysis. The results showed that for each 10 μg/m<sup>3</sup> increase in long-term exposures to PM<sub>1</sub>, PM<sub>2.5</sub>, PM<sub>10</sub>, and SO<sub>2</sub>, the pooled percent changes in FBG were 2.24% (95% CI: 0.54%, 3.96%), 1.72% (95% CI: 0.93%, 2.25%), 1.19% (95% CI: 0.41%, 1.97%), and 0.52% (95% CI:0.40%, 0.63%), respectively. Long-term exposures to ambient NO<sub>2</sub> and O<sub>3</sub> were not related to alterations in FBG. In conclusion, our findings support that long-term exposures to PMs of various aerodynamic diameters and SO<sub>2</sub> are associated with significantly elevated FBG levels.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fouling-Resistant Voltammetric Xylazine Sensors for Detection of the Street Drug "Tranq". 用于检测街头毒品 "Tranq "的抗结垢伏安法赛拉嗪传感器
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-30 DOI: 10.3390/toxics12110791
Joyce E Stern, Ann H Wemple, Charles W Sheppard, Arielle Vinnikov, Michael C Leopold
{"title":"Fouling-Resistant Voltammetric Xylazine Sensors for Detection of the Street Drug \"Tranq\".","authors":"Joyce E Stern, Ann H Wemple, Charles W Sheppard, Arielle Vinnikov, Michael C Leopold","doi":"10.3390/toxics12110791","DOIUrl":"10.3390/toxics12110791","url":null,"abstract":"<p><p>As the opioid crisis continues to wreak havoc on a global scale, it is increasingly critical to develop methodologies to detect the most dangerous drugs such as fentanyl and its derivatives, which have orders of magnitude higher potency than morphine. The scientific challenge for chemical detection of fentanyl and its derivatives is complicated by both the constantly increasing synthetic variations of the drug as well as the expanded use of adulterants. One tragically consequential example is the nocuous street drug known as \"Tranq\", which combines fentanyl or a fentanyl derivative with the veterinary sedative Rompun<sup>®</sup>, chemically identified as xylazine (XYL). This pervasive street cocktail is exacerbating the already staggering number of fentanyl-related deaths as its acute toxicity poses a danger to medical first-responders and complicates their initial assessment and treatment options for overdose victims. Given the widespread use of XYL as an adulterant, an electrochemical XYL sensor capable of on-site operation by non-experts as a fast-screening tool is a notable goal. This work presents a voltammetry-based sensor featuring carbon electrodes modified with carboxylic-acid functionalized multi-walled carbon nanotubes layered with cyclodextrin and polyurethane membranes for sensitivity and selectivity enhancements. The sensor has critical and robust fouling resistance while providing sensitivity at 950 μA/mM∙cm<sup>2</sup>, a low limit of detection (~5 ppm), and the ability to detect XYL in the presence of fentanyl and/or other non-fentanyl stimulants like cocaine. The demonstrated sensor can be applied to promote public health with its ability to detect and indicate XYL in the presence of opioids, serving to protect drug-users, first responders, medical examiners, and on-site forensic investigators from exposure to these dangerous mixtures.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracking Microplastics Contamination in Drinking Water Supply Chain in Haikou, China: From Source to Household Taps. 追踪中国海口饮用水供应链中的微塑料污染:从水源到家庭水龙头。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-30 DOI: 10.3390/toxics12110793
Xiangxiang Li, Yihan Yu, Mei Yang, Shaobai Wen, Jun Zhang
{"title":"Tracking Microplastics Contamination in Drinking Water Supply Chain in Haikou, China: From Source to Household Taps.","authors":"Xiangxiang Li, Yihan Yu, Mei Yang, Shaobai Wen, Jun Zhang","doi":"10.3390/toxics12110793","DOIUrl":"10.3390/toxics12110793","url":null,"abstract":"<p><p>The presence of microplastics (MPs) in aquatic environments has become a significant global concern due to their potential adverse effects on human health. This study aimed to investigate the contamination of MPs throughout the drinking water supply chain in Haikou City, China, and to conduct risk assessments regarding the relationship between MPs contamination and human health. The results revealed that the abundance of MPs in raw, treated, and tap water was 0.6 ± 0.6, 5.2 ± 2.7, and 1.2 ± 1.1 particles·L<sup>-1</sup>, respectively. Fragments were identified as the most prevalent shape across all samples, with the size category of 20-50 μm showing the highest abundance of MPs. Among the 11 types of polymers identified, polyethylene and polypropylene accounted for 50% and 29%, respectively. The potential risk index values were significantly higher for treated water (370.26) and tap water (303.85) compared to raw water (13.46), suggesting that plastic pipes may be a key contributor to MPs contamination in drinking water. Therefore, efforts should be directed toward developing pipes with low release rates of MPs, as well as improving detection methods for smaller particles and accurately assessing associated risks.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probabilistic Approach for Assessing the Occupational Risk of Olfactometric Examiners: Methodology Description and Application to Real Exposure Scenario. 评估嗅觉检验员职业风险的概率方法:方法说明及在真实暴露场景中的应用。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-29 DOI: 10.3390/toxics12110784
Elisa Polvara, Andrea Spinazzè, Marzio Invernizzi, Andrea Cattaneo, Domenico Maria Cavallo, Selena Sironi
{"title":"Probabilistic Approach for Assessing the Occupational Risk of Olfactometric Examiners: Methodology Description and Application to Real Exposure Scenario.","authors":"Elisa Polvara, Andrea Spinazzè, Marzio Invernizzi, Andrea Cattaneo, Domenico Maria Cavallo, Selena Sironi","doi":"10.3390/toxics12110784","DOIUrl":"10.3390/toxics12110784","url":null,"abstract":"<p><p>Human examiners, known as panelists, are exposed to an unknown occupational exposure risk while determining odor concentration (C<sub>od</sub>) using dynamic olfactometry. In the literature, a few papers, based on a deterministic approach, have been proposed to establish this occupational risk. As a result, the purpose of this study is to develop and apply a probabilistic approach, based on the randomization of exposure parameters, for assessing and evaluating the occupational exposure risk among olfactometric examiners. In this methodology, the risk is assessed by computing the hazard index (HI) and inhalation risk (IR) to determine the non-carcinogenic and carcinogenic risks. To randomize the exposure parameters, a Monte Carlo simulation was described and then applied in real exposure scenario to establish the exposure risk in terms of probability. Therefore, a one-year survey of the working activity of olfactometric examiners of <i>Laboratorio Olfattometrico</i> of Politecnico di Milano university was conducted. Based on this data collection (exposure parameters and chemical data, divided according to sample categories), a randomized exposure scenario was constructed to estimate the probability and cumulative distribution function of risk parameters. Different distributions were obtained for different industrial samples categories and were compared with respect to acceptability criteria (the value of HI and IR at 95th percentile of distribution). The elaboration provided evidence that negligible non-carcinogenic and carcinogenic risks are associated with the panelists' activity, according to an entire annual dataset. The application of probabilistic risk assessment provides a more comprehensive and effective characterization of the general exposure scenario for olfactometric examiners, surpassing the limitations of a deterministic approach. This method can be extended to future exposure scenarios and enables the selection of the most effective risk management strategies to protect the health of olfactometric examiners.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rice Husk as a Sustainable Amendment for Heavy Metal Immobilization in Contaminated Soils: A Pathway to Environmental Remediation. 稻壳作为污染土壤中重金属固定化的可持续改良剂:环境修复之路。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-29 DOI: 10.3390/toxics12110790
Riccardo Cecire, Aleandro Diana, Agnese Giacomino, Ornella Abollino, Paolo Inaudi, Laura Favilli, Stefano Bertinetti, Simone Cavalera, Luisella Celi, Mery Malandrino
{"title":"Rice Husk as a Sustainable Amendment for Heavy Metal Immobilization in Contaminated Soils: A Pathway to Environmental Remediation.","authors":"Riccardo Cecire, Aleandro Diana, Agnese Giacomino, Ornella Abollino, Paolo Inaudi, Laura Favilli, Stefano Bertinetti, Simone Cavalera, Luisella Celi, Mery Malandrino","doi":"10.3390/toxics12110790","DOIUrl":"10.3390/toxics12110790","url":null,"abstract":"<p><p>Rice husk is a waste byproduct of rice production. This material has a moderate cost and is readily available, representing 20-22% of the biomass produced by rice cultivation. This study focused on the properties of rice husk in the remediation of soils contaminated by heavy metals. The effect of particle size, pH, and the presence of organic ligands on sorption efficiency was evaluated for Cd, Cu, and Mn. The continuous flow method was used to select suitable operative conditions and maximize the retention of heavy metals. Subsequently, pot experiments were carried out by growing two broadleaf plants, <i>Lactuca sativa</i> and <i>Spinacia oleracea</i>, in aliquots of soil collected in a Piedmont (Northwest Italy) site heavily contaminated by Cu, Cr, and Ni. Rice husk was added to the contaminated soil to evaluate its effectiveness in immobilizing heavy metals. The availability of Cr, Mn, Ni, Cu, Zn, Cd, and Pb in soil was studied using Tessier's sequential extraction protocol. The content of the elements was also analyzed in plants and the uptake of heavy metals was evaluated in relation to the addition of rice husk. The growth of both plants was more efficient in the presence of rice husk due to its ability to reduce the mobility of heavy metals in the soil. The simplicity, cost-effectiveness, and scalability of its employment make the use of rice husk suitable for practical applications in soil remediation.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an Improved Thiosulfate-Utilizing Denitrifying Bacteria-Based Ecotoxicity Test with High Detection Sensitivity and Reproducibility. 开发一种基于硫代硫酸利用反硝化细菌的改进型生态毒性试验,具有高检测灵敏度和可重复性。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-29 DOI: 10.3390/toxics12110788
Heonseop Eom
{"title":"Development of an Improved Thiosulfate-Utilizing Denitrifying Bacteria-Based Ecotoxicity Test with High Detection Sensitivity and Reproducibility.","authors":"Heonseop Eom","doi":"10.3390/toxics12110788","DOIUrl":"10.3390/toxics12110788","url":null,"abstract":"<p><p>Microorganism-based ecotoxicity assessment has been widely used as a reliable tool showing direct biochemical impacts of contaminants on ecosystems and the environment. The present study aimed at developing a thiosulfate-utilizing denitrifying bacteria (TUDB)-based ecotoxicity test with high detection sensitivity and favorable reproducibility. To achieve this goal, existing TUDB toxicity tests were improved by employing a pure culture of <i>Thiobacillus thioparus</i> ATCC 8158 and optimizing test conditions, particularly in terms of inoculated microbial biomass, incubating temperature, and operational pH. From control tests, it was found that 4 h is a sufficient processing time for TUDB test kits. As a result of optimization, 20 mg VSS/L of initial bacterial biomass, 25 °C of incubating temperature, and 6 of operational pH were determined as the most favorable test conditions, providing enhanced detection sensitivity and reproducibility. Under these optimal test conditions, I conducted toxicity tests for diverse toxic metals and obtained 0.65 ± 0.03, 1.09 ± 0.04, 1.21 ± 0.07, 0.13 ± 0.01, 0.56 ± 0.04, 1.42 ± 0.03, 0.98 ± 0.02, and 2.12 ± 0.05 mg/L of 4 h EC<sub>50</sub> values for Ag<sup>+</sup>, As<sup>3+</sup>, Cd<sup>2+</sup>, Cr<sup>6+</sup>, Cu<sup>2+</sup>, Hg<sup>2+</sup>, Ni<sup>2+</sup>, and Pb<sup>2+</sup>, respectively. These EC<sub>50</sub> values are substantially lower than those from earlier TUDB tests, demonstrating the high detection sensitivity of the current TUDB tests. Moreover, the present TUDB tests attained very low coefficient of variation (CV) values (1.6-6.3%) for the EC<sub>50</sub>, showing favorable reproducibility of the test methodology. In addition, the current TUDB toxicity tests offer numerous advantages for ecotoxicity assessment, including versatility for diverse test samples, no requirement for advanced equipment, and no distortion of end-point measurement. These refinements render the TUDB tests a favorable ecotoxicity assessment with enhanced sensitivity and reproducibility.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial-Temporal Characteristics, Source Apportionment, and Health Risks of Atmospheric Volatile Organic Compounds in China: A Comprehensive Review. 中国大气挥发性有机化合物的时空特征、来源分配和健康风险:全面综述》。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-29 DOI: 10.3390/toxics12110787
Yangbing Wei, Xuexue Jing, Yaping Chen, Wenxin Sun, Yuzhe Zhang, Rencheng Zhu
{"title":"Spatial-Temporal Characteristics, Source Apportionment, and Health Risks of Atmospheric Volatile Organic Compounds in China: A Comprehensive Review.","authors":"Yangbing Wei, Xuexue Jing, Yaping Chen, Wenxin Sun, Yuzhe Zhang, Rencheng Zhu","doi":"10.3390/toxics12110787","DOIUrl":"10.3390/toxics12110787","url":null,"abstract":"<p><p>Volatile organic compounds (VOCs) are ubiquitous in the atmosphere, posing significant adverse impacts on air quality and human health. However, current research on atmospheric VOCs mainly focuses on specific regions or industries, without comprehensive national-level analysis. In this study, a total of 99 articles on atmospheric VOCs in China published from 2015 to 2024 were screened, and data on their concentrations, source apportionment, and health risks were extracted and summarized. The results revealed that the annual average concentrations of TVOCs and their groups in China generally increased and then decreased between 2011 and 2022, peaking in 2018-2019. A distinct seasonal pattern was observed, with the highest concentrations occurring in winter, followed by autumn, spring, and summer. TVOC emissions were highly concentrated in northern and eastern China, mainly contributed by alkanes and alkenes. Source apportionment of VOCs indicated that vehicle sources (32.9% ± 14.3%), industrial emissions (18.0% ± 12.8%), and other combustion sources (13.0% ± 13.0%) were the primary sources of VOCs in China. There was a significant positive correlation (<i>p</i> < 0.05) between the annual mean VOC concentration and population size, and a notable negative correlation (<i>p</i> < 0.05) with GDP per capita. Atmospheric VOCs had no non-carcinogenic risk (HI = 0.5) but exhibited a probable carcinogenic risk (7.5 × 10<sup>-5</sup>), with relatively high values for 1,2-dibromoethane, 1,2-dichloroethane, and naphthalene. The health risk was predominantly driven by halocarbons. These findings are essential for a better understanding of atmospheric VOCs and for developing more targeted VOC control measures.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Four Machine Learning Methods to Analyze the Association Between Polycyclic Aromatic Hydrocarbons and Visual Impairment in American Adults: Evidence from NHANES. 使用四种机器学习方法分析多环芳烃与美国成年人视力损伤之间的关联:来自 NHANES 的证据。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-29 DOI: 10.3390/toxics12110789
Xiaowei Zang, Wei Zhou, Hengguo Zhang, Xiaodong Zang
{"title":"Using Four Machine Learning Methods to Analyze the Association Between Polycyclic Aromatic Hydrocarbons and Visual Impairment in American Adults: Evidence from NHANES.","authors":"Xiaowei Zang, Wei Zhou, Hengguo Zhang, Xiaodong Zang","doi":"10.3390/toxics12110789","DOIUrl":"10.3390/toxics12110789","url":null,"abstract":"<p><p>The causes of visual impairment are complex and may be influenced by exposure to environmental pollutants. Using data from the 2003-2004 National Health and Nutrition Examination Survey (NHANES), we examined the association between exposure to ten polycyclic aromatic hydrocarbons (PAHs) and vision problems in 1149 U.S. adults. We employed various supervised learning methods, including variable selection techniques such as Lasso and elastic net, weighted quantile sum regression (WQS), and Bayesian kernel machine regression (BKMR), to assess the association between PAHs and the occurrence of visual impairments. The mediation effects between urinary 2-fluorene and inflammation were evaluated using mediation analysis. Both the lasso and elastic net models consistently identified two specific PAH congeners, 2-fluorene and 1-phenanthrene, as significant predictors. The WQS regression revealed a positive relationship between the PAH mixture and visual impairment, with notable contributions from urinary 2-fluorene (weight = 0.39) and 9-fluorene (weight = 0.21). BKMR analysis indicated that the likelihood of visual impairment increases with higher PAH exposure, showing a general upward trend. This trend also revealed a positive association between visual impairment and exposure to four specific PAH metabolites, including 2-fluorene. A significant mediation effect was observed for alkaline phosphatase (<i>p</i> = 0.03), with a proportion mediated of 10.48%. Our findings suggest a significant association between PAHs and visual impairment, with multiple statistical models consistently emphasizing the crucial role of 2-fluorene exposure. This study highlights the importance of considering environmental pollutants as significant contributors to visual health outcomes, providing insights for preventing visual impairment.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"12 11","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Environmental Impact of Municipal Waste on Energy Incineration Technology for Power Generation Using Life Cycle Assessment Methodology. 利用生命周期评估方法评估城市垃圾焚烧发电技术对环境的影响。
IF 3.9 3区 环境科学与生态学
Toxics Pub Date : 2024-10-29 DOI: 10.3390/toxics12110786
Yiting Luo, Mingqiang Ye, Yihui Zhou, Rongkui Su, Shunhong Huang, Hangqing Wang, Xiangrong Dai
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