Surgical Case Reports最新文献

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Intraoperative indocyanine green fluorescence for precise resection of nonocclusive mesenteric ischemia: a case report and diagnostic considerations based on pathology findings. 术中吲哚菁绿荧光精确切除非闭塞性肠系膜缺血:病例报告和基于病理结果的诊断考虑。
IF 0.7
Surgical Case Reports Pub Date : 2024-10-04 DOI: 10.1186/s40792-024-02024-3
Akihito Mizukami, Shinji Furuya, Koichi Takiguchi, Kensuke Shiraishi, Yuki Nakata, Hidenori Akaike, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa
{"title":"Intraoperative indocyanine green fluorescence for precise resection of nonocclusive mesenteric ischemia: a case report and diagnostic considerations based on pathology findings.","authors":"Akihito Mizukami, Shinji Furuya, Koichi Takiguchi, Kensuke Shiraishi, Yuki Nakata, Hidenori Akaike, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa","doi":"10.1186/s40792-024-02024-3","DOIUrl":"10.1186/s40792-024-02024-3","url":null,"abstract":"<p><strong>Background: </strong>Nonocclusive mesenteric ischemia (NOMI) is characterized by intestinal ischemia caused by spasms in the peripheral intestinal vessels without organic obstruction in the main mesenteric vessels. NOMI can be fatal in case of delayed diagnosis and treatment. Although the use of indocyanine green (ICG) fluorescence in assessing intestinal viability during NOMI surgery is well recognized, there is a paucity of reported cases using this technique. Herein, we present a case of NOMI that was successfully managed through accurate diagnosis and resection of the ischemic intestines guided by ICG fluorescence.</p><p><strong>Case presentation: </strong>An 81-year-old man presented with abdominal pain. Contrast-enhanced computed tomography revealed intrahepatic portal vein gas, superior mesenteric vein gas, and terminal ileal edema. Considering these findings, the patient was diagnosed with NOMI and emergency surgery was performed. Intestinal edema was observed 30 cm upstream of the terminal ileum without serosal discoloration. ICG fluorescence revealed areas of normal perfusion as well as mild and moderate hypoperfusion. The small bowel, including the hypoperfusion area, was resected. As no clinical signs of residual bowel ischemia were observed during the postoperative course, a second-look operation was deemed unnecessary. Intraoperative ICG fluorescence and histopathological findings indicated mucosal edema in the mildly hypoperfused area and mucosal necrosis in the moderately hypoperfused area.</p><p><strong>Conclusions: </strong>This case highlights the use of intraoperative ICG fluorescence in the disease. ICG fluorescence is invaluable in assessing the extent of bowel ischemia and guiding precise resection. Thus, future efforts should focus on identifying accumulation of cases and quantification of ICG fluorescence intensity to further improve diagnostic performance.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"230"},"PeriodicalIF":0.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive enteric necrosis caused by histiocytic sarcoma embolism: a case report. 组织细胞肉瘤栓塞引起的大面积肠坏死:病例报告。
IF 0.7
Surgical Case Reports Pub Date : 2024-10-04 DOI: 10.1186/s40792-024-02031-4
Yoshitaka Imoto, Masato Yamadera, Hiroki Ohno, Koichi Okamoto, Yoshiki Kajiwara, Yoji Kishi, Hideyuki Shimazaki, Susumu Matsukuma, Hideki Ueno
{"title":"Massive enteric necrosis caused by histiocytic sarcoma embolism: a case report.","authors":"Yoshitaka Imoto, Masato Yamadera, Hiroki Ohno, Koichi Okamoto, Yoshiki Kajiwara, Yoji Kishi, Hideyuki Shimazaki, Susumu Matsukuma, Hideki Ueno","doi":"10.1186/s40792-024-02031-4","DOIUrl":"10.1186/s40792-024-02031-4","url":null,"abstract":"<p><strong>Background: </strong>Histiocytic sarcoma (HS) is a rare disease characterized by the presence of neoplastic histiocytes. We herein report an unusual case of HS that caused massive tumor embolism-related transmural necrosis of the small intestine.</p><p><strong>Case presentation: </strong>A 64-year-old man presented with multiple nodules in the lungs, bone, mediastinum, and subcutaneous tissues that were incidentally detected on preoperative computed tomography for early transverse colon cancer. Approximately two months later, the patient presented with signs of peritoneal irritation suggestive of small intestinal necrosis. Emergency surgery was performed and the necrotic small intestine was resected. Pathological examination revealed small bowel necrosis due to multifocal HS embolism. The postoperative course was uneventful. The patient was unsuccessfully treated with chemotherapy for HS and died 122 days postoperatively.</p><p><strong>Conclusions: </strong>HS can cause massive enteric necrosis due to tumor embolism. Clinicians should be aware of this rare presentation of HS.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"228"},"PeriodicalIF":0.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic endoscopic cooperative surgery for gastric subepithelial lesion during laparoscopic sleeve gastrectomy for severe obesity. 腹腔镜袖状胃切除术治疗重度肥胖时的胃上皮下病变的腹腔镜内镜合作手术。
IF 0.7
Surgical Case Reports Pub Date : 2024-09-26 DOI: 10.1186/s40792-024-02027-0
Takumi Miwa, Yuji Ishibashi, Fumihiko Hatao, Kohei Shimoji, Kazuhiro Imamura, Yasuhiro Morita
{"title":"Laparoscopic endoscopic cooperative surgery for gastric subepithelial lesion during laparoscopic sleeve gastrectomy for severe obesity.","authors":"Takumi Miwa, Yuji Ishibashi, Fumihiko Hatao, Kohei Shimoji, Kazuhiro Imamura, Yasuhiro Morita","doi":"10.1186/s40792-024-02027-0","DOIUrl":"https://doi.org/10.1186/s40792-024-02027-0","url":null,"abstract":"<p><strong>Background: </strong>The frequency of pathologies detected incidentally before, during, and after a bariatric surgery, such as subepithelial lesion (SEL) of the stomach, is likely to rise as bariatric surgery becomes more common.</p><p><strong>Case presentation: </strong>A 49-year-old female patient presented with severe obesity, for which laparoscopic sleeve gastrectomy (LSG) was planned. During a preoperative examination, endoscopy revealed a 10 mm SEL in the posterior wall of the upper body of the stomach. Excision of the SEL was performed simultaneously with the LSG. Endoscopy demonstrated that the SEL was situated on the remnant side of the stomach. Endoscopic resection using laparoscopic endoscopic cooperative surgery was performed for the SEL, and the thinned gastric wall was closed by hand-sewing. Thereafter, LSG was performed. Pathological analysis of the SEL led to a diagnosis of leiomyoma. The patient was discharged on postoperative day 6.</p><p><strong>Conclusion: </strong>Surgeons should be prepared to manage incidentally detected pathologies before, during, and after bariatric surgery and to choose the surgical method most suitable to the individual patient.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"223"},"PeriodicalIF":0.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resected intramuscular hemangioma in the chest wall: a case report. 胸壁肌肉内血管瘤切除术:病例报告。
IF 0.7
Surgical Case Reports Pub Date : 2024-09-26 DOI: 10.1186/s40792-024-02023-4
Yoshiyuki Nakanishi, Takaki Akamine, Fumihiko Kinoshita, Mikihiro Kohno, Keigo Ozono, Takuya Hino, Taro Mori, Yoshinao Oda, Tomoyoshi Takenaka, Masafumi Nakamura
{"title":"Resected intramuscular hemangioma in the chest wall: a case report.","authors":"Yoshiyuki Nakanishi, Takaki Akamine, Fumihiko Kinoshita, Mikihiro Kohno, Keigo Ozono, Takuya Hino, Taro Mori, Yoshinao Oda, Tomoyoshi Takenaka, Masafumi Nakamura","doi":"10.1186/s40792-024-02023-4","DOIUrl":"https://doi.org/10.1186/s40792-024-02023-4","url":null,"abstract":"<p><strong>Background: </strong>Intramuscular hemangioma is an uncommon benign tumor found mainly in the limbs of adolescents and young adults. The local recurrence rate is high, ranging from 30 to 50%, necessitating wide local excision of intercostal intramuscular hemangiomas. However, preoperative diagnosis of intramuscular hemangiomas is challenging. Herein, we report a rare case of an intramuscular hemangioma arising from the chest wall.</p><p><strong>Case presentation: </strong>A healthy 29-year-old asymptomatic man was referred to our hospital after an abnormal shadow was observed on his chest radiography. Computed tomography and magnetic resonance imaging revealed a 30-mm-sized mass in the right second intercostal space. Neoplastic lesions, such as schwannomas or solitary fibrous tumors, were included in the preoperative differential diagnosis. Tumor resection was performed using video-assisted thoracoscopic surgery. The tumor, which had a smooth surface covered with parietal pleura, was dissected from the external intercostal muscle and costal bone. Postoperative histopathological examination revealed proliferation of spindle-shaped endothelial cells arranged in a capillary vascular structure accompanied by entrapped smooth muscle fibers, adipose tissue, and muscle vessels. The final diagnosis was an intramuscular hemangioma with negative surgical margins. There was no evidence of recurrence during the 1-year postoperative follow-up period.</p><p><strong>Conclusion: </strong>Intramuscular hemangiomas should be considered in the differential diagnosis of chest wall tumors, particularly in young people, owing to their potential for recurrence. Moreover, postoperative follow-up may be necessary for resected intramuscular intercostal hemangiomas.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"225"},"PeriodicalIF":0.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of isolated malrotation without midgut volvulus diagnosed prenatally and treated by laparoscopic surgery. 一例产前确诊的孤立性肠道旋转不良,但无中肠翻卷,经腹腔镜手术治疗。
IF 0.7
Surgical Case Reports Pub Date : 2024-09-26 DOI: 10.1186/s40792-024-02029-y
Kosuke Endo, Hiroaki Fukuzawa, Yumi Mizoue, Atsushi Higashio, Mari Sonoda, Tamaki Iwade, Masahito Sato
{"title":"A case of isolated malrotation without midgut volvulus diagnosed prenatally and treated by laparoscopic surgery.","authors":"Kosuke Endo, Hiroaki Fukuzawa, Yumi Mizoue, Atsushi Higashio, Mari Sonoda, Tamaki Iwade, Masahito Sato","doi":"10.1186/s40792-024-02029-y","DOIUrl":"https://doi.org/10.1186/s40792-024-02029-y","url":null,"abstract":"<p><strong>Background: </strong>Malrotation is a congenital condition that predisposes individuals to midgut volvulus, which can result in significant bowel resection. While most cases of malrotation are diagnosed by the age of 1 year, typically presenting with symptoms related to volvulus or bowel obstruction, some cases remain asymptomatic. In children with visceral malposition, gastroschisis, omphalocele, or diaphragmatic hernia, malrotation may be suspected before symptoms manifest. However, isolated malrotation without midgut volvulus diagnosed prenatally is rare. We herein present a case of isolated malrotation without midgut volvulus that was prenatally diagnosed and successfully treated with laparoscopic surgery.</p><p><strong>Case presentation: </strong>A 30-year-old woman (gravida 3, para 1) underwent routine obstetric ultrasound, which revealed increased blood flow in the lower uterine segment and abnormal placental attachment. To rule out placenta percreta, magnetic resonance imaging was performed at 34 weeks of gestation. Incidentally, abnormal fetal intestinal arrangement was noted, with the colon localized in the left hemi-abdomen and the small intestine distributed in the right hemi-abdomen, raising suspicion of malrotation. Postnatal contrast studies confirmed the diagnosis of malrotation without midgut volvulus. Given the risk of midgut volvulus, a laparoscopic Ladd's procedure was performed on day 6 of life. The postoperative course was uneventful, and the patient was still symptom-free 1 year postoperatively.</p><p><strong>Conclusions: </strong>This case illustrates that malrotation can be prenatally diagnosed using fetal magnetic resonance imaging. Considering the risk of midgut volvulus, prophylactic Ladd's procedure should be performed in neonatal period. In cases where malrotation is not complicated by midgut volvulus, a laparoscopic Ladd procedure can be safely performed in neonates.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"226"},"PeriodicalIF":0.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectum necrosis in a patient with severe COVID19 infection after CAR-T therapy: a case report. CAR-T疗法后一名COVID19严重感染患者的直肠坏死:病例报告。
IF 0.7
Surgical Case Reports Pub Date : 2024-09-26 DOI: 10.1186/s40792-024-02026-1
Kiyoshi Saeki, Hidenobu Nakagama, Yuichi Tanaka, Yoshitaka Goto, Kazuhisa Kaneshiro, Hiroshi Kono, Kosuke Yanai, Hirofumi Yamamoto, Reiko Yoneda, Takashi Shimakawa, Takashi Ueki
{"title":"Rectum necrosis in a patient with severe COVID19 infection after CAR-T therapy: a case report.","authors":"Kiyoshi Saeki, Hidenobu Nakagama, Yuichi Tanaka, Yoshitaka Goto, Kazuhisa Kaneshiro, Hiroshi Kono, Kosuke Yanai, Hirofumi Yamamoto, Reiko Yoneda, Takashi Shimakawa, Takashi Ueki","doi":"10.1186/s40792-024-02026-1","DOIUrl":"https://doi.org/10.1186/s40792-024-02026-1","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID19) can cause gastrointestinal complications as well as respiratory tract disease. Coagulation abnormalities and thrombosis frequently occur in COVID19, especially in cases with severe clinical outcome. The relationship between gastrointestinal perforation and coagulopathy due to COVID19 remains unclear.</p><p><strong>Case presentation: </strong>A 49-year-old female received Chimeric antigen receptor T (CAR-T) therapy for an early recurrence of diffuse large B-cell lymphoma (DLBCL) that was refractory to chemotherapy. She was diagnosed with cytokine release syndrome (CRS) because of a fever and oxygen desaturation, and administered tocilizumab. Forty days after completing CAR-T therapy, she was infected with COVID19 and transferred to our hospital. Her general condition worsened and she developed COVID19 pneumonia, and then steroid pulse therapy was started. While her respiratory condition improved, she experienced pain in the anal region and computed tomography (CT) revealed a rectal perforation. An emergency surgery was undertaken, and the lower rectum wall was found to be completely necrotic. Removal of the necrotic part of the rectum tissue, and drainage and lavage of necrotic tissue in the pelvic cavity were performed. The remaining rectum was resected with partial sigmoidectomy, but we could not make the anal stump closed. In addition, an end colostomy in the sigmoid colon was performed. Histopathological findings showed thromboses in the rectal mesentery veins. After the first surgery, the pelvic abscess cavity persisted and her high-grade fever continued. Reoperation was laparoscopically performed, and she underwent a resection of anal canal with residual necrotic rectal and mesorectal tissue, and a drainage of the pelvic abscess. After the reoperation, her general condition improved and CT showed that the abscess cavity had significantly improved.</p><p><strong>Conclusions: </strong>Gastrointestinal perforation, especially rectal necrosis due to coagulopathy caused by severe COVID19 infection, is a rare but life-threatening complication. Physicians should have a high degree of clinical suspicion for timely diagnosis and management, and surgical intervention is necessary in cases of rectal necrosis.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"227"},"PeriodicalIF":0.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An extremely rare case of thymic squamous cell carcinoma complicated with B3 thymoma and myasthenia gravis: a case report. 一例极为罕见的胸腺鳞状细胞癌并发 B3 胸腺瘤和重症肌无力:病例报告。
IF 0.7
Surgical Case Reports Pub Date : 2024-09-26 DOI: 10.1186/s40792-024-02025-2
Maiko Atari, Hideki Kawai, Takuo Tokairin
{"title":"An extremely rare case of thymic squamous cell carcinoma complicated with B3 thymoma and myasthenia gravis: a case report.","authors":"Maiko Atari, Hideki Kawai, Takuo Tokairin","doi":"10.1186/s40792-024-02025-2","DOIUrl":"https://doi.org/10.1186/s40792-024-02025-2","url":null,"abstract":"<p><strong>Background: </strong>Thymomas complicated with myasthenia gravis are conventionally treated during thoracic surgery. Particularly, invasive thymomas are resected alongside the surrounding organs. Here, we present a case where surgical and perioperative management was performed under the presumption of thymoma with myasthenia gravis. However, definitive pathology revealed the co-occurrence of B3 thymoma and thymic squamous cell carcinoma. This case highlights the unique presentation and exceptional rarity of thymomas that are complicated by myasthenia gravis and thymic carcinoma.</p><p><strong>Case presentation: </strong>A 65-year-old female presented with eyelid ptosis at our hospital. Following a comprehensive examination, the patient was diagnosed with myasthenia gravis. Her computed tomography (CT) scan revealed an anterior mediastinal tumor suggestive of a thymoma, prompting a referral to the Department of Thoracic Surgery. Moreover, preoperative assessment could not definitively exclude pericardial invasion. She subsequently underwent an extended thymectomy via a longitudinal sternal incision. The tumor exhibited partial invasion of the pericardium, necessitating resection and reconstruction. Definitive pathological examination confirmed the co-occurrence of B3 thymoma and thymic squamous cell carcinoma. Positive lymph node metastasis classified the patient as stage IVa according to the Union for International Cancer Control (UICC) TNM Classification of Malignant Tumors, 8th Edition, and she was started on adjuvant radiotherapy postoperatively. Currently, the patient remains under observation, with follow-up CT scans showing no signs of recurrence.</p><p><strong>Conclusions: </strong>This report describes an extremely rare case of thymoma complicated with myasthenia gravis and thymic squamous cell carcinoma.</p>","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"10 1","pages":"224"},"PeriodicalIF":0.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stage IV gastric cancer with microsatellite instability–high achieving long-term survival by gastrectomy after nivolumab as third-line therapy: a case report and literature review 微卫星不稳定的IV期胃癌--尼妥珠单抗作为三线疗法后通过胃切除术获得长期生存:病例报告和文献综述
IF 0.8
Surgical Case Reports Pub Date : 2024-09-19 DOI: 10.1186/s40792-024-02022-5
Hideki Kumagai, Shigeaki Baba, Haruka Nikai, Ryosuke Fujisawa, Misato Shimooki, Akira Sasaki
{"title":"Stage IV gastric cancer with microsatellite instability–high achieving long-term survival by gastrectomy after nivolumab as third-line therapy: a case report and literature review","authors":"Hideki Kumagai, Shigeaki Baba, Haruka Nikai, Ryosuke Fujisawa, Misato Shimooki, Akira Sasaki","doi":"10.1186/s40792-024-02022-5","DOIUrl":"https://doi.org/10.1186/s40792-024-02022-5","url":null,"abstract":"The prognosis for stage IV gastric cancer remains poor; however, the advent of immune checkpoint inhibitors (ICIs) such as nivolumab has increased the number of patients with long-term survival. Patients with microsatellite instability (MSI)–high gastric cancer have been recognized as a highly effective population for ICIs. Herein, we report a patient with MSI–high advanced gastric cancer treated with gastrectomy after the administration of nivolumab as third-line therapy. A 73-year-old woman presented with a type 3 tumor in the lower part of the gastric body, which was diagnosed as gastric cancer through biopsy. Staging laparoscopy revealed that the tumor had invaded the pancreas and the posterior lobe of the transverse mesocolon, and disseminated nodules were found near the ligament of Treitz. After 4 courses of S-1 plus cisplatin therapy, laparoscopic gastrojejunal bypass was performed because of difficulty in oral intake. She received S-1 plus oxaliplatin therapy after a gastrojejunal bypass; however, her regional lymph nodes were enlarged. After six courses of paclitaxel plus ramucirumab as second-line chemotherapy, computed tomography (CT) showed exacerbation of peritoneal dissemination; thus, nivolumab was selected as the third-line therapy. The tumor was characterized by MSI–high. At 24 courses, CT and gastroscopy revealed a complete clinical response of the tumor; however, re-growth of the primary tumor was observed at 36 courses. The patient underwent distal gastrectomy with D1 + lymph node dissection, and received S-1 monotherapy as adjuvant therapy for 1 year. No recurrence was noted at 39 months after the surgery. We report a patient with highly advanced gastric cancer with peritoneal dissemination, which worsened during second-line therapy and was successfully treated with gastrectomy after nivolumab administration as a third-line therapy. MSI–high gastric cancer is a target that should be actively considered for the administration of ICIs, such as nivolumab, and multidisciplinary treatment combined with chemotherapy and gastrectomy, including conversion surgery, can lead to patients’ long-term survival.","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"64 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful outcome achieved with adjuvant chemotherapy with irinotecan plus cisplatin in rectal neuroendocrine carcinoma: a case report 直肠神经内分泌癌辅助化疗伊立替康加顺铂取得成功:病例报告
IF 0.8
Surgical Case Reports Pub Date : 2024-09-19 DOI: 10.1186/s40792-024-02010-9
Yoshitaka Saegusa, Shintaro Akabane, Manabu Shimomura, Hiroshi Okuda, Takuya Yano, Tetsuya Mochizuki, Wako Inoue, Mizuki Yamaguchi, Shinji Yamaguchi, Kazuhiro Sentani, Masami Yamauchi, Kentaro Tokumo, Hideki Ohdan
{"title":"Successful outcome achieved with adjuvant chemotherapy with irinotecan plus cisplatin in rectal neuroendocrine carcinoma: a case report","authors":"Yoshitaka Saegusa, Shintaro Akabane, Manabu Shimomura, Hiroshi Okuda, Takuya Yano, Tetsuya Mochizuki, Wako Inoue, Mizuki Yamaguchi, Shinji Yamaguchi, Kazuhiro Sentani, Masami Yamauchi, Kentaro Tokumo, Hideki Ohdan","doi":"10.1186/s40792-024-02010-9","DOIUrl":"https://doi.org/10.1186/s40792-024-02010-9","url":null,"abstract":"Rectal neuroendocrine carcinomas (NECs) are rare and associated with poorer prognoses compared to conventional adenocarcinomas. The efficacy of adjuvant chemotherapy for resectable rectal NECs remains uncertain. Herein, we present a case of rectal NEC successfully treated with postoperative chemotherapy using irinotecan plus cisplatin. A 48-year-old woman with a history of endometrial cancer presented with an intramural rectal tumour detected on follow-up imaging. Colonoscopy revealed a 30 mm submucosal tumour, and laparoscopic low anterior resection was performed. Histopathological examination showed poorly differentiated atypical cells with solid growth patterns. Metastasis from the uterine cancer was ruled out due to histological differences between the primary uterine tumour and the rectal lesion, as well as the absence of hormone receptor immunohistochemical expression. Further immunohistochemical analysis revealed diffuse CD56 positivity, a high mitotic rate (> 20/10 high power fields) and a Ki-67 labelling index exceeding 70%. Based on these findings, a diagnosis of rectal NEC, T3N0M0, Stage IIB (UICC 8th edition), was established. Given the aggressive nature of the tumour evidenced by a high Ki-67 labelling index, adjuvant chemotherapy comprising six cycles of irinotecan plus cisplatin was administered to mitigate the risk of recurrence. At the 3-year follow-up, the patient was free of disease recurrence. This case highlights the importance of multidisciplinary surgical interventions followed by adjuvant chemotherapy in managing rectal NECs.","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"19 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant gallbladder cyst with acute cholecystitis: a case report 巨型胆囊囊肿伴急性胆囊炎:病例报告
IF 0.8
Surgical Case Reports Pub Date : 2024-09-19 DOI: 10.1186/s40792-024-02021-6
Takahiro Terashi, Kohjiro Shirabe, Shoichi Inokuchi, Satoshi Tsutsumi, Atsushi Sasaki, Masahiko Ikebe, Toshio Bandoh, Junpei Wada, Shogo Urabe, Tohru Utsunomiya
{"title":"Giant gallbladder cyst with acute cholecystitis: a case report","authors":"Takahiro Terashi, Kohjiro Shirabe, Shoichi Inokuchi, Satoshi Tsutsumi, Atsushi Sasaki, Masahiko Ikebe, Toshio Bandoh, Junpei Wada, Shogo Urabe, Tohru Utsunomiya","doi":"10.1186/s40792-024-02021-6","DOIUrl":"https://doi.org/10.1186/s40792-024-02021-6","url":null,"abstract":"Gallbladder cysts are rare diseases with very few reported cases, and no clinical or histological definition has been established. Furthermore, cases of giant cysts outside the gallbladder wall are extremely rare. We report a rare case of giant gallbladder cyst with acute cholecystitis. An 85-year-old woman with appetite loss and right lower abdominal pain lasting 2 days presented to our hospital. At first, the patient’s abdominal pain was mild to moderate with no fever. Blood tests revealed a white blood cell count of 10,950/mm3, and the C-reactive protein (CRP) level was 14.35 mg/dl. A contrast-enhanced computed tomography (CT) scan of the abdomen revealed a grossly distended gallbladder (14.5 × 14.5 × 8.7 cm) with an incarcerated stone in the cystic duct. The patient was treated by percutaneous transhepatic gallbladder drainage (PTGBD) with 735 ml of drainage fluid. Oral contrast magnetic resonance cholangiopancreatography (MRCP) revealed that gallbladder swelling remained (14.0 × 6.5 cm) 3 days after PTGBD. We performed laparoscopic cholecystectomy 6 days after PTGBD. Because of the severe adhesion around the junction of the cystic and common bile ducts, we performed open cholecystectomy. The resected specimen was 14 × 11 cm in size and consisted of a gallbladder (6 × 7 cm) with a stone (2.4 × 1.8 cm) in the gallbladder and a large cystic lesion (18 × 18 cm) outside the gallbladder wall. The cystic lesion had a wall thickness of 6 to 12 mm and internal septal structures and contained hemorrhagic and necrotic tissue. Histological examination revealed that the specimens showed a mildly swollen gallbladder and a cystic lesion on the outside of the gallbladder wall, adjacent to the gallbladder wall, with wall thickening and inflammation. The cystic lesion suggested gallbladder duplication, gallbladder diverticulum or extension of the Rokitansky-Aschoff sinus (RAS). There was no malignancy. The patient’s postoperative course was uneventful, and she was discharged 5 days after the operation. We present a very rare case of giant gallbladder cyst with acute cholecystitis revealed by cholecystectomy.","PeriodicalId":22096,"journal":{"name":"Surgical Case Reports","volume":"22 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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