Smart Materials in Medicine最新文献_第5页

Antibacterial silk sericin/poly (vinyl alcohol) hydrogel with antifungal property for potential infected large burn wound healing: Systemic evaluation 抗菌丝胶/聚乙烯醇水凝胶具有抗真菌性能，用于潜在感染的大面积烧伤创面愈合:系统评价

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.07.002

Bianza Moise Bakadia , Lallepak Lamboni , Abeer Ahmed Qaed Ahmed , Ruizhu Zheng , Biaou Oscar Ode Boni , Zhijun Shi , Shuyao Song , Tiatou Souho , Biampata Mutu Mukole , Fuyu Qi , Guang Yang

{"title":"Antibacterial silk sericin/poly (vinyl alcohol) hydrogel with antifungal property for potential infected large burn wound healing: Systemic evaluation","authors":"Bianza Moise Bakadia , Lallepak Lamboni , Abeer Ahmed Qaed Ahmed , Ruizhu Zheng , Biaou Oscar Ode Boni , Zhijun Shi , Shuyao Song , Tiatou Souho , Biampata Mutu Mukole , Fuyu Qi , Guang Yang","doi":"10.1016/j.smaim.2022.07.002","DOIUrl":"10.1016/j.smaim.2022.07.002","url":null,"abstract":"<div><p>Hydrogel-based burn wound dressings with excellent antibacterial, antifungal, and mechanical properties are ideal biomaterials to promote infected large burn wound healing. In this study, the hydrogel synthesized by repetitive freezing-thawing consists of poly (vinyl alcohol) (PVA), silk sericin (SS), and azithromycin (AZM), with genipin (GNP) as crosslinker. The FTIR showed that all hydrogel components were successfully blended. The swelling ratio, porosity, cell attachment, and proliferation improved with SS incorporation, while increased PVA content enhanced the mechanical performance of the hydrogel. The inclusion of AZM improved the antimicrobial property of the hydrogel towards <em>Staphylococcus aureus, Pseudomonas aeruginosa</em>, <em>Escherichia coli</em>, and <em>Candida albicans</em>. The hydrogel showed sustained SS and AZM releases as well as cytocompatibility on keratinocytes and fibroblasts. Furthermore, the hydrogel displays skin adhesion ability when freeze-dried. In the in vivo study using an infected mouse full-thickness burn model with a 10% total body surface area, it was shown that burn injury led to increased inflammatory cytokine responses and macroscopic and microscopic alterations in the spleen and liver. The kidneys, on the other hand, revealed neither change. Interestingly, the prepared hydrogel had a better burn wound healing effect than the commercial Tegaderm™ film dressing, minimizing systemic burn effects. Hence, this novel hydrogel is projected to be a promising candidate for accelerated healing of infected burn wounds.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48379945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Immunomodulation-based development engineering for advancing metal soft tissue implants 基于免疫调节的金属软组织植入物开发工程

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.005

Shoucheng Chen , Jiamin Shi , Guangqi Gao , Lv Xie, Yingye Zhang, Zhengjie Shan, Zhuwei Huang, Xinchun Zhang, Zhuofan Chen, Zetao Chen

{"title":"Immunomodulation-based development engineering for advancing metal soft tissue implants","authors":"Shoucheng Chen , Jiamin Shi , Guangqi Gao , Lv Xie, Yingye Zhang, Zhengjie Shan, Zhuwei Huang, Xinchun Zhang, Zhuofan Chen, Zetao Chen","doi":"10.1016/j.smaim.2023.04.005","DOIUrl":"10.1016/j.smaim.2023.04.005","url":null,"abstract":"<div><p>Metal materials have been widely applied clinically due to their superior mechanical properties. However, the integration of metallic implants with surrounding soft tissue remains challenging and may lead to severe infections and failure of treatments. Development of natural exemplar suggests that the establishment of the soft tissue integration around hard surfaces is a complex scenario associated with the coordination of epithelial tissue, connective tissue and immune cells. In addition, the influence of the peri-implant immune microenvironment on soft tissue integration reparative process has received increasing attention. Given that the properties of the metal implant could effectively modulate immune response, it is predictable to regulate the immune microenvironment around metal implants for optimized soft tissue integration. This review firstly compared the establishment of natural biological hard surface-soft tissue integration with metal implants, in which the important role of epithelial tissue, connective tissue and immune cells were emphasized. Furthermore, up-to-date research outcomes in the closely connections between the immune microenvironment and soft tissue integration were discussed and summarized. From the view of natural soft-hard tissue integration development and reparative process, the immunomodulation-based strategy is proposed to manipulate the immune microenvironment for the enhancement of soft tissue-metal implant integration.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49610449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Engineered multifunctional silk fibroin/gelatin hydrogel conduit loaded with miR-29a@ZIF-8 nanoparticles for peripheral nerve regeneration 负载miR-29a@ZIF-8纳米颗粒的工程多功能丝素/明胶水凝胶导管用于周围神经再生

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.02.002

Hao Wang , Hongxia Wan , Qiqi Wang , Ying Ma , Guorui Su , Xiaodong Cao , Huichang Gao

{"title":"Engineered multifunctional silk fibroin/gelatin hydrogel conduit loaded with miR-29a@ZIF-8 nanoparticles for peripheral nerve regeneration","authors":"Hao Wang , Hongxia Wan , Qiqi Wang , Ying Ma , Guorui Su , Xiaodong Cao , Huichang Gao","doi":"10.1016/j.smaim.2023.02.002","DOIUrl":"https://doi.org/10.1016/j.smaim.2023.02.002","url":null,"abstract":"<div><p>Peripheral nerve injury (PNI) is a common surgical disease. In recent years, with the development of tissue engineering materials, nerve guidance conduit (NGC) is expected to replace autologous nerve transplantation and become a new method for the treatment of PNI. In this work, we developed a multifunctional silk fibroin (SF)/gelatin-tyramine (GT) composite hydrogel conduit with flexible adjustable size by using a diffusion-driven cross-linking method. Furthermore, the ZIF-8 nanoparticles loaded with miR-29a (miR-29a@ZIF-8) delivery system was constructed and compounded into SF/GT hydrogel conduit to enhance its bioactivity and neural repair effects through sustained miR-29a release. In vitro cell experiments showed that SF/GT hydrogel conduit could significantly promote the myelination of Schwann cells (SCs), neuronal differentiation and axon extension of PC12 cells. In addition, it was worth mentioning that SF/GT hydrogel conduit could also regulate the immune microenvironment of nerve regeneration by promoting the transformation of macrophages from M1 phenotype to M2 phenotype, indicating a potential application as nerve guidance conduit in peripheral nerve repair.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49716944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Curcumin nano-prodrug induces multi-phase cell cycle arrest in colorectal cancer through suppression of CDKs and specific down-regulation of PLK1 姜黄素纳米前药通过抑制CDKs和特异性下调PLK1诱导结直肠癌多相细胞周期阻滞

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.06.001

Dong Xu , Xingzhi Feng , Yuxin Wan , Lanlan Yang , Qianling Gao , Zihuan Yang , Chang Du

{"title":"Curcumin nano-prodrug induces multi-phase cell cycle arrest in colorectal cancer through suppression of CDKs and specific down-regulation of PLK1","authors":"Dong Xu , Xingzhi Feng , Yuxin Wan , Lanlan Yang , Qianling Gao , Zihuan Yang , Chang Du","doi":"10.1016/j.smaim.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.smaim.2023.06.001","url":null,"abstract":"<div><p>Aberrant activation of cell cycle proteins leads to tumor progression in most cancer types. While 5-fluorouracil (5-Fu)-based chemotherapy remains the first-line treatment strategy for colorectal cancer (CRC), more than 40% of patients with advanced CRC do not benefit from the regimen. Herein, a chemically modified curcumin (mCur) was developed to explore its curative effect on CRC and reveal its potential role in cell cycle regulation. Amphiphilic mCur could self-assemble into positively charged nano-micelles, hence facilitating high cellular uptake and anticancer activity. Multi-phase cell cycle arrest, induced by both mCur and Cur, was first observed in HCT 116 cells. This phenomenon was mainly attributed to the Cur/mCur mediated downregulation of cyclin-dependent kinases (CDKs) and their direct interactions. Moreover, mCur and Cur treatments generated distinct phenotypic signatures. In particular, mCur induced distinct dynamic fluctuations in cell cycle and a relatively higher proportion of cells in the G2/M phase than Cur, and specifically triggered the impaired expression of polo-like kinase 1 (PLK1). An <em>in vivo</em> evaluation using a CRC patient-derived tumor xenograft (PDX) model indicated that mCur exhibited better antitumor effects via more significant downregulation of PLK1 in PLK1<sup>high</sup> PDX, with no obvious systemic toxicity. Collectively, our study revealed a unique multi-phase cell cycle arrest effect of Cur-based antitumor agents and highlighted the potential of mCur as a PLK1-targeted inhibitor for CRC therapy.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Erratum for previously published articles 以前发表的文章的勘误

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.10.001

引用次数: 0

Tumor microenvironment-responsive Zn/Cu nanoparticles for enhanced chemodynamic therapy 肿瘤微环境响应的锌/铜纳米颗粒增强化学动力学治疗

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.11.002

Zhen-Zhen Dong , Chao Yang , Zhiwei Wang , Zhangfeng Zhong , Man-Shing Wong , Hung-Wing Li

{"title":"Tumor microenvironment-responsive Zn/Cu nanoparticles for enhanced chemodynamic therapy","authors":"Zhen-Zhen Dong , Chao Yang , Zhiwei Wang , Zhangfeng Zhong , Man-Shing Wong , Hung-Wing Li","doi":"10.1016/j.smaim.2022.11.002","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.11.002","url":null,"abstract":"<div><p>Chemodynamic therapy (CDT) has emerged as an effective and safe anticancer therapeutic strategy by catalytic generation of hydroxyl radicals via Fenton chemistry to kill notorious cancer cells. Herein, we decorated the Cu-based nanoparticles with pH-responsive ZnO nanoparticles to give new Zn/Cu nanoparticles (Zn/Cu NPs) which showed good biocompatibility and stability for enhanced therapeutic efficacy of CDT. The newly developed Zn/Cu NPs had a small size of ∼20 nm, which could prolong blood circulation time of NPs and facilitate their accumulation in tumor tissues. The mode of therapeutic mechanism was experimentally verified. Upon arriving at the acidic cancer cells, ZnO on Zn/Cu NPs dissolved leading to the release of Cu<sup>2+</sup> ions which were then reduced by the overexpressed glutathione (GSH), yielding Cu<sup>+</sup> ions. The presence of Cu<sup>+</sup> ions favorably catalyzed the conversion of endogenous H<sub>2</sub>O<sub>2</sub> into hydroxyl radicals by Fenton-like reactions. Such generated ROS would cause serious oxidative damage to cellular constituents resulting in cell death. Importantly, as the Zn/Cu NPs are pH sensitive, they exhibited much higher cytotoxicity against tumor cells than normal cells. <em>In vivo</em> studies also demonstrated that Zn/Cu NPs could effectively inhibit tumor growth without adverse side effects. Therefore, these Zn/Cu NPs hold great potential for direct and effective tumor therapy for personalized medicine applications.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49735161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances of multifunctional hydrogels for periodontal disease 牙周病多功能水凝胶的研究进展

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.02.001

Yihung Lee , Yifan Gou , Xun Pan , Zhipeng Gu , Huixu Xie

引用次数: 5

A pH/temperature responsive nanocomposite for chemo-photothermal synergistic cancer therapy 用于化学-光热协同癌症治疗的pH/温度响应纳米复合材料

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.09.004

Rawand A. Mustafa , Meixin Ran , Yonghui Wang , Jiaqi Yan , Yu Zhang , Jessica M. Rosenholm , Hongbo Zhang

{"title":"A pH/temperature responsive nanocomposite for chemo-photothermal synergistic cancer therapy","authors":"Rawand A. Mustafa , Meixin Ran , Yonghui Wang , Jiaqi Yan , Yu Zhang , Jessica M. Rosenholm , Hongbo Zhang","doi":"10.1016/j.smaim.2022.09.004","DOIUrl":"10.1016/j.smaim.2022.09.004","url":null,"abstract":"<div><p>To optimize synergistic breast cancer treatment, a nanocomposite was fabricated with pH-temperature responsive and chemo-photothermal combination therapy. Herein, gold nanorods (AuNRs) are coated with [poly[(N-isopropylacrylamide)-co-(methacrylic acid)] (p(NIPAM-co-MAA)) modified mesoporous silica (MS) for Doxorubicin (DOX) delivery (AuNR@DOX-MS@p(NIPAM-co-MAA)). Upon NIR radiation, the AuNR core induced hyperthermia via generating heat. Simultaneously, the polymer layer collapsed in response to high temperature/low pH, which allowed the triggering of DOX release from the MS shell at the tumor site. With this nanocomposite, nearly zero premature release of DOX at physiological pH/temperature was detected, while effective DOX release was reported at higher temperature/lower pH values. In addition, <em>in vitro</em> studies demonstrated that the nanocomposite has a substantial uptake efficiency of MDA-MB-231 breast cancer cells, with a significant increase in suppressing MDA-MB-231 cell proliferation in response to laser irradiation. The <em>in vivo</em> experiments further verified the high efficiency of the fabricated nanocomposite in accumulating at the tumor site and the good capability in suppressing tumor growth in the mice upon intravenous injection, while exhibiting good biosafety in relation to major organs in the body. Thus, the synthesized nanocomposite could be a potential nanocarrier for breast cancer treatment with synergistic chemo-photothermal therapeutic capability.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44475381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Research hotspots and trends of biodegradable magnesium and its alloys 可生物降解镁及其合金的研究热点和发展趋势

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.01.002

Rui Zan , Sheng Shen , Yuanding Huang , Han Yu , Yaohui Liu , Shi Yang , Bohao Zheng , Zijun Gong , Wenhui Wang , Xiaonong Zhang , Tao Suo , Houbao Liu

{"title":"Research hotspots and trends of biodegradable magnesium and its alloys","authors":"Rui Zan , Sheng Shen , Yuanding Huang , Han Yu , Yaohui Liu , Shi Yang , Bohao Zheng , Zijun Gong , Wenhui Wang , Xiaonong Zhang , Tao Suo , Houbao Liu","doi":"10.1016/j.smaim.2023.01.002","DOIUrl":"10.1016/j.smaim.2023.01.002","url":null,"abstract":"<div><p>With the increasing demand for innovative therapies, biodegradable magnesium has attracted more and more attention, which could avoid secondary surgery and reduce complications. Until now, plenty of researchers take part in the research & development of this field, and many articles have been published every year. However, it is a huge challenge to predict research trends and definite topics for researchers, which could result in low research value, wasted resources and even slowed medical device transformation. Usually, reviews summarize a specific topic, such as alloy elements, coating designs, degradable properties, etc. Deriving key indicators from a large amount of data with the help of statistical analysis, make a historical review, current situation analysis, and future prediction more convincing. Herein, it has been conducted a bibliometric study according to 2669 publications collected from the Web of Science (WOS) database from 2005 to 2021. By analyzing some key factors, including annual publications, keywords, country contributions, authors as well as institutions, the evolution of biodegradable magnesium is objectively studied. The research trends of biodegradable magnesium alloys are corrosion resistance, the influence of microstructural control on mechanical behavior and bio-functions of implants in a chronological manner. The co-occurrence mapping of the countries and authors suggests that current in-depth research and development of magnesium is more emphasis on institutional and international cooperation.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44148398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Journey of smart material from composite to shape memory alloy (SMA), characterization and their applications-A review 智能材料从复合材料到形状记忆合金的历程、表征及其应用综述

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.10.002

Uddeshya Shukla , Kamal Garg

引用次数: 8