Smart Materials in Medicine最新文献

Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.002

Оlga Y. Аntonova, Olga Y. Kochetkova, Maxim Tailakov, Igor L. Kanev

{"title":"Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation","authors":"Оlga Y. Аntonova, Olga Y. Kochetkova, Maxim Tailakov, Igor L. Kanev","doi":"10.1016/j.smaim.2025.02.002","DOIUrl":"10.1016/j.smaim.2025.02.002","url":null,"abstract":"<div><div>The development of approaches and materials that combine several types of stimulatory effects on nerve tissue growth is a promising task for biotechnology. The aim of this work was a comparative study of the influence of intracellularly and extracellularly localized polydopamine-containing materials on the heat-mediated facilitation of neuronal differentiation. Scaffolds made from aligned nylon nanofibers, mimicking the structure of the extracellular matrix, were used as a matrix for immobilizing photothermal nanoparticles. The composite material combines an ultrastructure capable of accelerating and directing the growth of nerve extensions and the ability for controlled thermal remote influence on cell activity under NIR irradiation within the biological transparency range. The materials demonstrated high photostability and biocompatibility without the drawbacks associated with intracellular nanoparticle delivery, such as cytotoxicity and gradual elimination from the body. The immobilization of thermoplasmonic elements on the fibers surface allows for more controlled and manageable heating compared to intracellular introduction of PDA nanoparticles. The fibrous material's ultrastructure directs neurite growth and enhances elongation. Photothermal stimulation further enhances this process by increasing the proportion of cells with longer neurites, thus enhancing neuronal differentiation. Composite nanomaterials can be used for neuromodulation, managing the functional activity of cells, particularly where directed growth is needed, such as in the regeneration of peripheral nerve tissue. This work brings us closer to the creation of smart materials that are biocompatible and easy to manufacture for developing scalable thermal stimulation techniques in regenerative medicine.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 8-22"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles, a promising treatment for gastric cancer

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.01.002

Di Hua , Xiexing Wu , Zebin Wu , Chunyang Fan , Jiale Wang , Wei He , Yongkang Deng , Yao Zhang , Hengxiang Shu , Meng Shen , Dechun Geng , Kai Chen

{"title":"Nanoparticles, a promising treatment for gastric cancer","authors":"Di Hua , Xiexing Wu , Zebin Wu , Chunyang Fan , Jiale Wang , Wei He , Yongkang Deng , Yao Zhang , Hengxiang Shu , Meng Shen , Dechun Geng , Kai Chen","doi":"10.1016/j.smaim.2025.01.002","DOIUrl":"10.1016/j.smaim.2025.01.002","url":null,"abstract":"<div><div>Globally, gastric cancer (GC), as a fatal malignant tumor, remains a significant health challenge. Thus, it is imperative to explore novel treatment strategies. Despite the fact that the survival rate of GC has improved over the past few decades, the median survival for patients with advanced GC is still less than one year. Recently, nanoparticles (NPs), as a potential approach for designing new treatment strategies, such as gold NPs (AuNPs) and metal oxides NPs (MONPs), not only possesses advantages such as multi-functional imaging and high stability, but also can deliver drugs, simultaneously achieve diagnostic and therapeutic effects. With the development and maturation of this technology, an increasing number of nano-drugs have been utilized in the diagnosis and treatment of GC. In this review, we have provided a detailed and separate elaboration on the NPs that play diagnostic, therapeutic and dual-functional roles in GC-related research. We also introduce the clinical research of nanomedicine in GC over the past few decades. Furthermore, we probed into the limitations of contemporary nanomedicine treatments and the future research directions.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 23-55"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bright antimicrobial surfaces based on Schottky interfaces: From light illumination to bacterial charging

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.001

Zubair Ahmed , Zhong Wang , Muhammed Adil , Ijaz Ahmad Bhatti , Huiliang Cao

{"title":"Bright antimicrobial surfaces based on Schottky interfaces: From light illumination to bacterial charging","authors":"Zubair Ahmed , Zhong Wang , Muhammed Adil , Ijaz Ahmad Bhatti , Huiliang Cao","doi":"10.1016/j.smaim.2025.02.001","DOIUrl":"10.1016/j.smaim.2025.02.001","url":null,"abstract":"<div><div>The growing threat of resistant bacterial infections is a global concern. Therefore, it is crucial to discover new antimicrobial agents or alternative mechanisms to address this issue. This article explores the potential of smart antimicrobial surfaces based on Schottky interfaces for mitigating bacterial infections. The article proposes combining the biological features of bacterial cells with the physics of Schottky-Mott theory to describe and explain the disinfection behaviors of Schottky interfaces. The physicochemical properties and associated characterization methods of Schottky interfaces are examined to uncover their smart pathways leading to disinfection. The fabrication of antimicrobial Schottky interfaces is explored, focusing on techniques such as sputtering, evaporation, chemical deposition, and ion implantation. The advantages and challenges of each method are highlighted, along with recent research on their use to create antimicrobial surfaces over different activating procedures, ranging from light adsorption to bacterial charging and capacitive charge storage. Overall, this article provides a comprehensive overview of the knowledge and advancements in smart antimicrobial surfaces based on Schottky interfaces, emphasizing their potential in combating bacterial infections and offering insights into their properties, fabrication, and applications. The article concludes by illuminating the need for additional research to completely understand the dark behaviors of Schottky interfaces against microbes and harness their full potential in smart coating developments.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 67-94"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.003

Haochen Jiang , Xin Fu , Salma Althobaiti , Braeden Pinkerton , Shabnam Arash , Xiaoqing Du , Zhenshan Jia , Fang Yu , Kirk W. Foster , Geoffrey M. Thiele , Troy J. Plumb , Dong Wang

{"title":"A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects","authors":"Haochen Jiang , Xin Fu , Salma Althobaiti , Braeden Pinkerton , Shabnam Arash , Xiaoqing Du , Zhenshan Jia , Fang Yu , Kirk W. Foster , Geoffrey M. Thiele , Troy J. Plumb , Dong Wang","doi":"10.1016/j.smaim.2025.02.003","DOIUrl":"10.1016/j.smaim.2025.02.003","url":null,"abstract":"<div><div>Focal segmental glomerulosclerosis (FSGS) is chronic renal injury characterized by proteinuria and podocyte injury with glomerulus scarring and tubulointerstitial fibrosis. Glucocorticoids (GCs) are the current first-line treatment. Long-term use of GCs, however, is associated with numerous off-target adverse effects. Thus, there is an urgent unmet clinical need for novel FSGS therapies. Recognizing potent efficacy of GCs in managing FSGS, we proposed the use of a polyethylene glycol (PEG)-based nephrotropic dexamethasone (Dex) prodrug (ZSJ-0228 or PEG-Dex) to mitigate the GC side effects. The focus of the present study was to assess the therapeutic efficacy and safety of PEG-Dex in an Adriamycin-induced BALB/c mouse model of FSGS. A single dose of PEG-Dex treatment (35 mg/kg Dex dose equivalent) effectively reduced the proteinuria level, ameliorated FSGS lesions and restored kidney function when compared to the dose equivalent daily Dex treatment and Saline control. Additionally, PEG-Dex treatment also showed a much-improved safety profile than Dex with minimal adverse events detected. Collectively, these data suggest that PEG-Dex may be established as a promising drug candidate for more effective and safe clinical treatment of FSGS.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 56-66"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft bioelectronics for the diagnosis and treatment of heart diseases

Smart Materials in Medicine Pub Date : 2024-12-15 DOI: 10.1016/j.smaim.2024.12.002

Guangbo Ji , Wenjin Li , Yian Su , Tianjiao Cao , Meng Qian , Huan Wang , Qiang Zhao

引用次数: 0

Bioactive matters based on natural product for cardiovascular diseases 基于天然产物的生物活性物质治疗心血管疾病

Smart Materials in Medicine Pub Date : 2024-11-16 DOI: 10.1016/j.smaim.2024.11.001

Linfang Zhong , Xiaoying Tan , Wenhui Yang , Peishan Li , Lianbao Ye , Qi Luo , Honghao Hou

引用次数: 0

Current situation and challenges of polyhydroxyalkanoates-derived nanocarriers for cancer therapy 用于癌症治疗的聚羟基烷酸酯纳米载体的现状与挑战

Smart Materials in Medicine Pub Date : 2024-10-30 DOI: 10.1016/j.smaim.2024.10.004

Xiao-Yun Huang , Zheng-Dong Qi , Jin-Wei Dao , Dai-Xu Wei

{"title":"Current situation and challenges of polyhydroxyalkanoates-derived nanocarriers for cancer therapy","authors":"Xiao-Yun Huang , Zheng-Dong Qi , Jin-Wei Dao , Dai-Xu Wei","doi":"10.1016/j.smaim.2024.10.004","DOIUrl":"10.1016/j.smaim.2024.10.004","url":null,"abstract":"<div><div>The sustained-release system for chemotherapeutic drugs or photosensitizer based on drug-loaded biopolyester nanocarriers can effectively reduce the overall dosage and frequency of administration, thereby mitigating side effects such as immunosuppression and drug resistance caused by prolonged chemotherapy. Compared to polylactic acid (PLA), microorganism-derived polyhydroxyalkanoates (PHAs) exhibits superior biocompatibility and more flexible drug release behavior due to their diverse monomer compositions, slower degradation behavior, and milder acidic degradation products, 3-hydroxybutyric acid (3HB). It explains PHAs are more suitable carriers for chemotherapeutic drugs. In this review, we summarize the current situation of PHA-derived nanocarriers (PHA-NCs) for cancer therapy, including the advantages, preparation methods, and anticancer applications. Furthermore, we also analyzed the current limitations in the application of PHA-NCs for cancer therapy and proposed existing challenges along with strategies for future development. With the rapid advancements in synthetic biology and nanomedicine, we believe that PHA will once again attract significant attention.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"5 4","pages":"Pages 529-541"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobody-as versatile tool emerging in autoimmune diseases 纳米体--自身免疫性疾病中出现的多功能工具

Smart Materials in Medicine Pub Date : 2024-10-18 DOI: 10.1016/j.smaim.2024.10.003

Ling Wang , Ran Luo , Weilang Zhang , Hanyu Jiang , Yongkang Yu , Wenhu Zhou , Fan Zhang , Jian Ma , Lin Mei

引用次数: 0

Bioactive MXene hydrogel promotes structural and functional regeneration of skeletal muscle through improving autophagy and muscle innervation 生物活性 MXene 水凝胶通过改善自噬和肌肉神经支配促进骨骼肌的结构和功能再生

Smart Materials in Medicine Pub Date : 2024-10-12 DOI: 10.1016/j.smaim.2024.10.002

Li Zhou , Haixia Zhuang , Xinyu Ye , Wei Yuan , Kai Wang , Donghan Hu , Xiangya Luo , Qiuyu Zhang

{"title":"Bioactive MXene hydrogel promotes structural and functional regeneration of skeletal muscle through improving autophagy and muscle innervation","authors":"Li Zhou , Haixia Zhuang , Xinyu Ye , Wei Yuan , Kai Wang , Donghan Hu , Xiangya Luo , Qiuyu Zhang","doi":"10.1016/j.smaim.2024.10.002","DOIUrl":"10.1016/j.smaim.2024.10.002","url":null,"abstract":"<div><div>Complete skeletal muscle regeneration after traumatic injuries remains a challenge due to impaired regenerative capability and dysregulated microenvironments. Autophagy plays a crucial role in the muscle regeneration process by regulating myogenic and non-myogenic cells. Herein, we report a bioactive MXene hydrogel (FPGM) capable of upregulating autophagy and increasing muscle innervation to restore skeletal muscle structure and function. FPGM possessed excellent electrical conductivity, tissue adhesive ability and antioxidation, which could eliminate excess reactive oxygen species to reduce oxidative stress and decrease the secretion of pro-inflammatory cytokine. FPGM upregulated the autophagy level of myoblasts and promoted the migration and tube formation of endothelial cells as well as myogenic differentiation with negligible toxicity. FPGM accelerated muscle fiber formation and skeletal muscle regeneration by improving autophagy, which could regulate microenvironment through raising M2 macrophages to alleviate excessive inflammation, facilitating angiogenesis and decreasing fibrous scar tissue formation <em>in vivo</em>. Importantly, FPGM could efficiently restore muscle function by improving muscle innervation, tibialis anterior compound muscle action potential amplitude and neuromuscular conduction. This work demonstrates that bioactive MXene hydrogel should be a promising candidate for complete skeletal muscle regeneration.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"5 4","pages":"Pages 514-528"},"PeriodicalIF":0.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress of smart material in the repair of intervertebral disc degeneration 智能材料在修复椎间盘退变方面的进展

Smart Materials in Medicine Pub Date : 2024-10-09 DOI: 10.1016/j.smaim.2024.10.001

Yisi Liu , Jie Hu , Hao Jiang , Hui He , Liwei Yao , Qianglong Chen , Lijie Wang , Ting Liang , Bin Li , Fengxuan Han

{"title":"Progress of smart material in the repair of intervertebral disc degeneration","authors":"Yisi Liu , Jie Hu , Hao Jiang , Hui He , Liwei Yao , Qianglong Chen , Lijie Wang , Ting Liang , Bin Li , Fengxuan Han","doi":"10.1016/j.smaim.2024.10.001","DOIUrl":"10.1016/j.smaim.2024.10.001","url":null,"abstract":"<div><div>Intervertebral disc degeneration (IVDD) is a prevalent condition leading to back and leg pain as well as chronic disability. It refers to the degeneration of intervertebral disc structure, including the nucleus pulposus, annulus fibrosus, and cartilage endplate. Along with degeneration process, these components can deteriorate, causing pain and functional impairment. To address IVDD, researchers are exploring the use of smart materials as novel therapeutic approaches. This review aims to summarize the application of various stimuli-responsive smart materials (endogenous and exogenous stimuli-responsive materials) in the repair for Intervertebral disc. These smart materials, such as responsive hydrogels, shape-memory polymers, and nanoparticle-based delivery systems, have shown considerable potential in achieving targeted drug delivery and tissue regeneration, and improving clinical outcomes. The ongoing advancement of smart materials towards successful clinical translation holds promise for improving treatment outcomes for IVDD patients, providing more effective and safer therapeutic options.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"5 4","pages":"Pages 488-500"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0