Smart Materials in Medicine最新文献

Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.002

Оlga Y. Аntonova, Olga Y. Kochetkova, Maxim Tailakov, Igor L. Kanev

{"title":"Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation","authors":"Оlga Y. Аntonova, Olga Y. Kochetkova, Maxim Tailakov, Igor L. Kanev","doi":"10.1016/j.smaim.2025.02.002","DOIUrl":"10.1016/j.smaim.2025.02.002","url":null,"abstract":"<div><div>The development of approaches and materials that combine several types of stimulatory effects on nerve tissue growth is a promising task for biotechnology. The aim of this work was a comparative study of the influence of intracellularly and extracellularly localized polydopamine-containing materials on the heat-mediated facilitation of neuronal differentiation. Scaffolds made from aligned nylon nanofibers, mimicking the structure of the extracellular matrix, were used as a matrix for immobilizing photothermal nanoparticles. The composite material combines an ultrastructure capable of accelerating and directing the growth of nerve extensions and the ability for controlled thermal remote influence on cell activity under NIR irradiation within the biological transparency range. The materials demonstrated high photostability and biocompatibility without the drawbacks associated with intracellular nanoparticle delivery, such as cytotoxicity and gradual elimination from the body. The immobilization of thermoplasmonic elements on the fibers surface allows for more controlled and manageable heating compared to intracellular introduction of PDA nanoparticles. The fibrous material's ultrastructure directs neurite growth and enhances elongation. Photothermal stimulation further enhances this process by increasing the proportion of cells with longer neurites, thus enhancing neuronal differentiation. Composite nanomaterials can be used for neuromodulation, managing the functional activity of cells, particularly where directed growth is needed, such as in the regeneration of peripheral nerve tissue. This work brings us closer to the creation of smart materials that are biocompatible and easy to manufacture for developing scalable thermal stimulation techniques in regenerative medicine.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 8-22"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2024.12.003

Songtao Zhang , Ziyi Shao , Yihong Wu , Yongyi Song , Yaxi He , Zongyi Liu , Xiaodong Fu , Leyu Wang

{"title":"The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review","authors":"Songtao Zhang , Ziyi Shao , Yihong Wu , Yongyi Song , Yaxi He , Zongyi Liu , Xiaodong Fu , Leyu Wang","doi":"10.1016/j.smaim.2024.12.003","DOIUrl":"10.1016/j.smaim.2024.12.003","url":null,"abstract":"<div><div>Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence of inflammatory response, leading to the formation of non-contractile and non-conducting fibrotic scar tissue. Thus, it disrupts the mechano-electric coupling system of the heart, negatively influencing the heart function. Recently, the conductive cardiac patches with advantage of reconstructing electrical propagation have been extensively applied for cardiac repair. This review introduces a detailed overview of the recent progress in cardiac electrophysiology-inspired patches for cardiac repair from three parts of the construction and functionality of mechano-electric coupling cardiac patches, the construction and functionality of microstructure of the cardiac patches, the realtime detection based on mechano-electric transformation. Finally, the achievements and future perspective of conductive cardiac patches is discussed from the aspects of biosafety, further exploration of factors affecting mechano-electric coupling in cardiac patches and regulation of detection. It is hopeful to help researchers understand the functional components and development of conductive cardiac patches for cardiac repair, as well as to inspire them to synthesize novel cardiac patches for promoting clinical translation.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 108-119"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in graphene-based composites: A review of the emerging applications in healthcare

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.01.001

Farwa Batool , Saz Muhammad , Rabia Muazzam , Muhammad Waqas , Zia Ullah , Shubham Roy , Yinghe Zhang , Ke Wang , Bing Guo

{"title":"Advancements in graphene-based composites: A review of the emerging applications in healthcare","authors":"Farwa Batool , Saz Muhammad , Rabia Muazzam , Muhammad Waqas , Zia Ullah , Shubham Roy , Yinghe Zhang , Ke Wang , Bing Guo","doi":"10.1016/j.smaim.2025.01.001","DOIUrl":"10.1016/j.smaim.2025.01.001","url":null,"abstract":"<div><div>Graphene and related materials are emerging revolutionary materials due to fascinating stimuli-responsive physiochemical properties having widespread applications in developing advanced nano-systems for detection, diagnostics, and therapeutics in biomedical fields. Various materials like metal nanoparticles, polymers, dyes, drugs, and proteins could be combined yielding graphene-based composite materials (GBCMs) to synergistically fulfill different biomedical requirements. The 2D conjugated structure, easy surface functionalization <em>via</em> covalent or van der Waal interactions, and combination with different components for versatile functionalities altogether contribute to the development of GBCM for healthcare applications. This review specifically focuses on GBCMs and discusses specific material properties relevant to their material applications in healthcare. Furthermore, the synthesis, toxicity, and biocompatibility of these GBCMs, and their interactions with biological materials are thoroughly discussed. Importantly, the recent cutting-edge applications in the field of healthcare, including its role in the development of antibacterial, anti-viral, and photothermal therapies, wound healing, drug delivery, neurodegenerative disease therapy, and biosensing based on GBCMs are well-updated. Additionally, the applications of GBCMs in point-of-care devices, wearable electronics, and tissue engineering are well summarized. We hope this review opens up more possibilities to design more innovative healthcare materials derived from graphene.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 120-138"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2024.12.001

Panyu Zhou , Jiayi Wang , Hongrui Wang , Hao Pan , Hengsong Shi , Yu Fu , Yuan Yuan , Yang Wang , Qi Gan , Changsheng Liu

{"title":"Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration","authors":"Panyu Zhou , Jiayi Wang , Hongrui Wang , Hao Pan , Hengsong Shi , Yu Fu , Yuan Yuan , Yang Wang , Qi Gan , Changsheng Liu","doi":"10.1016/j.smaim.2024.12.001","DOIUrl":"10.1016/j.smaim.2024.12.001","url":null,"abstract":"<div><div>3D printing is regarded as an ideal method for large-scale bone defect repair. A rapid curing rate and strong mechanical properties throughout the product's shelf life are key development goals in 3D-printed bone repair biomaterials. To achieve this goal, we developed a 3D-printable organic/inorganic composite ink featuring rapid curing and highly customizable properties. After 3D printing, the nanocomposite ink of poly (glyceryl sebacate)-2-chlorocinnamoyl chloride/β-tricalcium phosphate (PGS-CC/β-TCP) undergoes short-term light crosslinking to form a biomimetic network of inorganic-organic composite materials. The resulting bone repair scaffold possesses excellent mechanical properties, significantly promotes cell adhesion and proliferation, and demonstrates good <em>in vitro</em> osteogenic activity, angiogenic performance, and mineralization capability. Moreover, the PGS-CC/β-TCP 3D-printed scaffold exhibits good degradation performance, retaining its mechanical properties even after four weeks of degradation. The PGS-CC(1:2)/β-TCP composite scaffold can effectively repair severe cranial bone defects in rats, showing optimal <em>in vivo</em> osteogenic and degradation performance at 6 and 12 weeks. With these advantages, this innovative 3D-printed biomaterial has great clinical application prospects for large segment bone repair and provides new opportunities for other complex reconstructions.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 95-107"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bright antimicrobial surfaces based on Schottky interfaces: From light illumination to bacterial charging

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.001

Zubair Ahmed , Zhong Wang , Muhammed Adil , Ijaz Ahmad Bhatti , Huiliang Cao

{"title":"Bright antimicrobial surfaces based on Schottky interfaces: From light illumination to bacterial charging","authors":"Zubair Ahmed , Zhong Wang , Muhammed Adil , Ijaz Ahmad Bhatti , Huiliang Cao","doi":"10.1016/j.smaim.2025.02.001","DOIUrl":"10.1016/j.smaim.2025.02.001","url":null,"abstract":"<div><div>The growing threat of resistant bacterial infections is a global concern. Therefore, it is crucial to discover new antimicrobial agents or alternative mechanisms to address this issue. This article explores the potential of smart antimicrobial surfaces based on Schottky interfaces for mitigating bacterial infections. The article proposes combining the biological features of bacterial cells with the physics of Schottky-Mott theory to describe and explain the disinfection behaviors of Schottky interfaces. The physicochemical properties and associated characterization methods of Schottky interfaces are examined to uncover their smart pathways leading to disinfection. The fabrication of antimicrobial Schottky interfaces is explored, focusing on techniques such as sputtering, evaporation, chemical deposition, and ion implantation. The advantages and challenges of each method are highlighted, along with recent research on their use to create antimicrobial surfaces over different activating procedures, ranging from light adsorption to bacterial charging and capacitive charge storage. Overall, this article provides a comprehensive overview of the knowledge and advancements in smart antimicrobial surfaces based on Schottky interfaces, emphasizing their potential in combating bacterial infections and offering insights into their properties, fabrication, and applications. The article concludes by illuminating the need for additional research to completely understand the dark behaviors of Schottky interfaces against microbes and harness their full potential in smart coating developments.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 67-94"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles, a promising treatment for gastric cancer

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.01.002

Di Hua , Xiexing Wu , Zebin Wu , Chunyang Fan , Jiale Wang , Wei He , Yongkang Deng , Yao Zhang , Hengxiang Shu , Meng Shen , Dechun Geng , Kai Chen

{"title":"Nanoparticles, a promising treatment for gastric cancer","authors":"Di Hua , Xiexing Wu , Zebin Wu , Chunyang Fan , Jiale Wang , Wei He , Yongkang Deng , Yao Zhang , Hengxiang Shu , Meng Shen , Dechun Geng , Kai Chen","doi":"10.1016/j.smaim.2025.01.002","DOIUrl":"10.1016/j.smaim.2025.01.002","url":null,"abstract":"<div><div>Globally, gastric cancer (GC), as a fatal malignant tumor, remains a significant health challenge. Thus, it is imperative to explore novel treatment strategies. Despite the fact that the survival rate of GC has improved over the past few decades, the median survival for patients with advanced GC is still less than one year. Recently, nanoparticles (NPs), as a potential approach for designing new treatment strategies, such as gold NPs (AuNPs) and metal oxides NPs (MONPs), not only possesses advantages such as multi-functional imaging and high stability, but also can deliver drugs, simultaneously achieve diagnostic and therapeutic effects. With the development and maturation of this technology, an increasing number of nano-drugs have been utilized in the diagnosis and treatment of GC. In this review, we have provided a detailed and separate elaboration on the NPs that play diagnostic, therapeutic and dual-functional roles in GC-related research. We also introduce the clinical research of nanomedicine in GC over the past few decades. Furthermore, we probed into the limitations of contemporary nanomedicine treatments and the future research directions.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 23-55"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects

Smart Materials in Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.003

Haochen Jiang , Xin Fu , Salma Althobaiti , Braeden Pinkerton , Shabnam Arash , Xiaoqing Du , Zhenshan Jia , Fang Yu , Kirk W. Foster , Geoffrey M. Thiele , Troy J. Plumb , Dong Wang

{"title":"A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects","authors":"Haochen Jiang , Xin Fu , Salma Althobaiti , Braeden Pinkerton , Shabnam Arash , Xiaoqing Du , Zhenshan Jia , Fang Yu , Kirk W. Foster , Geoffrey M. Thiele , Troy J. Plumb , Dong Wang","doi":"10.1016/j.smaim.2025.02.003","DOIUrl":"10.1016/j.smaim.2025.02.003","url":null,"abstract":"<div><div>Focal segmental glomerulosclerosis (FSGS) is chronic renal injury characterized by proteinuria and podocyte injury with glomerulus scarring and tubulointerstitial fibrosis. Glucocorticoids (GCs) are the current first-line treatment. Long-term use of GCs, however, is associated with numerous off-target adverse effects. Thus, there is an urgent unmet clinical need for novel FSGS therapies. Recognizing potent efficacy of GCs in managing FSGS, we proposed the use of a polyethylene glycol (PEG)-based nephrotropic dexamethasone (Dex) prodrug (ZSJ-0228 or PEG-Dex) to mitigate the GC side effects. The focus of the present study was to assess the therapeutic efficacy and safety of PEG-Dex in an Adriamycin-induced BALB/c mouse model of FSGS. A single dose of PEG-Dex treatment (35 mg/kg Dex dose equivalent) effectively reduced the proteinuria level, ameliorated FSGS lesions and restored kidney function when compared to the dose equivalent daily Dex treatment and Saline control. Additionally, PEG-Dex treatment also showed a much-improved safety profile than Dex with minimal adverse events detected. Collectively, these data suggest that PEG-Dex may be established as a promising drug candidate for more effective and safe clinical treatment of FSGS.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"6 1","pages":"Pages 56-66"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft bioelectronics for the diagnosis and treatment of heart diseases

Smart Materials in Medicine Pub Date : 2024-12-15 DOI: 10.1016/j.smaim.2024.12.002

Guangbo Ji , Wenjin Li , Yian Su , Tianjiao Cao , Meng Qian , Huan Wang , Qiang Zhao

引用次数: 0

Bioactive matters based on natural product for cardiovascular diseases 基于天然产物的生物活性物质治疗心血管疾病

Smart Materials in Medicine Pub Date : 2024-11-16 DOI: 10.1016/j.smaim.2024.11.001

Linfang Zhong , Xiaoying Tan , Wenhui Yang , Peishan Li , Lianbao Ye , Qi Luo , Honghao Hou

引用次数: 0

Current situation and challenges of polyhydroxyalkanoates-derived nanocarriers for cancer therapy 用于癌症治疗的聚羟基烷酸酯纳米载体的现状与挑战

Smart Materials in Medicine Pub Date : 2024-10-30 DOI: 10.1016/j.smaim.2024.10.004

Xiao-Yun Huang , Zheng-Dong Qi , Jin-Wei Dao , Dai-Xu Wei

{"title":"Current situation and challenges of polyhydroxyalkanoates-derived nanocarriers for cancer therapy","authors":"Xiao-Yun Huang , Zheng-Dong Qi , Jin-Wei Dao , Dai-Xu Wei","doi":"10.1016/j.smaim.2024.10.004","DOIUrl":"10.1016/j.smaim.2024.10.004","url":null,"abstract":"<div><div>The sustained-release system for chemotherapeutic drugs or photosensitizer based on drug-loaded biopolyester nanocarriers can effectively reduce the overall dosage and frequency of administration, thereby mitigating side effects such as immunosuppression and drug resistance caused by prolonged chemotherapy. Compared to polylactic acid (PLA), microorganism-derived polyhydroxyalkanoates (PHAs) exhibits superior biocompatibility and more flexible drug release behavior due to their diverse monomer compositions, slower degradation behavior, and milder acidic degradation products, 3-hydroxybutyric acid (3HB). It explains PHAs are more suitable carriers for chemotherapeutic drugs. In this review, we summarize the current situation of PHA-derived nanocarriers (PHA-NCs) for cancer therapy, including the advantages, preparation methods, and anticancer applications. Furthermore, we also analyzed the current limitations in the application of PHA-NCs for cancer therapy and proposed existing challenges along with strategies for future development. With the rapid advancements in synthetic biology and nanomedicine, we believe that PHA will once again attract significant attention.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"5 4","pages":"Pages 529-541"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0