Advanced oxygen therapeutics for treatments of acute hemorrhagic shock and organ preservation

Q1 Engineering

Smart Materials in Medicine Pub Date : 2025-04-18 DOI:10.1016/j.smaim.2025.04.001

Qinqi Wang , Jiazhen Yang , Meng Sun , Lei Dang , Liana Shestakova , Youry Ostrovsky , Wenliang Li , Leijiao Li , Jianxun Ding

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Abstract

Oxygen (O₂) is vital in respiratory process that maintains biological balance in mammals. O₂ therapeutics treat ischemic tissues by facilitating O₂ transport and alleviating cellular hypoxia. The development of O₂ carriers focuses on their interactions with molecular O₂ to achieve therapeutic effects. This review examines the distinct O₂-carrying mechanisms of hemoglobin-based oxygen carriers (HBOCs) and fluorocarbon-based oxygen carriers (FBOCs), emphasizing their chemical and physical differences. The rational design of O₂ carriers for biomedical applications and recent research advances are discussed, focusing on their therapeutic use in acute hemorrhagic shock and organ preservation. Moreover, this review highlights the need to explore the biomedical mechanisms underlying O₂ therapeutics further, offering insights for improving O₂-carrying capacity and optimizing their applications in medicine.

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先进的氧疗法治疗急性失血性休克和器官保存

氧气在哺乳动物的呼吸过程中起着维持生物平衡的重要作用。氧疗法通过促进氧运输和减轻细胞缺氧来治疗缺血组织。O2载体的发展主要集中在其与O2分子相互作用以达到治疗效果。本文综述了基于血红蛋白的氧载体（HBOCs）和基于碳氟化合物的氧载体（FBOCs）不同的o2携带机制，强调了它们的化学和物理差异。本文讨论了氧载体在生物医学应用中的合理设计及近年来的研究进展，重点介绍了氧载体在急性失血性休克和器官保存中的治疗应用。此外，本文还强调了进一步探索O2治疗药物的生物医学机制的必要性，为提高O2承载能力和优化其在医学中的应用提供了新的见解。

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