Smart Materials in Medicine最新文献_第10页

A study involving PC-3 cancer cells and novel carbamate gemini surfactants: Is zeta potential the key to control adhesion to cells? 一项涉及PC-3癌症细胞和新型氨基甲酸酯双子表面活性剂的研究：ζ电位是控制细胞粘附的关键吗？

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2022-09-12 DOI: 10.1016/j.smaim.2022.09.001

R.V. Pavlov, G.A. Gaynanova, D.M. Kuznetsov, Ya.A. Ivanov, S.K. Amerkhanova, A.P. Lyubina, A.D. Voloshina, L.Ya. Zakharova

{"title":"A study involving PC-3 cancer cells and novel carbamate gemini surfactants: Is zeta potential the key to control adhesion to cells?","authors":"R.V. Pavlov, G.A. Gaynanova, D.M. Kuznetsov, Ya.A. Ivanov, S.K. Amerkhanova, A.P. Lyubina, A.D. Voloshina, L.Ya. Zakharova","doi":"10.1016/j.smaim.2022.09.001","DOIUrl":"10.1016/j.smaim.2022.09.001","url":null,"abstract":"<div><p>Liposome surface potential effect on cellular uptake and cytotoxicity is evaluated using liposomes, modified with cationic lipid DOTAP, a series of cationic gemini surfactants with two carbamate fragments, and an amphiphilic peptide SSRGD. The surfactants used are novel representatives of the gemini family with improved self-assembling activity coupled with potential biodegradable properties and displayed increasing antibacterial activity and cytotoxicity with the shortening of hydrophobic alkyl tails. The longest alkyl tail surfactant, 14-6-14(Et), was the most biocompatible of the series, which was chosen for liposome modification. Prepared liposomes of various compositions are characterized from morphological and physicochemical standpoints in order to optimize their biocompatibility and stability. The carbamate gemini surfactants were also twice as effective at providing positive charge to liposomes and less toxic compared to DOTAP. On their own, carbamate surfactants were able to increase cellular uptake of liposomes by 190%. The mixed composition of 14-6-14(Et) surfactant and SSRGD amphiphilic peptide was the most readily absorbed formulation among different tested neutral, cationic and RGD-modified liposomes. The comparison between the cellular uptake promotion is conducted as to what is the most selective and efficient approach to enhance lipid nanoparticle uptake by cancerous cells.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 123-133"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49657172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Surface properties and bioactivity of PNIPAM-grafted-chitosan/chondroitin multilayers pnipam接枝壳聚糖/软骨素多层膜的表面性质和生物活性

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2022-12-12 DOI: 10.1016/j.smaim.2022.11.008

Yi-Tung Lu , Pei-Tzu Hung , Kui Zeng , Christian Woelk , Bodo Fuhrmann , Kai Zhang , Thomas Groth

{"title":"Surface properties and bioactivity of PNIPAM-grafted-chitosan/chondroitin multilayers","authors":"Yi-Tung Lu , Pei-Tzu Hung , Kui Zeng , Christian Woelk , Bodo Fuhrmann , Kai Zhang , Thomas Groth","doi":"10.1016/j.smaim.2022.11.008","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.11.008","url":null,"abstract":"<div><p>The thermoresponsive poly(<em>N</em>-isopropylacrylamide) (PNIPAM) is widely applied in the biomedical field particularly as thermoresponsive substrate for culture of cells. To be used as a stimuli-responsive coating for cell culture, combining PNIPAM with glycosaminoglycans might be an effective approach to improve its bioactivity. In this study, chitosan is grafted with PNIPAM moieties (PCHI) possessing a cloud point at 31 °C and used as a polycation to fabricate thermoresponsive polyelectrolyte multilayers (PEM) with the bioactive polyanion chondroitin sulfate (CS) at pH 4 by layer-by-layer technique. The <em>in-situ</em> investigation by surface plasmon resonance and quartz crystal microbalance with dissipation monitoring confirms that the formation of PEMs with CS can be achieved despite the bulky structure of PCHI at 25 °C. The stability of the PEMs is further improved at physiological pH 7.4 by chemical crosslinking using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/<em>N</em>-hydroxysuccinimide. Moreover, these PEMs exhibit de-swelling and swelling ability with different surface wettability in response to temperature, which triggers the adsorption and desorption of adhesive protein vitronectin on the PEMs. At 37 °C, the PEMs containing PNIPAM particularly associated with CS terminal layer supports protein adsorption and consequently enhances cell adhesion using multipotent murine stem cells. Overall, due to improved stability, crosslinked PNIPAM-modified biogenic multilayers are cytocompatible and hold great potential as culture substrate for different tissue cells and application in tissue engineering.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 356-367"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49716991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platinum nanoparticles enhance osteogenic differentiation of human dental follicle stem cells via scavenging ROS 铂纳米颗粒通过清除活性氧促进人牙滤泡干细胞成骨分化

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2023-06-10 DOI: 10.1016/j.smaim.2023.06.004

Zheng Wang , Jiaxun Wang , Jiacheng Liu , Yating Zhang , Jingyi Zhang , Ruimeng Yang , Zhaosong Meng , Xiaoqun Gong , Lei Sui

{"title":"Platinum nanoparticles enhance osteogenic differentiation of human dental follicle stem cells via scavenging ROS","authors":"Zheng Wang , Jiaxun Wang , Jiacheng Liu , Yating Zhang , Jingyi Zhang , Ruimeng Yang , Zhaosong Meng , Xiaoqun Gong , Lei Sui","doi":"10.1016/j.smaim.2023.06.004","DOIUrl":"https://doi.org/10.1016/j.smaim.2023.06.004","url":null,"abstract":"<div><p>The over-accumulation of ROS during prolonged <em>in vitro</em> expansion could negatively affect the properties of stem cells. This leads to a reduced capacity for self-renewal and a lower potential for multiple differentiation, ultimately hindering their applicability in regenerative medicine. Herein, we fabricated platinum nanoparticles (PtNPs) as a potential biocompatible antioxidant to efficiently eliminate the ROS accumulation in human dental follicle stem cells (hDFSCs) during <em>in vitro</em> expansion, thereby enhancing hDFSCs proliferation and osteogenic differentiation. Transcriptome analysis revealed that PI3K/AKT signaling pathway was activated in PtNPs-treated hDFSCs. Transplantation of PtNPs-treated rDFSCs could facilitate new bone formation compared to transplantation of PBS or un-treated rDFSCs, leading to efficient regeneration of bone tissue in rat mandibular bone defect models. In conclusion, PtNPs offered a novel antioxidative strategy to improve stem cell properties and stem-cells-based alveolar bone regeneration.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 621-638"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Core-shell nanostructures for improving dental restorative materials: A scoping review of composition, methods, and outcome 改善牙齿修复材料的核壳纳米结构:组成，方法和结果的范围审查

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2022-08-28 DOI: 10.1016/j.smaim.2022.08.002

Lamia Sami Mokeem , Isadora Martini Garcia , Yasmin Shahkarami , Lauren Blum , Abdulrahman A. Balhaddad , Fabrício Mezzomo Collares , Mary Ann Williams , Michael D. Weir , Mary Anne S. Melo

{"title":"Core-shell nanostructures for improving dental restorative materials: A scoping review of composition, methods, and outcome","authors":"Lamia Sami Mokeem , Isadora Martini Garcia , Yasmin Shahkarami , Lauren Blum , Abdulrahman A. Balhaddad , Fabrício Mezzomo Collares , Mary Ann Williams , Michael D. Weir , Mary Anne S. Melo","doi":"10.1016/j.smaim.2022.08.002","DOIUrl":"10.1016/j.smaim.2022.08.002","url":null,"abstract":"<div><p>Dental resin adhesives and composites are the most prevailing dental restorative materials used to treat cavitated tooth decay. These materials are challenged inside the mouth by bacterial acid attack, lack of bioactivity, and the scarcity of alternatives maintaining the mechanical properties over the lifetime service of these materials. Core-shell nanostructures are composed of various materials surrounded by a protective shell. They are acquiring considerable attention as innovative multipurpose carriers that show great potential in restorative dentistry. Herein, we systematically reviewed the recent studies on core-shell nanostructures incorporated into dental resin-based materials, their intended properties, synthesis methods, and assessment tests employed. This study used scoping review method, following Arksey and O'Malley's five stages framework using PubMed and Scopus (Elsevier) databases. From 149 initially identified manuscripts, 20 studies were eligible for full-text screening, and 15 were included for data extraction. The majority of included studies have used resin composite as parental material. Silica oxide was the most prevailing shell incorporated into dental resins. Almost all core-shell nanostructures were added to improve the material's strength and impart antibacterial properties. Designing strategies and drug release behaviors were discussed. In the end, current challenges and prospects in this promising field were highlighted.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 102-110"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42278386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Retraction notice to “Anti-microbial/oxidative/inflammatory nanogels accelerate chronic wound healing” [Smart Mater. Med. 3 (2022) 148–158] “抗菌/氧化/炎症纳米凝胶加速慢性伤口愈合”的撤回通知[Smart Mater.Med.3（2022）148–158]

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2023-05-09 DOI: 10.1016/j.smaim.2023.04.003

Amit Nain , Yu-Ting Tseng , Akash Gupta , Yu-Feng Lin , Arumugam Sangili , Yu-Fen Huang , Chih-Ching Huang , Huan-Tsung Chang

引用次数: 0

Current state of art smart coatings for orthopedic implants: A comprehensive review 骨科植入物智能涂层的现状:综合综述

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.06.005

Mansi Uday Joshi , Shruti Prakash Kulkarni , Mounika Choppadandi , M. Keerthana , Govinda Kapusetti

{"title":"Current state of art smart coatings for orthopedic implants: A comprehensive review","authors":"Mansi Uday Joshi , Shruti Prakash Kulkarni , Mounika Choppadandi , M. Keerthana , Govinda Kapusetti","doi":"10.1016/j.smaim.2023.06.005","DOIUrl":"https://doi.org/10.1016/j.smaim.2023.06.005","url":null,"abstract":"<div><p>Biomaterials play a pivotal role in modern orthopedics. There are a plethora of functional issues with orthopedic implants. These issues include things like aseptic loosening, lack of osseointegration, biofilm formation, and infections. Researchers have devised several surface modification procedures, including coating the implant surfaces, to address these problems. Implant coatings serve as a bridge between the implant and the surrounding bio components. One of the creative methods is to modify surfaces using smart coatings. Smart coatings can detect environmental cues like temperature, pH, light, and so on and in turn react facultatively to the tissues. A particular stimulus and its specific role in orthopedic implant coatings are of our interest. Some coatings, known as dual-acting coatings, allow for the utilization of one or more stimuli in addition to the individual stimulus as a trigger. Based on the stimuli that they react to, we have highlighted the most cutting-edge smart orthopedic implant coatings in the current review.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 661-679"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49716757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Phospholipid-based nanodrill technology for enhanced intracellular delivery of nano-sized cargos 基于磷脂的纳米钻技术用于增强纳米级货物的细胞内递送

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2023-03-11 DOI: 10.1016/j.smaim.2023.03.001

Doyeon Kim , Seung Soo Nam , Hyunbum Jeon , Youngheun Cho , Eunji Sim , Hyuncheol Kim

{"title":"Phospholipid-based nanodrill technology for enhanced intracellular delivery of nano-sized cargos","authors":"Doyeon Kim , Seung Soo Nam , Hyunbum Jeon , Youngheun Cho , Eunji Sim , Hyuncheol Kim","doi":"10.1016/j.smaim.2023.03.001","DOIUrl":"10.1016/j.smaim.2023.03.001","url":null,"abstract":"<div><p>Nanosized drug delivery systems typically enter the cell via endocytosis. However, a significant amount of the endocytosed cargo cannot effectively escape from the endosome, resulting in drug degradation. Therefore, there are several ongoing efforts to develop transmembrane delivery systems that could circumvent endocytosis. In this study, phospholipid nanotube nanodrills (LDs) were formed onto the surface of a human serum albumin nanoparticle via self-assembling phospholipids. The nanodrill technology enhanced the intracellular uptake efficiency of nanoparticles via energy-independent direct cell membrane permeation. The length of the nanodrills according to the DSPE-PEG to DSPC ratio was investigated both experimentally and theoretically. Our findings demonstrated that longer nanodrills were formed on the surface of the nanoparticles as the ratio of DSPC (i.e., a strongly hydrophobic lipid) in the two phospholipids increases. Moreover, the intracellular uptake efficiency increased as the length of phospholipid nanodrills increased. In addition to enhancing intracellular delivery, the phospholipid nanodrills could penetrate the extracellular matrix and enable the introduction of nanoparticles, thus highlighting the promising tissue penetration capacity of phospholipid nanodrill technology. The improved cell permeability of LD technology was demonstrated by effectively inhibiting specific genes via siRNA-based therapeutic delivery. Moreover, this approach enhanced the efficacy of chemotherapeutics against chemo-resistant cancer cells. Therefore, LD technology could be used to deliver genetic materials and chemical-based therapeutics both <em>in vitro</em> and <em>in vivo</em>.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 493-503"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46998912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structurally optimized electrospun scaffold for biomaterial-controlled synergistic enhancement of defective bone healing 结构优化的电纺支架用于生物材料控制的协同增强缺陷骨愈合

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2023-06-02 DOI: 10.1016/j.smaim.2023.05.002

Jeong In Kim , Thi Thu Trang Kieu , Sung-Ho Kook , Jeong-Chae Lee

{"title":"Structurally optimized electrospun scaffold for biomaterial-controlled synergistic enhancement of defective bone healing","authors":"Jeong In Kim , Thi Thu Trang Kieu , Sung-Ho Kook , Jeong-Chae Lee","doi":"10.1016/j.smaim.2023.05.002","DOIUrl":"10.1016/j.smaim.2023.05.002","url":null,"abstract":"<div><p>Bone repair processes are tightly affected by fiber topographies of scaffolds and can be promoted by coupling with chemotactic and/or angiogenic molecules. Here, we developed polycaprolactone (PCL) and collagen-based fibrous scaffolds expressing various architectures via a modified electrospinning set up. We conjugated the as-spun scaffolds with caffeic acid (CA) and/or a cartilage oligomeric matrix protein of angiopoietin 1 (COMP-Ang1). The CA-coupled PCL/collagen scaffold (PCL/col/CA) exhibited greater treatment efficacies for biomimetic and cellular mineralization, expression of osteogenic and chemotactic molecules, and cell migration than did the PCL/col treatment alone. Among the PCL/col/CA scaffolds, the radially symmetric grid-patterned scaffold (rG-PCL/col/CA) showed the greatest bioactivities. The linking of the rG-PCL/col/CA with COMP-Ang1 increased the expression of vascular endothelial growth factor by cells. The COMP-Ang1-linked rG-PCL/col/CA formed more new blood vessels and expressed more chemotactic molecules in a rat model of femoral defects than did the scaffold alone. Compared with PCL/col/CA scaffolds, the COMP-Ang1-coupled rG-PCL/col/CA scaffold stimulated faster and greater healing of femoral defects. Collectively, this study demonstrates that the coupling of a radially grid-patterned fibrous scaffold with CA and COMP-Ang1 greatly enhances scaffold-mediated bone healing via synergistic improvements in vascularization, cell migration, and formation and maturation of new bones in defected regions.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 603-620"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41758349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nanotherapies from an oncologist doctor's view 肿瘤医生眼中的纳米疗法

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2022-08-05 DOI: 10.1016/j.smaim.2022.07.005

Shuangqing Liu, Lijun Li, Xinyu Zhang, Qingwei Meng

引用次数: 1

Towards clinical translation of the cell sheet engineering: Technological aspects 细胞片工程的临床翻译：技术方面

Smart Materials in Medicine Pub Date : 2023-01-01 Epub Date: 2022-09-16 DOI: 10.1016/j.smaim.2022.09.002

Irina M. Zurina , Victoria S. Presniakova , Denis V. Butnaru , Peter S. Timashev , Yury A. Rochev , Xing-Jie Liang

{"title":"Towards clinical translation of the cell sheet engineering: Technological aspects","authors":"Irina M. Zurina , Victoria S. Presniakova , Denis V. Butnaru , Peter S. Timashev , Yury A. Rochev , Xing-Jie Liang","doi":"10.1016/j.smaim.2022.09.002","DOIUrl":"10.1016/j.smaim.2022.09.002","url":null,"abstract":"<div><p>Cell sheet engineering is a rapidly growing field of tissue engineering and regenerative medicine. The ease of cell sheet obtainment techniques and the resulting unique characteristics and microenvironment of these multicellular structures give rise to the wide range of their <em>in vivo</em> application. At the same time, there are also macroscale cell sheet properties such as thickness, shrinkage after detachment due to cytoskeleton relaxation, and resulting mechanical characteristics. The main topic of this review is the discussion of these properties and how they define the need to use special approaches to manipulating cell sheets during stacking several structures, transferring them to surgical sites, or cryopreserving them. We aimed to systematize the existing techniques of cell sheet transferring, and describe their principles, advantages, and drawbacks regarding cell sheet application during surgical procedures on various tissues and organs. Attention is also paid to such aspects and details as cell sheet positioning <em>in vivo</em>, their ability to spontaneous adhesion, and the requirement for additional fixation at particular surgical sites. Finally, the last section of this review covers the subject of cell sheet cryopreservation – the discussion of freezing and thawing protocols, the variety of cryoprotectants and their mixtures, as well as special requirements such as cryoprotectant loading systems, and cell sheet supporting systems that also stem from their unique macroscale characteristics. Altogether, this systematized review of existing technological approaches related to cell sheet application <em>in vivo</em> can be potentially helpful for the new and expert researchers in this area of tissue engineering.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 146-159"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44427945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2