Smart Materials in Medicine最新文献_第10页

Biomaterials based growth factor delivery for brain regeneration after injury 基于生物材料的生长因子输送用于损伤后脑再生

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.04.001

Zhen Xu , Siyu Liu , Min Liang , Haoyi Yang , Chunqi Chang

{"title":"Biomaterials based growth factor delivery for brain regeneration after injury","authors":"Zhen Xu , Siyu Liu , Min Liang , Haoyi Yang , Chunqi Chang","doi":"10.1016/j.smaim.2022.04.001","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.04.001","url":null,"abstract":"<div><p>Brain injury often caused irreversible loss of neural tissue and resulted in serious neurological disability. Owing to the extreme complexity of the brain, it is still challenging to regenerate the brain tissue from injury and restore its normal function. Growth factors are critical signaling molecules that promote endogenous neural stem/progenitor cells (NSPCs) proliferation, migration and differentiation, resulting in functional brain recovery from injury. However, the labile nature of growth factor motivated us to develop advanced growth factor delivery strategies to precisely control over its release profile <em>in vivo</em>. In this review, we will discuss growth factor delivery via biomaterials for brain regeneration after injury. This review begins with an overview of some major forms of brain injury. The characteristic properties of growth factors are described to provide a biological basis for their use in the brain regeneration. The specific biomaterials that generally used for delivering growth factor to treat brain injury are also detailed summarized. In particular, we focus on an engineering strategy that promote endogenous repair by creating growth factor concentration gradients <em>in vivo</em>. The last part of the review introduces current challenges and perspectives for growth factor delivery via biomaterials.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000175/pdfft?md5=c612067fbc525c4b31f3ca82ea919c88&pid=1-s2.0-S2590183422000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136839821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration 3D打印细胞明胶/丝素复合支架的FTY-720局部递送，增强血管化骨再生

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.01.007

Jin Yang , Changxu Deng , Muhammad Shafiq , Zhihui Li , Qianqian Zhang , Haibo Du , Shikai Li , Xiaojun Zhou , Chuanglong He

{"title":"Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration","authors":"Jin Yang , Changxu Deng , Muhammad Shafiq , Zhihui Li , Qianqian Zhang , Haibo Du , Shikai Li , Xiaojun Zhou , Chuanglong He","doi":"10.1016/j.smaim.2022.01.007","DOIUrl":"10.1016/j.smaim.2022.01.007","url":null,"abstract":"<div><p>Three-dimensional (3D) printing can construct products with accurate complex architecture. Engineered bone tissues that can promote vascularization and regulate directed differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) are considered as an ideal substitute the healing of bone for bone defects treatment. Herein, we fabricated a 3D printed BMSCs-laden scaffold using methacrylated gelatin and methacrylated silk fibroin (GelMA/SFMA) based bioinks along with localized sustained release of a small molecule drug fingolimod (FTY-720) for the synergistic interactions of vascularization and osteogenesis during bone repair. The GelMA/SFMA bioink showed significant advantages due to their tunable rheology, rapid thermal crosslinking, and improved shape fidelity following bioprinting. The <em>in vitro</em> experiments demonstrated that high cell viability of cells-laden constructs, while FTY-720-containing scaffolds significantly promoted migration and induced tube-like structure formation of human umbilical vein endothelial cells (HUVECs) as well as expressed high osteogenic-related genes expression of BMSCs. The implantation in a critical-size rat cranial defect model further revealed that FTY-720-loaded scaffolds significantly promoted vascularization and bone regeneration. Furthermore, scaffolds carrying BMSCs and FTY-720 were more osteogenic <em>in vivo</em> than scaffolds carrying BMSCs alone. Therefore, the constructed BMSCs-laden and FTY-720-loaded GelMA/SFMA scaffolds would be an ideal candidate with required structure and desired function for vascularization of bone regeneration.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000072/pdfft?md5=c732599182eabfbfc61cf0f0570f8b97&pid=1-s2.0-S2590183422000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45518828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications 可生物降解的Zn–Sr合金，具有增强的机械性能和生物相容性，用于生物医学应用

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2021.12.004

Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu

{"title":"Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications","authors":"Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu","doi":"10.1016/j.smaim.2021.12.004","DOIUrl":"10.1016/j.smaim.2021.12.004","url":null,"abstract":"<div><p>Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The <em>in vitro</em> and <em>in vivo</em> degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced <em>in vitro</em> and <em>in vivo</em> biocompatibility along with promising antibacterial properties.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183421000454/pdfft?md5=ce592af6840a7174c8f4d7fdce36165e&pid=1-s2.0-S2590183421000454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44785449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Recent progress on coatings of biomedical magnesium alloy 医用镁合金涂层研究进展

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2021.12.007

Peiduo Tong, Yulong Sheng, Ruiqing Hou, Mujahid Iqbal, Lan Chen, Jingan Li

{"title":"Recent progress on coatings of biomedical magnesium alloy","authors":"Peiduo Tong, Yulong Sheng, Ruiqing Hou, Mujahid Iqbal, Lan Chen, Jingan Li","doi":"10.1016/j.smaim.2021.12.007","DOIUrl":"10.1016/j.smaim.2021.12.007","url":null,"abstract":"<div><p>Magnesium (Mg) alloy has received thorough attention in the biomedical field due to its excellent mechanical properties, good biocompatibility, and biodegradability. However, Mg alloy usually shows excessive degradation rate in the physiological environment owning to its active chemical nature. At the same time, the hydrogen generated by the degradation of Mg will increase the pH of local tissues, which will harm the growth of surrounding tissues. Given the above problems, it has become a research hotspot to obtain various properties of Mg alloy for clinical application by surface modification. In this paper, the surface coatings of Mg alloy are reviewed according to different types, including metals (metal oxides, metal hydroxides), inorganic non-metals, polymers (synthetic polymers and natural polymers), and composite coatings. The preparation methods, corrosion resistance, and biocompatibility of different types of coatings are discussed, and the development prospect of biomedical Mg alloy surface coatings is also predicted.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259018342100048X/pdfft?md5=1152ff8e896118ad48e43e2447d87411&pid=1-s2.0-S259018342100048X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42590216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Signaling pathways implicated in enhanced stem/progenitor cell differentiation on electroactive scaffolds 电活性支架上干细胞/祖细胞分化增强的信号通路

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2021.11.003

Boon Chin Heng , Yunyang Bai , Xiaochan Li , Yanze Meng , Xuehui Zhang , Xuliang Deng

{"title":"Signaling pathways implicated in enhanced stem/progenitor cell differentiation on electroactive scaffolds","authors":"Boon Chin Heng , Yunyang Bai , Xiaochan Li , Yanze Meng , Xuehui Zhang , Xuliang Deng","doi":"10.1016/j.smaim.2021.11.003","DOIUrl":"10.1016/j.smaim.2021.11.003","url":null,"abstract":"<div><p>Cells are naturally surrounded by an electroactive extracellular matrix <em>in vivo</em>, which is composed of a diverse array of charged molecules such as glycosaminoglycans and proteoglycans, together with piezoelectric collagen fibers capable of generating electrical signals in response to mechanical stimuli. In recent years, electroactive scaffold materials have attracted much attention in tissue engineering and regenerative medicine applications, as a biomimetic strategy to recapitulate the natural physiological electrical microenvironment <em>in vivo</em>, which could enhance the differentiation of stem/progenitor cells into specific lineages, thus facilitating tissue repair and regeneration. The key to improving the functional design of electroactive scaffold biomaterials would be to understand the various intracellular signaling pathways that are activated by electrical stimuli. Therefore, this review critically examines the effects of electrical stimuli and/or scaffolds with electroactive properties on directing stem/progenitor cells towards the osteogenic, neurogenic and other lineages, with particular focus on the molecular signaling pathways involved.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183421000302/pdfft?md5=0939890f42d97fd1c54efdaa96c996d8&pid=1-s2.0-S2590183421000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48670925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Membrane fusion boosting drug transmembrane delivery 膜融合促进药物跨膜传递

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.01.009

Xing Gao, En Ren, Gang Liu

引用次数: 3

The increased ratio of Mg2+/Ca2+ from degrading magnesium alloys directs macrophage fate for functionalized growth of endothelial cells 来自降解镁合金的Mg2+/Ca2+比率的增加指导巨噬细胞的命运以实现内皮细胞的功能化生长

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.01.001

Ya-chen Hou , Frank Witte , Jingan Li , Shaokang Guan

{"title":"The increased ratio of Mg2+/Ca2+ from degrading magnesium alloys directs macrophage fate for functionalized growth of endothelial cells","authors":"Ya-chen Hou , Frank Witte , Jingan Li , Shaokang Guan","doi":"10.1016/j.smaim.2022.01.001","DOIUrl":"10.1016/j.smaim.2022.01.001","url":null,"abstract":"<div><p>Biomedical magnesium (Mg) alloys have been widely studied as important structural materials and biodegradable materials in cardiovascular stents system. However, excessively rapid degradation and delayed endothelialization are still the bottlenecks limiting the further application of Mg alloy stents. The core scientific problem lies in how Mg alloys and their degradation products direct the fate of cardiovascular cells to develop in favor of endothelialization, which is still unclear. The aggregation of macrophages (MA) is the earliest cellular response after stent implantation for atherosclerotic lesions, and our previous research proved that MA behaviors played crucial roles on endothelialization <em>in vitro</em>. Thus, the present study chooses a Mg alloy, Mg–Zn–Y-Nd, to investigate its degradation behavior on directing the fates of MA and endothelial cells (EC). Our data shows that the increased ratio of Mg<sup>2+</sup>/Ca<sup>2+</sup> in medium during the degradation of the Mg–Zn–Y-Nd alloy may regulate the MA to switch to their M2 phenotype, and the MA conditioned medium further promote the proliferation and CD31 expression of EC <em>in vitro</em>. Co-culture of MA and EC indicates that M2-type MA also contribute to proliferation and CD31 expression of EC. All these results suggest controlling the degradation behavior of Mg alloys will direct the fates of MA and EC, further improving endothelialization <em>in vitro</em>.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000011/pdfft?md5=721ce62f519d4c6e74b5f2f4edbd56a8&pid=1-s2.0-S2590183422000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46222983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Twisted fiber batteries for wearable electronic devices 可穿戴电子设备用扭曲纤维电池

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2021.11.001

Yunru Yu , Xiaocheng Wang , Chaoyu Yang , Luoran Shang

引用次数: 4

B12-dependent photoreceptor protein as an emerging tool for materials synthetic biology B12依赖性光感受器蛋白作为材料合成生物学的新兴工具

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.03.004

Hong Kiu Francis Fok , Fei Sun

引用次数: 1

Stimuli-responsive materials: A smart way to study dynamic cell responses 刺激反应材料:一种研究动态细胞反应的聪明方法

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.01.010

Maaike Bril , Sebastian Fredrich , Nicholas A. Kurniawan

{"title":"Stimuli-responsive materials: A smart way to study dynamic cell responses","authors":"Maaike Bril , Sebastian Fredrich , Nicholas A. Kurniawan","doi":"10.1016/j.smaim.2022.01.010","DOIUrl":"10.1016/j.smaim.2022.01.010","url":null,"abstract":"<div><p>Cells in the body reside within the extracellular matrix (ECM), a three-dimensional environment that not only provides structural support for the cells, but also influences cellular processes, like migration and differentiation. The ECM and the cells continuously engage in a complex and highly dynamic interplay, shaping both the matrix as well as the cellular outcome. To study these dynamic, bidirectional interactions in a systematic manner, the ability to dynamically control cellular environments is highly desirable. Stimuli-responsive materials are a class of materials that have been engineered to respond to external cues, e.g., light, electricity, or magnetic field, and therefore hold fascinating potentials as an ideal experimental platform to introduce changing spatiotemporal signals to cells. Here, we review the state of the art in stimuli-responsive materials and their design strategies, with an emphasis on the dynamic introduction of physical and mechanical cues. The effects of such dynamic stimuli on the responses of living cells are examined on three different levels: cellular phenotypes, intracellular and cytoskeletal changes, and nuclear and epigenetic effects. Finally, we discuss the current challenges and limitations as well as the potential outlooks in exploiting stimuli-responsive biomaterials.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000102/pdfft?md5=5e800d04e3b26c91221b4c2f5b532e91&pid=1-s2.0-S2590183422000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55207571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19