Smart Materials in Medicine最新文献_第10页

Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model 蛋壳衍生的无定形磷酸钙:合成、表征和生物功能作为新型三维成骨细胞球体模型的骨移植材料

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.001

Qianli Ma , Kristaps Rubenis , Ólafur Eysteinn Sigurjónsson , Torben Hildebrand , Therese Standal , Signe Zemjane , Janis Locs , Dagnija Loca , Håvard Jostein Haugen

{"title":"Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model","authors":"Qianli Ma , Kristaps Rubenis , Ólafur Eysteinn Sigurjónsson , Torben Hildebrand , Therese Standal , Signe Zemjane , Janis Locs , Dagnija Loca , Håvard Jostein Haugen","doi":"10.1016/j.smaim.2023.04.001","DOIUrl":"10.1016/j.smaim.2023.04.001","url":null,"abstract":"<div><p>A multitude of autogenous/allogeneic and semi-synthetic bone graft materials have been developed to reconstruct the defective bone tissue but with high bio-cost and potential environmental pollution. With high calcium content and several trace elements, chicken eggshells are no longer considered as wastes but attractive sources of high-value-added biomaterials. This study used chicken eggshells and synthetic hydroxyapatite (HAp) to synthesize amorphous calcium phosphate (ACP) bone graft materials, namely Control and Eggshell. The physiochemical characteristics, biosafety, and immunocompatibility of synthetic ACP particles were inspected. Their osteogenic activity was further investigated in a novel osteoblastic spheroids model. Eggshell ACP particles exhibited ideal cytocompatibility compared to the control ACP and were more resistant to re-crystallization. In osteoblastic spheroids, Eggshell ACP mediated typical osteogenic mRNA profiles of MC-3T3-E1 cells, accompanied by the increased formation of mineralized nodules and boosted synthesis of ECM proteins represented by OPN and collagen I. This study establishes a promising technique to synthesize stable, safe, and osteoinductive ACP graft particles from eggshell waste. Furthermore, the osteoblastic spheroids constructed in the present study provide a more practical model for biomaterial research, which reflect the three-dimensional interaction between host bone tissue and graft materials more realistically.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 522-537"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48966779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The versatile applications of polydopamine in regenerative medicine: Progress and challenges 多多巴胺在再生医学中的广泛应用:进展与挑战

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.11.005

Shundong Cai , Yuhang Cheng , Chenyue Qiu , Gang Liu , Chengchao Chu

{"title":"The versatile applications of polydopamine in regenerative medicine: Progress and challenges","authors":"Shundong Cai , Yuhang Cheng , Chenyue Qiu , Gang Liu , Chengchao Chu","doi":"10.1016/j.smaim.2022.11.005","DOIUrl":"10.1016/j.smaim.2022.11.005","url":null,"abstract":"<div><p>In recent decades, great progress has been made in regenerative medicine with the development of various functional scaffolds, many of which have been put into practical clinical applications. In this process, biomaterials with excellent properties have played an important role, such as medical metal materials, bioceramics, polymers, etc. Among them, melanin-like polymer polydopamine (PDA) attracts increasing scientific interest and shows good clinical application potential: i) PDA can be used as coating material to facilitate the loading of various bioactive molecules; ii) PDA can be applied as the main constituent material of scaffolds to optimize the performances. In this review, the preparation method and polymerization mechanism of PDA are first outlined, and then the advantages of PDA, including good biocompatibility, strong adhesion, antioxidant property, and excellent photothermal properties, are introduced. Next, this review highlights the significant applications of PDA in regenerative medicine, mainly focusing on wound healing, bone repair and regeneration, as well as different forms of tissue engineering. Finally, challenges and prospects on future clinical applications of PDA in regenerative medicine are discussed.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 294-312"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43411373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Recent advances in hyaluronic acid-based hydrogels for 3D bioprinting in tissue engineering applications 透明质酸基水凝胶在组织工程3D生物打印中的应用进展

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.07.003

Yan-Wen Ding , Xu-Wei Zhang , Chen-Hui Mi , Xin-Ya Qi , Jing Zhou , Dai-Xu Wei

{"title":"Recent advances in hyaluronic acid-based hydrogels for 3D bioprinting in tissue engineering applications","authors":"Yan-Wen Ding , Xu-Wei Zhang , Chen-Hui Mi , Xin-Ya Qi , Jing Zhou , Dai-Xu Wei","doi":"10.1016/j.smaim.2022.07.003","DOIUrl":"10.1016/j.smaim.2022.07.003","url":null,"abstract":"<div><p>3D bioprinting technology can rapidly process cell-loaded biomaterials to prepare personalized scaffolds for repairing defective tissues, tissue regeneration, and even printing tissues or organs. 3D bioprinting relies on bioinks with appropriate rheology and cytocompatibility, and hydrogels are among the most promising bioink materials for 3D bioprinting. Among many hydrogel precursor materials, hyaluronic acid (HA) stands out due to its excellent physicochemical and biological properties, such as biocompatibility, hydrophilicity, non-immunogenicity, and complete biodegradability, and has become the most attractive hydrogel precursor for bioinks. In this review, we discuss the strategies adopted for the application of HA-based hydrogels as bioinks, including printability, improving their mechanical properties, and printing with loaded cells. Finally, we summarize the application of 3D bioprinted HA-based hydrogels in various tissue engineering applications in recent years, with the aim to provide fresh inspiration for further development of HA-based hydrogels for 3D bioprinting.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 59-68"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42141585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Tumor microenvironment-responsive gold nanodendrites for nanoprobe-based single-cell Raman imaging and tumor-targeted chemo-photothermal therapy 肿瘤微环境响应金纳米树突用于基于纳米探针的单细胞拉曼成像和肿瘤靶向化学光热治疗

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.06.002

Yajun Shuai , Qing Bao , Hui Yue , Jie Wang , Tao Yang , Quan Wan , Yuxin Zhong , Zongpu Xu , Chuanbin Mao , Mingying Yang

{"title":"Tumor microenvironment-responsive gold nanodendrites for nanoprobe-based single-cell Raman imaging and tumor-targeted chemo-photothermal therapy","authors":"Yajun Shuai , Qing Bao , Hui Yue , Jie Wang , Tao Yang , Quan Wan , Yuxin Zhong , Zongpu Xu , Chuanbin Mao , Mingying Yang","doi":"10.1016/j.smaim.2023.06.002","DOIUrl":"10.1016/j.smaim.2023.06.002","url":null,"abstract":"<div><p>Nanodendrite particles (NDs) with densely branched structures and biomimetic architectures have exhibited great promise in tumor therapy owing to their prolonged <em>in vivo</em> circulation time and exceptional photothermal efficiency. Nevertheless, traditional NDs are deficient in terms of specific surface modification and targeting tumors, which restrict their potential for broader clinical applications. Here, we developed coronavirus-like gold NDs through a seed-mediated approach and using silk fibroin (SF) as a capping agent. Our results demonstrate that these NDs have a favorable drug-loading capacity (∼65.25%) and light-triggered release characteristics of doxorubicin hydrochloride (DOX). Additionally, NDs functionalized with specific probes exhibited exceptional surface-enhanced Raman scattering (SERS) characteristics, enabling high-sensitivity Raman imaging of unstained single cells. Moreover, these NDs allowed for real-time monitoring of endocytic NDs for over 24 h. Furthermore, ND@DOX conjugated with tumor-targeting peptides exhibited mild hyperthermia, minimal cytotoxicity, and effective targeting towards cancer cells <em>in vitro</em>, as well as responsiveness to the tumor microenvironment (TME) <em>in vivo.</em> These unique properties led to the highest level of synergistic tumor-killing efficiency when stimulated by a near-infrared (NIR) laser at 808 nm. Therefore, our virus-like ND functionalized with SF presents a novel type of nanocarrier that exhibits significant potential for synergistic applications in precision medicine.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 680-689"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42104846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Emerging polymeric biomaterials and manufacturing-based tissue engineering approaches for neuro regeneration-A critical review on recent effective approaches 新兴的高分子生物材料和基于制造的神经再生组织工程方法-对最近有效方法的重要回顾

Smart Materials in Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.smaim.2022.11.007

A. Akhtar, Vahideh Farzamrad, A. Moradi, M. Yar, Masoomeh Bazzar

引用次数: 6

Opinion paper: Membrane fusion boosting drug transmembrane delivery 意见书：膜融合促进药物跨膜递送

Smart Materials in Medicine Pub Date : 2022-02-01 DOI: 10.1016/j.smaim.2022.01.009

Xing Gao, En Ren, Gang Liu

引用次数: 3

Biomaterials based growth factor delivery for brain regeneration after injury 基于生物材料的生长因子输送用于损伤后脑再生

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.04.001

Zhen Xu , Siyu Liu , Min Liang , Haoyi Yang , Chunqi Chang

{"title":"Biomaterials based growth factor delivery for brain regeneration after injury","authors":"Zhen Xu , Siyu Liu , Min Liang , Haoyi Yang , Chunqi Chang","doi":"10.1016/j.smaim.2022.04.001","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.04.001","url":null,"abstract":"<div><p>Brain injury often caused irreversible loss of neural tissue and resulted in serious neurological disability. Owing to the extreme complexity of the brain, it is still challenging to regenerate the brain tissue from injury and restore its normal function. Growth factors are critical signaling molecules that promote endogenous neural stem/progenitor cells (NSPCs) proliferation, migration and differentiation, resulting in functional brain recovery from injury. However, the labile nature of growth factor motivated us to develop advanced growth factor delivery strategies to precisely control over its release profile <em>in vivo</em>. In this review, we will discuss growth factor delivery via biomaterials for brain regeneration after injury. This review begins with an overview of some major forms of brain injury. The characteristic properties of growth factors are described to provide a biological basis for their use in the brain regeneration. The specific biomaterials that generally used for delivering growth factor to treat brain injury are also detailed summarized. In particular, we focus on an engineering strategy that promote endogenous repair by creating growth factor concentration gradients <em>in vivo</em>. The last part of the review introduces current challenges and perspectives for growth factor delivery via biomaterials.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"3 ","pages":"Pages 352-360"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000175/pdfft?md5=c612067fbc525c4b31f3ca82ea919c88&pid=1-s2.0-S2590183422000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136839821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration 3D打印细胞明胶/丝素复合支架的FTY-720局部递送，增强血管化骨再生

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2022.01.007

Jin Yang , Changxu Deng , Muhammad Shafiq , Zhihui Li , Qianqian Zhang , Haibo Du , Shikai Li , Xiaojun Zhou , Chuanglong He

{"title":"Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration","authors":"Jin Yang , Changxu Deng , Muhammad Shafiq , Zhihui Li , Qianqian Zhang , Haibo Du , Shikai Li , Xiaojun Zhou , Chuanglong He","doi":"10.1016/j.smaim.2022.01.007","DOIUrl":"10.1016/j.smaim.2022.01.007","url":null,"abstract":"<div><p>Three-dimensional (3D) printing can construct products with accurate complex architecture. Engineered bone tissues that can promote vascularization and regulate directed differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) are considered as an ideal substitute the healing of bone for bone defects treatment. Herein, we fabricated a 3D printed BMSCs-laden scaffold using methacrylated gelatin and methacrylated silk fibroin (GelMA/SFMA) based bioinks along with localized sustained release of a small molecule drug fingolimod (FTY-720) for the synergistic interactions of vascularization and osteogenesis during bone repair. The GelMA/SFMA bioink showed significant advantages due to their tunable rheology, rapid thermal crosslinking, and improved shape fidelity following bioprinting. The <em>in vitro</em> experiments demonstrated that high cell viability of cells-laden constructs, while FTY-720-containing scaffolds significantly promoted migration and induced tube-like structure formation of human umbilical vein endothelial cells (HUVECs) as well as expressed high osteogenic-related genes expression of BMSCs. The implantation in a critical-size rat cranial defect model further revealed that FTY-720-loaded scaffolds significantly promoted vascularization and bone regeneration. Furthermore, scaffolds carrying BMSCs and FTY-720 were more osteogenic <em>in vivo</em> than scaffolds carrying BMSCs alone. Therefore, the constructed BMSCs-laden and FTY-720-loaded GelMA/SFMA scaffolds would be an ideal candidate with required structure and desired function for vascularization of bone regeneration.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"3 ","pages":"Pages 217-229"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000072/pdfft?md5=c732599182eabfbfc61cf0f0570f8b97&pid=1-s2.0-S2590183422000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45518828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications 可生物降解的Zn–Sr合金，具有增强的机械性能和生物相容性，用于生物医学应用

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2021.12.004

Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu

{"title":"Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications","authors":"Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu","doi":"10.1016/j.smaim.2021.12.004","DOIUrl":"10.1016/j.smaim.2021.12.004","url":null,"abstract":"<div><p>Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The <em>in vitro</em> and <em>in vivo</em> degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced <em>in vitro</em> and <em>in vivo</em> biocompatibility along with promising antibacterial properties.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"3 ","pages":"Pages 117-127"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183421000454/pdfft?md5=ce592af6840a7174c8f4d7fdce36165e&pid=1-s2.0-S2590183421000454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44785449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Recent progress on coatings of biomedical magnesium alloy 医用镁合金涂层研究进展

Smart Materials in Medicine Pub Date : 2022-01-01 DOI: 10.1016/j.smaim.2021.12.007

Peiduo Tong, Yulong Sheng, Ruiqing Hou, Mujahid Iqbal, Lan Chen, Jingan Li

{"title":"Recent progress on coatings of biomedical magnesium alloy","authors":"Peiduo Tong, Yulong Sheng, Ruiqing Hou, Mujahid Iqbal, Lan Chen, Jingan Li","doi":"10.1016/j.smaim.2021.12.007","DOIUrl":"10.1016/j.smaim.2021.12.007","url":null,"abstract":"<div><p>Magnesium (Mg) alloy has received thorough attention in the biomedical field due to its excellent mechanical properties, good biocompatibility, and biodegradability. However, Mg alloy usually shows excessive degradation rate in the physiological environment owning to its active chemical nature. At the same time, the hydrogen generated by the degradation of Mg will increase the pH of local tissues, which will harm the growth of surrounding tissues. Given the above problems, it has become a research hotspot to obtain various properties of Mg alloy for clinical application by surface modification. In this paper, the surface coatings of Mg alloy are reviewed according to different types, including metals (metal oxides, metal hydroxides), inorganic non-metals, polymers (synthetic polymers and natural polymers), and composite coatings. The preparation methods, corrosion resistance, and biocompatibility of different types of coatings are discussed, and the development prospect of biomedical Mg alloy surface coatings is also predicted.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"3 ","pages":"Pages 104-116"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259018342100048X/pdfft?md5=1152ff8e896118ad48e43e2447d87411&pid=1-s2.0-S259018342100048X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42590216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55