外泌体在血管稳态和血管移植中的调节和应用

Q1 Engineering
Xinyu Yang , Boxin Geng , Juan Yan , Lin Lin , Xingli Zhao , Haoran Xiao , Haoquan Hu , Lingtong Ye , Wenqi lv , Wen Zeng
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引用次数: 2

摘要

全球心血管疾病的发病率和死亡率逐年上升,其中血管疾病是导致死亡的主要原因。传统药物在治疗心血管疾病方面存在多重局限性,缺乏治疗心血管疾病的有效手段。外泌体作为重要的细胞间信息传递者,参与血管的正常生理和病理过程,与内膜增生、血管硬化和血栓形成密切相关。工程外泌体是通过对天然膜囊泡进行修饰而获得的,具有靶向性强、作用时间长、可检测性强等优点,是治疗心血管疾病的良好选择。当血管内稳态被破坏时,各种细胞分泌的外泌体是如何影响疾病消退的,以及工程外泌体是如何被调节以维持血管内稳态的,目前还没有相关的综述。因此,本文综述了外泌体在血管稳态相关疾病中的调控机制,简要介绍了工程外泌体在血管中的应用,探讨了工程外泌体在心血管疾病治疗中的潜力,为外泌体在血管疾病治疗中的精准调控提供了新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of exosomes in regulation and application of vascular homeostasis and vascular grafts

The global morbidity and mortality of cardiovascular diseases are increasing yearly, among which vascular diseases are the main cause of death. Traditional drugs have multiple limitations in the treatment of cardiovascular diseases, and there is a lack of effective means to treat cardiovascular diseases. Exosomes, as transmitters of important intercellular information, are involved in normal physiological and pathological processes of blood vessels and are closely associated with intimal hyperplasia, vascular sclerosis and thrombosis. Engineered exosomes are obtained by modification of natural membrane vesicles, and they have the advantages of targeting, extended duration of action and detectability, which can be an excellent alternative for cardiovascular disease treatment. There is an absence of reviews on how exosomes secreted by various cells affect disease regression when vascular homeostasis is disrupted and how engineered exosomes are regulated to maintain vascular homeostasis. Therefore, this paper reviews the regulatory mechanisms of exosomes in diseases related to vascular homeostasis, briefly describes the application of engineered exosomes in vessels, and explores the potential of engineered exosomes in the treatment of cardiovascular diseases, providing a new idea for the precise regulation of exosomes in the treatment of vascular diseases.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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