Smart Materials in Medicine最新文献_第9页

Emerging polymeric biomaterials and manufacturing-based tissue engineering approaches for neuro regeneration-A critical review on recent effective approaches 新兴的高分子生物材料和基于制造的神经再生组织工程方法-对最近有效方法的重要回顾

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.11.007

Amna Akhtar , Vahideh Farzam Rad , Ali-Reza Moradi , Muhammad Yar , Masoomeh Bazzar

{"title":"Emerging polymeric biomaterials and manufacturing-based tissue engineering approaches for neuro regeneration-A critical review on recent effective approaches","authors":"Amna Akhtar , Vahideh Farzam Rad , Ali-Reza Moradi , Muhammad Yar , Masoomeh Bazzar","doi":"10.1016/j.smaim.2022.11.007","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.11.007","url":null,"abstract":"<div><p>The nervous system is a crucial part of the human body that is damaged by traumatic injury, stroke, and neurodegenerative diseases. Recent studies also have shown that neurodegenerative diseases are associated with a subsequently increased risk of COVID-19-related death. Presently used pharmacological and therapeutic strategies are only the symptomatic treatments that involve the disruption of axonal tracts and are unable to repair and regenerate damaged CNS tissue thereby leading to significant unmet clinical needs involved in neural degeneration. The use of stem cell based regenerative medicine approaches is also limited due to heavy cost, ethical concerns and graft rejection. To address all these limitations, the neural tissue engineering philosophy has been developed that focuses on exploring and developing smart biomaterials for neural tissue repair and regeneration. A scaffold based upon natural and synthetic polymers has meant a very potential role to mimic the extracellular matrix of cells and permit the growth of different types of cells thereby improving the biological behavior in <em>vitro</em> and in vivo effects. They treat neurological disorders without the classic drug delivery limitations. Among these biopolymers, the collagen-based hydrogel is successfully applied conduits for clinical trials that ultimately replicate the native physiological environment of the neural tissues and control cell behavior and favor the regeneration of the damaged nerve tissue. The main objective of this review is to investigate the recent approaches and applications of next-generation polymeric biomaterials useful in the management of neurodegenerative diseases. We also discuss the outlook of the polymeric scaffolds that could pave the way for successful clinical practices.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Silk sericin-based biomaterials shine in food and pharmaceutical industries 丝胶基生物材料在食品和制药行业大放异彩

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.01.003

Chao Yang , Liang Yao , Lei Zhang

引用次数: 10

Promotion of wound healing by a thermosensitive and sprayable hydrogel with nanozyme activity and anti-inflammatory properties 具有纳米酶活性和抗炎特性的热敏和可喷雾水凝胶促进伤口愈合

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.08.004

Wei Zhang , Xingliang Dai , Xu Jin , Muchen Huang , Jie Shan , Xulin Chen , Haisheng Qian , Zenghong Chen , Xianwen Wang

{"title":"Promotion of wound healing by a thermosensitive and sprayable hydrogel with nanozyme activity and anti-inflammatory properties","authors":"Wei Zhang , Xingliang Dai , Xu Jin , Muchen Huang , Jie Shan , Xulin Chen , Haisheng Qian , Zenghong Chen , Xianwen Wang","doi":"10.1016/j.smaim.2022.08.004","DOIUrl":"10.1016/j.smaim.2022.08.004","url":null,"abstract":"<div><p>The rapid healing of wounds requires strategies that relieve oxidative stress resulting from overloaded free radicals and which promote angiogenesis, collagen deposition, and re-epithelialization of the wound. Nickel ions have been reported to be correlated with angiogenesis. However, several applications of metal salts or oxides to wounds lead to increased toxicity. The nickel metal-organic framework (Ni MOF) nanorods described herein can slowly release nickel ions, resulting in reduced toxicity and improved wound healing rates. More importantly, the Ni<sub>3</sub>(2,3,6,7,10,11-hexaiminotriphenylene)<sub>2</sub> (Ni<sub>3</sub>(HITP)<sub>2</sub>) nanorods with well-defined structures, superior conductivity and many catalytic sites showed superoxide dismutase (SOD)-like enzyme activity and scavenged various free radicals. In addition, the Ni<sub>3</sub>(HITP)<sub>2</sub> nanomaterials contributed to promotion of the migration of fibroblasts, angiogenesis and macrophage polarization from M1 to M2. The aqueous solution of Pluronic F127, a temperature-sensitive, nontoxic and phase-changing hydrogel material, was shown to be an effective choice for injectable and sprayable medical dressings. The Ni<sub>3</sub>(HITP)<sub>2</sub> MOF nanomaterials can be effectively encapsulated with the F127 hydrogel to achieve continuous long-term therapeutic effects. The toxicity test results suggested that the Ni<sub>3</sub>(HITP)<sub>2</sub> MOF nanomaterials exhibited excellent biosafety and no observable toxicity or side effects in mice. Therefore, the Ni<sub>3</sub>(HITP)<sub>2</sub> MOF nanorods hold promising potential in the biomedical field, and this work provides an effective solution to wound therapy.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45504953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Anti-inflammatory, antibacterial, antioxidative bioactive glass-based nanofibrous dressing enables scarless wound healing 抗炎、抗菌、抗氧化的生物活性玻璃基纳米纤维敷料可实现无瘢痕伤口愈合

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.01.001

Zhengchao Yuan, Lixiang Zhang, Shichao Jiang, Muhammad Shafiq, Youjun Cai, Yujie Chen, Jiahui Song, Xiao Yu, H. Ijima, Yuan Xu, X. Mo

引用次数: 8

Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers 脓毒症中的循环外泌体:作为诊断生物标志物、治疗和药物输送载体的潜在作用

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.06.007

Roushka Bhagwan Valjee , Usri H. Ibrahim , Kwanele Xulu , Saajida Mahomed , Irene Mackraj

{"title":"Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers","authors":"Roushka Bhagwan Valjee , Usri H. Ibrahim , Kwanele Xulu , Saajida Mahomed , Irene Mackraj","doi":"10.1016/j.smaim.2023.06.007","DOIUrl":"https://doi.org/10.1016/j.smaim.2023.06.007","url":null,"abstract":"<div><p>Sepsis and sepsis-related organ dysfunction have been identified as significant global life-threatening health threats, with a high mortality rate despite ongoing research in the area. Timely diagnosis is essential such that treatment could be initiated as early as possible to ensure the best outcome, since delayed intervention is associated with a higher mortality. Patient stratification and disease monitoring, present significant challenges in sepsis treatment and management strategies, largely due to the heterogenicity of sepsis signs and symptoms. Hence a focus on potential biomarkers to overcome these challenges is needed. Recently, extracellular vesicles (EVs), mainly the exosome subtype, have been investigated regarding their potential role in sepsis diagnostics, therapeutics and as drug delivery vehicles. Herein, we present an up-to-date review covering the role of circulating exosomes in the diagnosis and monitoring of the progression of sepsis and in therapeutics and drug delivery for sepsis. To provide context, sepsis pathophysiology and the role of circulating exosomes in sepsis have been highlighted. Future prospects, current challenges and recommendations regarding the role of exosomes in sepsis are also identified.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring the elasticity of nerve implants for regulating peripheral nerve regeneration 调节神经植入物弹性调节周围神经再生

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.11.004

Yan Kong , Jiawei Xu , Wenchao Guan , Shaolan Sun , Yumin Yang , Guicai Li

引用次数: 4

The role of exosomes in regulation and application of vascular homeostasis and vascular grafts 外泌体在血管稳态和血管移植中的调节和应用

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.002

Xinyu Yang , Boxin Geng , Juan Yan , Lin Lin , Xingli Zhao , Haoran Xiao , Haoquan Hu , Lingtong Ye , Wenqi lv , Wen Zeng

{"title":"The role of exosomes in regulation and application of vascular homeostasis and vascular grafts","authors":"Xinyu Yang , Boxin Geng , Juan Yan , Lin Lin , Xingli Zhao , Haoran Xiao , Haoquan Hu , Lingtong Ye , Wenqi lv , Wen Zeng","doi":"10.1016/j.smaim.2023.04.002","DOIUrl":"10.1016/j.smaim.2023.04.002","url":null,"abstract":"<div><p>The global morbidity and mortality of cardiovascular diseases are increasing yearly, among which vascular diseases are the main cause of death. Traditional drugs have multiple limitations in the treatment of cardiovascular diseases, and there is a lack of effective means to treat cardiovascular diseases. Exosomes, as transmitters of important intercellular information, are involved in normal physiological and pathological processes of blood vessels and are closely associated with intimal hyperplasia, vascular sclerosis and thrombosis. Engineered exosomes are obtained by modification of natural membrane vesicles, and they have the advantages of targeting, extended duration of action and detectability, which can be an excellent alternative for cardiovascular disease treatment. There is an absence of reviews on how exosomes secreted by various cells affect disease regression when vascular homeostasis is disrupted and how engineered exosomes are regulated to maintain vascular homeostasis. Therefore, this paper reviews the regulatory mechanisms of exosomes in diseases related to vascular homeostasis, briefly describes the application of engineered exosomes in vessels, and explores the potential of engineered exosomes in the treatment of cardiovascular diseases, providing a new idea for the precise regulation of exosomes in the treatment of vascular diseases.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44404783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Optical biosensors for diabetes management: Advancing into stimuli-responsive sensing mechanisms 用于糖尿病管理的光学生物传感器：进入刺激响应传感机制

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.08.003

Kanishk Singh , Tarun Agarwal , Utkarsh Kumar , Sampriti Pal , Ashish Runthala , Tung-Ming Pan , Ching Chow Wu

引用次数: 3

Chemical bonding of Epigallocatechin-3-gallate to the surface of nano-hydroxyapatite to enhance its biological activity for anti-osteosarcoma 表没食子儿茶素-3-没食子酸酯与纳米羟基磷灰石表面的化学键合增强其抗骨肉瘤的生物活性

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.12.003

Jian Ren , Lingli Sun , Cairong Xiao , Shuoshuo Zhou , Qingyou Liang , Shili Sun , Chunlin Deng

{"title":"Chemical bonding of Epigallocatechin-3-gallate to the surface of nano-hydroxyapatite to enhance its biological activity for anti-osteosarcoma","authors":"Jian Ren , Lingli Sun , Cairong Xiao , Shuoshuo Zhou , Qingyou Liang , Shili Sun , Chunlin Deng","doi":"10.1016/j.smaim.2022.12.003","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.12.003","url":null,"abstract":"<div><p>Post-surgical defect repair combined with the elimination of residual cancer cells remains a major clinical challenge for the therapy of malignant bone tumors. As a natural product extracted from green tea, epigallocatechin-3-gallate (EGCG) has a wide range of biological activities. In this study, we investigated the anti-osteosarcoma and osteogenic potential of the natural compound EGCG in combination with hydroxyapatite (HA) for the post-operative treatment of osteosarcoma. We have synthesized well-dispersed surface amino-functionalized hydroxyapatite nanoparticles by the template method combined with surface modification techniques. Then, we conjugated EGCG with HA nanoparticles via amido linkage to prevent burst release of the biomolecules and improve their stability. The results showed that the as-prepared HA-EGCG nanoparticles had the same antioxidant activity as pure EGCG. The HA-EGCG nanoparticles demonstrated efficient EGCG release upon enzyme interactions in an acidic tumor environment, facilitating the accumulation of EGCG in tumor tissues and improving its bioavailability. Compared with pure EGCG and HA, HA-EGCG exhibited enhanced anticancer activity in vitro and in vivo. Furthermore, HA-EGCG could effectively promote osteogenic differentiation. This covalent strategy provides a simple method to fabricate a pH and enzyme-mediated delivery platform to refine the stability and bioavailability of EGCG. This research provides a strategy into designing biomaterials combined with EGCG for the potential application in bone diseases.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49735176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model 蛋壳衍生的无定形磷酸钙:合成、表征和生物功能作为新型三维成骨细胞球体模型的骨移植材料

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.001

Qianli Ma , Kristaps Rubenis , Ólafur Eysteinn Sigurjónsson , Torben Hildebrand , Therese Standal , Signe Zemjane , Janis Locs , Dagnija Loca , Håvard Jostein Haugen

{"title":"Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model","authors":"Qianli Ma , Kristaps Rubenis , Ólafur Eysteinn Sigurjónsson , Torben Hildebrand , Therese Standal , Signe Zemjane , Janis Locs , Dagnija Loca , Håvard Jostein Haugen","doi":"10.1016/j.smaim.2023.04.001","DOIUrl":"10.1016/j.smaim.2023.04.001","url":null,"abstract":"<div><p>A multitude of autogenous/allogeneic and semi-synthetic bone graft materials have been developed to reconstruct the defective bone tissue but with high bio-cost and potential environmental pollution. With high calcium content and several trace elements, chicken eggshells are no longer considered as wastes but attractive sources of high-value-added biomaterials. This study used chicken eggshells and synthetic hydroxyapatite (HAp) to synthesize amorphous calcium phosphate (ACP) bone graft materials, namely Control and Eggshell. The physiochemical characteristics, biosafety, and immunocompatibility of synthetic ACP particles were inspected. Their osteogenic activity was further investigated in a novel osteoblastic spheroids model. Eggshell ACP particles exhibited ideal cytocompatibility compared to the control ACP and were more resistant to re-crystallization. In osteoblastic spheroids, Eggshell ACP mediated typical osteogenic mRNA profiles of MC-3T3-E1 cells, accompanied by the increased formation of mineralized nodules and boosted synthesis of ECM proteins represented by OPN and collagen I. This study establishes a promising technique to synthesize stable, safe, and osteoinductive ACP graft particles from eggshell waste. Furthermore, the osteoblastic spheroids constructed in the present study provide a more practical model for biomaterial research, which reflect the three-dimensional interaction between host bone tissue and graft materials more realistically.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48966779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3