Smart Materials in Medicine最新文献_第8页

Towards clinical translation of the cell sheet engineering: Technological aspects 细胞片工程的临床翻译：技术方面

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.09.002

Irina M. Zurina , Victoria S. Presniakova , Denis V. Butnaru , Peter S. Timashev , Yury A. Rochev , Xing-Jie Liang

{"title":"Towards clinical translation of the cell sheet engineering: Technological aspects","authors":"Irina M. Zurina , Victoria S. Presniakova , Denis V. Butnaru , Peter S. Timashev , Yury A. Rochev , Xing-Jie Liang","doi":"10.1016/j.smaim.2022.09.002","DOIUrl":"10.1016/j.smaim.2022.09.002","url":null,"abstract":"<div><p>Cell sheet engineering is a rapidly growing field of tissue engineering and regenerative medicine. The ease of cell sheet obtainment techniques and the resulting unique characteristics and microenvironment of these multicellular structures give rise to the wide range of their <em>in vivo</em> application. At the same time, there are also macroscale cell sheet properties such as thickness, shrinkage after detachment due to cytoskeleton relaxation, and resulting mechanical characteristics. The main topic of this review is the discussion of these properties and how they define the need to use special approaches to manipulating cell sheets during stacking several structures, transferring them to surgical sites, or cryopreserving them. We aimed to systematize the existing techniques of cell sheet transferring, and describe their principles, advantages, and drawbacks regarding cell sheet application during surgical procedures on various tissues and organs. Attention is also paid to such aspects and details as cell sheet positioning <em>in vivo</em>, their ability to spontaneous adhesion, and the requirement for additional fixation at particular surgical sites. Finally, the last section of this review covers the subject of cell sheet cryopreservation – the discussion of freezing and thawing protocols, the variety of cryoprotectants and their mixtures, as well as special requirements such as cryoprotectant loading systems, and cell sheet supporting systems that also stem from their unique macroscale characteristics. Altogether, this systematized review of existing technological approaches related to cell sheet application <em>in vivo</em> can be potentially helpful for the new and expert researchers in this area of tissue engineering.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 146-159"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44427945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Application of mesenchymal stem cell exosomes in the treatment of skin wounds 间充质干细胞外泌体在皮肤创伤治疗中的应用

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.006

Xinyu Zhao , Wei Zhang , Junjuan Fan , Xulin Chen , Xianwen Wang

{"title":"Application of mesenchymal stem cell exosomes in the treatment of skin wounds","authors":"Xinyu Zhao , Wei Zhang , Junjuan Fan , Xulin Chen , Xianwen Wang","doi":"10.1016/j.smaim.2023.04.006","DOIUrl":"10.1016/j.smaim.2023.04.006","url":null,"abstract":"<div><p>Mesenchymal stem cell exosomes (MSC-Exos) are a type of cell vesicle with biological function secreted by mesenchymal stem cells (MSCs). In tissue repair, MSC-Exos are more effective than MSCs, and they can be used as a cell-free alternative therapy to MSCs. This therapeutic system has a stable membrane structure that is coated with proteins, miRNAs, mRNA, lncRNA, DNA, and other macromolecular active substances. These molecules have a powerful effect on tissue regeneration. MSC-Exos can regulate the biological function of target cells through direct recognition, membrane fusion, and secretion of communication mediators. Skin wound healing consists mainly of blood coagulation, inflammation response, cell proliferation, and tissue remodeling. By regulating the four stages of wound healing, MSC-Exos effectively reduce tissue inflammation, reduce the immune response, promote enhanced cell migration and angiogenesis and regulate tissue remodeling, thus shortening the healing time and reducing scar formation. A variety of biological factors, genetic material and signaling pathways are involved in this process. This article reviews the efficacy and mechanism of MSC-Exos in promoting skin tissue repair.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 578-589"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45255078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Biofabrication of natural Au/bacterial cellulose hydrogel for bone tissue regeneration via in-situ fermentation 原位发酵制备用于骨组织再生的天然金/细菌纤维素水凝胶

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.06.001

Caoxing Huang , Qing Ye , Jian Dong , Lan Li , Min Wang , Yunyang Zhang , Yibo Zhang , Xucai Wang , Peng Wang , Qing Jiang

{"title":"Biofabrication of natural Au/bacterial cellulose hydrogel for bone tissue regeneration via in-situ fermentation","authors":"Caoxing Huang , Qing Ye , Jian Dong , Lan Li , Min Wang , Yunyang Zhang , Yibo Zhang , Xucai Wang , Peng Wang , Qing Jiang","doi":"10.1016/j.smaim.2022.06.001","DOIUrl":"https://doi.org/10.1016/j.smaim.2022.06.001","url":null,"abstract":"<div><p>Bacterial cellulose (BC) possesses the desirable properties of biocompatibility, high porosity, high surface area and noticeable mechanical strength as a scaffold in bone tissue engineering. However, the lack of osteogenic activity restricts its application. In this study, gold nanoparticles (GNPs) with excellent osteogenic differentiation ability were incorporated into the network of BC hydrogel (Au/BC hydrogels) by the in-situ fermentation. The effects of GNPs on physicochemical properties of BC hydrogel and subsequently <em>in vitro</em> osteogenic differentiation and <em>in vivo</em> bone regeneration of Au/BC hydrogels were comprehensively investigated. The results showed that the increased feeding amounts of GNPs could remarkablly enhance the Au/BC hydrogels with better mechanical properties, higher porosity, larger surface area, and biocompatibility. The sustainable release of GNPs endowed the hydrogels with an outstanding biological activity in facilitating osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). Mechanism research showed that autophagy might be a potential pathway for Au/BC hydrogels-induced osteogenic differentiation of hBMSCs. In addition, Au/BC hydrogel exhibited an excellent <em>in vivo</em> bone repair performance in a rabbit model of femoral defect, which was evidenced by the significant newly bone formation. Overall, the multifunctional Au/BC hydrogels fabricated by in-situ fermentation could serve as a good scaffold for promoting bone tissue regeneration in clinic.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 1-14"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49716760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive oxygen species-sensitive materials: A promising strategy for regulating inflammation and favoring tissue regeneration 活性氧物种敏感材料:调节炎症和促进组织再生的有前途的策略

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.01.004

Jing Zhou , Chao Fang , Chao Rong , Tao Luo , Junjie Liu , Kun Zhang

引用次数: 4

Chitosan-calcium carbonate scaffold with high mineral content and hierarchical structure for bone regeneration 高矿物质、分级结构的壳聚糖-碳酸钙骨再生支架

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.004

Xiaoyang Liu, Zhengke Wang

引用次数: 2

Biosensor-based therapy powered by synthetic biology 基于合成生物学的生物传感器疗法

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.10.003

Chi Wang , Han-Shi Zeng , Kai-Xuan Liu , Yi-Na Lin , Hao Yang , Xin-Ying Xie , Dai-Xu Wei , Jian-Wen Ye

{"title":"Biosensor-based therapy powered by synthetic biology","authors":"Chi Wang , Han-Shi Zeng , Kai-Xuan Liu , Yi-Na Lin , Hao Yang , Xin-Ying Xie , Dai-Xu Wei , Jian-Wen Ye","doi":"10.1016/j.smaim.2022.10.003","DOIUrl":"10.1016/j.smaim.2022.10.003","url":null,"abstract":"<div><p>The study of synthetic biology focusing on biosensor systems has resulted from a growing interest in developing customized biological devices with desired cellular functions. Recently, biosensors have been used for a variety of medical applications such as disease diagnosis, prevention, rehabilitation, patient health monitoring, and human health management. Meanwhile, the ability to track biomarkers based on biosensors allows researchers and medical practitioners to provide patients with individualized treatment regimens and health management. Biosensors that respond to electrochemical, optical, thermal, piezoelectric and magnetic signals have been developed and utilized for various disease therapies and biomedical applications. This study reviews recent developments in biosensor-based therapeutic tools by sensing diverse biomarkers in many diseases (e.g. cancer, infections, metabolic diseases), such as physical biomarkers (e.g. pressure, temperature) and chemical biomarkers (e.g. dissolved oxygen, glucose). Additionally, we highlight the challenges and problems of biosensor-based therapeutics and possible solutions for biosensor engineering thereof. Current biosensors enable for coarsely programable personal treatment and health management, however, new sensors with optimized dose-response functions, for example, fast response and tight-control performances, could significantly boost versatile uses in medical treatment in the coming future.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 212-224"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45644253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Epidermal growth factor-loaded microspheres/hydrogel composite for instant hemostasis and liver regeneration 表皮生长因子负载微球/水凝胶复合材料用于即时止血和肝脏再生

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.09.006

Rui Ding , Xinbo Wei , Youlan Liu, Yuqing Wang, Zheng Xing, Li Wang, Haifeng Liu, Yubo Fan

{"title":"Epidermal growth factor-loaded microspheres/hydrogel composite for instant hemostasis and liver regeneration","authors":"Rui Ding , Xinbo Wei , Youlan Liu, Yuqing Wang, Zheng Xing, Li Wang, Haifeng Liu, Yubo Fan","doi":"10.1016/j.smaim.2022.09.006","DOIUrl":"10.1016/j.smaim.2022.09.006","url":null,"abstract":"<div><p>Rapid hemostasis and effective healing for the non-compressible liver wounds which are not able to be sewn, especially for those large-area wounds, remain great clinical challenges. In this study, we fabricated epidermal growth factor (EGF)-loaded chitosan microspheres (CM) and then incorporated them into a photo-crosslinking gelatin methacryloyl (GelMA) hydrogel. The results showed that the EGF-loaded CM/GelMA precursor solution could transform into a hydrogel and cease bleeding at laceration sites without external stress. Subsequently, the sustained release of EGF accelerated wound closure and promoted liver regeneration. The in vitro experiments demonstrated that the microsphere/hydrogel composite could promote the proliferation and migration of L02 cells. Moreover, the histological and immunohistological analyses indicated that EGF-CM/GelMA composite could alleviate inflammation in the mouse liver and promote liver remodeling. Overall, this multi-functional microsphere/hydrogel composite will inspire the development of clinical applications for noncompressible hemostasis and successive wound closure.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 173-182"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43243822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Tube-shaped nanostructures for enhancing resin-based dental materials: A landscape of evidence and research advancement 增强树脂基牙科材料的管状纳米结构：证据和研究进展

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.03.002

Isadora Martini Garcia , Lamia Sami Mokeem , Yasmin Shahkarami , Lauren Blum , Victoria Sheraphim , Robert Leonardo , Abdulrahman A. Balhaddad , Mary Anne S. Melo

{"title":"Tube-shaped nanostructures for enhancing resin-based dental materials: A landscape of evidence and research advancement","authors":"Isadora Martini Garcia , Lamia Sami Mokeem , Yasmin Shahkarami , Lauren Blum , Victoria Sheraphim , Robert Leonardo , Abdulrahman A. Balhaddad , Mary Anne S. Melo","doi":"10.1016/j.smaim.2023.03.002","DOIUrl":"10.1016/j.smaim.2023.03.002","url":null,"abstract":"<div><p>With the advent of nanotechnology, incorporating nanoscale fillers in dental resins seems promising to improve therapeutic features and provide more excellent physicochemical properties for dental materials. The use of nanotubes has been raised due to their excellent mechanical properties, carry and delivery of drugs capabilities, and bioactive properties. These features depend on the composition of nanotubes and their application. This scoping review aims to describe previous studies about incorporating nanotubes in restorative resin-based materials. The main goals here addresses are: (1) to identify which are the most used nanotubes in the development of these dental materials; (2) to verify which the molecules/particles associated with these nanotubes; (3) to report the objectives of the incorporation of nanotubes to these dental materials and main results. The searches were performed using PubMed and Scopus databases in December 2022, identifying 534 manuscripts. After the selection process, 43 studies were included in the review. We mainly analyzed and discussed the nanotubes' composition, the parental materials in which the nanotubes were incorporated, the purposes of adding these particles to the dental materials, how the materials were analyzed, and the primary studies' outcomes. The outcomes are stimulating and reveal a promising advance in dental resins with the possibility of improving the maintenance of restorations and patients' quality of life. Further studies should address the abovementioned topics to expand the understanding and options of using nanotubes in resin-based restorative materials.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 504-513"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45334109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances on nerve guide conduits based on textile methods 基于纺织方法的神经导管研究进展

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.12.001

Shihan Gao, Xiangshang Chen, Beining Lu, Kai Meng, Ke-Qin Zhang, Huijing Zhao

{"title":"Recent advances on nerve guide conduits based on textile methods","authors":"Shihan Gao, Xiangshang Chen, Beining Lu, Kai Meng, Ke-Qin Zhang, Huijing Zhao","doi":"10.1016/j.smaim.2022.12.001","DOIUrl":"10.1016/j.smaim.2022.12.001","url":null,"abstract":"<div><p>Peripheral nerve injury (PNI) is a common and complex clinical disease with high morbidity, limited treatment options and poor clinical outcomes. Several million cases of PNI in the world every year have brought a heavy burden to the patients and the social economy. Autologous nerve grafting has long been the “gold standard” in the treatment of PNI repair, but it still has some shortcomings, such as donor area injury, limited graft source and mismatch of nerve thickness after transplantation. In recent years, many artificial nerve guidance conduits (NGCs) have emerged for replacing autologous nerve grafts, and their effectiveness has been proven. Currently, there are already clinical products obtained from the European CE Certification, and approved by the Food and Drug Administration (FDA), China Food and Drug Administration (CFDA), Therapeutic Goods Administration (TGA) in Australia, etc. The preparation of NGCs requires interdisciplinary studies and has received considerable attention from researchers in recent years. At present, among emerging and mature manufacturing technologies, textile methods to prepare NGCs are relatively simple and have wide material sources, which has become a hotspot in textile research. This paper mainly reviewed the current situation and recent technological achievements of NGCs that were prepared by textile methods. Several other common methods were also briefly summarized. Furthermore, current NGCs products and their clinical applications were reported. Finally, the future development direction of textile-based NGCs is discussed in this review.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 368-383"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46818489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Developments of microfluidics for orthopedic applications: A review 微流体在骨科应用中的发展综述

Smart Materials in Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.07.001

Miao Sun , Jiaxing Gong , Wushi Cui , Congsun Li , Mengfei Yu , Hua Ye , Zhanfeng Cui , Jing Chen , Yong He , An Liu , Huiming Wang

{"title":"Developments of microfluidics for orthopedic applications: A review","authors":"Miao Sun , Jiaxing Gong , Wushi Cui , Congsun Li , Mengfei Yu , Hua Ye , Zhanfeng Cui , Jing Chen , Yong He , An Liu , Huiming Wang","doi":"10.1016/j.smaim.2022.07.001","DOIUrl":"10.1016/j.smaim.2022.07.001","url":null,"abstract":"<div><p>With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent conclusions in previous studies. Microfluidic technology has shown its advantages in the field of orthopedic research, especially in providing bionic mechanical stimulation environment. The microfluidic device can simulate the complex internal environment through the fine and complex structure and perfusion control system, and provide a stable, controllable and efficient culture system. Moreover, it can serve as a manufacturing device, which can produce bone grafts or bone like organs for tissue engineering with bionic structure. It can also simultaneously act as a detection device, which can realize high-throughput detection of small samples at low cost. In addition, we can establish in vitro physiological or pathological models on microfluidic systems to assist in the diagnosis and treatment of orthopedic diseases. This paper reviews the medical application of microfluidic devices in orthopedics.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"4 ","pages":"Pages 111-122"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48388251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4