原位静电纺芦荟纳米纤维膜用于慢性伤口愈合

Q1 Engineering
Chang Liu , Yun Wang , Pei Wang , Yan Gong , Bingcheng Yi , Jing Ruan , Xiansong Wang
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引用次数: 1

摘要

缓解过度炎症,同时加速慢性伤口愈合以预防伤口感染仍然具有挑战性,尤其是在由SARS-CoV-2引起的2019冠状病毒病(新冠肺炎)大流行期间,患者在获得适当的医疗保健方面遇到困难。我们通过开发手持式电纺芦荟纳米纤维膜(ANFMs)来解决这个问题,该膜具有方便、环保的特性和伤口闭合的治疗能力。我们的研究结果表明,用高分子量聚乙烯醇(PVA)在静电纺丝过程中制备的ANFM具有均匀的纤维结构和多孔结构。鉴于芦荟凝胶在加速伤口愈合方面的价值,ANFMs的液体提取物显著下调促炎基因白细胞介素-6(IL-6)和诱导型一氧化氮合酶(iNOS)的表达,并显著抑制脂多糖诱导的RAW264.7巨噬细胞中活性氧(ROS)的产生。这些结果表明ANFMs具有良好的抗氧化和抗炎作用。在原位植入小鼠糖尿病伤口模型12天后,ANFMs通过促进血管生成和增强细胞活力显著加速了慢性伤口愈合。我们的ANFM由手持式静电纺丝原位愈合的慢性伤口产生,为患者在不同条件下治愈自己的伤口提供了一种方便且有前景的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In situ electrospun aloe-nanofiber membrane for chronic wound healing

Alleviating excessive inflammation while accelerating chronic wound healing to prevent wound infection has remained challenging, especially during the coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 when patients experienced difficulties with receive appropriate healthcare. We addressed this issue by developing handheld electrospun aloe-nanofiber membranes (ANFMs) with convenient, environmentally friendly properties and a therapeutic capacity for wound closure. Our results showed that ANFMs fabricated with high molecular weight polyvinyl alcohol (PVA) to form fibers during electrospinning had uniform fibrous architecture and a porous structure. Given the value of aloe gel in accelerating wound healing, liquid extracts from ANFMs significantly downregulated the expression of the pro-inflammatory genes, interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS), and markedly suppress the generation of reactive oxygen species (ROS) induced by lipopolysaccharide in RAW264.7 macrophages. These results indicated the excellent antioxidant and anti-inflammatory effects of ANFMs. After implantation into a mouse diabetic wound model for 12 days in situ, ANFMs notably expedited chronic wound healing via promoting angiogenesis and enhancing cell viability. Our ANFMs generated by handheld electrospinning in situ healed chronic wounds offer a convenient and promising alternative for patients to heal their own wounds under variable conditions.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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