The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review

Q1 Engineering
Songtao Zhang , Ziyi Shao , Yihong Wu , Yongyi Song , Yaxi He , Zongyi Liu , Xiaodong Fu , Leyu Wang
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引用次数: 0

Abstract

Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence of inflammatory response, leading to the formation of non-contractile and non-conducting fibrotic scar tissue. Thus, it disrupts the mechano-electric coupling system of the heart, negatively influencing the heart function. Recently, the conductive cardiac patches with advantage of reconstructing electrical propagation have been extensively applied for cardiac repair. This review introduces a detailed overview of the recent progress in cardiac electrophysiology-inspired patches for cardiac repair from three parts of the construction and functionality of mechano-electric coupling cardiac patches, the construction and functionality of microstructure of the cardiac patches, the realtime detection based on mechano-electric transformation. Finally, the achievements and future perspective of conductive cardiac patches is discussed from the aspects of biosafety, further exploration of factors affecting mechano-electric coupling in cardiac patches and regulation of detection. It is hopeful to help researchers understand the functional components and development of conductive cardiac patches for cardiac repair, as well as to inspire them to synthesize novel cardiac patches for promoting clinical translation.

Abstract Image

心脏电生理激励贴片修复心肌梗死的研究进展
心肌梗死因其在世界范围内的高发病率和死亡率,已成为严重威胁人类健康的疾病。主要问题是有限再生心肌细胞的损失和炎症反应的发生,导致非收缩性和非传导性纤维化瘢痕组织的形成。因此,它破坏了心脏的机电耦合系统,对心脏功能产生负面影响。近年来,心脏传导贴片以其重构电传播的优点在心脏修复中得到了广泛的应用。本文从机电耦合心脏贴片的结构和功能、心脏贴片微观结构的结构和功能、基于机电转换的心脏电生理贴片的实时检测等三个方面详细介绍了心脏电生理贴片修复的最新进展。最后,从生物安全性、心脏贴片机电耦合影响因素及检测调控等方面探讨了导电心脏贴片的研究成果及未来展望。这将有助于研究人员了解心脏修复导电性心脏贴片的功能组成和发展,并启发他们合成新的心脏贴片以促进临床翻译。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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