Anti-fouling coatings for blood-contacting devices

Q1 Engineering
Shiyu Yao , Hui Yan , Shiyu Tian , Rifang Luo , Yuancong Zhao , Jin Wang
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引用次数: 0

Abstract

Blood-contacting medical devices, such as vascular stents, intravascular catheters, and artificial heart valves, frequently encounter complications in clinical practice, including thrombosis, inflammatory reactions, and infections. These challenges pose significant obstacles in the effective application of blood-contacting medical devices. Given that protein adhesion serves as the primary trigger for detrimental events upon contact with blood, this review focuses on various anti-fouling coating strategies aimed at inhibiting protein adsorption. Currently, surface modification of blood-contacting medical devices primarily involves the construction of active or passive anti-fouling coatings. This review explores the implementation of active and passive anti-fouling coating strategies utilizing chemistry, physics, and biotechnology. Examples of anti-fouling coatings discussed include hydrophilic polymer coatings, zwitterionic polymer coatings, superhydrophobic coatings, and composite coatings. Furthermore, we propose implementation approaches for these coatings to address inflammation and infection challenges associated with blood-contacting devices. The review concludes with a brief overview of current surface modification technologies employed in commercial anti-fouling coatings and offers insights into the future of anti-fouling coating technologies for blood-contacting material surfaces. These advancements are essential for the advancement of design, development, and application of blood-contacting materials.

血液接触设备的防污涂层
血管支架、血管内导管和人工心脏瓣膜等与血液接触的医疗器械在临床实践中经常会遇到血栓形成、炎症反应和感染等并发症。这些挑战对血液接触医疗器械的有效应用构成了重大障碍。鉴于蛋白质吸附是导致与血液接触后发生有害事件的主要诱因,本综述将重点介绍旨在抑制蛋白质吸附的各种防污涂层策略。目前,血液接触医疗器械的表面改性主要涉及主动或被动防污涂层的构建。本综述将探讨如何利用化学、物理和生物技术实施主动和被动防污涂层策略。讨论的防污涂层实例包括亲水性聚合物涂层、齐聚亚铵盐聚合物涂层、超疏水性涂层和复合涂层。此外,我们还提出了这些涂层的实施方法,以解决与血液接触设备相关的炎症和感染难题。综述最后简要概述了目前商用防污涂层所采用的表面改性技术,并对血液接触材料表面防污涂层技术的未来发展提出了见解。这些进步对于推动血液接触材料的设计、开发和应用至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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