Current Research on Laser Use in Oncology最新文献_第3页

Methods of optical tomography in biomedicine 生物医学中的光学断层成像方法

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.639946

I. Turchin, N. Shakhova, V. Kamensky, A. Orlova

引用次数: 0

Modern copper and gold vapor laser setups used in oncology 用于肿瘤学的现代铜和金蒸汽激光装置

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.639956

I. S. Kolobkov, V. Klimenko, N. A. Lyabin, G. Paramonova, A. Chursin, A. Kazaryan, M. Kazaryan, E. Morozova, N. M. Lepekhin, Y. Priseko, V. Philipov, A. M. Shakhzadeyan

引用次数: 0

PDT opportunities in oncology practice PDT在肿瘤学实践中的机会

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640040

M. Gelfond

引用次数: 4

Multifunctional laser therapeutic device: new technologies in medicine 多功能激光治疗仪:医学新技术

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640142

V. N. Svirin, V. Chernenko

{"title":"Multifunctional laser therapeutic device: new technologies in medicine","authors":"V. N. Svirin, V. Chernenko","doi":"10.1117/12.640142","DOIUrl":"https://doi.org/10.1117/12.640142","url":null,"abstract":"This paper considers the problems of application of high-power semiconductor lasers for designing multifunctional laser therapeutic devices (MLTD) and the prospects of their use in oncology and other areas of medicine. It is shown that the MLTD allows the realization of the method of combined photodynamic therapy (PDT) and laser-induced thermotherapy (LITT) in treatment of oncology diseases of different localizations. The technology for treatment of cancer based on the method of combined PDT and LITT and the MLTD device conforms to the advanced world tends in treatment of oncology diseases with the use of laser radiation. The problems of interaction of laser radiation with a biological tissue in oncology and therapy of various pathologies are briefly considered, and the list of the main functional parameters of the MLTD is formulated. The problems of designing the hardware and algorithrmc software of the MLTD, the technical and user characteristics are considered, including the features of automatic digital c ontrol of laser power depending on the level of temperature of a biological tissue. The areas of medicine where the MLTD can be used with the most efficiency are shown.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"79 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125919763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vivo evaluation of accumulation of sensitizers for oncological diagnostics and therapy using the method of diffuse reflectance spectroscopy 用漫反射光谱学方法评估肿瘤诊断和治疗中致敏剂的体内积累

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640052

I. Meerovich, A. A. Stratonnikov, A. V. Ryabova, G. Meerovich, N. Oborotova, A. Brandis, E. Lukyanets, O. Kaliya, P. Bendel, V. Loschenov, A. Scherz, A. Baryshnikov

引用次数: 2

Photodynamic therapy and fluorescent diagnostics of head and neck cancer with second-generation photosensitizers 第二代光敏剂对头颈癌的光动力治疗和荧光诊断

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640039

E. Vakulovskaya

{"title":"Photodynamic therapy and fluorescent diagnostics of head and neck cancer with second-generation photosensitizers","authors":"E. Vakulovskaya","doi":"10.1117/12.640039","DOIUrl":"https://doi.org/10.1117/12.640039","url":null,"abstract":"Photodynamic Therapy (PDT) and fluorescent diagnostics (FD) using Photosense was provided in 50 patients with head and neck cancer T1-3 stage, in 89 patients with skin cancer, using Radaclorine (RC) in 42 patients with T1-4 stage basal cell carcinoma (BCC),in 6 patients with oral cancer. Detection of borders of tumor, intensity of accumulation of photosensitizers in tumor, normal tissues were done by Spectral-fluorescent Complex. We've got fluorescence of a11 tumors and additional fluorescence zones were found with cytological verification. We used semiconductive lasers: Milon - λ = 660+2nm, light dose 200 - 300 J/cm2 and Biospec (λ=672+2nm), multiple laser surface and interstitial irradiation with total light dose till 400-600 J/cm2. After PDT with PS in head and neck cancer we've had complete response (CR) in 66.0% and partial response (PR) in 30.0%, with RC CR in BCC T1-2NOMO - 92.9%, in recurrencies CR - 60,6%, PR - 39,4%. The efficacy of PDT with PS was higher (CR - 86.7%, PR - 13,3%) and the recurrence rate in 6 months lower. Our experience show pronounced efficacy of PDT for head and neck tumors of different localization and histology, FD is providing diagnostically significant information, demonstrated high sensitivity and specificity.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128973278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fluorescent and photodynamic properties of near-infrared photosensitizer bacteriochlorophyllide-serine 近红外光敏剂细菌叶绿素丝氨酸的荧光和光动力学性质

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640051

I. Meerovich, I. Kubasova, N. Oborotova, G. Meerovich, S. Demura, A. Brandis, V. Rosenbach‐Belkin, A. Baryshnikov, A. Scherz

引用次数: 1

Enhancing photoditazine-mediated photodynamic therapy of tumours 增强光二嗪介导的肿瘤光动力治疗

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640048

D. Vassiliev, A. N. Stukov

引用次数: 1

Comparative study of photo-induced activity of di- and tri-sulfonated derivatives of metal-free phthalocyanine and Photosens 无金属酞菁二磺酸和三磺酸衍生物光诱导活性的比较研究

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640050

R. Yakubovskaya, N. Morozova, T. Karmakova, Anna D. Plutinskaya, V. Chissov, V. Derkacheva, E. Luk'yanets, G. Vorozhtsov

{"title":"Comparative study of photo-induced activity of di- and tri-sulfonated derivatives of metal-free phthalocyanine and Photosens","authors":"R. Yakubovskaya, N. Morozova, T. Karmakova, Anna D. Plutinskaya, V. Chissov, V. Derkacheva, E. Luk'yanets, G. Vorozhtsov","doi":"10.1117/12.640050","DOIUrl":"https://doi.org/10.1117/12.640050","url":null,"abstract":"Di- and tri-sulfonated derivatives of metal-free phthalocyanine and Photosens have been compared in this study. In vitro phototoxicity was studied on HEp2, A549, and Colo26 cell cultures. It has been shown that phototoxicity of di- and tri- sulfonated derivatives of metal-free phthalocyanine exceeds phototoxicity of Photosens 5- and 8-times on HEp2 cell line, 8- and 6-times on A549 cell line, and 22-times on Colo26 cell line, respectively. In vivo photo-induced antitumor activity of metal-free phthalocyanine and Photosens was evaluated on mice with transplanted P388 lymphocytic leukemia. Dependence of photodynamic therapy efficiency on photosensitizer dose and time interval between preparation administration and irradiation was studied. It has been shown that Photosens is the most efficient in 5 mgikg of animal body weight dose and at 24-hour interval between injection and irradiation (tumor growth inhibition (TGI) - 82.2-95.6%). Metal-free phthalocyanine is the most efficient in 0.5 mg/kg dose which is 10- times lower than Photosens dose and when irradiated 4 hours later the injection (TGI - 78.6-100%). Metal-free di- and tri-sulfonated phthalocyanines are promising photosensitizers for photodynamic therapy. Taking into account its physical and chemical properties metal-free tri-sulfonated phthalocyanine named \"Phthalosens\" has been chosen for further thorough study.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126575806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formalization of PDT-photosensitizer spectral data with spectral coordinates method 用光谱坐标法形式化pdt光敏剂光谱数据

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640133

E. Kustov, M. Loshchenov

引用次数: 0