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Current Research on Laser Use in Oncology最新文献

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Kinetic characteristics of porphyrin distribution in the blood 卟啉在血液中分布的动力学特征
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375257
V. Zorin, I. Khludeyev, I. S. Mikhalovsky, T. Zorina, V. Savitsky, S. B. Mel'nov, Nina D. Kochubeyeva, I. Kravchenko
{"title":"Kinetic characteristics of porphyrin distribution in the blood","authors":"V. Zorin, I. Khludeyev, I. S. Mikhalovsky, T. Zorina, V. Savitsky, S. B. Mel'nov, Nina D. Kochubeyeva, I. Kravchenko","doi":"10.1117/12.375257","DOIUrl":"https://doi.org/10.1117/12.375257","url":null,"abstract":"The objectives of the present work were to compare the kinetics of porphyrin exchange between different plasma lipoproteins and biological membranes. Isolated proteins were loaded by porphyrins (chlorin e6 derivatives and Zn- phthalocyanine) and the kinetics of pigment transfer from protein carrier to pigment-free proteins or biological membranes were analyzed by spectroscopic techniques. It was obtained that the rate of exchange depended strongly on the pigment polarity. A main trend was that the time required for equilibrium redistribution increased with decreasing dyes polarity. Its values changed from seconds for polar sensitizers to tens of minutes in the case of apolar dyes. Extremely slow redistribution (several hours) was observed when the recovery of apolar pigments (chlorin e6 trimethylester and Zn-phthalocyanine) from LDL was studied. The results clear indicate that the rate of pigment exchange between proteins and cells may contribute to the control of sensitizer distribution in blood and solid tissues.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"325 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122741602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Multifrequency Nd:YAG laser application for tumor fluorescence diagnosis 多频Nd:YAG激光在肿瘤荧光诊断中的应用
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375250
D. Yova, Konstantinos N. Halkiotis, A. Manolopoulos, N. Ouzounoglou, V. Hovhannisyan, L. Avanessian
{"title":"Multifrequency Nd:YAG laser application for tumor fluorescence diagnosis","authors":"D. Yova, Konstantinos N. Halkiotis, A. Manolopoulos, N. Ouzounoglou, V. Hovhannisyan, L. Avanessian","doi":"10.1117/12.375250","DOIUrl":"https://doi.org/10.1117/12.375250","url":null,"abstract":"A computerized fiber-optic spectrofluorometer based on a multifrequency Nd:YAG laser ((lambda) equals 355, 440, 532 and 660 nm, f equals 25 Hz, E equals 1 - 10 mJ, (tau) equals 12 ns) for tissue fluorescence registration in vivo and ex vivo has been developed. The less intensive fluorescence from a tumor of Sarcoma-45 bearing animal model in comparison with the surrounding normal tissue was observed at the spectral region around 450 nm. The influence of reabsorption, energy transfer and other physical factors on tumor fluorescence, sensitized by Photohem (hematoporphyrin derivative), disodium salt of fluorescein (FL) and chlorin e6 (Chl) was investigated. The pharmacokinetic behavior of Chl in different organs and tumors of the animal models has been estimated. The most intensive Chl fluorescence of tumor tissue was observed at 18 hours after photosensitizer injection. The maximum of the tumor-to-healthy tissue ratio of fluorescence was reached 10 at 27 hours after pigment injection. The fluorescence spectra from different types of human tumors after i/v injection with FL or topical application of ALA were studied. A simple model of Nd:YAG laser system for tumor fluorescence diagnosis has been elaborated. Advantages of the laser fluorescence diagnosis of malignant tumors by solid state multifrequency Nd:YAG laser and the increase in accuracy and specificity of this method is discussed.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125560564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic therapy for recurrent and residual malignant tumors of the oropharyngeal area 口咽区复发及残留恶性肿瘤的光动力治疗
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375271
Eugeny P. Stranadko, Max I. Garbusov, Nikolai A. Markitchev, M. Riabov
{"title":"Photodynamic therapy for recurrent and residual malignant tumors of the oropharyngeal area","authors":"Eugeny P. Stranadko, Max I. Garbusov, Nikolai A. Markitchev, M. Riabov","doi":"10.1117/12.375271","DOIUrl":"https://doi.org/10.1117/12.375271","url":null,"abstract":"The frequency of tumor recurrences, according to the modern literature, remains high even in early stages of cancer (15% to 35%), the efficacy of conventional therapy for recurrent tumors is insufficient. In the State Research Center for Laser Medicine in 1992-97 photodynamic therapy with russian photosensitizers Photoheme ((lambda) equals 630 nm) and Photosense ((lambda) equals 670 nm) has been applied to 42 patients with recurrent and/or residual tumors (size corresponding to T1 - T4 symbols) of oropharyngeal area. We used laser irradiation for 3 - 30 minutes, power density used was from 0.05 to 1.0 W/cm2, energy density - 300 J/cm2. Therapeutic effect in term from 3 to 45 months was achieved in 39 (92.9%) patients. Complete resorption of tumors took place in 23 (54.8%) cases, partial resorption - in 16 (38.1%); in 3 cases (7.1%) the results of PDT were assessed as no response (tumor size decrease by less than 50%). Absolute resistance to PDT has not been noticed. The data obtained shows that PDT is a promising treatment modality for managing recurrent and residual tumors of oropharyngeal area.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116142902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of low-level laser radiation in children's oncology with complications caused by chemoradiation 低水平激光在儿童肿瘤伴放化疗并发症中的应用
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375272
S. Balakirev, L. Gusev, A. A. Grabovschiner, V. N. Khristoforov, J. Ivanova, E. I. Shyshkova
{"title":"Application of low-level laser radiation in children's oncology with complications caused by chemoradiation","authors":"S. Balakirev, L. Gusev, A. A. Grabovschiner, V. N. Khristoforov, J. Ivanova, E. I. Shyshkova","doi":"10.1117/12.375272","DOIUrl":"https://doi.org/10.1117/12.375272","url":null,"abstract":"The present work is based on a 12 month clinical observation period of 155 patients aged from 6 months to 15 years with multiple complications after chemoradiant treatment of hemoblastos and solid tumors. The application of Magnetic Infrared Laser therapy for different complications caused by chemoradiation treatment of children's malignant tumors is an entirely new method and for the first time has been tried in children's oncology.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"131 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128686227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Alteration of photosensitizer content and parameters of free radical reactions in a patient's blood under photodynamic therapy of malignant tumors 恶性肿瘤光动力治疗下患者血液中光敏剂含量及自由基反应参数的改变
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375261
G. N. Lubchenko, T. V. Chichuk, Eugeny P. Stranadko
{"title":"Alteration of photosensitizer content and parameters of free radical reactions in a patient's blood under photodynamic therapy of malignant tumors","authors":"G. N. Lubchenko, T. V. Chichuk, Eugeny P. Stranadko","doi":"10.1117/12.375261","DOIUrl":"https://doi.org/10.1117/12.375261","url":null,"abstract":"The purpose of this study was to determine the changes in concentrations of the two Russian photosensitizers in blood plasma of patients under Photodynamic therapy. In this work were used two sensitizers of domestic production: Photohem (hematoporphyrin derivative) and Photosense (sulfonated aluminium phtalocyanine). It was found that one month after injection the concentrations of the photosensitizers in blood plasma remained high enough. Was shown alteration of level of apo-(beta) -lipoproteins oxidation and antioxidant activity of blood plasma under the influence of Photodynamic therapy.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"4059 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128986689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncological aspects of the biological action of low-level laser radiation: I. Experimental foundation for LLLR use in oncology 低水平激光辐射生物作用的肿瘤学方面:1 . LLLR在肿瘤学应用的实验基础
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375251
A. Ivanov
{"title":"Oncological aspects of the biological action of low-level laser radiation: I. Experimental foundation for LLLR use in oncology","authors":"A. Ivanov","doi":"10.1117/12.375251","DOIUrl":"https://doi.org/10.1117/12.375251","url":null,"abstract":"In this paper the results of an experimental-clinical study substantiating the use of low level laser radiation (LLLR) at certain wavelengths for treatment of cancer patients are given. In the first part of this study, with animal experiments, laser action parameters providing reliable renewal and regeneration stimulation are selected. It is shown that, under the effect of LLLR, the speed and quality of regeneration in wounds after tumor removal are changed as well as the intensity of dissemination and tumor growth. A change also occurs in the functional properties of lymphocytes, which have immunological control in the organism. On the basis of the experimental data obtained, the contingent of cancer patients for whom LLLR can be recommended was determined.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133399790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-vivo analysis of human cancer cells by means of laser phase microscopy 用激光相位显微镜对人癌细胞的体内分析
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375267
E. Perevedentseva, G. Graschev, Evangelos Balanos, C. Dressler, J. Beuthan, P. Schlag
{"title":"In-vivo analysis of human cancer cells by means of laser phase microscopy","authors":"E. Perevedentseva, G. Graschev, Evangelos Balanos, C. Dressler, J. Beuthan, P. Schlag","doi":"10.1117/12.375267","DOIUrl":"https://doi.org/10.1117/12.375267","url":null,"abstract":"Phase images of human colon carcinoma cells CX1, HCT15, HCT116 and human urinary bladder carcinoma cells EJ28 were obtained with laser phase microscope and have been analyzed. The phase shift images are compared with conventional light microscopy and confocal laser scanning microscopy data in order to detect the correspondence between morphological peculiarities and phase characteristics of measured cell. Influence of interactions between human carcinoma cells and specific antibodies (CC18 monoclonal antibody to cytokeratin and MRK 16 monoclonal antibody) on the cells phase images was studied.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116988175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitized action of low-level laser radiation mechanism 低能级激光辐射机理的敏化作用
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375253
Tatyana V. Chichuk, Eugeny P. Stranadko, G. N. Lubchenko, E. V. Podgornaya, E. E. Pozdnyakova, Gennady I. Klebanov
{"title":"Sensitized action of low-level laser radiation mechanism","authors":"Tatyana V. Chichuk, Eugeny P. Stranadko, G. N. Lubchenko, E. V. Podgornaya, E. E. Pozdnyakova, Gennady I. Klebanov","doi":"10.1117/12.375253","DOIUrl":"https://doi.org/10.1117/12.375253","url":null,"abstract":"The goal of this work is to study the laser-induced photosensitized oxidation of lipids of the artificial (lyposomes) and cell's (erythrocytes, leukocytes) membranes and human blood lipoproteins. As a exogenous photosensitizers we are used hematoporphyrin derivatives (HPD) and sulfonated phthalocyanine aluminum (Pc). Irradiation was performed by helium-neon laser (632.8 nm). It was found out the increasing of the products of lipid oxidation in the suspensions of a lyposomes, human blood apo-(beta) -lipoproteins, erythrocytes and leucocytes. Accumulation of the lipid oxidation products depend on as irradiation dose as HPD or Pc concentrations. Interaction of photosensitizers with the lyposomes, lipoproteins and erythrocytes was investigated.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116990162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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