V. Sokolov, N. N. Zharkova, E. Filonenko, L. Telegina, E. Karpova
{"title":"Present-day potentialities of endoscopic diagnostics and treatment of early cancer in respiratory and digestive tracts","authors":"V. Sokolov, N. N. Zharkova, E. Filonenko, L. Telegina, E. Karpova","doi":"10.1117/12.375248","DOIUrl":"https://doi.org/10.1117/12.375248","url":null,"abstract":"The paper presents the latest potentialities of the endoscopic fluorescent diagnostics as well as endoscopic electric-, laser surgery and photodynamic therapy (PDT) of the early cancer in the respiratory and digestive tracts. We present in detail indication and factors determining the application of the endoscopic resection of the tumor. The advantages of the combination application of PDT, electro-, Nd:YAG laser surgery and brachitherapy are stressed. The near and remote results of endoscopic treatment of the early cancer in larynx (37), lung (109), esophagus (39) and stomach (58) are shown.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131243976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histochemical stains as promising means for the laser histochemical surgery of a number of pathologies","authors":"L. Piruzyan, Y. Mikhailovskiy, A. Piruzyan","doi":"10.1117/12.375263","DOIUrl":"https://doi.org/10.1117/12.375263","url":null,"abstract":"The directions of laboratory and clinical studies oriented to experimental confirmation of the priority concept of `laser histochemical surgery' are presented. The goal of the studies is reproduction on experimental model of a number of pathologies (in vivo and in vitro) of the `sensitization to laser radiation by staining' effect. Testing of the histochemical stains as sensitizers to laser irradiation of their `address substrates', i.e. vitally stained intracellular structures which participate in the pathologic processes evolution is under planning. The processes include: (a) metabolic disorders in the brain cells, i.e. disseminated sclerosis; (b) generalized metabolic disorders- -mucopolysaccharidosis and collagenosises (periarteritis nodosa, rheumatism, rheumatoid arthritis, sclerodermia); (3) metabolic disorders in individual organs--vessel atherosclerosis, hypercholesterolemia, myocardial infarction, cardiosclerosis, caries and parodontosis. The conditions of the studies are detailed in the recommendations along the positions: (1) disease name; (2) disease characteristics: (a) pathomorphologic, (b) biochemical; (3) stains revealing the disease signs and recommended for testing; (4) `address substrates' of the stains that are targets for laser radiation; (5) lasers recommended for the testing after the cells staining in vivo in the corresponding pathology; (6) experimental models of the pathologies suggested for the testing; (7) criteria of the stain efficiency as target sensitizer to the laser light (criteria of the `laser sensitization by staining' efficiency). Possible perspectives for the experimental clinical medicine are indicated of common histochemical stains and lasers use and of practice introduction of the `laser histochemical surgery' in the case the described concept is confirmed in experiments and clinically.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120959727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eugeny P. Stranadko, V. M. Meshkov, U. M. Koraboyev, M. Riabov
{"title":"Clinical photodynamic therapy using Russian photosensitizers Photoheme and Photosense: six-year experience","authors":"Eugeny P. Stranadko, V. M. Meshkov, U. M. Koraboyev, M. Riabov","doi":"10.1117/12.375269","DOIUrl":"https://doi.org/10.1117/12.375269","url":null,"abstract":"Background and objective Unsatisfactory results of traditional treatment of malignant tumors force oncologists to search new therapeutic modalities. Photodynamic therapy (PDT) is one ofthe promising and intensively developing techniques in cancer treatment. Materials and methods The results of application of photodynamic therapy for treatment of malignant tumors of various localizations were assessed. In 1992 - 1998 more than 1270 malignant tumors in 308 patients have been treated with PDT. Most of the patients have been taken into PDT for tumor recurrences or mtradermal metastases after surgery, gamma-therapy or combined treatment. Russian photosensitizers Photoheme and Photosense were used. Results Up to date we obtain the follow-up data in term from 2 months to 6 years. Therapeutic effect took place in 94.7% of cases. including complete tumor resorption in 55 .5% and partial resorption in 39.2% of cases. Conclusion The results of PDT application for treating malignant tumors allow one to estimate PDT as adequate technique. In some tumor localizations PDT may become optional technique.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116775326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fiberscope for spatially selective laser therapy","authors":"A. Karmenyan, A. Polutov","doi":"10.1117/12.375266","DOIUrl":"https://doi.org/10.1117/12.375266","url":null,"abstract":"For using in the complex for diagnostics and therapy tumors with the aid photodynamic therapy the special fiberscope was developed. Ergonomic principles are incorporated in the design of these compact and lightweight control heads. The efficiency of phototreatment could be improved by reducing the traumatism of normal tissues during the phototherapeutic procedures with achieving the homogeneous distribution of laser emission intensity on the tumor surface and with decreasing the labor intensiveness of phototreatment. The method forming and delivering the image of phototreatment to tumor with the aid special fiberscope was described.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"413 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133876292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oncological aspects of the biological action of low-level laser radiation: II. Investigation of primary mechanisms and clinical applications","authors":"A. Ivanov, S. Zakharov","doi":"10.1117/12.375252","DOIUrl":"https://doi.org/10.1117/12.375252","url":null,"abstract":"The second part of this paper presents the results of many years of research on the primary stages of the biological mechanism of LLLR action. The scanning electron microscopy method revealed some activation of the cell membrane in the irradiated human lymphocytes. This is shown in ultrastructure surface change. In the study on magnetic characteristics paramagnetic properties were fond at 633 nm irradiation of cell suspension, connected wit the formation of free-radical products as a result of primary photochemical processes. In order to identify the primary photoacceptor that sets off a chain of biochemical, structural and metabolic changes in the cell, biological action spectra were studied. With the laser cytodiffractometer coincidence between the action spectra and the absorption band of molecular oxygen was established.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130955248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Uzdensky, A. V. Ivanov, A. V. Reshetnickov, G. Ponomarev, O. Dergacheva, A. Zhavoronkova
{"title":"Photodynamic effect of deuteroporphyrin IX derivatives on isolated nerve cell","authors":"A. Uzdensky, A. V. Ivanov, A. V. Reshetnickov, G. Ponomarev, O. Dergacheva, A. Zhavoronkova","doi":"10.1117/12.375258","DOIUrl":"https://doi.org/10.1117/12.375258","url":null,"abstract":"Deuteroporphyrin IX derivatives are prospective PDT porphyrin photosensitizers (PS). The photodynamic effects of 6 new amphiphilic deuteroporphyrin derivatives with different hydrophobicity, as well as effects of known photosensitizers Photoheme and Photosens (used for comparison) on the firing of isolated crayfish mechanoreceptor neuron have been studied. After 30 min photosensitization, neurons were irradiated with He-Ne laser (632.8 nm, 0.3 W/cm2), and changes in neuron firing frequency were recorded. It has been shown that neuron firing is very sensitive to photodynamic impact and can serve as a sensitive indicator of cell photodamage.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129492251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laser correlation spectrometry: a new approach to organizing oncological screening for a population exposed to chronic irradiation","authors":"A. Akleyev, I. Pashkov, M. Kisselyov, L. Noskin","doi":"10.1117/12.375274","DOIUrl":"https://doi.org/10.1117/12.375274","url":null,"abstract":"The issue of stochastic effects of radiation exposure (mostly leukemia and cancer), and early detection of malignant tumors, as a key aspect of the problem, is of crucial importance to the population chronically exposed due to the activities of the Mayak Production Association in the Urals region (Russia). Given the large number of exposed population, screening is considered to be the most expedient method to organize medical observation of exposed persons. As was shown by the results of medical examinations conducted for 1 391 residents of the Techa riverside villages, laser correlation spectrometry (LCS) of blood plasma has proved to be a highly effective screening method for early (pre-clinical) detection of malignant neoplasms and pre-cancerous conditions. It was established that LC- spectra of blood plasma in persons with cancer and pre- cancer can easily be differentiated from non-cancer conditions. Of particular diagnostic significance is the high-frequency range of the spectrum. The development of a diagnostic algorithm has allowed to carry out a computer- based classification of blood plasma LC spectra as a component of exposed population health monitoring system.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115620888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mathematical simulation as a key point of the laser fluorescence diagnostic technique in oncology","authors":"D. Rogatkin, V. Tchernyi","doi":"10.1117/12.375249","DOIUrl":"https://doi.org/10.1117/12.375249","url":null,"abstract":"Today, it is real the use of the laser fluorescence diagnostic systems and procedures for optical noninvasive clinical diagnostic testing of oncologic, burn, suppurative and other destructive-inflammatory processes in tissues and organs. A lot of pathology cases are accompanied by the laser induced backfluorescing flux from soft tissues. And the intensity of that can provide a medical information of disorder's state. But it can be shown, that without mathematical calculations the correct biomedical informations can't be obtained because a number of phenomena answer for increasing of intensity of backfluorescence light. So, the mathematical inverse optical task solution has to be applied in medical fluorescence diagnostic systems.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132063523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Kursova, M. A. Kaplan, R. G. Nikitina, Antonina I. Maligina
{"title":"Prophylaxis and treatment of acute radiation ulcers in rats with low-power infrared laser radiation","authors":"L. Kursova, M. A. Kaplan, R. G. Nikitina, Antonina I. Maligina","doi":"10.1117/12.375255","DOIUrl":"https://doi.org/10.1117/12.375255","url":null,"abstract":"Exposure of radiation ulcers in rats to low-power infrared laser radiation (LPLR) (wavelength--890 nm, pulse power--6 W, frequency--150 and 300 Hz, irradiation time--10 min) noticeably accelerates their healing, reduces exudative processes, increases number of specialized cells in wound. Application of LPLR prior to radiation damage decreases ulcer dimensions.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131950867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Vetshev, L. Ippolitov, V. Loschenov, A. Kazaryan, M. Minnibaev, S. P. Vetshev
{"title":"Laser autofluorescent spectroscopy in adrenal tumor surgery","authors":"P. Vetshev, L. Ippolitov, V. Loschenov, A. Kazaryan, M. Minnibaev, S. P. Vetshev","doi":"10.1117/12.375275","DOIUrl":"https://doi.org/10.1117/12.375275","url":null,"abstract":"Determination of a histological type of adrenal lesion at the preoperative or intraoperative stage allows to choose the optimal volume of surgery and in the short time effectively correct the postoperative hormonal therapy. 12 patients with different adrenal tumours (3 - lightcellular adenoma, 3 - mixedcellular adenoma, 1 - darkcellular adenoma, 1 - trabecular adenoma, 1 - malignant lymphoma, 3 - aldosteroma, 1 - pheochromocytoma, including the chance of combination of mixedcellular adenoma and aldosteroma of left adrenal) were operated on. The patients' aged varied from 33 to 62 years. For the first time we made intraoperative laser autofluorescent spectroscopy (IOLAS). The laser ve1ength was 632.8 nm. We defined a autofluorescent intensity. Portable equipment was used. The duration of the procedure did not exceed 2mm. The autofluorescent peak of adrenal tissue was 1.33±0.05 relativistic unit (RU) at 685 nm. The autofiurescent peaks of adrenal adenomas were 1 .07 RU, 0.9-1 .15 RU, 1.7-1 .9 RU, 3.4 RU accordingly for trabecular adenoma, lightcellular adenoma, mixedcellular adenoma, darkcellular adenoma Besides greater contribution of longwave component to auflurescence is characteristic for mixecellular adenoma and especially for darkcellular adenoma. The autofiurescent peaks of aldosteroma and pheochromocytoma were accordingly 1.2-1.4 RU and 2.2 RU. Spectral distribution of intensity was like mixedcellular adenoma's one. In the case of malignant lymphoma the autofiurescence peak was 2,3 RU and we also noted displacement of maximum of autoflurescence (-15 nm, from 685 nm to 670 nm).The results of IOLAS application as a adjuvant diagnosticmethod point to promise for intraoperative rapid diagnostics of adrenal tumours.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124519182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}