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Current Research on Laser Use in Oncology最新文献

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Novel drug form of chlorin e6 氯气e6的新剂型
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375256
O. Abakumova, R. P. Baum, N. Y. Ermakova, A. T. Gradyushko, T. N. Guseva-Donskaya, A. Karmenyan, U. M. Koraboyev, V. P. Laptev, V. M. Mechkov, L. Mikhailova, N. G. Panferova, A. G. Rebeko, A. V. Reshetnickov, M. Ryabov, Eugeny P. Stranadko, T. A. Tsvetkova, O. Zhukova
{"title":"Novel drug form of chlorin e6","authors":"O. Abakumova, R. P. Baum, N. Y. Ermakova, A. T. Gradyushko, T. N. Guseva-Donskaya, A. Karmenyan, U. M. Koraboyev, V. P. Laptev, V. M. Mechkov, L. Mikhailova, N. G. Panferova, A. G. Rebeko, A. V. Reshetnickov, M. Ryabov, Eugeny P. Stranadko, T. A. Tsvetkova, O. Zhukova","doi":"10.1117/12.375256","DOIUrl":"https://doi.org/10.1117/12.375256","url":null,"abstract":"A novel stable water-soluble form of well known photosensitizer chlorin e6 named `Photodithazine' has been obtained from Spirulina Platensis cyanobacteria as a noncovalent complex with N-methyl-D-glucosamine, and its biological characteristics evaluate, which proved to be as follows: in vitro photocytotoxicity was 1 (mu) M (EC50) as determined by the extent of DNA synthesis inhibition in CaOv cells after irradiation with 650 - 900 nm light, and 5 (mu) M (EC65) as determined using MTT test on PC12 cells after irradiation with 670 nm laser light at the doses of 15 and 20 J/cm2, respectively, with Al-sulfophthalocyanine `Photosense' (Russia) and oligomerized hematoporphyrin-IX mixture `Photogen' (Russia) being used as permitted reference drugs.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"4059 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129851287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Selective laser hyperthermia of malignant neoplasms: experimental and clinical research 恶性肿瘤选择性激光热疗的实验与临床研究
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375259
M. Gelfond, I. Mizgirev, A. Barchuk, V. V. Hudoley, D. Vasilyev, F. V. Balluzek, A. A. Venkov, V. P. Chaly, A. Ter-Martirosyan
{"title":"Selective laser hyperthermia of malignant neoplasms: experimental and clinical research","authors":"M. Gelfond, I. Mizgirev, A. Barchuk, V. V. Hudoley, D. Vasilyev, F. V. Balluzek, A. A. Venkov, V. P. Chaly, A. Ter-Martirosyan","doi":"10.1117/12.375259","DOIUrl":"https://doi.org/10.1117/12.375259","url":null,"abstract":"Experimental study of various modes of the semiconductor laser irradiation upon Ehrlich carcinoma in mice was carried out. Optimal patterns for distance laser scanning irradiation resulting in practically complete healing of experimental animals, were found. Selective damage of tumor tissue subjected to laser irradiation at 800 nm was evidenced in the absence of a photosensitizing agent. The results of a clinical trial completely corresponded to the experimental data. The treatment proved to be efficient in all 28 patients.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133846105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New approaches to photodynamic therapy of tumors with Al phthalocyanine 酞菁Al光动力治疗肿瘤的新途径
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375270
Elena G. Vakoulovskaya, V. V. Chental, Yury P. Kuvshinov, Boris K. Poddubny
{"title":"New approaches to photodynamic therapy of tumors with Al phthalocyanine","authors":"Elena G. Vakoulovskaya, V. V. Chental, Yury P. Kuvshinov, Boris K. Poddubny","doi":"10.1117/12.375270","DOIUrl":"https://doi.org/10.1117/12.375270","url":null,"abstract":"The aim of the study was to determine the efficacy of photodynamic therapy (PDT) of tumors of different localization and histology with new photosensitizer aluminum sulfonated phthalocyanine (Photosense, Russia). PDT have been provided in 106 patients with different tumors. The initial dose (2.0 - 2.5 mg/kg) of PHS was significantly reduced till 0.5 - 0.8 mg/kg during clinical trials because of phototoxicity. The results of PDT, side effects and ways of their correction and prevention, as well as possibility to work out less toxic regimes of PDT with photosense, choice of laser and type of irradiation are discussed. Efficacy of PDT depended on tumor size and it's histological type. Using low doses of PHS we've reduced the phototoxicity of sensitizer with the same direct effectiveness of treatment. Undesirable changes in plasma content of antioxidants by means of high pressure liquid chromatography have been found in patients after PHS injection. Influence of short-term and long-term supplementation with beta- carotene and vitamin E on this parameters are discussed.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117236271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Photodynamic effect of different aluminum and zinc phthalocyanines on isolated nerve cell 不同酞菁铝锌对离体神经细胞的光动力效应
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375260
A. Uzdensky, A. Zhavoronkova, O. Dergacheva, V. Derkacheva
{"title":"Photodynamic effect of different aluminum and zinc phthalocyanines on isolated nerve cell","authors":"A. Uzdensky, A. Zhavoronkova, O. Dergacheva, V. Derkacheva","doi":"10.1117/12.375260","DOIUrl":"https://doi.org/10.1117/12.375260","url":null,"abstract":"The photodynamic effects of sulphonated zinc (ZnPcS2, ZnPcS3 and ZnPcS4) and aluminum (AlPcS3) phthalocyanines as well as phosphonated aluminum phthalocyanine on the firing of isolated crayfish mechanoreceptor neurons were studied. After 30 min photosensitization neurons were irradiated with He-Ne laser (632.8 nm, 0.3 W/cm2) and changes in neuron firing frequency were recorded. Neuron firing was found to be very sensitive to photodynamic impact and served as a sensitive indicator of cell photodamage. The dynamics of the neuron responses to photodynamic effects included stages of firing activation and/or inhibition prior to irreversible firing abolition and depended on the photosensitizer type and concentration. The comparison of the dependencies of neuron lifetime on photosensitizer concentrations showed that the most effective photosensitizer was ZnPcS2. High photodynamic efficiencies of phthalocyanines was related with the weak dependence of photodynamic effect on sensitizer concentration indicating to the initiation about 3 secondary chain processes such as free radical membrane damage caused by photon absorption by one photosensitizer molecule.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133050906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Radiotherapy of malignant tumors using low-intensity laser radiation as a radiosensitizer 使用低强度激光作为放射增敏剂的恶性肿瘤放疗
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375273
P. Polyakov, O. Bychenkov, N. Larionova, D. Rogatkin
{"title":"Radiotherapy of malignant tumors using low-intensity laser radiation as a radiosensitizer","authors":"P. Polyakov, O. Bychenkov, N. Larionova, D. Rogatkin","doi":"10.1117/12.375273","DOIUrl":"https://doi.org/10.1117/12.375273","url":null,"abstract":"A new method of radiosensitization is offered using low- intensity laser radiation (LILR). Theoretic and methodological aspects involved as well as specially developed apparatus are discussed. Radiotherapy combined with LILR was approved in 78 patients with cutaneous and oropharyngeal tumors II-IV. Combined treatment with LILR as a radiosensitizing procedure and subsequent radiotherapy doesn't increase the degree of local reactions in response to radiation, and provide the reliable improvement of the therapy outcome: the total index of significant plus pronounced tumor regression, owing to the radiosensitization, trustworthy rises from 65.7 +/- 5.8% to 84.3 +/- 4.3% (t equals 2.58; p < 0.05), the three-year survival index--from 44.6 +/- 5.5% up to 60.3 +/- 5.5% (t equals 2.02; p < 0.05).","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133358968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser hybrid and phototherapeutic technologies for oncology 肿瘤激光混合和光治疗技术
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375264
V. Zharov, Y. Menyaev, Konstantin L. Kalinin, A. Borisov, A. S. Latyshev, M. L. Stakhanov, L. Velsher, M. B. Zhitkova, V. Sokolov, D. Sukhin, V. Sarantsev
{"title":"Laser hybrid and phototherapeutic technologies for oncology","authors":"V. Zharov, Y. Menyaev, Konstantin L. Kalinin, A. Borisov, A. S. Latyshev, M. L. Stakhanov, L. Velsher, M. B. Zhitkova, V. Sokolov, D. Sukhin, V. Sarantsev","doi":"10.1117/12.375264","DOIUrl":"https://doi.org/10.1117/12.375264","url":null,"abstract":"This review reflect the latest achievements of Russian science in the field of creating laser and phototherapeutic combined technologies for oncology. This article tackles the problem of further developing laser-ultrasonic medical technologies and its applications in oncology. The comparison and the features of alternative sources for photodynamic therapy including the lasers, the lamps with spectral filters and LED array are considered. The application photomatrix system for treatment posmastectomy oedema are presented. The possibilities of laser transcutaneous photosensitizer delivery methods are discussed.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"4059 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129083383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
High-power laser diodes: new design provides reliability and stability 高功率激光二极管:新设计提供可靠性和稳定性
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375268
D. M. Demidov, N. I. Katsavets, A. Ter-Martirosyan, Dimitry Croupsky
{"title":"High-power laser diodes: new design provides reliability and stability","authors":"D. M. Demidov, N. I. Katsavets, A. Ter-Martirosyan, Dimitry Croupsky","doi":"10.1117/12.375268","DOIUrl":"https://doi.org/10.1117/12.375268","url":null,"abstract":"The new design of high power laser diodes, based on partly phase-locked laser arrays was developed in this work. The high temporal and spatial stability of such design laser diodes make them more preferable for high stable diode- pumped solid-state lasers than broad-area stripe contact laser diodes. Furthermore, the long lifetime of laser diodes with partly phase-locked array permits to use them in the field of material processing and medical applications.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"82 20","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120818708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
High-spatial-resolution tunable laser system for photodynamic therapy 用于光动力治疗的高空间分辨率可调谐激光系统
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375265
M. Kazaryan, S. Kazaryan, Y. Mokrushin, O. Shakin
{"title":"High-spatial-resolution tunable laser system for photodynamic therapy","authors":"M. Kazaryan, S. Kazaryan, Y. Mokrushin, O. Shakin","doi":"10.1117/12.375265","DOIUrl":"https://doi.org/10.1117/12.375265","url":null,"abstract":"A possibility to construct an optical system with laser brightness amplifier for transformation with size reduction of tissues images recorded on liquid crystal matrix element or using TV laser acousto-optical system has been demonstrated. The active elements of copper, gold and strontium vapor lasers and titanium-sapphire or dye lasers were used as amplifying or generating elements for color images. The optical scheme has been created for the laser processing of tissue with the beam formed corresponding to the tissue shape or any other desired configuration.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128746043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Address substrates as promising targets for laser histochemical surgery as a nontraditional line in medicine 将底物作为激光组织化学手术的有希望的靶标作为一种非传统的医学路线
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375262
L. Piruzyan, Y. Mikhailovskiy, A. Piruzyan
{"title":"Address substrates as promising targets for laser histochemical surgery as a nontraditional line in medicine","authors":"L. Piruzyan, Y. Mikhailovskiy, A. Piruzyan","doi":"10.1117/12.375262","DOIUrl":"https://doi.org/10.1117/12.375262","url":null,"abstract":"The priority concept of the laser histochemical surgery as a potentially novel line in medicine is presented. The histochemical stains, selectively coloring some targets (address substrates), that are cells or their biochemical ingredients, sensitize them to the laser irradiation. Such sensitization to laser irradiation by staining turns the colored targets into targets for the laser beam. The action of the irradiation onto its specific targets beats out of the cell its ingredients which participate in a pathology process. In particular, the beating of a stained ferment out of the general stage of biochemical processes characteristic for the pathology interrupts their currence. The laser beam, when beating out its stained targets without any damage of the unstained tissues, acts like a scalpel that cuts off affected tissues not brushing healthy ones. A scheme for testing stains as sensitizers of the `address substrates' to the laser irradiation is presented. As the criterion of the stain sensitization the fact was chosen of absence or weakness of pathomorphologic and biochemical signs of the disease in an experimental model of the pathology irradiated with laser after a stain use, while the pathology signs are present in a control sample. The basis is done for study of the histochemical stains as potential means for the laser histochemical surgery of disseminated sclerosis, mucopolysaccharidosis, hypercholesterolemia, myocardial infarction, cardiosclerosis, caries and parodontosis.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121630364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser-induced priming of human blood leukocytes 激光诱导人体血液白细胞启动
Current Research on Laser Use in Oncology Pub Date : 1999-12-30 DOI: 10.1117/12.375254
T. V. Chichuk, Eugeny P. Stranadko, I. A. Strashkevich, G. I. Klebanov
{"title":"Laser-induced priming of human blood leukocytes","authors":"T. V. Chichuk, Eugeny P. Stranadko, I. A. Strashkevich, G. I. Klebanov","doi":"10.1117/12.375254","DOIUrl":"https://doi.org/10.1117/12.375254","url":null,"abstract":"We investigated the influence of He-Ne ((lambda) equals 632.8 nm) laser irradiation (LI) on a functional activity of human blood leucocytes. The method of luminol-dependent chemiluminescence with the zymosan-activated phagocytes was used. The leucocytes were irradiated without and in the presence of autologic human blood plasma, containing of the endogenous (porphyrins) and/or exogenous (phthalocyanine) photosensitizers. The LI initiated a priming of the leucocytes. Priming revealed itself after the activation of the phagocytes by zymosan. The changes of the calcium concentration in leucocytes cytoplasm were studied too. Fluorimetric method with Fura-2AM was used for this. The laser irradiation initiated the changes of the calcium concentration in the leucocytes cytoplasm. All the investigating parameters depended on the irradiation dose and on the concentration of photosensitizers. The results of this work allowed to formulate the main theses of the free radical mechanism of the low intensive laser irradiation action on human blood leucocytes.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133573004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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