O. Abakumova, R. P. Baum, N. Y. Ermakova, A. T. Gradyushko, T. N. Guseva-Donskaya, A. Karmenyan, U. M. Koraboyev, V. P. Laptev, V. M. Mechkov, L. Mikhailova, N. G. Panferova, A. G. Rebeko, A. V. Reshetnickov, M. Ryabov, Eugeny P. Stranadko, T. A. Tsvetkova, O. Zhukova
{"title":"Novel drug form of chlorin e6","authors":"O. Abakumova, R. P. Baum, N. Y. Ermakova, A. T. Gradyushko, T. N. Guseva-Donskaya, A. Karmenyan, U. M. Koraboyev, V. P. Laptev, V. M. Mechkov, L. Mikhailova, N. G. Panferova, A. G. Rebeko, A. V. Reshetnickov, M. Ryabov, Eugeny P. Stranadko, T. A. Tsvetkova, O. Zhukova","doi":"10.1117/12.375256","DOIUrl":null,"url":null,"abstract":"A novel stable water-soluble form of well known photosensitizer chlorin e6 named `Photodithazine' has been obtained from Spirulina Platensis cyanobacteria as a noncovalent complex with N-methyl-D-glucosamine, and its biological characteristics evaluate, which proved to be as follows: in vitro photocytotoxicity was 1 (mu) M (EC50) as determined by the extent of DNA synthesis inhibition in CaOv cells after irradiation with 650 - 900 nm light, and 5 (mu) M (EC65) as determined using MTT test on PC12 cells after irradiation with 670 nm laser light at the doses of 15 and 20 J/cm2, respectively, with Al-sulfophthalocyanine `Photosense' (Russia) and oligomerized hematoporphyrin-IX mixture `Photogen' (Russia) being used as permitted reference drugs.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"4059 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1999-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research on Laser Use in Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.375256","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
A novel stable water-soluble form of well known photosensitizer chlorin e6 named `Photodithazine' has been obtained from Spirulina Platensis cyanobacteria as a noncovalent complex with N-methyl-D-glucosamine, and its biological characteristics evaluate, which proved to be as follows: in vitro photocytotoxicity was 1 (mu) M (EC50) as determined by the extent of DNA synthesis inhibition in CaOv cells after irradiation with 650 - 900 nm light, and 5 (mu) M (EC65) as determined using MTT test on PC12 cells after irradiation with 670 nm laser light at the doses of 15 and 20 J/cm2, respectively, with Al-sulfophthalocyanine `Photosense' (Russia) and oligomerized hematoporphyrin-IX mixture `Photogen' (Russia) being used as permitted reference drugs.
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