Current Research on Laser Use in Oncology最新文献

Nonsensitized photoinduced destruction of tumor in experiments 非致敏光致肿瘤破坏实验

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640144

B. Dzhagarov, S. A. Bizyuk, M. V. Parkhats, E. Zhavrid, Y. Istomin

引用次数: 2

Smart CO2 laser surgical system based on autodyne monitoring of laser-evaporated biotissues: first results in oncology 基于激光蒸发生物组织的自动力监测的智能CO2激光手术系统:在肿瘤学上的首次成果

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640143

A. Dmitriev, G. A. Varev, A. Konovalov, V. Kortunov, V. Panchenko, I. Reshetov, O. V. Matorin, V. F. Maiboroda, V. A. Ul’yanov

引用次数: 2

The light-oxygen effect as the analogue of photodynamic effect and its possibility in tumour therapy 光氧效应作为光动力效应的类似物及其在肿瘤治疗中的可能性

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640540

A. V. Ivanov, S. Zakharov, A. A. Mashalov

引用次数: 2

Physical factors influence for biologic systems 物理因素对生物系统的影响

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640218

L. Piruzyan

{"title":"Physical factors influence for biologic systems","authors":"L. Piruzyan","doi":"10.1117/12.640218","DOIUrl":"https://doi.org/10.1117/12.640218","url":null,"abstract":"Physical methods are widely spread in diagnostics and therapy of different pathologies, especially in oncology. The application of lasers occurred to be the perspective approach for combined methods application in medicine. Our work is devoted to investigation of thermal effect of focused laser beam in the model of Garding-Passi melanoma and also to the study of free radicals activity after the radiation with non-focused laser beam. The histologic alterations correlated with theoretical calculations of temperature distribution in irradiated tissue for energies 30-60 J attracted our interest. The values of maximal temperatures in depths of tissue for energies 30-60 J were carried out. In the model of permanent magnetic field (PMF) effect for mice ascites sarcoma 37 we have showed the linear dependence of tumor growth inhibition from the period of PMF treatment. Simultaneously we investigated PMF influence for free radical's (FR) concentrations in mice organs and tissues and potentially appearing questions of PMF effect for biopotential in connection with FR formation. We have also studied the alterations of K, Na and Ca ions concentrations in ascetic fluids after animal's PMF treatment. We revealed some reasons of biopotential generation and concluded that biopotential is not the result of specific ions gradient only but its generation can be followed by free radicals states appearance and occurrence of semi-conductivity in biostructures.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"557 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134478374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aluminium hydroxide tetra-3-phenylthiophthalocyanine as new photosensitizer for photodynamic therapy and fluorescent diagnostics 氢氧化铝四-3-苯噻吩酞菁作为光动力治疗和荧光诊断的新型光敏剂

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640120

I. Meerovich, Z. Smirnova, N. Oborotova, Evgeny Lukyanets, G. Meerovich, V. Derkacheva, A. P. Polozkova, I. Kubasova, A. Baryshnikov

引用次数: 2

New method of acne disease fluorescent diagnostics in natural and fluorescent light and treatment control 痤疮病在自然光和荧光灯下的荧光诊断及治疗控制新方法

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640223

L. Karimova, A. Berezin, S. Shevchik, S. Kharnas, S. Kusmin, V. Loschenov

引用次数: 0

Recombinant modular transporters on the basis of epidermal growth factor for targeted intracellular delivery of photosensitizers 基于表皮生长因子的光敏剂细胞内靶向递送重组模块化转运体

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640049

D. G. Gilyazova, A. A. Rosenkranz, P. Gulak, V. Lunin, O. Sergienko, M. Grin, A. Mironov, A. Rubin, A. S. Sobolev

{"title":"Recombinant modular transporters on the basis of epidermal growth factor for targeted intracellular delivery of photosensitizers","authors":"D. G. Gilyazova, A. A. Rosenkranz, P. Gulak, V. Lunin, O. Sergienko, M. Grin, A. Mironov, A. Rubin, A. S. Sobolev","doi":"10.1117/12.640049","DOIUrl":"https://doi.org/10.1117/12.640049","url":null,"abstract":"The search for new pharmaceuticals has raised interest in locally-acting drugs which act over short distances within the cell, and for which different cell compartments have different sensitivities. Thus, photosensitizers used in anti-cancer therapy should be transported to the most sensitive subcellular compartments where their action is most pronounced. Earlier, we described the effects of bacterially expressed modular recombinant transporters for photosensitizers comprising a-melanocyte-stimulating hormone as an internalizable, cell-specific ligand, an optimized nuclear localization sequence, an Escherichia coli hemoglobin-like protein as a carrier, and an endosomolytic amphipathic polypeptide. These transporters delivered photosensitizers into the murine melanoma cells nuclei to result in cytotoxic effects 2 orders of magnitude greater than those of nonmodified photosensitizers. Here we describe new transporters possessing the same modules except for a ligand that is replaced with epidermal growth factor specific for other cancer cell types. The new transporter modules retained their functional activities within the chimera, this transporter delivered photosensitizers into the human carcinoma cells nuclei to result in photocytotoxic effects almost 3 orders of magnitude greater than those of nonmodified photosensitizers. The obtained results show that ligand modules of such transporters are interchangeable, meaning that they can be tailored for particular applications.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126268066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Multiparametric testing of blood protein solutions with diagnostic purpose 具有诊断目的的血液蛋白溶液的多参数检测

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.639939

S. Alekseev, A. Ivanov, S. Sviridov, G. Petrova, Y. M. Petrusevich, A. Boiko, Dmitry I. Ten

引用次数: 6

Lasers for the treatment of psoriasis 激光治疗牛皮癣

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640225

A. Piruzian, I. Korsunskaya, I. Goldenkova, A. Hertsen, M. Sarkisova, L. Egorenkova

{"title":"Lasers for the treatment of psoriasis","authors":"A. Piruzian, I. Korsunskaya, I. Goldenkova, A. Hertsen, M. Sarkisova, L. Egorenkova","doi":"10.1117/12.640225","DOIUrl":"https://doi.org/10.1117/12.640225","url":null,"abstract":"Psoriasis is a chronic, genetically-determined disease, characterized by an immuno-mediated pathogenesis. Treatment of psoriasis is often complicated and remains a challenge. Along with the many new immunomodulatory approaches, various laser systems have been employed for chronic plaque psoriasis treatment. Recently, it has been demonstrated that the light produced by xenon-chloride excimers (generated by sophisticated devices with peak emission of 308 nm) is effective in the treatment of several psoriasis forms. We treated patients, ranging in age from 35 to 55 years, affected by plaque-type psoriasis vulgaris with monochromatic excimer light (MEL). We used MEL in a complex with basic treatment. Therapy was administered three times a week. At the end of the 3th week of treatment all patients showed an improvement, as evidenced by flattening of plaques, decreased scaling and erythema, and decreased vesicle and pustule formation. Unwanted side effects such as pain, blistering was not observed. Minimal erythema and a hyperpigmentation were noted in some patients. It was concluded that the MEL therapy may be a valuable option for treatment of plaque-type psoriasis vulgaris in shorter time compare with traditional NB UVB, with exposure to lower cumulative doses","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132583254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy of locally advanced basal cell skin cancer 局部晚期基底细胞皮肤癌的光动力治疗

Current Research on Laser Use in Oncology Pub Date : 2005-08-08 DOI: 10.1117/12.640042

Mikhail V. Riabov, E. Stranadko

引用次数: 0