S. Klyucharyova, S. Danilov, S. E. Tankopyeva, I. Chuprov
{"title":"Epidemiological study of cutaneous basal-cell carcinoma, potentials of its high-energy laser treatment","authors":"S. Klyucharyova, S. Danilov, S. E. Tankopyeva, I. Chuprov","doi":"10.1117/12.640137","DOIUrl":"https://doi.org/10.1117/12.640137","url":null,"abstract":"The results of the 5-year epidemiological and pathological investigations of cutaneous basal-cell carcinomas from inhabitants of the St. Petersburg area, removed with COz and Yachroma-Med copper vapor laser are presented. By our analysis of the intensity of exogenous impacts upon the tumor morbidity rate, we have concluded the industrial hazardous factors to be a dominant in this influence. The correlation between histological type and wide range of clinical behavior was proved.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114765896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Sokolov, I. G. Russakov, A. Teplov, E. Filonenko, R. V. Ul'yanov, A. A. Bystrov
{"title":"Adjuvant photodynamic therapy (PDT) of the superficial bladder cancer","authors":"V. Sokolov, I. G. Russakov, A. Teplov, E. Filonenko, R. V. Ul'yanov, A. A. Bystrov","doi":"10.1117/12.640043","DOIUrl":"https://doi.org/10.1117/12.640043","url":null,"abstract":"Superficial transitional cell carcinoma represents 50 to 80% of newly diagnosed bladder cancer in various countries. Transurethral resection of the urinary bladder is the standard procedure for biopsy and treatment superficial bladder cancer. However recurrence tumors after transurethral resection alone is high enough (50-90%). Intravesical chemotherapy for prophylaxis after complete transurethral resection is reducing recurrence rate about 1 5%. Adjuvant intravesical Bacillus of Calmette and Guerin (BCG) is reducing recurrence rate about 30%, but frequency side effects of this therapy is very high. Purpose of this study is appreciate efficacy adjuvant PDT with photosensitizer Photogeme (Russia) of superficial bladder cancer for prophylaxis after complete transurethral resection. The follow up was from 3 to 63 months (27 months, on average). Sixty-five patients (75.6%) showed no recurrence. For the follow up period, the recurrence was revealed in 21 (24.4%) patient, in two of them it was progressing (one case of invasive growth and one case of remote metastases). Four cases of recurrence were revealed 4 months after the surgery. In other cases, the recurrence was diagnosed from 9 to 18 months.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128174923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-intensity infrared laser radiation influence on the tumor growth","authors":"A. A. Cheida, E. Efimova","doi":"10.1117/12.640185","DOIUrl":"https://doi.org/10.1117/12.640185","url":null,"abstract":"Infrared laser radiation of low intensity in exposition dose of 25-35 mJicm2 does not cause progress the tumor process. Moreover, disturbing the blood flow in the tumor due to changing synthesis of norepinephrine and histamine this radiation contributes to the damage of the tumor tissue accompanied by the beginning of adaptation reaction in the organism.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124625730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cellular vitality of PC12 cells revealed through auto-fluorescence induced by two-photon excitation","authors":"E. Perevedentseva, A. Karmenyan, F. Kao","doi":"10.1117/12.640220","DOIUrl":"https://doi.org/10.1117/12.640220","url":null,"abstract":"The combination of fluorescence spectroscopy and optical trapping under an integrated laser scanning microscopy platform has presented to be a powerful tool in manipulating and positioning the cells as well as standardizing the conditions of measurements. This platform was applied to investigate the autofluorescence of PC12 cells. Under 2-p excitation, the PC12 cells exhibit fluorescence in the range of 500-530 nm. It was shown that intensity of 2-p autofluorescence from PC12 cells is very sensitive to the cells' condition. Therefore autofluorescence from the cells may be a convenient and noninvasive method for monitoring the cell's or another biological object's condition, metabolism, and/or vitality under various physical and chemical influences.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128399405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Akleyev, Yulia Romanskaya, M. Kisselyov, A. Vazhenin
{"title":"Laser spectroscopy as a method for diagnosing cancer and assessing the efficacy of treatment of malignant neoplasms","authors":"A. Akleyev, Yulia Romanskaya, M. Kisselyov, A. Vazhenin","doi":"10.1117/12.639944","DOIUrl":"https://doi.org/10.1117/12.639944","url":null,"abstract":"The issues of early diagnosis and effective treatment of malignant neoplasms are of vital importance for the Urals region which in 1950-1960 became the site of several radiation incidents with the resultant overexposures of dozens of thousands of residents who have manifested increased risks of leukemia and solid cancer incidence. The present study has demonstrated the efficacy of the method of laser-correlation spectrometry (LCS) of blood plasma and serum for early diagnosis of malignant neoplasms and prediction of relapses of tumor following radical treatment. The LCS method is characterized by a sufficiently high diagnostic sensitivity in relation to malignant tumors. It has been established that LC spectra obtained for patients with malignant neoplasms differ significantly from those for patients with non-cancer pathology of the same sites. The LCS methodology has manifested a sufficiently high prognostic sensitivity (76.6%) in relation to complete regression after radical treatment and progression (78.0%) of the tumor process. A positive prognostic criterion of the course of a malignant neoplasm after radical treatment in patients without relapse and metastases is a statistically significant (p Current Research on Laser Use in Oncology LUO 0 2004-01-01|2004-01-03 Current Research on Laser Use in Oncology: 2000-2004 CRL04 1086089 Moscow, Russian Federation Current Research on Laser Use in Oncology: 2000-2004 5973 Modern Methods of Diagnostics and Oncology Research Instruments and Devices 1","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132813033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photodynamic action of chlorin e6 on thymocyte plasmatic and mitochondrial membrane potentials","authors":"G. Gyulkhandanyan","doi":"10.1117/12.640132","DOIUrl":"https://doi.org/10.1117/12.640132","url":null,"abstract":"Transmembrane potentials appear to be cell state sensitive characteristics and can give information about cell damage initial stage. Photodynamic action of the photosensitizer chlorin e6 on plasmatic and mitochondrial membrane potentials of the rat thymus lymphocytes was studied using voltage-sensitive dye rhodamine 6G. It has been revealed that mitochondrial membrane potential is more sensitive characteristic of membrane disfunction than plasmatic one at the cell photodamage.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114218271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photoditazine mediated chemosensitized blood photomodification: advanced tumor treatment preliminary results","authors":"M. Gelfond, D. Vassiliev","doi":"10.1117/12.640216","DOIUrl":"https://doi.org/10.1117/12.640216","url":null,"abstract":"Beside the classical photodynamic therapy (PDT) procedure, another possible mode of PDT treatment exists. In the latter case the light does not have to be delivered directly to tumor as soon as it is not always technically possible. In some cases systemic cytotoxic effects of photomodified blood can cause tumor damage. Possibly this happens due to apoptosis induction. These observations broaden possible PDT applications significantly.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115609782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Chernyshova, V. Roshchin, D. M. Kulakov, A. Ivanov
{"title":"Comparison of laser wound morphology in skin at different irradiation conditions","authors":"L. Chernyshova, V. Roshchin, D. M. Kulakov, A. Ivanov","doi":"10.1117/12.640145","DOIUrl":"https://doi.org/10.1117/12.640145","url":null,"abstract":"Under high-intensity laser pulses the morphology and size of the crater induced in biotissue depends both on biotissue properties and on irradiation conditions. The objective of this study is to correlate the wound morphology and patterns of microdestruction with the mechanisms of interaction. Along with the regime of superficial layerwise evaporation of tissue induced by C02 medical, or selective photocoagulation induced by copper vapor lasers, the present work describes the regime of bulk selective damage of coloration centers that are irregularly distributed in the deep of the tissue. Photo induced disruption is the mechanism responsible for it.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126841299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of electronic paramagnetic, nuclear magnetic, γ-nuclear magnetic resonance, and defibrillation in experimental biology and medecine","authors":"L. Piruzyan","doi":"10.1117/12.640219","DOIUrl":"https://doi.org/10.1117/12.640219","url":null,"abstract":"Nowadays an attention is paid to pathbreaking approaches to the therapy of different pathologies with EPR, NMR and NGR dialysis and mechanisms of physical factors influence in prophylactics and therapy of a number of diseases. Any pathology is evidently begins its development in atomic-molecular levels earlier then any morphologic alterations in tissues can be detected. We have studied the alterations of FR content in liver, spleen and brain in hypoxia and hyperoxia conditions. Under hypoxia and hyperoxia the FR concentrations are equal in all organs and tissues. However this ratio is different for some forms of leucosis. For different leucosis types gas mixtures the most adequate for the current pathology should be developed. Then we represent the method of biologic objects treatment with the energy of super-high frequency field (SIT) and the instrument for its performance. The study of magnetic heterogeneity of biologic systems proposes the new approach and a set of methods for medical and scientific purpose. Application of combined with chemotherapy extraction of anionic and cationic radicals from bloodstream using EPRD, NMRD and NGRD influence and also the single ions separate extraction using NGRD are able to detect and perhaps to cure their appearance in a period before neoformation. These studies should be carried out experimentally and clinically.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123034929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phototherapeutic technologies for oncology","authors":"Y. Menyaev, V. Zharov","doi":"10.1117/12.640217","DOIUrl":"https://doi.org/10.1117/12.640217","url":null,"abstract":"This short review reflects the latest achievements of technical science for medicine in the field of creating phototherapeutic technologies for oncology. The article discuss the problem of further developing and applying matrix phototherapeutic apparatus. The comparison and the features of alternative sources based on light emitted diodes structures are considered. The application of photomatrix system for photodynamic therapy and for postmastectomy oedema treatment are presented.","PeriodicalId":219206,"journal":{"name":"Current Research on Laser Use in Oncology","volume":"5973 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128969836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}