Sensitized action of low-level laser radiation mechanism

Abstract

The goal of this work is to study the laser-induced photosensitized oxidation of lipids of the artificial (lyposomes) and cell's (erythrocytes, leukocytes) membranes and human blood lipoproteins. As a exogenous photosensitizers we are used hematoporphyrin derivatives (HPD) and sulfonated phthalocyanine aluminum (Pc). Irradiation was performed by helium-neon laser (632.8 nm). It was found out the increasing of the products of lipid oxidation in the suspensions of a lyposomes, human blood apo-(beta) -lipoproteins, erythrocytes and leucocytes. Accumulation of the lipid oxidation products depend on as irradiation dose as HPD or Pc concentrations. Interaction of photosensitizers with the lyposomes, lipoproteins and erythrocytes was investigated.