Enhancing photoditazine-mediated photodynamic therapy of tumours

Abstract

Chlorine E6 derivative "Photoditazine" mediates photodynamic therapy (PDT) of tumours more effectively at higher doses. Both local and systemic effects were found in vivo. Synchronous PDT and selective distant laser hyperthermia (HT) are not advantageous. Excessive PDT and HT regimens leading to tumour necrosis increase the risk of tumour generalization.