SAGE Open Medicine最新文献

{"title":"Identification of metabolism-associated molecular classification for effect and prognosis in lung adenocarcinoma based on multidatabases including the cancer genome atlas and gene expression omnibus.","authors":"Lilin Que, Zhibing Liu, Yinghui Wu, Lan Luo, Leifeng Liang","doi":"10.1177/20503121251341114","DOIUrl":"10.1177/20503121251341114","url":null,"abstract":"<p><strong>Background: </strong>Lung adenocarcinoma is a highly heterogeneous group of diseases with distinct molecular genetic features, pathological characteristics, metabolic profiles, and clinical behaviors. However, the clinical relevance of metabolic characteristics of lung adenocarcinoma remains unclear. This study aimed to describe the molecular characteristics of lung adenocarcinoma.</p><p><strong>Methods: </strong>The gene expression profiles of 1037 lung adenocarcinoma samples were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. This study is based on sample data from 2006 to 2020. The long-time span and sufficient sample size ensure the robustness of the research findings. Using unsupervised transcriptome analysis, we identified three distinct subtypes (C1, C2, and C3). We then compared the prognostic traits, transcriptome characteristics, metabolic signatures, immune infiltration, clinical features, and drug sensitivity of the lung adenocarcinoma subclasses. A classifier was generated to determine lung adenocarcinoma classification, and we verified the clinical value of this classifier in other tumors.</p><p><strong>Results: </strong>Our results indicated that C1 possessed the most abundant metabolic pathways. Compared with C2 and C3, C1 possessed 35 metabolic pathways that exhibited significant differences. The immune score, matrix score, and immune infiltration for subtype C1 were significantly lower than those for subtypes C2 and C3, suggesting that C1 is a metabolically active subtype. Five metabolic pathways were observed in C2. Subtype C2 was associated with the best prognosis and exhibited the lowest tumor mutation burden and copy number variation. Subtype C3 comprised five metabolic pathways. Immune checkpoint analysis revealed that C3 cells may potentially benefit from immunotherapy.</p><p><strong>Conclusions: </strong>Our study deepens the understanding of the metabolic characteristics of lung adenocarcinoma and may provide valuable information for immunotherapy.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251341114"},"PeriodicalIF":2.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of Mental Health Literacy Assessment Scale among community health workers in Nepal.","authors":"Shishir Paudel, Anisha Chalise, Prashabdhi Shakya, Tulsi Ram Bhandari","doi":"10.1177/20503121251341423","DOIUrl":"10.1177/20503121251341423","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate the Mental Health Literacy Assessment Scale for assessing mental health literacy among community health workers.</p><p><strong>Method: </strong>A total of 24 items were initially generated and refined through cognitive interviews and expert evaluation. The final scale consisted of 20 items. Face validity was ensured through cognitive interviews conducted in two phases with community health workers and volunteers. Content validity was assured based on the ratings of six experts. Cross-sectional survey was performed among 233 community health workers. Exploratory factor analysis using Varimax rotation was performed to identify latent variables with factor loadings > 0.4. Confirmatory factor analysis was employed to validate the model, using root mean square error of approximation < 0.05, standardized root mean square residual < 0.08, comparative fit index ⩾ 0.90, and Tucker-Lewis index ⩾ 0.90. Reliability was assessed through Cronbach's alpha where alpha coefficient > 0.70 indicated internal consistency.</p><p><strong>Results: </strong>Exploratory factor analysis identified four factors explaining 50.75% of variance explained by positive mental health behaviors (21.44%), misconceptions about mental health (14.24%), symptoms of mental distress (8.70%), and mental health stigma (6.37%). The confirmatory factor analysis demonstrated excellent model fit, with indices such as the normed Chi-square (1.31), comparative fit index (0.95), Tucker-Lewis index (0.94), and root mean square error of approximation (0.03). The scale displayed strong convergent and discriminant validity, with an average variance extracted > 0.43 and composite reliability > 0.70 for all factors. Internal consistency was confirmed, with a Cronbach's alpha value of 0.78 for the overall scale.</p><p><strong>Conclusion: </strong>The Mental Health Literacy Assessment Scale has demonstrated robust psychometric properties and comprehensive coverage of mental health literacy components, making it a valuable tool for both research and practical applications among Community health workers in Nepal. While these findings support its utility in this context, further validation is needed to establish its applicability across other low- and middle-income countries to assess its effectiveness in diverse cultural and geographic settings.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251341423"},"PeriodicalIF":2.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life utilization of sentinel lymph node mapping in endometrial cancer: Patterns of practice in unmapped patients and effect on treatment and outcomes.","authors":"Danielle Glassman, Raadhika Kher, Cande V Ananth, Eugenia Girda","doi":"10.1177/20503121251342047","DOIUrl":"10.1177/20503121251342047","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the real-life utilization of sentinel lymph node mapping for surgical staging of patients with endometrial cancer. We evaluated patterns of surgical staging in unmapped patients and studied how this practice affected adjuvant therapies and survival.</p><p><strong>Methods: </strong>We conducted a retrospective chart review of patients with newly diagnosed endometrial cancer who underwent minimally invasive surgical staging, including sentinel lymph node mapping with cervical injection of indocyanine green from January 2019 to December 2021. Patient demographics, surgical findings, sentinel lymph node mapping, adjuvant therapy, and recurrence rates were collected. Sentinel lymph node detection rates were calculated, and reasons for omitting lymphadenectomy in unmapped patients were evaluated.</p><p><strong>Results: </strong>Among 121 patients, 80 (66%) had successful sentinel lymph node mapping and 41 (34%) failed mapping. Our yearly detection rate was 63%, 68%, and 70% for 2019, 2020, and 2021, respectively. In patients with successful sentinel lymph node mapping, 73.8% were low-grade and 26.2% were high-grade histology. For patients with failed mapping, 75.6% were low-grade and 24.4% were high-grade histology. For the failed mapping cohort, 23 patients (56.1%) had a complete lymphadenectomy performed, of which 3 (13.0%) had positive lymph nodes. Reasons for omitting lymphadenectomy were documented as: (1) intraoperative pathologic evaluation; (2) inability to tolerate Trendelenburg; (3) difficulty with anatomical dissection/visualization; and (4) evidence of locally advanced disease. There were 18 incompletely staged patients, including 8 (44.4%) with low-risk disease, 2 (11.1%) with locally advanced disease, and 1 (5.6%) with serous histology. The remaining 7 (38.9%) unstaged patients were offered and/or received adjuvant radiation based on final pathology. During a short-term follow-up period, no patients in the unmapped or incompletely staged cohorts had a recurrence of the disease.</p><p><strong>Conclusions: </strong>The rate of sentinel lymph node detection is improving. Low-risk disease identified on intraoperative pathology was the most common reason for omitting lymphadenectomy in unmapped patients, and that practice did not seem to affect adjuvant therapy or recurrence of disease.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251342047"},"PeriodicalIF":2.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of basic cardiopulmonary resuscitation training on the knowledge and attitudes of professional football players and coaches.","authors":"Rafael González-Moret, Isabel Almodóvar-Fernández, Sara Simón-Montolio, Héctor Usó-Vicent, Paula Sánchez Thevenet, Antonio Real-Fernández","doi":"10.1177/20503121251341107","DOIUrl":"10.1177/20503121251341107","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the change in attitudes and knowledge about basic cardiopulmonary resuscitation in football professionals following a training intervention and to examine its correlation with sociodemographic variables.</p><p><strong>Method: </strong>The study consists of two phases. The first phase involves an observational cross-sectional study to assess the level of attitude and knowledge in cardiopulmonary resuscitation. The second phase includes an educational intervention consisting of a training and practical session on basic cardiopulmonary resuscitation, with a pre-post single-group study. The questionnaire was completed by football professionals from the Spanish first division and their coaches, with <i>N</i> = 206 in the first phase and <i>N</i> = 70, 30 days after the training intervention in the second phase. A possible limitation is that the final sample size is smaller than the initial one; however, it still exceeds the estimated minimum. A two-phase statistical analysis was conducted: a cross-sectional analysis using nonparametric tests (Wilcoxon, Kruskal-Wallis and Spearman) assessed baseline attitude and knowledge in relation to sociodemographic variables, followed by a pre-post intervention analysis using parametric (<i>t</i>-tests, ANOVA, and Pearson) or nonparametric tests depending on data distribution to evaluate intra- and inter-group changes. Normality was tested with the Shapiro-Wilk test and appropriate tests were applied accordingly.</p><p><strong>Results: </strong>There is a significant increase (<i>p</i> < 0.001) in the average attitude of participants between before (4.25 ± 0.39) and after (4.40 ± 0.41) the intervention. Knowledge also shows a significant increase (<i>p</i> < 0.001) between before (5.66 ± 1.92) and after (7.60 ± 1.84) the intervention. There is no significant correlation with age, gender, professional category, or levels of knowledge and attitudes.</p><p><strong>Conclusions: </strong>The basic cardiopulmonary resuscitation training intervention has proven beneficial, regardless of gender, educational level, or category studied (players/coaches).</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251341107"},"PeriodicalIF":2.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to recovery from diabetic ketoacidosis and its predictors among children with type 1 diabetes at selected governmental hospitals in Addis Ababa, Ethiopia; A five-year retrospective follow-up study.","authors":"Shimeles Tefera Mamo, Tigistu Gebreyohannis Gebretensaye, Feven Mulugeta, Gemechu Gelan Bekele","doi":"10.1177/20503121251343175","DOIUrl":"10.1177/20503121251343175","url":null,"abstract":"<p><strong>Background: </strong>Diabetic ketoacidosis, a severe complication of type 1 diabetes, remains a major cause of morbidity and mortality in children, particularly in resource-limited settings such as Ethiopia. Despite its high burden, data on recovery time and predictors of diabetic ketoacidosis in this population are scarce. Therefore, this study aimed to assess the time to recovery from diabetic ketoacidosis and its predictors among children with diabetic ketoacidosis at selected governmental hospitals in Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A 5-year retrospective follow-up study was conducted among 391 hospitalized children with diabetic ketoacidosis in selected governmental hospitals in Addis Ababa, from January 1, 2018 to December 30, 2022. Participants and hospitals were selected using a simple random sampling method. A structured data collection checklist was adapted from similar studies and modified. The data were checked for completeness and entered into Stata version 16 for analysis. Variables with <i>p</i>-value < 0.05 in the multivariate Cox proportional hazards model were considered significant predictors of the time to recovery from diabetic ketoacidosis.</p><p><strong>Results: </strong>A total of 423 records of children with diabetic ketoacidosis with 391 (92.4%) response rates were included in the final analysis. Out of these, 370 were recovered and discharged. The remaining 21 cases were censored. The overall median time taken to resolution from diabetic ketoacidosis was 27 h, with an interquartile range of 16-38. Diabetic mellitus history (Adjusted Hazard Ratio (AHR) = 0.41, 95% CI: 0.30-0.56), severity of diabetic ketoacidosis (AHR = 2.35, 95% CI: 1.34-6.1), presence of comorbidity (AHR = 1.76, 95% CI: 1.37-2.26), and blood sugar level (AHR = 0.61, 95% CI: 0.39-0.96) were all independent predictors of time to recovery from diabetic ketoacidosis.</p><p><strong>Conclusion and recommendation: </strong>The median diabetic ketoacidosis recovery time was 27 h. Key predictors included admission glucose, comorbidities, diabetic ketoacidosis severity, and diabetes history. Early diagnosis, thorough assessment, and optimized management are crucial to reducing risks and improving outcomes.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251343175"},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food taboos among indigenous pregnant women of Khagrachari District, Bangladesh.","authors":"Labanya Tripura, Shahrin Emdad Rayna, Anirban Chakma, Khan Mohammad Thouhidur Rahman, Md Syed Shariful Islam, Md Khalequzzaman","doi":"10.1177/20503121251342979","DOIUrl":"10.1177/20503121251342979","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore food taboos among indigenous pregnant women in Bangladesh.</p><p><strong>Methods: </strong>A mixed-method study was conducted among the Tripura, Chakma, and Marma communities in Khagrachari district of Bangladesh. To identify the list of existing tabooed foods, six focus group discussions were conducted with 36 women aged 15 years and above. For the quantitative part, 75 indigenous pregnant women were interviewed face-to-face to identify the commonly avoided food items during their current pregnancy. All the interviews were conducted in the participant's native language.</p><p><strong>Results: </strong>A total of 64 different items were identified as tabooed food during pregnancy. Among the current pregnant, 46.6% were adhering to food taboos. The most commonly avoided fruits were pineapple (33.3%) and papaya (20.0%). For vegetables, organic sweet potato (4.0%) and pumpkin (2.6%) were the most common. For animal products, 8.0% of participants avoided fish of any kind, and 2.6% restricted duck meat. Cold food (4.0%) was the most avoided beverages and snacks. Betel leaf and nut (2.6%) were also in the list of tabooed food. Distinct locally grown Ghut Ghutte, Chinese yam, and wild yam were also refrained. The health and well-being of the baby were the main concerns behind the food taboos.</p><p><strong>Conclusion: </strong>There is a high prevalence of food taboo practices among the indigenous pregnant women of Bangladesh. Tailored intervention programs to address misunderstandings, dispel myths, and encourage healthier food choices during pregnancy among the indigenous communities of Bangladesh can be beneficial for both pregnant and babies.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251342979"},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of hematological indices in severe septic acute kidney injury to predict hospital mortality and need for renal replacement therapy at discharge.","authors":"Diana Carolina Vargas Ángel, Camilo Andrés Chaparro, Oscar Mauricio Muñoz, Kateir Contreras-Villamizar, Camilo Alberto González, Daniel Augusto Martín, Laura Viviana Galindo","doi":"10.1177/20503121251333691","DOIUrl":"10.1177/20503121251333691","url":null,"abstract":"<p><strong>Objective: </strong>Recent studies have identified the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and neutrophil/lymphocyte × platelet ratio as promising prognostic markers in patients with sepsis. This study aims to evaluate the discriminatory ability of these ratios to predict mortality and requirement for renal replacement therapy at discharge, in patients with septic acute kidney injury.</p><p><strong>Methods: </strong>Diagnostic test study based on a multicenter retrospective cohort of adult patients with septic acute kidney injury requiring renal support. Hematologic ratios were calculated for three disease moments (admission, diagnosis of acute kidney injury, initiation of renal replacement therapy). Receiver operating characteristic curves were used to analyze the discriminative ability of the different hematological ratios at each disease moment.</p><p><strong>Results: </strong>A total of 152 patients were included. In-hospital mortality occurred in 61.8%, and 24.2% of survivors required renal replacement therapy at discharge. Measurements taken at the initiation of renal replacement therapy had the best discriminatory ability to predict adverse outcomes. For neutrophil/lymphocyte ratio the area under the curve to predict mortality was 0.596; (95% CI: 0.500-0.692), and to predict the requirement of renal replacement therapy 0.592 (95% CI: 0.286-0.898). In all proposed scenarios, the neutrophil/lymphocyte ratio and neutrophil/lymphocyte × platelet ratio demonstrated superior performance in comparison to the platelet/lymphocyte ratio. All three ratios exhibited comparable poor discriminatory ability.</p><p><strong>Conclusions: </strong>Hematological ratios have poor discriminatory capacity for predicting adverse outcomes in cases of septic acute kidney injury. The neutrophil-to-lymphocyte ratio taken at the initiation of renal replacement therapy is a potentially useful, economical, and easily applicable tool to be included in predictive models of mortality and dialysis dependence.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251333691"},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing academic impact through a bibliometrics analysis: Gastroesophageal reflux disease in the context of obesity treatment and bariatric surgery.","authors":"Akbayan Imanbayeva, Bazylbek Zhakiev, Asset Yelemessov, Kairat Adaibayev, Kymbat Tussupkaliyeva, Dulat Turebayev, Saltanat Urazova, Laura Mamesheva, Alireza Afshar","doi":"10.1177/20503121251336304","DOIUrl":"https://doi.org/10.1177/20503121251336304","url":null,"abstract":"<p><strong>Aims: </strong>The global rise in obesity rates has led to increased use of bariatric surgery, which can potentially exacerbate or induce gastroesophageal reflux disease. This study aimed to assess the academic impact and trends in research on gastroesophageal reflux disease in the context of obesity treatment and bariatric surgery through a comprehensive bibliometric analysis.</p><p><strong>Materials and methods: </strong>A bibliometric analysis was conducted using data from Web of Science and Scopus databases, covering publications from 1993 to 2024. The study utilized the Bibliometrix R package to analyze publication trends, collaborative networks, and research topics.</p><p><strong>Results: </strong>The analysis encompassed 257 documents from 82 sources, with 6192 total citations and an 8.2% annual growth rate in publications. The United States emerged as the leading contributor with 90 publications. Key research topics included bariatric surgery, sleeve gastrectomy, and gastroesophageal reflux disease, with increasing focus on complications and revisional bariatric surgery in recent years. Two main research clusters were identified: one focusing on general health aspects and demographics, and another on specialized bariatric procedures and outcomes. However, the analysis is constrained by its reliance on data from only two bibliographic databases, which may not encompass all pertinent studies, and by a geographic bias toward high-income countries. Moreover, our deep literature reviews highlighted that obesity is a known risk factor for gastroesophageal reflux disease, and while Roux-en-Y gastric bypass often reduces gastroesophageal reflux disease symptoms, sleeve gastrectomy may exacerbate or cause de novo gastroesophageal reflux disease postoperatively.</p><p><strong>Conclusions: </strong>This bibliometric study reveals a significant increase in research activity on gastroesophageal reflux disease in relation to obesity treatment and bariatric surgery, particularly since 2017. The findings highlight the growing importance of this field and the need for continued international research efforts to optimize surgical protocols and improve patient outcomes.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251336304"},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke-related restless leg syndrome in hemorrhagic and ischemic stroke patients.","authors":"Do Xuan Tinh, Dinh Viet Hung, Do Duc Thuan, Dang Phuc Duc, Dang Minh Duc, Nguyen Dang Cuong, Phan The Ha, Nguyen Dang Hai, Nguyen Duc Thuan, Tran Minh Tuan, Huynh Ngoc Lang, Nguyen Trong Nghia, Pham Ngoc Thao","doi":"10.1177/20503121251336900","DOIUrl":"https://doi.org/10.1177/20503121251336900","url":null,"abstract":"<p><strong>Objectives: </strong>The incidence of stroke-related restless legs syndrome (RLS) has been reported to be high but varies regionally. Therefore, this study aimed to investigate the incidence and some of the factors related to restless legs syndrome after stroke onset in patients in Vietnam.</p><p><strong>Methods: </strong>Data were collected from a total of 423 patients who had stroke, including 283 ischemic and 140 hemorrhagic strokes, which were confirmed by magnetic resonance imaging within 7 days after the onset of symptoms, at the Department of Stroke, Military Hospital 103 from September 2023 to April 2024. Restless legs syndrome was diagnosed 1 month after the stroke onset according to the criteria of the International Restless Legs Syndrome Study Group.</p><p><strong>Results: </strong>Restless legs syndrome was diagnosed in 59 patients (11.6%), including 37 (13.1%) who had ischemic stroke and 12 (8.6%) who had hemorrhagic stroke. An increased rate of restless legs syndrome was observed in stroke patients with brain lesions in the thalamus and lentiform nucleus; those who smoked; and those with a family history of restless legs syndrome.</p><p><strong>Conclusions: </strong>This study found that the incidence of restless legs syndrome after stroke was 11.6% overall and 13.1% and 8.6% after ischemic and hemorrhagic strokes, respectively. Lesion in the thalamus and lentiform nucleus, smoking history, and family history of restless legs syndrome were the predictors of restless legs syndrome after stroke onset.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251336900"},"PeriodicalIF":2.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a new long peripheral catheter in hospitalized patients - a retrospective observational study.","authors":"Yoav Weber, Doron Cohn-Schwartz, Shadi Khamis, Ami Neuberger, Gidon Berger","doi":"10.1177/20503121251337197","DOIUrl":"https://doi.org/10.1177/20503121251337197","url":null,"abstract":"<p><strong>Background: </strong>Venous access is a vital component of medical care for hospitalized patients, especially patients who present with difficult intravenous access and require long-term hospitalization. A promising solution for these challenges is the use of long peripheral catheters. This report highlights our experience with an innovative, easily inserted, over-the-needle-long peripheral catheter.</p><p><strong>Methods: </strong>A retrospective, observational study included patients admitted to internal medicine departments and underwent a new long peripheral catheter insertion. We provide data on patient characteristics, indications for long peripheral catheter insertion, insertion success rates, dwell times, and complications rates.</p><p><strong>Results: </strong>The study included 109 patients with a total of 128 long peripheral catheters. The leading indications for long peripheral catheter insertion were IV administration of antibiotics and vasopressors. A first-time user inserted 65% of long peripheral catheters on the first attempt, with an average insertion time of 131 ± 11 s. Success rates increased in parallel with experience gained (<i>p</i> < 0.05). The average dwell time was 8.8 ± 0.63 days. The long peripheral catheter was removed as the therapy was completed in 33.5% of the patients. The complication rate was 13/1000 catheter days, including dislodgement, occlusion, phlebitis and infiltration. In addition, 23 individuals were successfully discharged with the long peripheral catheter to complete therapy at home. The long peripheral catheters was used to draw blood in 28 patients and for vasopressor administration in 22 patients.</p><p><strong>Conclusions: </strong>The new long peripheral catheter provides a safe, rapid, and effective means of venous access. Its straightforward insertion technique, convenience, and suitability for \"point of care\" use make it a valuable option for patients requiring continuous intravenous therapy.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251337197"},"PeriodicalIF":2.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}