SAGE Open Medicine最新文献

{"title":"Lack of standardization of blood donor recruitment processes: A two-center mixed-methods audit study in Ghana.","authors":"Daniel Baah, Joseph Kofi Amponsah, Ama Gyasiwaah Owusu-Poku, Joseph Boachie, Patrick Adu","doi":"10.1177/20503121251380641","DOIUrl":"https://doi.org/10.1177/20503121251380641","url":null,"abstract":"<p><strong>Objective: </strong>Sub-Saharan African countries perennially suffer acute donor blood shortfalls. Clinical audit is a quality improvement strategy that enables the identification of actionable points to improve healthcare delivery. This study audited the blood donor recruitment processes at two Ghanaian secondary healthcare facilities to identify areas that can be leveraged to improve donor blood stocks.</p><p><strong>Methods: </strong>This was a sequential, exploratory mixed-methods study. First, 30 real-time observations of prospective blood donor-laboratorian interactions were undertaken using checklists. Subsequently, 2 sets of semi-structured questionnaires were used to collect data on pre-donation screening, blood donor privacy, and postblood donation care from the perspectives of 135 blood donors and 134 laboratory staff.</p><p><strong>Results: </strong>The observational data collection found a general inter- and intrapractitioner variation in blood donor recruitment procedures. Overwhelmingly, prospective donors were males (91.1%), or 20-39 years old (80.7%). Also, only 5.9% of prospective donors were voluntary nonremunerated, whereas 34.8% were deferred. Overwhelmingly, laboratory staff and prospective donors indicated that neither donor information leaflet (97.0% versus 98.5%, respectively), nor medication deferral list (93.3% versus 97.8%, respectively) was employed during the blood donor screening process. Also, whereas 88.2% of successful donors indicated being unaware of any focal person to contact in the event of adverse postdonation symptoms, laboratorians indicated that there was no focal person for handling issues related to successful (94.8%) or deferred (90.0%) blood donors. Furthermore, 42.3% of laboratorians indicated that prospective donors with permanent deferral results are fully informed, compared to 58.2% who indicated uneasiness when disclosing reactive screening results.</p><p><strong>Conclusions: </strong>The adoption of standard operating procedures may help prevent interfacility and interpractitioner variability in blood donor recruitment practices. Interventional implementation research may help to improve pre- and postdonation services offered to both successful and deferred donors in the study settings.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251380641"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous bacterial peritonitis and associated factors among patients with cirrhotic ascites attending public hospitals in Harari region, eastern Ethiopia.","authors":"Yimaje Mohammed, Tekabe Abdosh, Kirubel Minsamo Mishore, Mohammed Ahmed, Hassen Abdi Adem, Ahmedin Aliyi Usso, Rudwan Yasin Abrahim, Abdulhakim Ahmed Siyo, Alo Edin","doi":"10.1177/20503121251366773","DOIUrl":"https://doi.org/10.1177/20503121251366773","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Spontaneous bacterial peritonitis is a potentially fatal complication and a serious sequel occurring in patients with cirrhotic ascites. Although the complications of cirrhotic ascites are high and lethal, there was limited information on the burden and risk factors of spontaneous bacterial peritonitis in Ethiopia and the study setting. Our study aims to determine the prevalence of spontaneous bacterial peritonitis and associated factors among patients with cirrhotic ascites attending public hospitals in Harari region, eastern Ethiopia, from December 15 to 31, 2022.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An institution-based retrospective cross-sectional study was conducted among randomly selected 319 patients with cirrhotic ascites attending public hospitals in Harari region from January 1, 2021 to December 15, 2022. Data were extracted from individual medical records, patient cards, and follow-up charts using a semi-structured questionnaire/checklist. Data were entered using EpiData version 3.1 and analyzed using the Statistical Package for Social Science version 22. Bivariable and multivariable logistic regression analyses were conducted to identify factors associated with spontaneous bacterial peritonitis. An adjusted odds ratio (with 95% confidence interval) was used to report the adjusted association, and statistical significance was declared at &lt;i&gt;p&lt;/i&gt; &lt; 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The prevalence of spontaneous bacterial peritonitis was 34.8% (95% confidence interval: 30.1%-40.2%). In this study, gastrointestinal bleeding (adjusted odds ratio = 1.99 (1.13-3.50)), alcohol intake (adjusted odds ratio = 2.17 (1.02-4.65)), hepatitis infection (adjusted odds ratio = 1.95 (1.09-3.46)), serum electrolytes abnormalities (adjusted odds ratio = 6.36 (3.61-11.23)), and low peritoneal fluid protein (adjusted odds ratio = 4.52 (2.51-8.12)) were important factors associated with spontaneous bacterial peritonitis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;More than one out of three patients with cirrhotic ascites had spontaneous bacterial peritonitis in eastern Ethiopia. In this study, alcohol intake, gastrointestinal bleeding, hepatitis, electrolyte imbalances, and low levels of peritoneal fluid protein were predictors of spontaneous bacterial peritonitis. Reducing alcohol intake, preventing hepatitis infection and cirrhotic complications, and managing serum electrolytes and peritoneal fluid protein levels would be essential to prevent and reduce the risks of spontaneous bacterial peritonitis and its lethal consequences. Therefore, a prospective large-scale study is crucial to understanding the burden and associated factors with spontaneous bacterial peritonitis in patients with cirrhotic ascites. Furthermore, improving access to diagnostic tools such as ultrasound in local health facilities and providing short training for local health providers to guide early diagnosis and treatment of spontaneous bacterial peritonitis.&lt;/","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251366773"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pharmacists and nurses in the management of oral mucositis in head and neck cancer patients during antineoplastic therapy: A scoping review.","authors":"Palizhati Kaisha, Xinxin Li, Yiqun Tang, Yufen Zheng","doi":"10.1177/20503121251339581","DOIUrl":"10.1177/20503121251339581","url":null,"abstract":"<p><strong>Objective: </strong>This scoping review aims to examine studies led or participated in by clinical pharmacists or nurses, investigating the work performed and roles played by clinical pharmacists and nurses in managing patients' adverse reactions such as oral mucositis, summarizing the existing research foundation and evidence.</p><p><strong>Methods: </strong>This scoping review followed the methodology defined by the Joanna Briggs Institute, and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. Literature search was conducted in February 2024 across PubMed, Scopus, Cochrane, and Embase. Two independent researchers initially screened titles and abstracts in Covidence, followed by a full-text review. The extracted information and summaries were organized using Excel.</p><p><strong>Results: </strong>Twelve publications were included (randomized controls <i>n</i> = 8; retrospective descriptive studies <i>n</i> = 2; prospective cohort studies <i>n</i> = 2). Three publications studied clinical pharmacists providing pharmaceutical care to patients, while nine publications focused on nurses monitoring adverse reactions.</p><p><strong>Conclusion: </strong>In the chemoradiotherapy of head and neck cancers, the effective prevention and management of oral mucositis are crucial for improving patient prognosis. Clinical pharmacists and nurses, with their expertise and skills, play vital roles in the multidisciplinary treatment team, providing optimized treatment plans and comprehensive care support to patients. The direct care model implemented by pharmacists and nurses effectively alleviates symptoms and enhances the quality of life, thus fostering better treatment outcomes and patient satisfaction.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251339581"},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life among women with pelvic organ prolapse in West Ethiopia: A hospital-based study.","authors":"Leta Hinkosa Dinsa, Asfaw Tadesse Mengesha, Dereje Chala Diriba, Demisew Amenu Sori","doi":"10.1177/20503121251372748","DOIUrl":"10.1177/20503121251372748","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ prolapse is among the common gynecologic problems worldwide. Although mortality from pelvic organ prolapse is rare, it burdens social, psychological, economic, daily activities, and sexual life.</p><p><strong>Objectives: </strong>To assess the quality of life and associated factors among women with pelvic organ prolapse attending hospitals in Western, Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at four hospitals in West Ethiopia, from January 1 to June 15, 2023, involving women with pelvic organ prolapse. A single population proportion formula (95% confidence, 23.52% prevalence, 0.05 margin of error) yielded a sample size of 276. A validated quality of life tool by Digesu (2005) on the Prolapse quality of life questionnaire was administered by trained staff to assess quality of life. Data were analyzed using SPSS (version 26), employing descriptive statistics and bivariate analyses, with candidate variables for multivariable analysis selected at a <i>p</i> value of 0.25. Multivariable linear regression was performed after assessing model fit, considering a <i>p</i> < 0.05 as statistically significant.</p><p><strong>Results: </strong>A total of 232 (84.1% response rate) women attending or followed by four participating hospitals were involved in the study. The mean age of all women was 50.7 ± 9.2 years. Most of the participants (81.9%) were married; however, three women (1.3%) who were not married also developed a prolapse. Nearly a third (30.2%) had attended primary school; however, only 70 (30.2%) had no formal education. More than three-fourths (78.9%) had no mental or medical illnesses. The prolapse quality of life score was 45.3 ± 4.1. The higher quality of life was contributed to by sleep/energy and severity measures. Attending tertiary education and living with comorbidities were associated with quality of life.</p><p><strong>Conclusion: </strong>The quality of life of women living with pelvic organ prolapse was similar. It is affected by education levels and the presence of comorbidities. Further studies are warranted to establish the factors associated with quality of life by recruiting subjects through probability sampling methods.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251372748"},"PeriodicalIF":2.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring coping strategies for perinatal bereaved mothers with loss and its associated factors in public health facilities in Southwest Ethiopia.","authors":"Endale Tamiru Burayu, Gemechu Gelan Bekele, Zalika Kadir Shifaw","doi":"10.1177/20503121251376262","DOIUrl":"10.1177/20503121251376262","url":null,"abstract":"<p><strong>Background: </strong>Perinatal death, which includes stillbirth and early neonatal death, represents a profoundly distressing experience for mothers, particularly in low-resource environments where formal bereavement support is frequently inadequate. Despite the significant occurrence of perinatal loss in southwest Ethiopia, there is a lack of evidence regarding maternal coping mechanisms and the factors that influence them.</p><p><strong>Objective: </strong>The purpose of this study was to explore the coping strategies of perinatally bereaved mothers in public health facilities in Southwest Ethiopia, 2025.</p><p><strong>Methods: </strong>A descriptive cross-sectional study based in facilities was carried out from January to June 2025, involving 417 mothers with a history of perinatal death who were receiving maternal health services at public health facilities in Ilubabor and Buno Bedele Zones. Data collection was performed via the culturally adapted Brief Coping Orientation to Problems Experienced Inventory through face-to-face interviews. Multivariate logistic regression analysis was employed to determine the predictors of coping strategies via statistical software (Statistical Package for the Social Sciences 24 version) with a 95% confidence interval and a <i>p</i> < 0.05.</p><p><strong>Results: </strong>The prevalence of positive coping strategies among participants was 55.4% (95% confidence interval: 50.6%-60.2%). Significant factors of positive coping included sufficient social support (adjusted odds ratio = 4.10; 95% confidence interval: 1.91-8.81), maternal education at the secondary level or higher (adjusted odds ratio = 2.42; 95% confidence interval: 1.12-5.21), attendance at antenatal care (adjusted odds ratio = 2.37; 95% confidence interval: 1.05-5.33), high levels of religious involvement (adjusted odds ratio = 2.18; 95% confidence interval: 1.01-4.72), and access to bereavement counselling (adjusted odds ratio = 3.19; 95% confidence interval: 1.38-7.39). Negative coping strategies are often associated with stigma, low educational attainment, and inadequate access to healthcare.</p><p><strong>Conclusion: </strong>More than 44% of mothers resorted to negative coping strategies, highlighting a significant deficiency in bereavement support. Improving social, educational, and health system interventions-especially by incorporating bereavement counselling into public maternal health services-has the potential to enhance maternal mental health outcomes.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251376262"},"PeriodicalIF":2.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of electrolyte abnormalities in older adults with COVID-19 and delirium.","authors":"Milenko Petrovic, Esther Park, Gohar Azhar, Jeanne Wei","doi":"10.1177/20503121251380640","DOIUrl":"10.1177/20503121251380640","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective cohort study investigated the impact of COVID-19 on altered sodium and potassium in older adults with delirium compared to a non-COVID pneumonia control group.</p><p><strong>Methods: </strong>Electronic Medical Records (EMRs) from a university hospital database were reviewed for electrolyte abnormalities and delirium. We identified 319 patients with COVID-19, of which 108 (33.8%) had an episode of delirium during COVID. In a second cohort of 306 older adults with non-COVID pneumonias, we identified 106 (34.6%) with delirium during pneumonia.</p><p><strong>Results: </strong>Electrolyte disturbances were more commonly present in non-COVID pneumonias versus in those with COVID (<i>p</i> < 0.001). Hypokalemia was more frequent in the non-COVID group (<i>p</i> < 0.006), while hypernatremia was more often identified in the COVID group (<i>p</i> < 0.0321). Delirium in COVID patients was more commonly associated with hypernatremia than with other electrolyte abnormalities.</p><p><strong>Conclusions: </strong>Because hypernatremia can be associated with seizures and cerebral hemorrhage, our findings highlight the need for careful monitoring and management of hypernatremia in hospitalized COVID patients, especially in light of its observed association with delirium.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251380640"},"PeriodicalIF":2.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of second trimester uterine artery doppler in early prediction of preeclampsia and intrauterine growth restriction among high-risk Bahamian residents.","authors":"Azaria Clare, Vrunda Sakharkar","doi":"10.1177/20503121251378109","DOIUrl":"10.1177/20503121251378109","url":null,"abstract":"<p><strong>Background: </strong>Uterine artery doppler velocimetry has proven to be efficient in the prediction of preeclampsia and intrauterine growth restriction. We aimed to determine its value among high-risk Bahamian women and the most predictive parameter.</p><p><strong>Methods: </strong>We prospectively observed 128 women to detect the frequency of preeclampsia and intrauterine growth restriction development in relation to uterine artery doppler velocimetry. The main outcome measures were resistance index, pulsatility index and notching.</p><p><strong>Results: </strong>The mean difference of 0.082 (±0.011; 95% CI: -0.096, -0.069) in the resistance index and 0.122 (±0.011; 95% CI: -0.144, -0.100) in the pulsatility index between those without preeclampsia and those with, was statistically significant (<i>p</i> < 0.001). The mean RI had a better prognostic value than the mean pulsatility index (OR: 2.623E+51 (95% CI: 2.577E+25, 2.671E+77); <i>p</i> < 0.001. Notching showed a statistically significant with the development of intrauterine growth restriction.</p><p><strong>Conclusion: </strong>The best predictor of preeclampsia was the Resistance Index indices, while end diastolic notching was the best predictor for intrauterine growth restriction.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251378109"},"PeriodicalIF":2.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional and cultural determinants of condom use attitudes among HIV seropositive heterosexuals in Ghana: A cross-sectional study.","authors":"Abdul-Karim Abubakari, Janet Gross, Emmanuel Adusei-Poku, Isaac Kwabena Boateng, Richard Odame Asare, Phanuel Kelvin Dzamefe","doi":"10.1177/20503121251379306","DOIUrl":"10.1177/20503121251379306","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;There is a growing number of new Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome infections in Ghana despite the implementation of condom utilisation campaigns. Attitudes toward the use of condoms are culturally dependent, but most condom use attitude studies ignore this. Obstacles such as embarrassment to purchase or inability to negotiate use are due to Ghana's strong adversarial cultural norms against condom use.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;From February 2025 to April 2025, an institution-based cross-sectional study was carried out using a systematic sampling approach to select 1748 seropositive heterosexual participants from four regions of Ghana. The study utilised the University of Chicago Los Angeles Multidimensional Condom Attitudes Scale as the instrument for data collection. Condom use attitudes were evaluated based on the mean scores of the five psychometric properties of the scale. Multivariable logistic regression established the associations between dependent and independent variables. Outcome variables with a &lt;i&gt;p&lt;/i&gt;-value &lt; 0.05 were deemed statistically significant. The odds ratio with a 95% confidence interval was computed to determine the strength of an association.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Despite more than half of the respondents having positive condom use attitudes (&lt;i&gt;n&lt;/i&gt; = 884; 50.6%), the majority (&lt;i&gt;n&lt;/i&gt; = 1171; 67%) of respondents engaged in unprotected sex. While few participants in the Ashanti Region (&lt;i&gt;n&lt;/i&gt; = 120; 27.1%) and Bono Region (&lt;i&gt;n&lt;/i&gt; = 150; 34.4%) had a positive condom use attitude, the majority of participants in the Volta Region (&lt;i&gt;n&lt;/i&gt; = 336; 77.6%) and Central Regions (&lt;i&gt;n&lt;/i&gt; = 278; 63.3%) had a positive condom use attitude. Based on the means, perceived embarrassment about condom negotiation and use was high in the Ashanti Region (4.87 ± 1.12), Bono Region (4.68 ± 1.18), Central Region (4.41 ± 1.64), except the Volta Region (3.98 ± 1.38). Perceived embarrassment about condom purchase was high in the Ashanti Region (4.43 ± 1.10), Bono Region (4.19 ± 1.01), but low among counterparts in the Central (3.71 ± 1.35) and Volta (3.17 ± 1.89) Regions based on the means. Compared to participants in Ashanti Region, counterparts in the Bono Region (aOR = 0.64, 95% CI = 0.45-0.91), Central Region (aOR = 0.17, 95% CI = 0.12-0.25), and Volta Regions (aOR = 0.11, 95% CI = 0.08-0.17) had a lower likelihood of consistent condom use. Relative to participants who were sexually inactive, those who were sexually active had lower odds of using condoms (aOR = 0.74, 95% CI = 0.57-0.97).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Regions from which antiretroviral medications were obtained, engaging in sexual activity and frequency of condom use in the previous year, and the likelihood of condom use in the future were the determinants of condom use attitude. The Ashanti and Bono Regions had a negative condom use attitude due to high perceived sexual health stigma, h","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251379306"},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing guidelines-based multidisciplinary diabetic limb salvage programme: A 100-day review of clinical characteristics and outcomes.","authors":"Jaime Hui Xian Lin, Nicole Yi Xin Lim, Wai Han Hoi, Kwang Wei Tham, Caroline Hoong, Huilin Koh, Melvin Lee, Ye Ni Tham, Shaun Lee, Jo Ann Lim, Faezah Binte Sani, Seri Musfirah Binte Mustafah, Hannah Leong, James Siow, Kaamini Ravindran Pillay, Daniel Seng, Ernest Kwek, Yanli Shao, Sabariah Binte Kaspon, Yuan Teng Cho, Shaun Chan, Pravin Lingam, Sadhana Chandrasekar, Zhiwen Joseph Lo","doi":"10.1177/20503121251368698","DOIUrl":"10.1177/20503121251368698","url":null,"abstract":"<p><strong>Objectives: </strong>A newly established hospital in Singapore has introduced a pioneering multidisciplinary diabetic foot programme to provide comprehensive care for patients with diabetic foot ulcers. This study evaluates the early outcomes of a multidisciplinary diabetic limb salvage programme. Over the first 100 days of operation, the diabetic foot programme managed 106 patients.</p><p><strong>Methods: </strong>A descriptive statistical analysis was conducted to evaluate clinical characteristics and outcomes at 100 days of follow-up.</p><p><strong>Results: </strong>The majority of patients were Malay (46.2%) and male (61.3%), with a median age of 63.5 years. Most patients had long-standing diabetes and poor glycaemic control (77.8%), leading to high rates of diabetes-related complications. A total of 18.3% of patients had osteomyelitis, and 11.7% had gangrene. Of the 106 patients, 61.3% required inpatient management, 25.5% underwent revascularisation, and 34.9% had diabetic foot ulcer-related surgeries. According to Wound, Ischaemia and Foot Infection 12-month risk stratification, nearly 30% of patients were at medium to high risk of major lower extremity amputation. Minor lower extremity amputation occurred in 15.1% of patients and 4.7% required major lower extremity amputation. The 30-day mortality rate was 3.8%, and the average length of stay was 15.7 days. The time from admission to revascularisation was 4.4 days, and the time to diabetic foot ulcer-related surgery was 4.2 days. Wound healing was documented in 34.8% of patients at 100 days of follow-up, with a healing time of 63.2 days.</p><p><strong>Conclusion: </strong>Our guidelines based, multidisciplinary diabetic limb salvage programme demonstrated favourable limb salvage outcomes despite high predicted amputation risks. The early outcomes of this programme highlight the effectiveness of early medical optimisation, infection control, revascularisation and active wound care.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251368698"},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of anterior scleral thickness in Posner-Schlossman syndrome.","authors":"Mu Li, Dan Zhao, Xiaoqin Yan, Zhiqi Chen","doi":"10.1177/20503121251379680","DOIUrl":"10.1177/20503121251379680","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate changes in anterior scleral thickness (AST) in patients with Posner-Schlossman Syndrome (PSS).</p><p><strong>Methods: </strong>Sixty-two patients with PSS were enrolled. AST was measured using swept-source optical coherence tomography at 0 mm (AST0), 1 mm (AST1), 2 mm (AST2), and 3 mm (AST3) from the scleral spur.</p><p><strong>Results: </strong>AST0, AST1, AST2, and AST3 were significantly reduced in PSS-affected eyes compared with that in fellow eyes. Furthermore, we divided patients into two subgroups based on the course of PSS: the short-term (PSS course < 1 year) subgroup and the long-term (PSS course ⩾ 1 year) subgroup. In the short-term subgroup, no significant differences in AST parameters (AST0, AST1, AST2, and AST3) were observed in PSS-affected and fellow eyes, while in the long-term subgroup, all the AST parameters (AST0, AST1, AST2, and AST3) were significantly reduced in PSS-affected eyes compared with that in fellow eyes.</p><p><strong>Conclusions: </strong>PSS-affected eyes demonstrated significantly reduced AST compared with that in fellow eyes. Moreover, a significant reduction of the AST was observed in long-term PSS-affected eyes, but not in short-term PSS-affected eyes. This indicates that changes in AST in PSS are time-dependent and progressive. Significant reduction of the AST is observed only after a certain period of time.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251379680"},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}