Assessment of electrolyte abnormalities in older adults with COVID-19 and delirium.

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

SAGE Open Medicine Pub Date : 2025-09-28 eCollection Date: 2025-01-01 DOI:10.1177/20503121251380640

Milenko Petrovic, Esther Park, Gohar Azhar, Jeanne Wei

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Abstract

Objectives: This retrospective cohort study investigated the impact of COVID-19 on altered sodium and potassium in older adults with delirium compared to a non-COVID pneumonia control group.

Methods: Electronic Medical Records (EMRs) from a university hospital database were reviewed for electrolyte abnormalities and delirium. We identified 319 patients with COVID-19, of which 108 (33.8%) had an episode of delirium during COVID. In a second cohort of 306 older adults with non-COVID pneumonias, we identified 106 (34.6%) with delirium during pneumonia.

Results: Electrolyte disturbances were more commonly present in non-COVID pneumonias versus in those with COVID (p < 0.001). Hypokalemia was more frequent in the non-COVID group (p < 0.006), while hypernatremia was more often identified in the COVID group (p < 0.0321). Delirium in COVID patients was more commonly associated with hypernatremia than with other electrolyte abnormalities.

Conclusions: Because hypernatremia can be associated with seizures and cerebral hemorrhage, our findings highlight the need for careful monitoring and management of hypernatremia in hospitalized COVID patients, especially in light of its observed association with delirium.

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老年COVID-19伴谵妄患者电解质异常的评估。

目的：本回顾性队列研究探讨了与非COVID-19肺炎对照组相比，COVID-19对老年谵妄患者钠钾改变的影响。方法：对某大学医院数据库中电解质异常和谵妄的电子病历（EMRs）进行分析。我们确定了319例COVID-19患者，其中108例（33.8%）在COVID-19期间出现谵妄发作。在第二组306例非covid - 19肺炎老年人队列中，我们发现106例（34.6%）在肺炎期间出现谵妄。结论：由于高钠血症可能与癫痫发作和脑出血相关，我们的研究结果强调了住院的COVID患者需要仔细监测和管理高钠血症，特别是考虑到其与谵妄的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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