SAGE Open Medicine最新文献

{"title":"Marginal B-cell lymphoma: A 10-year retrospective study at national institute of hematology and blood transfusion, Vietnam.","authors":"Binh Duc Vu, Hung Quang Nguyen, Chiem Quang Le, Cuong Ba Nguyen, Tuong Quang Le, Anh Vu-Bao Nguyen, Thanh Hoang Nguyen, Tai Phu Le, Hieu Van Nguyen","doi":"10.1177/20503121251334508","DOIUrl":"https://doi.org/10.1177/20503121251334508","url":null,"abstract":"<p><strong>Objective: </strong>The prognostic factors of patients diagnosed with marginal zone B-cell lymphoma at the National Institute of Hematology and Blood Transfusion between January 2014 and January 2024 were analyzed.</p><p><strong>Subjects and methods: </strong>This cross-sectional descriptive study included 86 newly diagnosed and treated marginal zone B-cell lymphoma patients. Myelogram, histopathology, and immunohistochemical staining were performed for all patients. Diagnosis and classification were conducted according to the WHO 2008 criteria, while disease staging was determined using the Ann Arbor staging system.</p><p><strong>Results: </strong>All three subtypes of marginal zone B-cell lymphoma were identified: mucosa-associated lymphoid tissue lymphoma (73.3%), nodal marginal zone lymphoma (20.9%), and splenic marginal zone lymphoma (5.8%). The most frequently affected extranodal sites were the stomach (25.6%) and eyes (24.4%). The likelihood of stages III-IV disease was found to be 14 times higher in patients with B symptoms, 17 times higher in those with elevated lactate dehydrogenase, 34 times higher in those with increased B2-M levels, and 5.7 times higher in those with a Ki67 index > 30%. Bone marrow invasion was observed to be 14.8 times more likely in patients with elevated lactate dehydrogenase, 40 times more likely in those with increased B2-M levels, and 4.4 times more likely in those with a Ki67 index > 30%. A significant correlation was identified among hemoglobin concentration, lactate dehydrogenase, B2-M, and Ki67, indicating their potential as prognostic markers.</p><p><strong>Conclusion: </strong>Lactate dehydrogenase, B2-M, and Ki67 were found to be significantly associated with the prognosis of patients with marginal zone B-cell lymphoma.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251334508"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-energy computed tomography may reduce delayed diagnosis of occult hip fractures: Experiences at a single center.","authors":"Hirotaka Kawakami, Hiromi Sasaki, Junichi Kamizono, Yuki Yasutake, Kana Yamada, Suguru Saho, Takehiro Kawauchi, Noboru Taniguchi","doi":"10.1177/20503121251336301","DOIUrl":"https://doi.org/10.1177/20503121251336301","url":null,"abstract":"<p><strong>Objectives: </strong>Early surgical intervention within 48 h is critical for reducing mortality and morbidity in patients with hip fractures. However, occult hip fractures are often missed, leading to treatment delays. Dual-energy computed tomography allows visualization of bone marrow edema and bone contusions, which are challenging to detect using conventional computed tomography. This study aimed to evaluate the effectiveness of dual-energy computed tomography in diagnosing occult hip fractures.</p><p><strong>Methods: </strong>Eighteen dual-energy computed tomography scans obtained between May 2018 and March 2024 were analyzed. Magnetic resonance imaging was performed in all cases. A trained musculoskeletal radiologist interpreted the dual-energy computed tomography and magnetic resonance imaging scans, which were then reviewed by two senior orthopedic surgeons. The confirmed diagnoses included 14 femoral trochanteric fractures and 4 femoral neck fractures. Four junior orthopedic surgeons independently reviewed the dual-energy computed tomography scans only and conducted diagnostic examinations. Patients were subsequently categorized into two groups: those with unanimous diagnostic agreement (unanimity group) and those with discrepancies (objection group).</p><p><strong>Results: </strong>For femoral trochanteric fractures, sensitivity, specificity, accuracy, and Cohen's kappa coefficient were 94%, 81%, 0.91, and 0.75, respectively. For femoral neck fractures, sensitivity, specificity, accuracy, and Cohen's kappa coefficient were 68%, 96%, 0.90, and 0.69, respectively. A significant difference in diagnostic ease was noted (<i>p</i> = 0.04), with agreement achieved for 12 of the 14 femoral trochanteric fractures and one of the four femoral neck fractures. Logistic regression analysis yielded a regression coefficient for femoral trochanteric fractures of 3.05 (<i>p</i> = 0.03), indicating that these fractures were more easily diagnosed than femoral neck fractures.</p><p><strong>Conclusions: </strong>Dual-energy computed tomography demonstrated high sensitivity and specificity in detecting occult hip fractures, particularly those of the femoral trochanter. However, its sensitivity was lower for femoral neck fractures, indicating limited reliability in their diagnosis. Further investigation and magnetic resonance imaging scans are recommended for suspected femoral neck fractures.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251336301"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of fall risk in hospitalized patients and associated factors: A cross-sectional study and path analysis.","authors":"Ye Luo, Yuanfei Liu, Suxian Tan, Tian Xu, Guanjun Bao","doi":"10.1177/20503121251335811","DOIUrl":"https://doi.org/10.1177/20503121251335811","url":null,"abstract":"<p><strong>Background and purposes: </strong>Evidence regarding patients' perception of fall risk is scarce. This study aimed to investigate the current situation and the associated factors of patients' perception of fall risk, explore the mechanisms, and identify the subgroup of patients who may be at greater risk of having an erroneous perception.</p><p><strong>Methods: </strong>Participants were recruited from three wards of two tertiary general hospitals in China. Three-step multiple linear regression analyses were conducted including the demographic characteristics, health status factors, and fall-related factors as independent variables and Fall Risk Perception Questionnaire scores as dependent variable. The interactions of age, gender, and ward with fall-related factors were explored to test the potential moderating effects. We also examined the mediating role of fear of falling in the relationship of previous falls and age and perception of fall risk.</p><p><strong>Results: </strong>Patients who were in their older age, female, from endocrinology ward, had comorbidities, ambulatory aids, and fear of falling demonstrated a higher perception of fall risk which may or may not align with their actual risk of fall. The impact of previous fall injuries on perception of fall risk was significantly higher in older adults. The effects of fall-related training on patients' perception of fall risk varied across wards. The fear of falling is a significant mediator between age and perception of fall risk.</p><p><strong>Conclusion: </strong>By understanding the self-perception of fall risk, health professionals would identify the population at higher risk of having an erroneous perception of their fall risk. This study increases health professional's awareness and informs administrators to design and implement effective intervention and strategies that target patients' perception of fall risk to promote patient safety.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251335811"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving team dynamics in an acute older people care unit to improve quality and safety of care.","authors":"Rachid Akrour, Anja Pattschull, Suzana Stamenkovic, Catherine Courret Gilgen, Alberto Garcia Manjon, Yvan Bourgeois, Joachim Rapin","doi":"10.1177/20503121251333314","DOIUrl":"https://doi.org/10.1177/20503121251333314","url":null,"abstract":"<p><strong>Introduction: </strong>Several studies have demonstrated that the team dynamic among healthcare professionals has an impact on the quality of care, as well as the satisfaction of healthcare team members at work. The Input-Process-Output and Intervention model is one way to structure complex interventions with the aim of improving the team dynamic and evaluating their impact on the healthcare professional team, patients, and the organization.</p><p><strong>Objective: </strong>The objective of the study was to describe the steps and results of a quality improvement project aimed at improving the team dynamic of healthcare professionals in the acute older people care unit of a university hospital and improving outcomes for the healthcare professional team, patients, and the organization.</p><p><strong>Method: </strong>The project was based on the Deming cycle framework (Plan-Do-Check-Act) for improving the quality of care. It consisted of the following steps: (1) Implementation plan with an iterative process; (2) interventions according to the Input-Process-Output and Intervention model; and (3) evaluation of the impact of these interventions.</p><p><strong>Results: </strong>The results demonstrated an improvement in most healthcare professional team outcomes, particularly in terms of satisfaction and absenteeism, as well as organizational outcomes. Patient outcomes were highly satisfactory and relatively stable throughout the process.</p><p><strong>Conclusion: </strong>The integration of a healthcare professional team dynamic improvement model into quality and safety of care processes should be considered to optimize clinical and organizational outcomes.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251333314"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-related potential biomarkers in temporal lobe epilepsy: N170, vertex positive potential, late positive potential, and P3 signatures of depression comorbidity.","authors":"Weifeng Peng, Zihan Hu, Jia Liang, Jing Ding, Xin Wang","doi":"10.1177/20503121251335468","DOIUrl":"https://doi.org/10.1177/20503121251335468","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify which components of the event-related potentials N170, vertex positive potential, late positive potential, and P3 were most significantly associated with depression in temporal lobe epilepsy.</p><p><strong>Methods: </strong>Patients with temporal lobe epilepsy were divided into two groups based on the presence or absence of comorbid depression as diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: those with depression (epilepsy patients with depression group) and those without depression (epilepsy patients without depression group). Both groups were matched for age, education, and seizure-related parameters. A control group of volunteers without epilepsy and depression was also included. Participants underwent electroencephalographic recordings while performing the Oddball task, and the emotional conflict Stroop face-word task. The electroencephalographic data were analyzed using the EEGLAB software.</p><p><strong>Results: </strong>The study included 20 patients in the epilepsy patients with depression group and 16 in the epilepsy without depression group, matched for age, gender, and seizure-related parameters. In the epilepsy patients with depression group, the N170 peak amplitude and latency, the vertex positive potential peak latency, and the area under the late positive potential waveform were significantly greater, while the P3 peak latency was shorter compared to the epilepsy without depression group. The areas under the curve for N170, vertex positive potential, late positive potential, and P3 were 0.755, 0.692, 0.645, and 0.731, respectively. Notably, when these four event-related potential components were combined, the areas under the curve increased to 0.922, with a sensitivity of 0.950 and specificity of 0.812 for assessing depression based on the 17-item Hamilton Depression Rating Scale score.</p><p><strong>Conclusion: </strong>Specific features of N170, vertex positive potential, late positive potential, and P3 components were significantly associated with depression in patients with temporal lobe epilepsy. These findings suggest that event-related potential components may provide an objective and quantitative approach to enhance the assessment and treatment of depression in epilepsy.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251335468"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-based violence against men, a southeast Asian qualitative study.","authors":"Sashini Jayaratne, Kumudu Wijewardena","doi":"10.1177/20503121251335145","DOIUrl":"https://doi.org/10.1177/20503121251335145","url":null,"abstract":"<p><strong>Background and objectives: </strong>Gender-based violence is a major public health concern. Although, in many instances, violence against women and girls encompasses the entire spectrum of gender-based violence in the public eye, violence against men is a very real threat that is obscure and obliterated within cultural norms. Identification of the legal and cultural barriers men face is a very important step forward toward promoting gender equity. There is a severe paucity of research on gender-based violence against men in Sri Lanka.</p><p><strong>Methods: </strong>A qualitative study was conducted to explore the causes, effects, and help-seeking behaviors of men subjected to gender-based violence in the Colombo district, Sri Lanka. Two focus group discussions and two in-depth interviews were carried out among seventeen purposefully selected victims of gender-based violence and ten key informant interviews were carried out among service providers recruited purposefully in the Colombo district. Transcript analysis was done by using the thematic analysis method.</p><p><strong>Results: </strong>The study participants of the focus group discussions described themes of preconceived notions about the male sex, gender bias, power play, and masculinity norms as causes leading to gender-based violence. Many participants described their own or a peer's life experience to explain the experiences and consequences of gender-based violence. The key informant interview revealed certain aspects of the support systems which need revision in order to make the services more accessible to men.</p><p><strong>Conclusion: </strong>This study provides evidence regarding the hitherto undiscussed topic of gender-based violence against men in Sri Lanka. The findings highlight the importance of taking into consideration and inclusion of men in the development of policies for gender-based violence in Sri Lanka.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251335145"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study.","authors":"Weiran Hu, Kai Zhang, Guang Yang, Haoxu Wang, Yanzheng Gao","doi":"10.1177/20503121251335513","DOIUrl":"https://doi.org/10.1177/20503121251335513","url":null,"abstract":"<p><strong>Objective: </strong>Previous observational studies reported that ankylosing spondylitis is closely related to hypertension. However, it is still controversial whether the association between ankylosing spondylitis and hypertension is causal. The effects of ankylosing spondylitis on diastolic and systolic blood pressure deserve further investigation. The objective of our study is to explore whether ankylosing spondylitis is causally associated with blood pressure.</p><p><strong>Methods: </strong>A bidirectional two-sample Mendelian randomization (MR) analysis was performed by employing five Mendelian randomization analysis methods. MR Egger regression, weighted median, inverse variance weighted, and weight mode methods were performed in the two-sample Mendelian randomization analysis. We performed Mendelian randomization to investigate the association between ankylosing spondylitis (finn-b-M13_ANKYLOSPON) and hypertension (ukb-b-14057), diastolic blood pressure (ebi-a-GCST90000062) and systolic blood pressure (ebi-a-GCST90000059). We also performed reverse Mendelian randomization between exposures and outcomes. Another new validation cohort (ukb-b-18194) was also performed. The heterogeneity, horizontal pleiotropy, and possible outliers were examined in the MR analysis results.</p><p><strong>Results: </strong>The inverse variance weighted results showed that ankylosing spondylitis has no genetic causal relationship with hypertension (<i>p</i> = 0.441, OR = 1.001, 95% CI: 0.999-1.002). The inverse variance weighted results showed that ankylosing spondylitis has no genetic causal relationship with systolic blood pressure (<i>p</i> = 0.301, OR = 1.006, 95% CI: 0.995-1.018). The inverse variance weighted results showed that ankylosing spondylitis has no genetic causal relationship with diastolic blood pressure (<i>p</i> = 0.778, OR = 1.002, 95% CI: 0.988-1.016). The reverse Mendelian randomization between exposures and outcomes is negative. Another new validation cohort also confirmed the results. No heterogeneity was observed by the MR-pleiotropy residual sum and outlier test. The \"leave-one-out\" analysis indicated that the results of MR analysis were not affected by a single nucleotide polymorphism.</p><p><strong>Conclusion: </strong>This study represents the first two-sample Mendelian randomization analysis aimed at investigating the causal genetic relationship between ankylosing spondylitis and blood pressure. Our Mendelian randomization analysis results revealed a lack of causal association between ankylosing spondylitis and hypertension, diastolic blood pressure, as well as systolic blood pressure.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251335513"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center.","authors":"Haifa M Algethamy, Rufaydah Nasser Alhazmi, Firyal Kamal Alghalayini, Sarah Yasir Bahowarth, Nirmeen M Bukhari, Layan Bandar Alnosani, Samaher Khalid Dubaei, Razan Abdulelah Sait, Raghad Abdulaziz Mulla, Yasser Abdelghaffar Own, Adel M Alshabasy","doi":"10.1177/20503121251336069","DOIUrl":"https://doi.org/10.1177/20503121251336069","url":null,"abstract":"<p><strong>Background: </strong>Complicated skin and soft tissue infections often lead to poor health outcomes, with necrotizing skin and soft tissue infections occurring in 70%-80% of hospitalized patients and a mortality rate typically exceeding 20%. The current study's main objective was to identify early predictors of sepsis, intensive care unit admission, and mortality in hospitalized complicated skin and soft tissue infection patients.</p><p><strong>Methods: </strong>A retrospective review of records from 235 adult complicated skin and soft tissue infection patients admitted from 2012 to 2022 was conducted. Collected data included demographics, medical history, clinical presentation, treatment, and outcomes. Laboratory results were used to calculate the Laboratory Risk Indicator for Necrotizing Fasciitis score for diagnosing necrotizing fasciitis. Predictors of sepsis, intensive care unit admission, and death were identified using logistic regression analysis.</p><p><strong>Results: </strong>Of the 235 patients, 42.1% were wheelchair-bound or bedridden; 93.2% had diabetes, 76.2% had cardiovascular disease, and 33.6% had kidney disease. Necrotizing fasciitis criteria were met by 75% of patients. Sepsis was diagnosed in 27.7% of patients, while 30.6% required intensive care unit admission, and 20.4% did not survive hospital discharge. Low mean arterial pressure and vasopressor use were significant predictors of all three severe outcomes, with pre-existing kidney disease also a predictor of in-hospital death. The Glasgow Coma Scale predicted both intensive care unit admission and sepsis, but not death.</p><p><strong>Conclusions: </strong>Low mean arterial pressure, vasopressor use, and pre-existing kidney disease are key predictors of in-hospital death in patients hospitalized for complicated skin and soft tissue infection. The former two, and the patient's Glasgow Coma Scale, also appear to predict both intensive care unit admission and sepsis.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251336069"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thematic analysis of prognostic, diagnostic, and therapeutic of circulating miRNA biomarkers in bortezomib-resistant multiple myeloma.","authors":"Shafisha Bamfield-Cummings, Jeane Silva, Zubair A Karim","doi":"10.1177/20503121251328486","DOIUrl":"https://doi.org/10.1177/20503121251328486","url":null,"abstract":"<p><strong>Objective: </strong>The increasing demand for precision medicine has spurred molecular diagnostic investigations to emphasize the utility of miRNA as significant biomarkers. Recent studies have underscored miRNA's role as prognostic, diagnostic, and therapeutic biomarkers in managing and monitoring multiple myeloma patients. This review aims to present the latest insights on the potential of circulating miRNA as prognostic, diagnostic, and therapeutic biomarkers in bortezomib-resistant multiple myeloma.</p><p><strong>Methods: </strong>For this purpose, a comprehensive thematic literature review from January 2014 and August 2024 was conducted utilizing the databases CINAHL, Pubmed, and Google Scholar. Twenty pertinent studies were meticulously analyzed and categorized into the following sections: Bortezomib (BTZ) resistance in multiple myeloma, the predictive role of miRNAs in BTZ resistance, the impact of circulating miRNAs in multiple myeloma, and the potential of circulating miRNA as prognostic, diagnostic, and therapeutic biomarkers.</p><p><strong>Results: </strong>Of note, eight studies identified circulating miRNAs as diagnostic miRNA biomarkers (i.e., miR-744, miR-130a, let-7d, let-7e, miR-34a, etc.). In comparison, nine studies identified several circulating miRNAs that can be used as prognostic biomarkers (i.e., miR-20a, miR-483-5p, mir-1246, let-7a, let-7e, etc.). Moreover, five studies identified circulating miRNAs as promising therapeutic biomarkers (i.e., mir-15a, mir-92a, mir-19a, etc.). This discovery can significantly enhance early detection, accurate diagnosis, prognosis, overall survival rates, and quality of life for patients with multiple myeloma.</p><p><strong>Conclusion: </strong>Based on this evidence, exploring circulating miRNAs as a potential noninvasive biomarker for multiple myeloma represents a noteworthy advancement. This is attributed to the abundance of miRNAs in plasma or serum, which exhibits remarkable stability against enzymatic degradation.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251328486"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating adverse events of pegvaliase-pqpz in phenylketonuria treatment: A comprehensive safety assessment.","authors":"Kai Yan, Li Zhang, Guang Yang, Lixuan Yan, Li Wu, Peifeng He, Qi Yu","doi":"10.1177/20503121251330187","DOIUrl":"https://doi.org/10.1177/20503121251330187","url":null,"abstract":"<p><strong>Objectives: </strong>In 2018, the Food and Drug Administration approved pegvaliase-pqpz as an enzyme replacement therapy to lower blood phenylalanine levels in adults with phenylketonuria. However, its potential side effects have not been fully explored in a real-world setting. This study aimed to examine pegvaliase-pqpz-related adverse events and investigate their associated risk factors to offer important insights into clinical drug applications.</p><p><strong>Methods: </strong>We extracted reports on adverse events from Food and Drug Administration Adverse Event Reporting System database from 2018Q2 to 2024Q3. The analyses included demographic data, time-to-onset, sex, age, dosage, reporting personnel, and subgroup signals. The Reporting Odds Ratio, Proportional Reporting Ratio, Bayesian Confidence Propagation Neural Network, and Multi-item Gamma Poisson Shrinker were used for disproportionality analysis. A screening procedure was implemented for designated medical events, focusing on medication-related adverse events.</p><p><strong>Results: </strong>A total of 6264 reports were identified. Arthralgia was the most frequently reported adverse events. Lymphadenopathy, serum sickness, and tunnel vision were identified as unexpected signals. Weibull distribution analysis revealed that the incidence of adverse events decreased over time.</p><p><strong>Conclusions: </strong>Our study provides a deeper insight into the safety profile of pegvaliase-pqpz, thereby aiding healthcare professionals in clinical surveillance and risk identification.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"13 ","pages":"20503121251330187"},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}